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SLC16A3 (solute carrier family 16, member 3 (monocarboxylic acid transporter 4))

Written2010-03Céline Pinheiro, Fátima Baltazar
Life, Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal

(Note : for Links provided by Atlas : click)


Alias (NCBI)MCT3
HGNC (Hugo) SLC16A3
HGNC Alias symbMCT3
HGNC Previous name"solute carrier family 16 (monocarboxylic acid transporters), member 3
 solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
 solute carrier family 16 (monocarboxylate transporter), member 3"
LocusID (NCBI) 9123
Atlas_Id 44573
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 82229011 and ends at 82239499 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping SLC16A3.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAIAP2 (17q25.3) / SLC16A3 (17q25.3)HEXDC (17q25.3) / SLC16A3 (17q25.3)SLC16A3 (17q25.3) / FTH1 (11q12.3)
SLC16A3 (17q25.3) / MRPL4 (19p13.2)SLC16A3 (17q25.3) / RNF213 (17q25.3)SLC16A3 (17q25.3) / SLC16A3 (17q25.3)


Note SLC16A3 was first cloned from human circulating blood by Price et al. (1998).
Description 11077 bp lenght, 5 exons.
Transcription 3 transcripts have been described for this gene (all with protein product): SLC16A3-201, (5 exons; 2033 bps transcript length; 465 residues translation length); SLC16A3-202 (4 exons; 4222 bps transcript length; 465 residues translation length); SLC16A3-203 (5 exons; 2054 bps transcript length; 465 residues translation length).


  Protein diagram drawn following UniProtKB/Swiss-Prot database prediction, using TMRPres2D software.
Description 465 residues; 49469 Da; 12 transmembrane domains; intracellular N- and C-terminals.
Expression SLC16A3/MCT4 is expressed in tissues such as white skeletal muscle fibres, astrocytes, white blood cells, chondrocytes, testis, lung, placenta, heart and some mammalian cell lines (Halestrap and Meredith, 2004; Meredith and Christian, 2008).
Localisation Plasma membrane.
Function Proton-linked monocarboxylate transporter. Catalyzes plasma membrane transport of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Homology Belongs to the major facilitator superfamily (MFS). Monocarboxylate porter (TC 2.A.1.13) family. The SLC16A3 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and M. grisea.

Implicated in

Entity Colorectal carcinoma
Note SLC16A3/MCT4 protein is overexpressed in colorectal cancer (Pinheiro et al., 2008a).
Entity Cervical cancer
Note SLC16A3/MCT4 protein is overexpressed in cervical cancer (Pinheiro et al., 2008b). SLC16A3/MCT4 protein overexpression in cervical cancer correlated with positivity for high-risk HPV (Pinheiro et al., 2008b).
Entity Bladder cancer
Note SLC16A3 gene expression was upregulated in some bladder tumours and induced by hypoxia in bladder cancer cell lines, but not in cultures of normal urothelium (Ord et al., 2005).
Entity Breast cancer
Note Induction was also seen in two breast cancer cell lines. Expression of SLC16A3 gene is higher in breast cancer distant metastasis as compared to primary tumours or regional metastasis. SLC16A3 gene was then included in the 'VEGF profile' of breast cancer, associated with promotion of vessel formation, survival under anaerobic conditions and loss of dependence upon fibroblasts (Hu et al., 2009).
Entity Ovarian cancer
Note SLC16A3 gene expression was described to be downregulated in malignant ovarian tumours as compared to normal ovarian surface epithelial cells. Additionally, the non-tumorigenic cell line TOV-81D presented higher expression that tumorigenic cell lines (Wojnarowicz et al., 2008).
SLC16A3 gene, among other transporter genes, was differentially expressed in a chemotherapy resistant ovarian cancer cell line and tumour tissue as compared to a chemosensitive cell line and tumour tissue. It was suggested that these transporters might be involved in drug influx/efflux, modulating chemotherapy response (Cheng et al., 2010).
Entity Mitochondrial myopathy
Note SLC16A3/MCT4 overexpression was described in a patient with a mitochondrial myopathy (Baker et al., 2001).
Entity Chronic obstructive pulmonary disease
Note SLC16A3/MCT4 downregulation was described in the vastus lateralis muscle of patients with chronic obstructive pulmonary disease as compared with healthy controls (Green et al., 2008).


