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STEAP1 (Six Transmembrane Epithelial Antigene of the Prostate 1)

Written2009-06Cecília Santos, Sílvia Socorro, Cláudio Maia
Universidade da Beira Interior, Research Centre of Health Sciences, Av. Infante D. Henrique, 6200-506, Covilha, Portugal

(Note : for Links provided by Atlas : click)


six transmembrane epithelial antigen of the prostate
six transmembrane epithelial antigen of the prostate 1
STEAP1 metalloreductase
Alias_symbol (synonym)PRSS24
Other aliasMGC19484
LocusID (NCBI) 26872
Atlas_Id 44482
Location 7q21.13  [Link to chromosome band 7q21]
Location_base_pair Starts at 90154375 and ends at 90164827 bp from pter ( according to hg19-Feb_2009)  [Mapping STEAP1.png]
Local_order Other genes in the vicinity of STEAP1 include ZNF804B (zinc finger protein 804B), dpy-19-like 2 pseudogene 4 (from C. elegans) and STEAP2.
  Surrounding genes from Entrez (updated 12-Feb-2009).
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFAP69 (7q21.13) / STEAP1 (7q21.13)


Description 10,4Kb consisting of 5 exons.
Transcription 1,330Kb transcript; 1195bp ORF.


  STEAP gene organization, mRNA transcripts and predicted protein structure. Green boxes correspond to exons.
Description 339 amino acids (NCBI: AF186249); MW 40kDa, contains 6 transmembrane helical domains (table 1) and a theoretical pI of 9.28.
  Table 1-Sequence of the 6 transmembrane helices.
Expression Cell lines: Prostate-LnCAP, LAPC4, PC3, DU145, breast-MCF7, melanoma-624mel, 697mel, 888mel, MM331, gastrointestinal tract-MKN45, WiDR, lung-1355.
Normal murine tissues: bone marrow, brain, colon, duodenum, liver, heart, ileum, kidney, lung, pancreas, placenta, prostate, skeletal muscle, thymus, testis.
Localisation Cell membrane.
Function STEAP1 was first identified as a prostate-specific cell-surface antigen, over-expressed in human prostate cancer, and in the spontaneous transgenic mouse model of prostate cancer, by suppressive subtractive hybridization. It is also expressed in several human cancer cell lines obtained from prostate, breast, pancreas, bladder, gastrointestinal tract, testis, ovary, cervix, Ewing sarcoma, and melanomas, and in malignant tumours from several different tissues (eg. Prostate, breast, bladder, lung), with little or no expression in vital organs. Recent data showed that STEAP1 is involved in intercellular communication between adjacent cells in culture, and that it seems to favour tumour development. Its structure prediction, and location at cell-cell junctions, suggest that STEAP1 must be a channel, or a transport protein. Its cell surface location in all tumour types analyzed so far, and its absence in most vital organs in humans, turned STEAP1 into a potential target for anti-tumour immunotherapy, which has already been used in animal models of cancer with promising results. In addition, high levels of STEAP mRNA have been detected in the circulation of cancer patients increasing the potential of STEAP as a diagnosing marker for human cancer.
Homology Highest levels of homology with the other members of the family in the following order: STEAP2, STEAP3 and STEAP4.


Note No mutations have been identified so far.

Implicated in

Entity Various cancers
Note Prostate cancer, breast cancer, bladder cancer, lung cancer. STEAP1 is overexpressed in all these types of tumours compared to normal tissue.


STEAP, a prostate tumor antigen, is a target of human CD8+ T cells.
Alves PM, Faure O, Graff-Dubois S, Cornet S, Bolonakis I, Gross DA, Miconnet I, Chouaib S, Fizazi K, Soria JC, Lemonnier FA, Kosmatopoulos K.
Cancer Immunol Immunother. 2006 Dec;55(12):1515-23. Epub 2006 Apr 19.
PMID 16622681
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo.
Challita-Eid PM, Morrison K, Etessami S, An Z, Morrison KJ, Perez-Villar JJ, Raitano AB, Jia XC, Gudas JM, Kanner SB, Jakobovits A.
Cancer Res. 2007 Jun 15;67(12):5798-805.
PMID 17575147
In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer.
Garcia-Hernandez Mde L, Gray A, Hubby B, Kast WM.
Cancer Res. 2007 Feb 1;67(3):1344-51.
PMID 17283172
STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors.
Hubert RS, Vivanco I, Chen E, Rastegar S, Leong K, Mitchell SC, Madraswala R, Zhou Y, Kuo J, Raitano AB, Jakobovits A, Saffran DC, Afar DE.
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14523-8.
PMID 10588738
Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper T lymphocytes in a human leukocyte antigen class II-restricted manner.
Kobayashi H, Nagato T, Sato K, Aoki N, Kimura S, Murakami M, Iizuka H, Azumi M, Kakizaki H, Tateno M, Celis E.
Cancer Res. 2007 Jun 1;67(11):5498-504.
PMID 17545632
Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy.
Machlenkin A, Paz A, Bar Haim E, Goldberger O, Finkel E, Tirosh B, Volovitz I, Vadai E, Lugassy G, Cytron S, Lemonnier F, Tzehoval E, Eisenbach L.
Cancer Res. 2005 Jul 15;65(14):6435-42.
PMID 16024648
STEAP1 is over-expressed in breast cancer and down-regulated by 17beta-estradiol in MCF-7 cells and in the rat mammary gland.
Maia CJ, Socorro S, Schmitt F, Santos CR.
Endocrine. 2008 Aug-Dec;34(1-3):108-16. Epub 2008 Oct 29.
PMID 18958632
Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes.
Rodeberg DA, Nuss RA, Elsawa SF, Celis E.
Clin Cancer Res. 2005 Jun 15;11(12):4545-52.
PMID 15958640
Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice.
Yang D, Holt GE, Velders MP, Kwon ED, Kast WM.
Cancer Res. 2001 Aug 1;61(15):5857-60.
PMID 11479226


