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STEAP1 (Six Transmembrane Epithelial Antigene of the Prostate 1)

Written2009-06Cecília Santos, Sílvia Socorro, Cláudio Maia
Universidade da Beira Interior, Research Centre of Health Sciences, Av. Infante D. Henrique, 6200-506, Covilha, Portugal

(Note : for Links provided by Atlas : click)

Identity

Alias_namesSTEAP
six transmembrane epithelial antigen of the prostate
six transmembrane epithelial antigen of the prostate 1
STEAP1 metalloreductase
Alias_symbol (synonym)PRSS24
Other aliasMGC19484
HGNC (Hugo) STEAP1
LocusID (NCBI) 26872
Atlas_Id 44482
Location 7q21.13  [Link to chromosome band 7q21]
Location_base_pair Starts at 90154375 and ends at 90164827 bp from pter ( according to hg19-Feb_2009)  [Mapping STEAP1.png]
Local_order Other genes in the vicinity of STEAP1 include ZNF804B (zinc finger protein 804B), dpy-19-like 2 pseudogene 4 (from C. elegans) and STEAP2.
 
  Surrounding genes from Entrez (updated 12-Feb-2009).
Fusion genes
(updated 2016)
CFAP69 (7q21.13) / STEAP1 (7q21.13)

DNA/RNA

Description 10,4Kb consisting of 5 exons.
Transcription 1,330Kb transcript; 1195bp ORF.

Protein

 
  STEAP gene organization, mRNA transcripts and predicted protein structure. Green boxes correspond to exons.
Description 339 amino acids (NCBI: AF186249); MW 40kDa, contains 6 transmembrane helical domains (table 1) and a theoretical pI of 9.28.
 
  Table 1-Sequence of the 6 transmembrane helices.
Expression Cell lines: Prostate-LnCAP, LAPC4, PC3, DU145, breast-MCF7, melanoma-624mel, 697mel, 888mel, MM331, gastrointestinal tract-MKN45, WiDR, lung-1355.
Normal murine tissues: bone marrow, brain, colon, duodenum, liver, heart, ileum, kidney, lung, pancreas, placenta, prostate, skeletal muscle, thymus, testis.
Localisation Cell membrane.
Function STEAP1 was first identified as a prostate-specific cell-surface antigen, over-expressed in human prostate cancer, and in the spontaneous transgenic mouse model of prostate cancer, by suppressive subtractive hybridization. It is also expressed in several human cancer cell lines obtained from prostate, breast, pancreas, bladder, gastrointestinal tract, testis, ovary, cervix, Ewing sarcoma, and melanomas, and in malignant tumours from several different tissues (eg. Prostate, breast, bladder, lung), with little or no expression in vital organs. Recent data showed that STEAP1 is involved in intercellular communication between adjacent cells in culture, and that it seems to favour tumour development. Its structure prediction, and location at cell-cell junctions, suggest that STEAP1 must be a channel, or a transport protein. Its cell surface location in all tumour types analyzed so far, and its absence in most vital organs in humans, turned STEAP1 into a potential target for anti-tumour immunotherapy, which has already been used in animal models of cancer with promising results. In addition, high levels of STEAP mRNA have been detected in the circulation of cancer patients increasing the potential of STEAP as a diagnosing marker for human cancer.
Homology Highest levels of homology with the other members of the family in the following order: STEAP2, STEAP3 and STEAP4.

Mutations

Note No mutations have been identified so far.

Implicated in

Note
  
Entity Various cancers
Note Prostate cancer, breast cancer, bladder cancer, lung cancer. STEAP1 is overexpressed in all these types of tumours compared to normal tissue.
  

