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STAT3 (Signal Transducer and Activator of Transcription 3)

Written2004-05Brent H Cochran
Dept. of Physiology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)Acute Phase Response Factor, APRF
HGNC (Hugo) STAT3
HGNC Alias symbAPRF
HGNC Previous namesignal transducer and activator of transcription 3 (acute-phase response factor)
LocusID (NCBI) 6774
Atlas_Id 444
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42313324 and ends at 42388442 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping STAT3.png]
Local_order STAT3 is flanked by STAT5a and PTRF
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EZH1 (17q21.2) / STAT3 (17q21.2)NDST2 (10q22.2) / STAT3 (17q21.2)RAB37 (17q25.1) / STAT3 (17q21.2)
RARA (17q21.2) / STAT3 (17q21.2)SREBF1 (17p11.2) / STAT3 (17q21.2)STAT3 (17q21.2) / CAVIN1 (17q21.2)
STAT3 (17q21.2) / STAT1 (2q32.2)STAT3 (17q21.2) / STAT3 (17q21.2)STAT5B (17q21.2) / STAT3 (17q21.2)

DNA/RNA

Note 24 exons spanning 74444 bp.
Transcription There are two major transcripts, STAT3a and STAT3b. STAT3a mRNA is 4973 bp. The STAT3b arises due to an alternate splice acceptor site in exon 23 which gives rise to a protein that is essentially truncated after amino acid 715. Another variant differs by 1 amino acid.

Protein

 
Description There are two major isoforms of STAT3. The long form is known as STAT3 (or STAT3a) and is a 770 amino acid protein (93 kDa on gels). Notable features are STAT family DNA binding domain, an SH2 domain, a major tyrosine phosphorylation site at Y705 and a major serine phosphorylation site at S727. Phosphorylation leads to dimerization of STAT3 via intermolecular pTyr-SH2 interactions. STAT3 can also heterodimerize with STAT1. (Recent data suggests that STAT3 can possibly form a dimmer without tyrosine phosphorylation and that phosphorylation leads to changes dimmer conformation). Tyrosine of the protein activates its high affinity DNA binding activity (TTCNNNGAA) and can stimulate nuclear translocation of the protein. Stimulation of STAT3 tyrosine phosphorylation occurs in response to a variety of cytokines and growth factors including LIF, OSM, IL-6, leptin, EGF, PDGF, and HGF. The C terminal domain is a transcriptional activation domain whose activity is enhanced by phosphorylation of serine 727. The STAT3 beta isoform (84 kDa) is missing this domain (1-715 + 7 unique amino acids resulting from frameshift) and is sometimes used as a dominant negative though there is also evidence that it regulates distinct genes as well.
Expression near ubiquitous
Localisation Cytoplasmic, but translocates to the nucleus upon tyrosine phosphorylation.
Function Transcription regulation.
Homology Shares homology with the other 6 mammalian STAT genes: STAT1, STAT2, STAT4, STAT5A, STAT5B, STAT6.

Implicated in

Note
Disease Upregulated in many cancers including glioblastoma, head and neck cancer, prostate cancer, and breast cancer. A constitutively active form of STAT3 is oncogenic, though these mutations have not been identified in human cancer as yet. STAT 3 activation is associated with Crohn's disease, and other inflammatory diseases such as pulmonary fibrosis and acute lung injury. STAT3 is critical for leptin signaling and its mutation leads to obesity in mice.
  

Bibliography

Roles of STAT3 defined by tissue-specific gene targeting.
Akira S
Oncogene. 2000 ; 19 (21) : 2607-2611.
PMID 10851059
 
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T
Cell. 1994 ; 77 (1) : 63-71.
PMID 7512451
 
STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG Jr
Nature. 2003 ; 421 (6925) : 856-859.
PMID 12594516
 
Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Becker S, Groner B, Müller CW
Nature. 1998 ; 394 (6689) : 145-151.
PMID 9671298
 
