SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. |
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British journal of haematology. 2005 ; 130 (2) : 209-217. |
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Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. |
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SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. |
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A new protein containing an SH2 domain that inhibits JAK kinases. |
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The Journal of clinical investigation. 2006 ; 116 (1) : 90-100. |
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Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients. |
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British journal of cancer. 2003 ; 89 (2) : 338-343. |
PMID 12865927 |
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SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. |
Galm O, Yoshikawa H, Esteller M, Osieka R, Herman JG |
Blood. 2003 ; 101 (7) : 2784-2788. |
PMID 12456503 |
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IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. |
Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A |
The Journal of experimental medicine. 2006 ; 203 (6) : 1391-1397. |
PMID 16717119 |
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The SOCS-1 gene methylation in chronic myeloid leukemia patients. |
Hatirnaz O, Ure U, Ar C, Akyerli C, Soysal T, Ferhanoglu B, Ozçelik T, Ozbek U |
American journal of hematology. 2007 ; 82 (8) : 729-730. |
PMID 17315216 |
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SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. |
He Y, Zhang W, Zhang R, Zhang H, Min W |
The Journal of biological chemistry. 2006 ; 281 (9) : 5559-5566. |
PMID 16407264 |
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Twenty proteins containing a C-terminal SOCS box form five structural classes. |
Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA |
Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (1) : 114-119. |
PMID 9419338 |
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Regulation of cytokine receptor signaling by SOCS1. |
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Immunological reviews. 2003 ; 192 : 196-211. |
PMID 12670405 |
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Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia. |
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British journal of haematology. 2005 ; 129 (1) : 60-65. |
PMID 15801956 |
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Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. |
Komazaki T, Nagai H, Emi M, Terada Y, Yabe A, Jin E, Kawanami O, Konishi N, Moriyama Y, Naka T, Kishimoto T |
Japanese journal of clinical oncology. 2004 ; 34 (4) : 191-194. |
PMID 15121754 |
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A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13. |
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Somatic cell and molecular genetics. 1998 ; 24 (2) : 131-133. |
PMID 9919312 |
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Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia. |
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British journal of haematology. 2003 ; 123 (4) : 654-661. |
PMID 14616969 |
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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. |
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Cell. 1999 ; 98 (5) : 609-616. |
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Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. |
Melzner I, Weniger MA, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Leithäuser F, Ritz O, Dyer MJ, Barth TF, Möller P |
International journal of cancer. Journal international du cancer. 2006 ; 118 (8) : 1941-1944. |
PMID 16287070 |
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Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). |
Metcalf D, Mifsud S, Di Rago L, Nicola NA, Hilton DJ, Alexander WS |
Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (2) : 943-948. |
PMID 11782537 |
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Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma. |
Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K |
Journal of gastroenterology. 2004 ; 39 (6) : 563-569. |
PMID 15235874 |
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Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis. |
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Journal of hepatology. 2001 ; 34 (3) : 416-421. |
PMID 11322203 |
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Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. |
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Journal of human genetics. 2003 ; 48 (2) : 65-69. |
PMID 12601549 |
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SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. |
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The Journal of biological chemistry. 1997 ; 272 (43) : 27178-27182. |
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Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis. |
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Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 ; 9 (14) : 5295-5298. |
PMID 14614012 |
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Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma. |
Oshimo Y, Kuraoka K, Nakayama H, Kitadai Y, Yoshida K, Chayama K, Yasui W |
International journal of cancer. Journal international du cancer. 2004 ; 112 (6) : 1003-1009. |
PMID 15386345 |
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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. |
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PMID 9826711 |
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A family of cytokine-inducible inhibitors of signalling. |
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TRIM8/GERP RING finger protein interacts with SOCS-1. |
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The Journal of biological chemistry. 2002 ; 277 (40) : 37315-37322. |
PMID 12163497 |
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SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. |
Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB |
Molecular and cellular biology. 2004 ; 24 (20) : 9092-9101. |
PMID 15456882 |
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Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. |
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Oncogene. 2006 ; 25 (18) : 2679-2684. |
PMID 16532038 |
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Clinical implications of SOCS1 methylation in myelodysplastic syndrome. |
Wu SJ, Yao M, Chou WC, Tang JL, Chen CY, Ko BS, Huang SY, Tsay W, Chen YC, Shen MC, Wang CH, Yeh YC, Tien HF |
British journal of haematology. 2006 ; 135 (3) : 317-323. |
PMID 16978223 |
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The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. |
Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU |
The Journal of clinical investigation. 2003 ; 111 (4) : 469-478. |
PMID 12588885 |
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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. |
Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A |
The Journal of experimental medicine. 2004 ; 199 (12) : 1701-1707. |
PMID 15197228 |
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SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. |
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Nature genetics. 2001 ; 28 (1) : 29-35. |
PMID 11326271 |
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A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. |
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PMID 7796808 |
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Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. |
Zardo G, Tiirikainen MI, Hong C, Misra A, Feuerstein BG, Volik S, Collins CC, Lamborn KR, Bollen A, Pinkel D, Albertson DG, Costello JF |
Nature genetics. 2002 ; 32 (3) : 453-458. |
PMID 12355068 |
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