Bibliography

STEAP, a prostate tumor antigen, is a target of human CD8+ T cells.
Alves PM, Faure O, Graff-Dubois S, Cornet S, Bolonakis I, Gross DA, Miconnet I, Chouaib S, Fizazi K, Soria JC, Lemonnier FA, Kosmatopoulos K.
Cancer Immunol Immunother. 2006 Dec;55(12):1515-23. Epub 2006 Apr 19.
PMID 16622681
 
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo.
Challita-Eid PM, Morrison K, Etessami S, An Z, Morrison KJ, Perez-Villar JJ, Raitano AB, Jia XC, Gudas JM, Kanner SB, Jakobovits A.
Cancer Res. 2007 Jun 15;67(12):5798-805.
PMID 17575147
 
In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer.
Garcia-Hernandez Mde L, Gray A, Hubby B, Kast WM.
Cancer Res. 2007 Feb 1;67(3):1344-51.
PMID 17283172
 
STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors.
Hubert RS, Vivanco I, Chen E, Rastegar S, Leong K, Mitchell SC, Madraswala R, Zhou Y, Kuo J, Raitano AB, Jakobovits A, Saffran DC, Afar DE.
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14523-8.
PMID 10588738
 
Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper T lymphocytes in a human leukocyte antigen class II-restricted manner.
Kobayashi H, Nagato T, Sato K, Aoki N, Kimura S, Murakami M, Iizuka H, Azumi M, Kakizaki H, Tateno M, Celis E.
Cancer Res. 2007 Jun 1;67(11):5498-504.
PMID 17545632
 
Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy.
Machlenkin A, Paz A, Bar Haim E, Goldberger O, Finkel E, Tirosh B, Volovitz I, Vadai E, Lugassy G, Cytron S, Lemonnier F, Tzehoval E, Eisenbach L.
Cancer Res. 2005 Jul 15;65(14):6435-42.
PMID 16024648
 
STEAP1 is over-expressed in breast cancer and down-regulated by 17beta-estradiol in MCF-7 cells and in the rat mammary gland.
Maia CJ, Socorro S, Schmitt F, Santos CR.
Endocrine. 2008 Aug-Dec;34(1-3):108-16. Epub 2008 Oct 29.
PMID 18958632
 
Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes.
Rodeberg DA, Nuss RA, Elsawa SF, Celis E.
Clin Cancer Res. 2005 Jun 15;11(12):4545-52.
PMID 15958640
 
Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice.
Yang D, Holt GE, Velders MP, Kwon ED, Kast WM.
Cancer Res. 2001 Aug 1;61(15):5857-60.
PMID 11479226
 

Citation

This paper should be referenced as such :
Santos, C ; Socorro, S ; Maia, C
STEAP1 (Six Transmembrane Epithelial Antigene of the Prostate 1)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(5):482-484.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/STEAP1ID44482ch7q21.html


