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MMP11 (matrix metalloproteinase 11 (stromelysin 3))

Written2000-03Paul Basset, Marie-Christine Rio
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM U184/ULP BP 163, Illkirch, CU de Strasbourg, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)ST3 (stromelysin-3)
MMP-11 (matrix metalloproteinase 11)
HGNC (Hugo) MMP11
HGNC Previous nameSTMY3
HGNC Previous namematrix metalloproteinase 11 (stromelysin 3)
 stromelysin 3
LocusID (NCBI) 4320
Atlas_Id 200
Location 22q11.23  [Link to chromosome band 22q11]
Location_base_pair Starts at 23772849 and ends at 23784316 bp from pter ( according to hg19-Feb_2009)  [Mapping MMP11.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MMP11 (22q11.23) / YKT6 (7p13)MMP11 (22q11.23) / ZNF714 (19p12)


Description 8 exons and 7 introns spanning 11.5 kb; cDNA: 2247 bp, coding sequence 1464 bp
Transcription expression is induced by retinoic acid and TPA through a DR1-type responsive element and a C/EBP binding site, respectively, expression is induced by epithelial cells in a paracrin manner


Description 488 amino-acids; 51 kDa; functional domains: signal peptide, targeting the protein to the secretory pathway, prodomain containing a furin-type cleavage site responsible for the intracellular activation, catalytic domain containing a zinc binding site, hemopexin-like domain
Expression cells of mesenchymal origin, notably fibroblastic cells, macrophages, osteoclasts
Function extracellular zinc-dependent proteinase expressed during tissu remodelling processes (development, wound healing) and whose specific substrate is unknown
Homology member of the matrix metalloproteinases (MMP) subfamily of matrixins

Implicated in

Entity various cancer:
Disease expression of ST3 in 80 to 100% invasive carcinomas of the breast, colon, head and neck, lung, ovary, pancreas, prostate, skin (basal cell carcinoma), uterus (cervix carcinoma and endometrial carcinoma) and in some non-invasive carcinomas that have a high risk of evolving towards invasion; also expression in: fibroblastic stromal cells in the close vicinity of cancerous epithelial cells
Prognosis prognostic factor of invasion and aggressiveness of the tumors


Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression.
Ahmad A, Hanby A, Dublin E, Poulsom R, Smith P, Barnes D, Rubens R, Anglard P, Hart I
The American journal of pathology. 1998 ; 152 (3) : 721-728.
PMID 9502414
Structure and promoter characterization of the human stromelysin-3 gene.
Anglard P, Melot T, Guérin E, Thomas G, Basset P
The Journal of biological chemistry. 1995 ; 270 (35) : 20337-20344.
PMID 7657606
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P
Nature. 1990 ; 348 (6303) : 699-704.
PMID 1701851
High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma.
Chenard MP, O'Siorain L, Shering S, Rouyer N, Lutz Y, Wolf C, Basset P, Bellocq JP, Duffy MJ
International journal of cancer. Journal international du cancer. 1996 ; 69 (6) : 448-451.
PMID 8980245
Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism.
Mari BP, Anderson IC, Mari SE, Ning Y, Lutz Y, Kobzik L, Shipp MA
The Journal of biological chemistry. 1998 ; 273 (1) : 618-626.
PMID 9417124
In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy.
Masson R, Lefebvre O, Noël A, Fahime ME, Chenard MP, Wendling C, Kebers F, LeMeur M, Dierich A, Foidart JM, Basset P, Rio MC
The Journal of cell biology. 1998 ; 140 (6) : 1535-1541.
PMID 9508784
Stromelysin-3 gene expression in human cancer: an overview.
Rouyer N, Wolf C, Chenard MP, Rio MC, Chambon P, Bellocq JP, Basset P
Invasion & metastasis. 1994 19 95 ; 14 (1-6) : 269-275.
PMID 7657519


This paper should be referenced as such :
Basset, P ; Rio, MC
MMP11 (matrix metalloproteinase 11 (stromelysin 3))
Atlas Genet Cytogenet Oncol Haematol. 2000;4(2):52-53.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(19;22)(p12;q11) MMP11/ZNF714

