Atlas of Genetics and Cytogenetics in Oncology and Haematology
PU.1
| Identity |
| Other names | SPI-1 |
| HGNC | SPI1 |
| Location | 11p11-22 |
| DNA/RNA |
 | |
| Description | genomic locus around 50kb; 5 exons |
| Transcription | 1,4kb. open reading frame (ORF): 991bp |
| Protein |
 | |
| Description | 264 amino acids. DNA binding protein with a ETS consensus motif |
| Expression | hematopoietic specific; mainly in B lymphocytes and myeloid lineages; faintly expressed in erythroid progenitors |
| Localisation | nuclear |
| Function | transcriptional regulator; specific DNA binding sites with a G/AGAA minimal element in promoter and enhancers of myeloid and B lymphoid genes; involved both in transcriptional regulation of genes and in splicing regulation of pre-mRNAs |
| Homology | ETS genes family |
| Mutations |
| Germinal | unknown |
| Somatic | unknown in human pathologies and cancers; insertional mutagenesis in murine erythroleukemia |
| Implicated in |
| Entity | Oncogenesis in mouse; mouse gene name: Spi-1 (SFFV Proviral Integration 1) |
| Disease | murine acute erythroleukemia induced by the Friend retrovirus SFFV (Spleen Focus Forming Virus) |
| Prognosis | 100% |
| Hybrid/Mutated Gene | no |
| Abnormal Protein | No; overexpression of the normal protein in the proerythroblast |
| External links |
| Bibliography |
| Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. |
| Moreau-Gachelin F, Tavitian A, Tambourin P |
| Nature. 1988 ; 331 (6153) : 277-280. |
| PMID 2827041 |
| The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. |
| Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA |
| Cell. 1990 ; 61 (1) : 113-124. |
| PMID 2180582 |
| Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. |
| McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA |
| The EMBO journal. 1996 ; 15 (20) : 5647-5658. |
| PMID 8896458 |
| Spi-1/PU.1 transgenic mice develop multistep erythroleukemias. |
| Moreau-Gachelin F, Wendling F, Molina T, Denis N, Titeux M, Grimber G, Briand P, Vainchenker W, Tavitian A |
| Molecular and cellular biology. 1996 ; 16 (5) : 2453-2463. |
| PMID 8628313 |
| PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. |
| Scott EW, Fisher RC, Olson MC, Kehrli EW, Simon MC, Singh H |
| Immunity. 1997 ; 6 (4) : 437-447. |
| PMID 9133423 |
| The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. |
| Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F |
| The Journal of biological chemistry. 1998 ; 273 (9) : 4838-4842. |
| PMID 9478924 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 11-2000 | Françoise Moreau-Gachelin |
| INSERM U528, Laboratoire de Transduction du Signal et Oncogenèse, Section de Recherche -Institut Curie, 26, rue d'Ulm, 75 248 Paris cedex 05, France |
| Citation |
| This paper should be referenced as such : |
| Moreau-Gachelin F . PU.1. Atlas Genet Cytogenet Oncol Haematol. November 2000 . URL : http://AtlasGeneticsOncology.org/Genes/SPI1ID269.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 11 21:17:39 2008 |
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