| Note | The N-terminal 1-19 is the single peptide of the protein. The C-terminal 30-85 of the protein contains a typical x(8)-C-x(6)-C-x(7)-C-x(6)-Y-x(3)-C-x(2,3)-C-x(17)-C conserve region, coding a Kazal type serine protease inhibitors (Kazal) domain. |
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| Description | The molecular weight of the encoding protein contained 85 amino acids is about 9.23 kDa. ECRG2 gene contains a typical Kazal serine protease inhibitors conserved domain about 56 amino acids at its C-terminal and three kinase phosphorlation site (protein kinase C, Casein kinase II and Tyrosine kinase). |
| Expression | ECRG2 gene was expressed in normal tissues, such as esophagus, liver, colon and lung. But it was less expressed in the cancerous tissues, especially low frequency of expression of ECRG2 gene in esophageal cancer but was less expressed in the cancerous tissues, especially low frequency of expression of ECRG2 gene in esophageal cancer. |
| Localisation | The protein was localized on the cell membrane. |
| Function | The expression of ECRG2 can inhibit the migratory ability of high metastasic tumor cells. |
| Homology | The sequence of the ECRG2 gene did not reveal remarkable similarity to the known sequence in the homology analysis with the public database of GenBank while the deduced amino acid sequence showed 97% homology to a tumor associated KAZAL-type serine protease inhibitor peptide (US patent 5851987). |
| [Cloning and identification of cDNA fragments related to human esophageal cancer] |
| Su T, Liu H, Lu S |
| Zhonghua zhong liu za zhi [Chinese journal of oncology]. 1998 ; 20 (4) : 254-257. |
| PMID 10920976 |
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| Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. |
| Cui YP, Wang JB, Zhang XY, Bi MX, Guo LP, Lu SH |
| World journal of gastroenterology : WJG. 2003 ; 9 (9) : 1892-1896. |
| PMID 12970870 |
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| ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. |
| Cui Y, Wang J, Zhang X, Lang R, Bi M, Guo L, Lu SH |
| Biochemical and biophysical research communications. 2003 ; 302 (4) : 904-915. |
| PMID 12646258 |
| |
| Short tandem repeat polymorphism in a novel esophageal cancer-related gene (ECRG2) implicates susceptibility to esophageal cancer in Chinese population. |
| Yue CM, Bi MX, Tan W, Deng DJ, Zhang XY, Guo LP, Lin DX, Lu SH |
| International journal of cancer. Journal international du cancer. 2004 ; 108 (2) : 232-236. |
| PMID 14639608 |
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| Monoclonal antibodies to esophageal cancer-related gene2 protein. |
| Huang G, Wang D, Guo L, Zhao N, Li Y, Lu SH |
| Hybridoma (2005). 2005 ; 24 (2) : 86-91. |
| PMID 15857172 |
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| [Inhibitory effects of esophageal cancer related gene 2 on proliferation of human esophageal cancer cell EC9706] |
| Li MN, Huang G, Guo LP, Lu SH |
| Zhonghua yi xue za zhi. 2005 ; 85 (39) : 2785-2788. |
| PMID 16324322 |
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| Short tandem repeat polymorphisms of exon 4 in Kazal-type gene ECRG2 in pancreatic carcinoma and chronic pancreatitis. |
| Kaifi JT, Cataldegirmen G, Wachowiak R, Schurr PG, Kleinhans H, Kosti G, Yekebas EF, Mann O, Kutup A, Kalinin V, Strate T, Izbicki JR |
| Anticancer research. 2007 ; 27 (1A) : 69-73. |
| PMID 17352218 |
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