External links

HGNC (Hugo)MMP11   7157
Entrez_Gene (NCBI)MMP11  4320  matrix metallopeptidase 11
AliasesSL-3; ST3; STMY3
GeneCards (Weizmann)MMP11
Ensembl hg19 (Hinxton)ENSG00000099953 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099953 [Gene_View]  ENSG00000099953 [Sequence]  chr22:23772849-23784316 [Contig_View]  MMP11 [Vega]
ICGC DataPortalENSG00000099953
TCGA cBioPortalMMP11
AceView (NCBI)MMP11
Genatlas (Paris)MMP11
SOURCE (Princeton)MMP11
Genetics Home Reference (NIH)MMP11
Genomic and cartography
GoldenPath hg38 (UCSC)MMP11  -     chr22:23772849-23784316 +  22q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP11  -     22q11.23   [Description]    (hg19-Feb_2009)
GoldenPathMMP11 - 22q11.23 [CytoView hg19]  MMP11 - 22q11.23 [CytoView hg38]
genome Data Viewer NCBIMMP11 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK075448 AK125911 AK129792 BC057788 DA747742
RefSeq transcript (Entrez)NM_005940
RefSeq genomic (Entrez)NC_000022 NG_029443 NT_187633
Consensus coding sequences : CCDS (NCBI)MMP11
Alternative Splicing GalleryENSG00000099953
Gene ExpressionMMP11 [ NCBI-GEO ]   MMP11 [ EBI - ARRAY_EXPRESS ]   MMP11 [ SEEK ]   MMP11 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP11 [ Firebrowse - Broad ]
GenevisibleExpression of MMP11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4320
GTEX Portal (Tissue expression)MMP11
Human Protein AtlasENSG00000099953-MMP11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24347   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24347  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24347
Splice isoforms : SwissVarP24347
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   [ MEROPS ]
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_dom_sf    Hemopexin-like_repeat    Hemopexin_CS    M10A_MMP    MetalloPept_cat_dom_sf    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_Zn_BS    Peptidase_Metallo    Stromelysin-3   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)   
Domain families : Pfam (NCBI)pfam00045    pfam00413   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP11
DMDM Disease mutations4320
Blocks (Seattle)MMP11
Human Protein Atlas [tissue]ENSG00000099953-MMP11 [tissue]
Peptide AtlasP24347
IPIIPI00306778   IPI00435926   IPI00979323   IPI00880022   IPI00878228   IPI00877681   
Protein Interaction databases
IntAct (EBI)P24347
Ontologies - Pathways
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  Golgi lumen  proteolysis  multicellular organism development  zinc ion binding  extracellular matrix disassembly  extracellular matrix organization  collagen fibril organization  collagen catabolic process  collagen catabolic process  extracellular matrix  negative regulation of fat cell differentiation  basement membrane organization  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  Golgi lumen  proteolysis  multicellular organism development  zinc ion binding  extracellular matrix disassembly  extracellular matrix organization  collagen fibril organization  collagen catabolic process  collagen catabolic process  extracellular matrix  negative regulation of fat cell differentiation  basement membrane organization  
REACTOMEP24347 [protein]
REACTOME PathwaysR-HSA-1592389 [pathway]   
NDEx NetworkMMP11
Atlas of Cancer Signalling NetworkMMP11
Wikipedia pathwaysMMP11
Orthology - Evolution
GeneTree (enSembl)ENSG00000099953
Phylogenetic Trees/Animal Genes : TreeFamMMP11
Homologs : HomoloGeneMMP11
Homology/Alignments : Family Browser (UCSC)MMP11
Gene fusions - Rearrangements
Fusion : MitelmanMMP11/ZNF714 [22q11.23/19p12]  
Fusion : Fusion_HubMMP11--GAS2L1    MMP11--YKT6   
Fusion : QuiverMMP11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP11
Exome Variant ServerMMP11
GNOMAD BrowserENSG00000099953
Varsome BrowserMMP11
Genetic variants : HAPMAP4320
Genomic Variants (DGV)MMP11 [DGVbeta]
DECIPHERMMP11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP11 
ICGC Data PortalMMP11 
TCGA Data PortalMMP11 
Broad Tumor PortalMMP11
OASIS PortalMMP11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMMP11
Mutations and Diseases : HGMDMMP11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP11
DgiDB (Drug Gene Interaction Database)MMP11
DoCM (Curated mutations)MMP11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP11 (select a term)
NCG6 (London) select MMP11
Cancer3DMMP11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry MMP11
NextProtP24347 [Medical]
Target ValidationMMP11
Huge Navigator MMP11 [HugePedia]
snp3D : Map Gene to Disease4320
BioCentury BCIQMMP11
Clinical trials, drugs, therapy
Protein Interactions : CTD4320
Pharm GKB GenePA30869
Clinical trialMMP11
canSAR (ICR)MMP11 (select the gene name)
DataMed IndexMMP11
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 16:54:03 CEST 2020

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