This paper should be referenced as such :
Santos, C ; Socorro, S ; Maia, C
STEAP1 (Six Transmembrane Epithelial Antigene of the Prostate 1)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(5):482-484.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

HGNC (Hugo)STEAP1   11378
Entrez_Gene (NCBI)STEAP1  26872  STEAP family member 1
AliasesPRSS24; STEAP
GeneCards (Weizmann)STEAP1
Ensembl hg19 (Hinxton)ENSG00000164647 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164647 [Gene_View]  ENSG00000164647 [Sequence]  chr7:90154375-90164827 [Contig_View]  STEAP1 [Vega]
ICGC DataPortalENSG00000164647
Genatlas (Paris)STEAP1
SOURCE (Princeton)STEAP1
Genetics Home Reference (NIH)STEAP1
Genomic and cartography
GoldenPath hg38 (UCSC)STEAP1  -     chr7:90154375-90164827 +  7q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STEAP1  -     7q21.13   [Description]    (hg19-Feb_2009)
GoldenPathSTEAP1 - 7q21.13 [CytoView hg19]  STEAP1 - 7q21.13 [CytoView hg38]
Mapping of homologs : NCBISTEAP1 [Mapview hg19]  STEAP1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF186249 AK304076 AK308452 BC011802 BI549469
RefSeq transcript (Entrez)NM_012449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STEAP1
Alternative Splicing GalleryENSG00000164647
Gene ExpressionSTEAP1 [ NCBI-GEO ]   STEAP1 [ EBI - ARRAY_EXPRESS ]   STEAP1 [ SEEK ]   STEAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)STEAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26872
GTEX Portal (Tissue expression)STEAP1
Human Protein AtlasENSG00000164647-STEAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHE8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHE8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHE8
Splice isoforms : SwissVarQ9UHE8
Catalytic activity : Enzyme1.16.1.- [ Enzyme-Expasy ]   1.16.1.-1.16.1.- [ IntEnz-EBI ]   1.16.1.- [ BRENDA ]   1.16.1.- [ KEGG ]   
Domains : Interpro (EBI)Fe3_Rdtase_TM_dom   
Domain families : Pfam (Sanger)Ferric_reduct (PF01794)   
Domain families : Pfam (NCBI)pfam01794   
Conserved Domain (NCBI)STEAP1
DMDM Disease mutations26872
Blocks (Seattle)STEAP1
Human Protein Atlas [tissue]ENSG00000164647-STEAP1 [tissue]
Peptide AtlasQ9UHE8
IPIIPI00005846   IPI00892954   
Protein Interaction databases
IntAct (EBI)Q9UHE8
Ontologies - Pathways
Ontology : AmiGOtransporter activity  endosome  plasma membrane  integral component of plasma membrane  cell-cell junction  ion transport  endosome membrane  channel activity  membrane  oxidoreductase activity  metal ion binding  iron ion homeostasis  transmembrane transport  oxidation-reduction process  
Ontology : EGO-EBItransporter activity  endosome  plasma membrane  integral component of plasma membrane  cell-cell junction  ion transport  endosome membrane  channel activity  membrane  oxidoreductase activity  metal ion binding  iron ion homeostasis  transmembrane transport  oxidation-reduction process  
Pathways : KEGGMineral absorption   
NDEx NetworkSTEAP1
Atlas of Cancer Signalling NetworkSTEAP1
Wikipedia pathwaysSTEAP1
Orthology - Evolution
GeneTree (enSembl)ENSG00000164647
Phylogenetic Trees/Animal Genes : TreeFamSTEAP1
Homologs : HomoloGeneSTEAP1
Homology/Alignments : Family Browser (UCSC)STEAP1
Gene fusions - Rearrangements
Fusion : FusionGDB7341   
Fusion : Fusion_HubC7ORF63--STEAP1   
Fusion : QuiverSTEAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTEAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STEAP1
Exome Variant ServerSTEAP1
ExAC (Exome Aggregation Consortium)ENSG00000164647
GNOMAD BrowserENSG00000164647
Varsome BrowserSTEAP1
Genetic variants : HAPMAP26872
Genomic Variants (DGV)STEAP1 [DGVbeta]
DECIPHERSTEAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTEAP1 
ICGC Data PortalSTEAP1 
TCGA Data PortalSTEAP1 
Broad Tumor PortalSTEAP1
OASIS PortalSTEAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTEAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTEAP1
Mutations and Diseases : HGMDSTEAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STEAP1
DgiDB (Drug Gene Interaction Database)STEAP1
DoCM (Curated mutations)STEAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STEAP1 (select a term)
NCG5 (London)STEAP1
Cancer3DSTEAP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry STEAP1
NextProtQ9UHE8 [Medical]
Target ValidationSTEAP1
Huge Navigator STEAP1 [HugePedia]
snp3D : Map Gene to Disease26872
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26872
Chemical/Pharm GKB GenePA36193
Clinical trialSTEAP1
canSAR (ICR)STEAP1 (select the gene name)
DataMed IndexSTEAP1
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 16:21:51 CET 2020

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