| Description | 488 amino-acids; 51 kDa; functional domains: signal peptide, targeting the protein to the secretory pathway, prodomain containing a furin-type cleavage site responsible for the intracellular activation, catalytic domain containing a zinc binding site, hemopexin-like domain |
| Expression | cells of mesenchymal origin, notably fibroblastic cells, macrophages, osteoclasts |
| Function | extracellular zinc-dependent proteinase expressed during tissu remodelling processes (development, wound healing) and whose specific substrate is unknown |
| Homology | member of the matrix metalloproteinases (MMP) subfamily of matrixins |
| A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. |
| Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P |
| Nature. 1990 ; 348 (6303) : 699-704. |
| PMID 1701851 |
| |
| Stromelysin-3 gene expression in human cancer: an overview. |
| Rouyer N, Wolf C, Chenard MP, Rio MC, Chambon P, Bellocq JP, Basset P |
| Invasion & metastasis. 1994 19 95 ; 14 (1-6) : 269-275. |
| PMID 7657519 |
| |
| Structure and promoter characterization of the human stromelysin-3 gene. |
| Anglard P, Melot T, Guˆ©rin E, Thomas G, Basset P |
| The Journal of biological chemistry. 1995 ; 270 (35) : 20337-20344. |
| PMID 7657606 |
| |
| High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma. |
| Chenard MP, O'Siorain L, Shering S, Rouyer N, Lutz Y, Wolf C, Basset P, Bellocq JP, Duffy MJ |
| International journal of cancer. Journal international du cancer. 1996 ; 69 (6) : 448-451. |
| PMID 8980245 |
| |
| Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism. |
| Mari BP, Anderson IC, Mari SE, Ning Y, Lutz Y, Kobzik L, Shipp MA |
| The Journal of biological chemistry. 1998 ; 273 (1) : 618-626. |
| PMID 9417124 |
| |
| Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression. |
| Ahmad A, Hanby A, Dublin E, Poulsom R, Smith P, Barnes D, Rubens R, Anglard P, Hart I |
| The American journal of pathology. 1998 ; 152 (3) : 721-728. |
| PMID 9502414 |
| |
| In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. |
| Masson R, Lefebvre O, Noˆ´l A, Fahime ME, Chenard MP, Wendling C, Kebers F, LeMeur M, Dierich A, Foidart JM, Basset P, Rio MC |
| The Journal of cell biology. 1998 ; 140 (6) : 1535-1541. |
| PMID 9508784 |
| |