Expression of MCT1 and MCT4 in a patient with mitochondrial myopathy.
Baker SK, Tarnopolsky MA, Bonen A.
Muscle Nerve. 2001 Mar;24(3):394-8.
PMID 11353425
Analysis of chemotherapy response programs in ovarian cancers by the next-generation sequencing technologies.
Cheng L, Lu W, Kulkarni B, Pejovic T, Yan X, Chiang JH, Hood L, Odunsi K, Lin B.
Gynecol Oncol. 2010 Feb 22. [Epub ahead of print]
PMID 20181382
Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease.
Green HJ, Burnett ME, D'Arsigny CL, O'Donnell DE, Ouyang J, Webb KA.
J Appl Physiol. 2008 Sep;105(3):879-86. Epub 2008 Jul 17.
PMID 18635880
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.
Halestrap AP, Meredith D.
Pflugers Arch. 2004 Feb;447(5):619-28. Epub 2003 May 9.
PMID 12739169
A compact VEGF signature associated with distant metastases and poor outcomes.
Hu Z, Fan C, Livasy C, He X, Oh DS, Ewend MG, Carey LA, Subramanian S, West R, Ikpatt F, Olopade OI, van de Rijn M, Perou CM.
BMC Med. 2009 Mar 16;7:9.
PMID 19291283
The SLC16 monocaboxylate transporter family.
Meredith D, Christian HC.
Xenobiotica. 2008 Jul;38(7-8):1072-106. (REVIEW)
PMID 18668440
Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer.
Ord JJ, Streeter EH, Roberts IS, Cranston D, Harris AL.
Br J Cancer. 2005 Aug 8;93(3):346-54.
PMID 16052224
Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma.
Pinheiro C, Longatto-Filho A, Ferreira L, Pereira SM, Etlinger D, Moreira MA, Jube LF, Queiroz GS, Schmitt F, Baltazar F.
Int J Gynecol Pathol. 2008b Oct;27(4):568-74.
PMID 18753962
Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.
Price NT, Jackson VN, Halestrap AP.
Biochem J. 1998 Jan 15;329 ( Pt 2):321-8.
PMID 9425115
Construction of a chromosome 17 transcriptome in serous ovarian cancer identifies differentially expressed genes.
Wojnarowicz PM, Breznan A, Arcand SL, Filali-Mouhim A, Provencher DM, Mes-Masson AM, Tonin PN.
Int J Gynecol Cancer. 2008 Sep-Oct;18(5):963-75. Epub 2007 Nov 20.
PMID 18028382


This paper should be referenced as such :
Pinheiro, C ; Baltazar, F
SLC16A3 (solute carrier family 16, member 3 (monocarboxylic acid transporter 4))
Atlas Genet Cytogenet Oncol Haematol. 2010;14(12):1157-1159.
Free journal version : [ pdf ]   [ DOI ]

