| Identity |
| HGNC (Hugo) | SYK |
| LocusID (NCBI) | 6850 |
| Location | 9q22 |
| Location_base_pair | Starts at 93564012 and ends at 93660842 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Transcription | 2639 mRNA complete codons |
| Protein |
| Description | 635 amino acids, 72 kDa in the long isoform; contains in N-term 2 tandem SH2 (SRC homology 2) domains separated y an interdomain A, an interdomain B, and a protein kinase domain in C-term; contains a number of autophosphorylation sites on tyrosines; the short form, 612 amino acids, lacks part of interdomain B |
| Expression | wide |
| Function | non-receptor type protein-tyrosine kinase; tyrosine phosphorylation of many proteins; role in signaling pathways;SYK is activated by oxidative stress; putative tumor suppressor; role in the differentiation of B-cells and many other cell types |
| Mutations |
| Somatic | ETV6-SYK hybrid gene can be created by t(9;12) translocation (see below); SYK can also be inactivated by epigenetic modifications (i.e. hypermethylation) |
| Implicated in |
| Entity | t(9;12)(q22;p12) |
| Disease | found in a case of myelodysplastic syndrome |
| Oncogenesis | ETV6-SYK is constituvely tyrosine phosphorylated |
| Entity | Breast cancer |
| Oncogenesis | SYK has been found inactivated in a subset of breast cancers |
| External links |
| Bibliography |
| Hypermethylation leads to silencing of the SYK gene in human breast cancer. |
| Yuan Y, Mendez R, Sahin A, Dai JL |
| Cancer research. 2001 ; 61 (14) : 5558-5561. |
| PMID 11454707 |
| Syk: a new player in the field of breast cancer. |
| Stewart ZA, Pietenpol JA |
| Breast cancer research : BCR. 2001 ; 3 (1) : 5-7. |
| PMID 11250739 |
| Structure and function of Syk protein-tyrosine kinase. |
| Sada K, Takano T, Yanagi S, Yamamura H |
| Journal of biochemistry. 2001 ; 130 (2) : 177-186. |
| PMID 11481033 |
| Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12). |
| Kuno Y, Abe A, Emi N, Iida M, Yokozawa T, Towatari M, Tanimoto M, Saito H |
| Blood. 2001 ; 97 (4) : 1050-1055. |
| PMID 11159536 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 02-2002 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . SYK (spleen tyrosine kinase). Atlas Genet Cytogenet Oncol Haematol. February 2002 . URL : http://AtlasGeneticsOncology.org/Genes/SYKID394.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37844/1/02-2002-SYKID394.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Apr 28 15:07:19 CEST 2012 |
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