STATs dimerize in the absence of phosphorylation.
Braunstein J, Brutsaert S, Olson R, Schindler C
The Journal of biological chemistry. 2003 ; 278 (36) : 34133-34140.
PMID 12832402
 
Stat3 as an oncogene.
Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr
Cell. 1999 ; 98 (3) : 295-303.
PMID 10458605
 
STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription.
Caldenhoven E, van Dijk TB, Solari R, Armstrong J, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP
The Journal of biological chemistry. 1996 ; 271 (22) : 13221-13227.
PMID 8675499
 
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, Fujita DJ, Ethier SP, Jove R
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1997 ; 8 (12) : 1267-1276.
PMID 9419415
 
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.
Horvath CM, Wen Z, Darnell JE Jr
Genes & development. 1995 ; 9 (8) : 984-994.
PMID 7774815
 
Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells.
Konnikova L, Kotecki M, Kruger MM, Cochran BH
BMC cancer. 2003 ; 3 : page 23.
PMID 13678425
 
Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease.
Lovato P, Brender C, Agnholt J, Kelsen J, Kaltoft K, Svejgaard A, Eriksen KW, Woetmann A, Ødum N
The Journal of biological chemistry. 2003 ; 278 (19) : 16777-16781.
PMID 12615922
 
A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation.
Ma J, Zhang T, Novotny-Diermayr V, Tan AL, Cao X
The Journal of biological chemistry. 2003 ; 278 (31) : 29252-29260.
PMID 12746441
 
The STAT3 isoforms alpha and beta have unique and specific functions.
Maritano D, Sugrue ML, Tininini S, Dewilde S, Strobl B, Fu X, Murray-Tait V, Chiarle R, Poli V
Nature immunology. 2004 ; 5 (4) : 401-409.
PMID 15021879
 
Activation of the STAT pathway in acute lung injury.
Severgnini M, Takahashi S, Rozo LM, Homer RJ, Kuhn C, Jhung JW, Perides G, Steer M, Hassoun PM, Fanburg BL, Cochran BH, Simon AR
American journal of physiology. Lung cellular and molecular physiology. 2004 ; 286 (6) : L1282-L1292.
PMID 14729509
 
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
Wen Z, Zhong Z, Darnell JE Jr
Cell. 1995 ; 82 (2) : 241-250.
PMID 7543024
 
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock.
Yoo JY, Huso DL, Nathans D, Desiderio S
Cell. 2002 ; 108 (3) : 331-344.
PMID 11853668
 
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
Zhong Z, Wen Z, Darnell JE Jr
Science (New York, N.Y.). 1994 ; 264 (5155) : 95-98.
PMID 8140422
 

Citation

This paper should be referenced as such :
Cochran, BH
STAT3 (signal transducer, activator of transcription 3)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):201-202.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 10 ]
  Anaplastic large cell lymphoma, ALK-negative
Breast implant-associated anaplastic large cell lymphoma
del(4)(q12q12) FIP1L1/PDGFRA
Acute lymphoblastic leukemia in Down syndrome
t(2;11)(p21;q24) MIR125B1/?
t(3;5)(p21;q32) RBM6/CSF1R
t(6;10)(q22;q24) NFKB2/ROS1
t(6;12)(q22;q24) NCOR2/ROS1
t(20;21)(q13.2;q22.12) ZFP64/RUNX1
t(17;17)(q21;q21) STAT5B/STAT3