External links

Nomenclature
HGNC (Hugo)STEAP1   11378
Cards
AtlasSTEAP1ID44482ch7q21
Entrez_Gene (NCBI)STEAP1  26872  STEAP family member 1
AliasesPRSS24; STEAP
GeneCards (Weizmann)STEAP1
Ensembl hg19 (Hinxton)ENSG00000164647 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164647 [Gene_View]  chr7:90154375-90164827 [Contig_View]  STEAP1 [Vega]
ICGC DataPortalENSG00000164647
TCGA cBioPortalSTEAP1
AceView (NCBI)STEAP1
Genatlas (Paris)STEAP1
WikiGenes26872
SOURCE (Princeton)STEAP1
Genetics Home Reference (NIH)STEAP1
Genomic and cartography
GoldenPath hg38 (UCSC)STEAP1  -     chr7:90154375-90164827 +  7q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STEAP1  -     7q21.13   [Description]    (hg19-Feb_2009)
EnsemblSTEAP1 - 7q21.13 [CytoView hg19]  STEAP1 - 7q21.13 [CytoView hg38]
Mapping of homologs : NCBISTEAP1 [Mapview hg19]  STEAP1 [Mapview hg38]
OMIM604415   
Gene and transcription
Genbank (Entrez)AF186249 AK304076 AK308452 BC011802 BI549469
RefSeq transcript (Entrez)NM_012449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STEAP1
Cluster EST : UnigeneHs.61635 [ NCBI ]
CGAP (NCI)Hs.61635
Alternative Splicing GalleryENSG00000164647
Gene ExpressionSTEAP1 [ NCBI-GEO ]   STEAP1 [ EBI - ARRAY_EXPRESS ]   STEAP1 [ SEEK ]   STEAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)STEAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26872
GTEX Portal (Tissue expression)STEAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHE8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHE8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHE8
Splice isoforms : SwissVarQ9UHE8
Catalytic activity : Enzyme1.16.1.- [ Enzyme-Expasy ]   1.16.1.-1.16.1.- [ IntEnz-EBI ]   1.16.1.- [ BRENDA ]   1.16.1.- [ KEGG ]   
PhosPhoSitePlusQ9UHE8
Domains : Interpro (EBI)Fe3_Rdtase_TM_dom   
Domain families : Pfam (Sanger)Ferric_reduct (PF01794)   
Domain families : Pfam (NCBI)pfam01794   
Conserved Domain (NCBI)STEAP1
DMDM Disease mutations26872
Blocks (Seattle)STEAP1
SuperfamilyQ9UHE8
Human Protein AtlasENSG00000164647
Peptide AtlasQ9UHE8
HPRD05106
IPIIPI00005846   IPI00892954   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHE8
IntAct (EBI)Q9UHE8
FunCoupENSG00000164647
BioGRIDSTEAP1
STRING (EMBL)STEAP1
ZODIACSTEAP1
Ontologies - Pathways
QuickGOQ9UHE8
Ontology : AmiGOtransporter activity  endosome  plasma membrane  integral component of plasma membrane  cell-cell junction  cupric reductase activity  endosome membrane  channel activity  copper ion import  membrane  metal ion binding  ferric-chelate reductase (NADPH) activity  iron ion homeostasis  transmembrane transport  oxidation-reduction process  
Ontology : EGO-EBItransporter activity  endosome  plasma membrane  integral component of plasma membrane  cell-cell junction  cupric reductase activity  endosome membrane  channel activity  copper ion import  membrane  metal ion binding  ferric-chelate reductase (NADPH) activity  iron ion homeostasis  transmembrane transport  oxidation-reduction process  
Pathways : KEGGMineral absorption   
NDEx NetworkSTEAP1
Atlas of Cancer Signalling NetworkSTEAP1
Wikipedia pathwaysSTEAP1
Orthology - Evolution
OrthoDB26872
GeneTree (enSembl)ENSG00000164647
Phylogenetic Trees/Animal Genes : TreeFamSTEAP1
HOVERGENQ9UHE8
HOGENOMQ9UHE8
Homologs : HomoloGeneSTEAP1
Homology/Alignments : Family Browser (UCSC)STEAP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTEAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STEAP1
dbVarSTEAP1
ClinVarSTEAP1
1000_GenomesSTEAP1 
Exome Variant ServerSTEAP1
ExAC (Exome Aggregation Consortium)STEAP1 (select the gene name)
Genetic variants : HAPMAP26872
Genomic Variants (DGV)STEAP1 [DGVbeta]
DECIPHERSTEAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTEAP1 
Mutations
ICGC Data PortalSTEAP1 
TCGA Data PortalSTEAP1 
Broad Tumor PortalSTEAP1
OASIS PortalSTEAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTEAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTEAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STEAP1
DgiDB (Drug Gene Interaction Database)STEAP1
DoCM (Curated mutations)STEAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STEAP1 (select a term)
intoGenSTEAP1
NCG5 (London)STEAP1
Cancer3DSTEAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604415   
Orphanet
MedgenSTEAP1
Genetic Testing Registry STEAP1
NextProtQ9UHE8 [Medical]
TSGene26872
GENETestsSTEAP1
Target ValidationSTEAP1
Huge Navigator STEAP1 [HugePedia]
snp3D : Map Gene to Disease26872
BioCentury BCIQSTEAP1
ClinGenSTEAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26872
Chemical/Pharm GKB GenePA36193
Clinical trialSTEAP1
Miscellaneous
canSAR (ICR)STEAP1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTEAP1
EVEXSTEAP1
GoPubMedSTEAP1
iHOPSTEAP1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon May 22 09:24:20 CEST 2017

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