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SLPI (secretory leukocyte peptidase inhibitor)

Identity

Alias_namessecretory leukocyte protease inhibitor (antileukoproteinase)
Alias_symbol (synonym)HUSI-I
ALK1
ALP
BLPI
HUSI
WAP4
WFDC4
Other aliasMPI
HGNC (Hugo) SLPI
LocusID (NCBI) 6590
Atlas_Id 46048
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 45252239 and ends at 45254564 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C16orf74 (16q24.1) / SLPI (20q13.12)SEC14L2 (22q12.2) / SLPI (20q13.12)SLPI (20q13.12) / APPBP2 (17q23.2)
SLPI (20q13.12) / ARHGAP10 (4q31.23)SLPI (20q13.12) / LRP1 (12q13.3)SLPI (20q13.12) / SEC14L2 (22q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLPI   11092
Cards
Entrez_Gene (NCBI)SLPI  6590  secretory leukocyte peptidase inhibitor
AliasesALK1; ALP; BLPI; HUSI; 
HUSI-I; MPI; WAP4; WFDC4
GeneCards (Weizmann)SLPI
Ensembl hg19 (Hinxton)ENSG00000124107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124107 [Gene_View]  chr20:45252239-45254564 [Contig_View]  SLPI [Vega]
ICGC DataPortalENSG00000124107
TCGA cBioPortalSLPI
AceView (NCBI)SLPI
Genatlas (Paris)SLPI
WikiGenes6590
SOURCE (Princeton)SLPI
Genetics Home Reference (NIH)SLPI
Genomic and cartography
GoldenPath hg38 (UCSC)SLPI  -     chr20:45252239-45254564 -  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLPI  -     20q13.12   [Description]    (hg19-Feb_2009)
EnsemblSLPI - 20q13.12 [CytoView hg19]  SLPI - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBISLPI [Mapview hg19]  SLPI [Mapview hg38]
OMIM107285   
Gene and transcription
Genbank (Entrez)AF114471 AK312192 AX772818 BC020708 DQ891365
RefSeq transcript (Entrez)NM_003064
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLPI
Cluster EST : UnigeneHs.517070 [ NCBI ]
CGAP (NCI)Hs.517070
Alternative Splicing GalleryENSG00000124107
Gene ExpressionSLPI [ NCBI-GEO ]   SLPI [ EBI - ARRAY_EXPRESS ]   SLPI [ SEEK ]   SLPI [ MEM ]
Gene Expression Viewer (FireBrowse)SLPI [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6590
GTEX Portal (Tissue expression)SLPI
Protein : pattern, domain, 3D structure
UniProt/SwissProtP03973   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP03973  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP03973
Splice isoforms : SwissVarP03973
PhosPhoSitePlusP03973
Domaine pattern : Prosite (Expaxy)WAP (PS51390)   
Domains : Interpro (EBI)ALP    WAP_dom   
Domain families : Pfam (Sanger)WAP (PF00095)   
Domain families : Pfam (NCBI)pfam00095   
Domain families : Smart (EMBL)WAP (SM00217)  
Conserved Domain (NCBI)SLPI
DMDM Disease mutations6590
Blocks (Seattle)SLPI
PDB (SRS)2Z7F    4DOQ   
PDB (PDBSum)2Z7F    4DOQ   
PDB (IMB)2Z7F    4DOQ   
PDB (RSDB)2Z7F    4DOQ   
Structural Biology KnowledgeBase2Z7F    4DOQ   
SCOP (Structural Classification of Proteins)2Z7F    4DOQ   
CATH (Classification of proteins structures)2Z7F    4DOQ   
SuperfamilyP03973
Human Protein AtlasENSG00000124107
Peptide AtlasP03973
HPRD00121
IPIIPI00008580   
Protein Interaction databases
DIP (DOE-UCLA)P03973
IntAct (EBI)P03973
FunCoupENSG00000124107
BioGRIDSLPI
STRING (EMBL)SLPI
ZODIACSLPI
Ontologies - Pathways
QuickGOP03973
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular space  Golgi apparatus  immune response  negative regulation of endopeptidase activity  antibacterial humoral response  antibacterial humoral response  enzyme binding  extracellular matrix  negative regulation of protein binding  response to lipopolysaccharide  specific granule lumen  neutrophil degranulation  negative regulation of viral genome replication  innate immune response  extracellular exosome  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  extracellular space  Golgi apparatus  immune response  negative regulation of endopeptidase activity  antibacterial humoral response  antibacterial humoral response  enzyme binding  extracellular matrix  negative regulation of protein binding  response to lipopolysaccharide  specific granule lumen  neutrophil degranulation  negative regulation of viral genome replication  innate immune response  extracellular exosome  
Pathways : BIOCARTAProepithelin Conversion to Epithelin and Wound Repair Control [Genes]   
NDEx NetworkSLPI
Atlas of Cancer Signalling NetworkSLPI
Wikipedia pathwaysSLPI
Orthology - Evolution
OrthoDB6590
GeneTree (enSembl)ENSG00000124107
Phylogenetic Trees/Animal Genes : TreeFamSLPI
HOVERGENP03973
HOGENOMP03973
Homologs : HomoloGeneSLPI
Homology/Alignments : Family Browser (UCSC)SLPI
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLPI [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLPI
dbVarSLPI
ClinVarSLPI
1000_GenomesSLPI 
Exome Variant ServerSLPI
ExAC (Exome Aggregation Consortium)SLPI (select the gene name)
Genetic variants : HAPMAP6590
Genomic Variants (DGV)SLPI [DGVbeta]
DECIPHERSLPI [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLPI 
Mutations
ICGC Data PortalSLPI 
TCGA Data PortalSLPI 
Broad Tumor PortalSLPI
OASIS PortalSLPI [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLPI  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLPI
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLPI
DgiDB (Drug Gene Interaction Database)SLPI
DoCM (Curated mutations)SLPI (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLPI (select a term)
intoGenSLPI
Cancer3DSLPI(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107285   
Orphanet
MedgenSLPI
Genetic Testing Registry SLPI
NextProtP03973 [Medical]
TSGene6590
GENETestsSLPI
Target ValidationSLPI
Huge Navigator SLPI [HugePedia]
snp3D : Map Gene to Disease6590
BioCentury BCIQSLPI
ClinGenSLPI
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6590
Chemical/Pharm GKB GenePA35944
Clinical trialSLPI
Miscellaneous
canSAR (ICR)SLPI (select the gene name)
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLPI
EVEXSLPI
GoPubMedSLPI
iHOPSLPI
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:56:25 CEST 2017

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