External links

Nomenclature
HGNC (Hugo)STAT3   11364
LRG (Locus Reference Genomic)LRG_112
Cards
AtlasSTAT3ID444
Entrez_Gene (NCBI)STAT3    signal transducer and activator of transcription 3
AliasesADMIO; ADMIO1; APRF; HIES
GeneCards (Weizmann)STAT3
Ensembl hg19 (Hinxton)ENSG00000168610 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168610 [Gene_View]  ENSG00000168610 [Sequence]  chr17:42313324-42388442 [Contig_View]  STAT3 [Vega]
ICGC DataPortalENSG00000168610
TCGA cBioPortalSTAT3
AceView (NCBI)STAT3
Genatlas (Paris)STAT3
SOURCE (Princeton)STAT3
Genetics Home Reference (NIH)STAT3
Genomic and cartography
GoldenPath hg38 (UCSC)STAT3  -     chr17:42313324-42388442 -  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAT3  -     17q21.2   [Description]    (hg19-Feb_2009)
GoldenPathSTAT3 - 17q21.2 [CytoView hg19]  STAT3 - 17q21.2 [CytoView hg38]
ImmunoBaseENSG00000168610
genome Data Viewer NCBISTAT3 [Mapview hg19]  
OMIM102582   147060   615952   
Gene and transcription
Genbank (Entrez)AB451232 AF029311 AI631896 AJ012463 AK024535
RefSeq transcript (Entrez)NM_001369512 NM_001369513 NM_001369514 NM_001369516 NM_001369517 NM_001369518 NM_001369519 NM_001369520 NM_001384984 NM_001384985 NM_001384986 NM_001384987 NM_001384988 NM_001384989 NM_001384990 NM_001384991 NM_001384992 NM_001384993 NM_003150 NM_139276 NM_213662
Consensus coding sequences : CCDS (NCBI)STAT3
Alternative Splicing GalleryENSG00000168610
Gene ExpressionSTAT3 [ NCBI-GEO ]   STAT3 [ EBI - ARRAY_EXPRESS ]   STAT3 [ SEEK ]   STAT3 [ MEM ]
Gene Expression Viewer (FireBrowse)STAT3 [ Firebrowse - Broad ]
GenevisibleExpression of STAT3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6774
GTEX Portal (Tissue expression)STAT3
Human Protein AtlasENSG00000168610-STAT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40763   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40763
PhosPhoSitePlusP40763
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    SH2    SH2_dom_sf    STAT    STAT3_SH2    STAT_N_sf    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_N    STAT_TF_prot_interaction   
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)STAT_int (SM00964)  
Conserved Domain (NCBI)STAT3
PDB (RSDB)5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
PDB Europe5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
PDB (PDBSum)5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
PDB (IMB)5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
Structural Biology KnowledgeBase5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
SCOP (Structural Classification of Proteins)5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
CATH (Classification of proteins structures)5AX3    5U5S    6NJS    6NUQ    6QHD    6TLC   
SuperfamilyP40763
AlphaFold pdb e-kbP40763   
Human Protein Atlas [tissue]ENSG00000168610-STAT3 [tissue]
HPRD00026
Protein Interaction databases
DIP (DOE-UCLA)P40763
IntAct (EBI)P40763
BioGRIDSTAT3
STRING (EMBL)STAT3
ZODIACSTAT3
Ontologies - Pathways
QuickGOP40763
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  chromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  temperature homeostasis  eye photoreceptor cell differentiation  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytoplasm  cytoplasm  mitochondrial inner membrane  cytosol  cytosol  plasma membrane  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  protein import into nucleus  defense response  acute-phase response  inflammatory response  signal transduction  receptor signaling pathway via JAK-STAT  receptor signaling pathway via JAK-STAT  nervous system development  aging  transcription factor binding  cell population proliferation  negative regulation of cell population proliferation  negative regulation of autophagy  positive regulation of gene expression  positive regulation of gene expression  negative regulation of hydrogen peroxide biosynthetic process  postsynaptic density  phosphorylation  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  protein kinase binding  protein phosphatase binding  sexual reproduction  positive regulation of cell migration  intracellular receptor signaling pathway  chromatin DNA binding  CCR5 chemokine receptor binding  response to estradiol  positive regulation of interleukin-1 beta production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  cellular response to hormone stimulus  leptin-mediated signaling pathway  leptin-mediated signaling pathway  somatic stem cell population maintenance  glucocorticoid receptor binding  interleukin-15-mediated signaling pathway  interleukin-7-mediated signaling pathway  interleukin-9-mediated signaling pathway  