| Written | 2011-10 | Renty B Franklin, Leslie C Costello |
| Department of Oncology, Diagnostic Sciences, Dental School, The Greenebaum Cancer Center, University of Maryland, Baltimore, MD, 21201, USA |
| Identity |
| Alias (NCBI) | ZIP1 | ZIRTL |
| HGNC (Hugo) | SLC39A1 |
| HGNC Alias symb | ZIP1 |
| HGNC Previous name | ZIRTL |
| HGNC Previous name | zinc/iron regulated transporter-like | solute carrier family 39 (zinc transporter), member 1 |
| LocusID (NCBI) | 27173 |
| Atlas_Id | 46571 |
| Location | 1q21.3 [Link to chromosome band 1q21] |
| Location_base_pair | Starts at 153959110 and ends at 153967725 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping SLC39A1.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| HSD11B2 (16q22.1) / SLC39A1 (1q21.3) | SLC39A1 (1q21.3) / BLK (8p23.1) | SLC39A1 (1q21.3) / CRTC2 (1q21.3) | |
| SLC39A1 (1q21.3) / PARD3 (10p11.22) | SLC39A1 (1q21.3) / RAB13 (1q21.3) |
| DNA/RNA |
| Description | The SLC39A1 gene contains 5 exons, three of which are coding. The length of the gene is 8600 base pairs according to the Entrez Gene database. Several transcripts have been reported containing either 3, 4, or 5 exons. However, the coding sequence for SLC39A1 is the same for all reported transcripts. |
| Transcription | Only a single isoform has been reported; mRNA 2445 bases in length; coding region of 975 bases. |
| Pseudogene | None reported. |
| Protein |
| Description | SLC39A1 encodes Zrt/Irt-like protein family member 1 (ZIP1). ZIP1 is a 35 kDa molecular weight protein consisting of 324 amino acids. The protein contains 8 transmembrane spanning domains and shows the characteristics of a zinc transporter (Gaither and Eide, 2001). |
| Expression | ZIP1 is ubiquitously expressed in mammalian cells (Gaither and Eide, 2001). Expression is down regulated in prostate malignancy (Franklin et al., 2005). Its constitutive expression is reported to be regulated by SP and CREB1 (Makhov et al., 2009). Down regulation of expression in prostate malignancy is reported due to transcription repression by ras response element binding protein-1 (RREB-1) (Milon et al., 2010). |
| Localisation | ZIP1 is located at the cell membrane. |
| Function | ZIP1 is a facilitated zinc uptake transporter (Franklin et al., 2003). Activity of the transporter results in the intracellular accumulation of zinc. ZIP1 is involved in apoptosis induction in prostate cancer cells. |
| Homology | Mus musculus Slc39a1; Rattus norvegicus Slc39a1; Bos taurus Slc39a1; Danio rerio slc39a1. |
| Mutations |
| Note | No diseases related to mutation are reported. |
| Implicated in |
| Note | |
| Entity | Prostate cancer |
| Note | SLC39A1 is down regulated in prostate cancer (Franklin et al., 2005). Knockdown of the SLC39A1 expression decreases cellular zinc and increases growth of PC-3 cells (Franklin et al., 2003). Over expression of SLC39A1 inhibits prostate tumor growth in a xenograft model (Golovine et al., 2008). |
| Bibliography |
| hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. |
| Franklin RB, Feng P, Milon B, Desouki MM, Singh KK, Kajdacsy-Balla A, Bagasra O, Costello LC. |
| Mol Cancer. 2005 Sep 9;4:32. |
| PMID 16153295 |
| The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. |
| Gaither LA, Eide DJ. |
| J Biol Chem. 2001 Jun 22;276(25):22258-64. Epub 2001 Apr 11. |
| PMID 11301334 |
| Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. |
| Golovine K, Makhov P, Uzzo RG, Shaw T, Kunkle D, Kolenko VM. |
| Clin Cancer Res. 2008 Sep 1;14(17):5376-84. |
| PMID 18765529 |
| Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cells. |
| Makhov P, Golovine K, Uzzo RG, Wuestefeld T, Scoll BJ, Kolenko VM. |
| Gene. 2009 Feb 15;431(1-2):39-46. Epub 2008 Nov 5. |
| PMID 19026724 |
| Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells. |
| Milon BC, Agyapong A, Bautista R, Costello LC, Franklin RB. |
| Prostate. 2010 Feb 15;70(3):288-96. |
| PMID 19802870 |
| Citation |
| This paper should be referenced as such : |
| Franklin, RB ; Costello, LC |
| SLC39A1 (solute carrier family 39 (zinc transporter), member 1) |
| Atlas Genet Cytogenet Oncol Haematol. 2012;16(3):218-219. |
| Free journal version : [ pdf ] [ DOI ] |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
SLC39A1/CRTC2 (1q21)
SLC39A1/CRTC2 (1q21) SLC39A1/CRTC2 (1q21) |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Jan 1 19:01:35 CET 2021 |
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