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;19)(q25;p13) SLC16A3/MRPL4

External links

HGNC (Hugo)SLC16A3   10924
Entrez_Gene (NCBI)SLC16A3    solute carrier family 16 member 3
AliasesMCT; MCT; MCT-3; MCT-4; 
GeneCards (Weizmann)SLC16A3
Ensembl hg19 (Hinxton)ENSG00000141526 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141526 [Gene_View]  ENSG00000141526 [Sequence]  chr17:82229011-82239499 [Contig_View]  SLC16A3 [Vega]
ICGC DataPortalENSG00000141526
TCGA cBioPortalSLC16A3
AceView (NCBI)SLC16A3
Genatlas (Paris)SLC16A3
SOURCE (Princeton)SLC16A3
Genetics Home Reference (NIH)SLC16A3
Genomic and cartography
GoldenPath hg38 (UCSC)SLC16A3  -     chr17:82229011-82239499 +  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC16A3  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathSLC16A3 - 17q25.3 [CytoView hg19]  SLC16A3 - 17q25.3 [CytoView hg38]
genome Data Viewer NCBISLC16A3 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA448579 AK127319 AK223040 BC112267 BC112269
RefSeq transcript (Entrez)NM_001042422 NM_001042423 NM_001206950 NM_001206951 NM_001206952 NM_004207
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC16A3
Alternative Splicing GalleryENSG00000141526
Gene ExpressionSLC16A3 [ NCBI-GEO ]   SLC16A3 [ EBI - ARRAY_EXPRESS ]   SLC16A3 [ SEEK ]   SLC16A3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC16A3 [ Firebrowse - Broad ]
GenevisibleExpression of SLC16A3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9123
GTEX Portal (Tissue expression)SLC16A3
Human Protein AtlasENSG00000141526-SLC16A3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15427   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15427  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15427
Splice isoforms : SwissVarO15427
Domaine pattern : Prosite (Expaxy)MFS (PS50850)   
Domains : Interpro (EBI)MCT    MCT4    MFS    MFS_dom    MFS_trans_sf   
Domain families : Pfam (Sanger)MFS_1 (PF07690)   
Domain families : Pfam (NCBI)pfam07690   
Conserved Domain (NCBI)SLC16A3
Blocks (Seattle)SLC16A3
Human Protein Atlas [tissue]ENSG00000141526-SLC16A3 [tissue]
Peptide AtlasO15427
Protein Interaction databases
IntAct (EBI)O15427
Ontologies - Pathways
Ontology : AmiGORNA binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  pyruvate metabolic process  monocarboxylic acid transmembrane transporter activity  lactate transmembrane transporter activity  symporter activity  monocarboxylic acid transport  membrane  integral component of membrane  nuclear membrane  plasma membrane lactate transport  leukocyte migration  parallel fiber to Purkinje cell synapse  integral component of postsynaptic density membrane  
Ontology : EGO-EBIRNA binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  pyruvate metabolic process  monocarboxylic acid transmembrane transporter activity  lactate transmembrane transporter activity  symporter activity  monocarboxylic acid transport  membrane  integral component of membrane  nuclear membrane  plasma membrane lactate transport  leukocyte migration  parallel fiber to Purkinje cell synapse  integral component of postsynaptic density membrane  
REACTOMEO15427 [protein]
REACTOME PathwaysR-HSA-70268 [pathway]   
NDEx NetworkSLC16A3
Atlas of Cancer Signalling NetworkSLC16A3
Wikipedia pathwaysSLC16A3
Orthology - Evolution
GeneTree (enSembl)ENSG00000141526
Phylogenetic Trees/Animal Genes : TreeFamSLC16A3
Homologs : HomoloGeneSLC16A3
Homology/Alignments : Family Browser (UCSC)SLC16A3
Gene fusions - Rearrangements
Fusion : MitelmanSLC16A3/MRPL4 [17q25.3/19p13.2]  
Fusion : Fusion_HubAATK--SLC16A3    ACTB--SLC16A3    ALDOA--SLC16A3    ASPSCR1--SLC16A3    B2M--SLC16A3    BAIAP2--SLC16A3    BSG--SLC16A3    C17ORF62--SLC16A3    CIZ1--SLC16A3    CXCR4--SLC16A3    DDX5--SLC16A3    HDAC4--SLC16A3    HEXDC--SLC16A3    IGF2--SLC16A3    KDM4B--SLC16A3   
MBP--SLC16A3    MEG3--SLC16A3    METRNL--SLC16A3    MNT--SLC16A3    OAZ1--SLC16A3    PFKFB3--SLC16A3    PGS1--SLC16A3    SBNO2--SLC16A3    SECTM1--SLC16A3    SH2B2--SLC16A3    SLC16A3--C17ORF62    SLC16A3--CTBP1    SLC16A3--FMNL1    SLC16A3--FTH1    SLC16A3--KDM6B   
SLC16A3--METRNL    SLC16A3--MUC5B    SLC16A3--NELFB    SLC16A3--PER1    SLC16A3--RNF213    SLC16A3--RXRA    SLC16A3--SECTM1    SLC16A3--SLC16A3    SLC16A3--TG    TAPBP--SLC16A3    TTN--SLC16A3   
Fusion : QuiverSLC16A3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC16A3 [hg38]
Exome Variant ServerSLC16A3
GNOMAD BrowserENSG00000141526
Varsome BrowserSLC16A3
Genomic Variants (DGV)SLC16A3 [DGVbeta]
DECIPHERSLC16A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC16A3 
ICGC Data PortalSLC16A3 
TCGA Data PortalSLC16A3 
Broad Tumor PortalSLC16A3
OASIS PortalSLC16A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC16A3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC16A3
Mutations and Diseases : HGMDSLC16A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC16A3
DgiDB (Drug Gene Interaction Database)SLC16A3
DoCM (Curated mutations)SLC16A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC16A3 (select a term)
NCG6 (London) select SLC16A3
Cancer3DSLC16A3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry SLC16A3
NextProtO15427 [Medical]
Target ValidationSLC16A3
Huge Navigator SLC16A3 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA35815
Clinical trialSLC16A3
canSAR (ICR)SLC16A3 (select the gene name)
DataMed IndexSLC16A3
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 19 18:00:20 CET 2021

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