interleukin-21-mediated signaling pathway  interleukin-23-mediated signaling pathway  regulation of multicellular organism growth  regulation of cell population proliferation  response to drug  positive regulation of tyrosine phosphorylation of STAT protein  glucose homeostasis  eating behavior  mRNA transcription by RNA polymerase II  identical protein binding  protein homodimerization activity  response to peptide hormone  cellular response to leptin stimulus  response to leptin  response to ethanol  positive regulation of erythrocyte differentiation  positive regulation of Notch signaling pathway  positive regulation of angiogenesis  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of mitochondrial membrane permeability  protein dimerization activity  astrocyte differentiation  modulation of chemical synaptic transmission  positive regulation of NF-kappaB transcription factor activity  regulation of cell cycle  radial glial cell differentiation  regulation of feeding behavior  growth hormone receptor signaling pathway  growth hormone receptor signaling pathway via JAK-STAT  growth hormone receptor signaling pathway via JAK-STAT  growth hormone receptor signaling pathway via JAK-STAT  RNA polymerase II-specific DNA-binding transcription factor binding  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-35-mediated signaling pathway  primary miRNA binding  cellular response to cytokine stimulus  cellular response to organic cyclic compound  T-helper 17 type immune response  T-helper 17 cell lineage commitment  RNA polymerase II transcription regulator complex  RNA polymerase II transcription regulator complex  energy homeostasis  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynapse to nucleus signaling pathway  positive regulation of cytokine production involved in inflammatory response  negative regulation of neuron death  positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of metalloendopeptidase activity  positive regulation of vascular endothelial cell proliferation  positive regulation of miRNA mediated inhibition of translation  negative regulation of primary miRNA processing  positive regulation of gene silencing by miRNA  negative regulation of stem cell differentiation  positive regulation of ATP biosynthetic process  negative regulation of neuron migration  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  chromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  temperature homeostasis  eye photoreceptor cell differentiation  DNA binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytoplasm  cytoplasm  mitochondrial inner membrane  cytosol  cytosol  plasma membrane  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  protein import into nucleus  defense response  acute-phase response  inflammatory response  signal transduction  receptor signaling pathway via JAK-STAT  receptor signaling pathway via JAK-STAT  nervous system development  aging  transcription factor binding  cell population proliferation  negative regulation of cell population proliferation  negative regulation of autophagy  positive regulation of gene expression  positive regulation of gene expression  negative regulation of hydrogen peroxide biosynthetic process  postsynaptic density  phosphorylation  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  protein kinase binding  protein phosphatase binding  sexual reproduction  positive regulation of cell migration  intracellular receptor signaling pathway  chromatin DNA binding  CCR5 chemokine receptor binding  response to estradiol  positive regulation of interleukin-1 beta production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of tumor necrosis factor production  cellular response to hormone stimulus  leptin-mediated signaling pathway  leptin-mediated signaling pathway  somatic stem cell population maintenance  glucocorticoid receptor binding  interleukin-15-mediated signaling pathway  interleukin-7-mediated signaling pathway  interleukin-9-mediated signaling pathway  interleukin-21-mediated signaling pathway  interleukin-23-mediated signaling pathway  regulation of multicellular organism growth  regulation of cell population proliferation  response to drug  positive regulation of tyrosine phosphorylation of STAT protein  glucose homeostasis  eating behavior  mRNA transcription by RNA polymerase II  identical protein binding  protein homodimerization activity  response to peptide hormone  cellular response to leptin stimulus  response to leptin  response to ethanol  positive regulation of erythrocyte differentiation  positive regulation of Notch signaling pathway  positive regulation of angiogenesis  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of mitochondrial membrane permeability  protein dimerization activity  astrocyte differentiation  modulation of chemical synaptic transmission  positive regulation of NF-kappaB transcription factor activity  regulation of cell cycle  radial glial cell differentiation  regulation of feeding behavior  growth hormone receptor signaling pathway  growth hormone receptor signaling pathway via JAK-STAT  growth hormone receptor signaling pathway via JAK-STAT  growth hormone receptor signaling pathway via JAK-STAT  RNA polymerase II-specific DNA-binding transcription factor binding  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-35-mediated signaling pathway  primary miRNA binding  cellular response to cytokine stimulus  cellular response to organic cyclic compound  T-helper 17 type immune response  T-helper 17 cell lineage commitment  RNA polymerase II transcription regulator complex  RNA polymerase II transcription regulator complex  energy homeostasis  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynapse to nucleus signaling pathway  positive regulation of cytokine production involved in inflammatory response  negative regulation of neuron death  positive regulation of growth factor dependent skeletal muscle satellite cell proliferation  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of metalloendopeptidase activity  positive regulation of vascular endothelial cell proliferation  positive regulation of miRNA mediated inhibition of translation  negative regulation of primary miRNA processing  positive regulation of gene silencing by miRNA  negative regulation of stem cell differentiation  positive regulation of ATP biosynthetic process  negative regulation of neuron migration  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]    PDGF Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    EGF Signaling Pathway [Genes]    IL-10 Anti-inflammatory Signaling Pathway [Genes]    TPO Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Stat3 Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    IL22 Soluble Receptor Signaling Pathway [Genes]   
Pathways : KEGGChemokine signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway    Adipocytokine signaling pathway    Toxoplasmosis    Hepatitis C    Hepatitis B    Measles    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    MicroRNAs in cancer    Pancreatic cancer    Acute myeloid leukemia    Inflammatory bowel disease (IBD)   
NDEx NetworkSTAT3
Atlas of Cancer Signalling NetworkSTAT3
Wikipedia pathwaysSTAT3
Orthology - Evolution
OrthoDB6774
GeneTree (enSembl)ENSG00000168610
Phylogenetic Trees/Animal Genes : TreeFamSTAT3
Homologs : HomoloGeneSTAT3
Homology/Alignments : Family Browser (UCSC)STAT3
Gene fusions - Rearrangements
Fusion : MitelmanRARA/STAT3 [17q21.2/17q21.2]  
Fusion : MitelmanSREBF1/STAT3 [17p11.2/17q21.2]  
Fusion : MitelmanSTAT3/PTRF [17q21.2/17q21.2]  
Fusion : MitelmanSTAT5B/STAT3 [17q21.2/17q21.2]  
Fusion PortalRARA 17q21.2 STAT3 17q21.2 BRCA
Fusion PortalSREBF1 17p11.2 STAT3 17q21.2 PRAD
Fusion : QuiverSTAT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT3
dbVarSTAT3
ClinVarSTAT3
MonarchSTAT3
1000_GenomesSTAT3 
Exome Variant ServerSTAT3
GNOMAD BrowserENSG00000168610
Varsome BrowserSTAT3
Genomic Variants (DGV)STAT3 [DGVbeta]
DECIPHERSTAT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAT3 
Mutations
ICGC Data PortalSTAT3 
TCGA Data PortalSTAT3 
Broad Tumor PortalSTAT3
OASIS PortalSTAT3 [ Somatic mutations - Copy number]
Cancer Gene: CensusSTAT3 
Somatic Mutations in Cancer : COSMICSTAT3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTAT3
Mutations and Diseases : HGMDSTAT3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch STAT3
DgiDB (Drug Gene Interaction Database)STAT3
DoCM (Curated mutations)STAT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STAT3 (select a term)
OncoKBSTAT3
NCG6 (London) select STAT3
Cancer3DSTAT3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102582    147060    615952   
Orphanet839    23366   
DisGeNETSTAT3
MedgenSTAT3
Genetic Testing Registry STAT3
NextProtP40763 [Medical]
GENETestsSTAT3
Target ValidationSTAT3
Huge Navigator STAT3 [HugePedia]
ClinGenSTAT3
Clinical trials, drugs, therapy
MyCancerGenomeSTAT3
Protein Interactions : CTDSTAT3
Pharm GKB GenePA337
Pharm GKB PathwaysPA162356267   
PharosP40763
Clinical trialSTAT3
Miscellaneous
canSAR (ICR)STAT3
HarmonizomeSTAT3
DataMed IndexSTAT3
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTAT3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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