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TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

Identity

Other namesTAFIIN
TAF2N (TATA box binding protein (TBP)-associated factor, RNA polymerase II, N)
RBP56 (RNA binding protein 56)
TAFII68
HGNC (Hugo) TAF15
Location 17q11.1-q11.2
Location_base_pair Starts at 31160601 and ends at 31198351 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Description spans 37kb; 16 exons
Transcription 2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp

Protein

Description 589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term
Expression wide; in the fetus and in the adult
Localisation nuclear
Function single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription
Homology with EWSR1 and FUS

Mutations

Somatic overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation

Implicated in

Entity extraskeletal myxoid chondrosarcomas with t(9;17)(q22;q11) --> 5 prime TAF2N/ 3 prime TEC
Disease a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities
  

Breakpoints

 

External links

Nomenclature
HGNC (Hugo)TAF15   11547
Entrez_Gene (NCBI)TAF15  8148  TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Cards
AtlasTAF2NID256
GeneCards (Weizmann)TAF15
Ensembl (Hinxton)ENSG00000172660 [Gene_View]  TAF15 [Vega]
AceView (NCBI)TAF15
Genatlas (Paris)TAF15
euGene (Indiana)8148
SOURCE (Stanford)NM_003487 NM_139215
Genomic and cartography
GoldenPath (UCSC)TAF15  -     chr17:31160601-31198351 +  17q11.1-q11.2   [Description]    (hg18-Mar_2006)
EnsemblTAF15 - 17q11.1-q11.2 [CytoView]
Mapping of homologs : NCBITAF15 [Mapview]
OMIM601574   612237   
Gene and transcription
Gene : Genbank (Entrez)AK304520 AK307637 AK313223 AK314194 BC030591
Reference sequence (RefSeq transcript) :SRSNM_003487 NM_139215
Reference transcript : EntrezNM_003487 NM_139215
RefSeq genomic : SRSAC_000060 AC_000149 NC_000017 NT_010799 NW_001838432 NW_926772
RefSeq genomic : EntrezAC_000060 AC_000149 NC_000017 NT_010799 NW_001838432 NW_926772
Consensus coding sequences : CCDS NCBITAF15
Cluster EST : UnigeneHs.402752 [ SRS ] Hs.402752 [ NCBI ]
Alternative Splicing : Fast-db (Paris)8596
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ92804 (SRS) Q92804 (Expasy) Q92804 (Uniprot)
With graphics : InterProQ92804
Splice isoforms : VarSplice FASTAQ92804(VarSplice FASTA)
Domaine pattern : Prosite (SRS)RRM (PS50102)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domain pattern : Prosite (Expaxy)RRM (PS50102)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (SRS)RRM_RNP1    Znf_RanBP2   
Domains : Interpro (EBI)RRM_RNP1    Znf_RanBP2   
Related proteins : CluSTrQ92804
Domain families : Pfam SRSRRM_1 (PF00076)    zf-RanBP (PF00641)   
Domain families : Pfam SangerRRM_1 (PF00076)    zf-RanBP (PF00641)   
Domain families : Pfam NCBIpfam00076    pfam00641   
Domain families : Smart EMBLRRM (SM00360)ZnF_RBZ (SM00547)
Blocks (Seattle)Q92804
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD09031
Protein Interaction databases
DIP (DOE-UCLA)Q92804
IntAct (EBI)Q92804
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITAF15
SNP : GeneSNP UtahTAF15
SNP : HGBaseTAF15
Genetic variants : HAPMAPTAF15
Somatic Mutations in Cancer : COSMICTAF15 
Translocation Breakpoints in Cancer : TICdbTAF15 
Mutations and Diseases : HGMDTAF15
Hereditary diseases : OMIM601574    612237   
Hereditary diseases : GENETests601574    612237   
Diseases : Genetic AssociationTAF15
General knowledge
Homologs : HomoloGeneTAF15
Homology/Alignments : Family Browser UCSCTAF15
Phylogenetic Trees/Animal Genes : TreeFamTAF15
Chemical/Protein Interactions : CTD8148
Keywords Ontology : AmiGODNA binding  RNA binding  intracellular  nucleus  zinc ion binding  metal ion binding  
Keywords Ontology : EGO-EBIDNA binding  RNA binding  intracellular  nucleus  zinc ion binding  metal ion binding  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTAF15 Related clones (RZPD - Berlin)
Literature
PubMed25 Pubmed reference(s) in Entrez
PubGeneTAF15

Bibliography

Yeast TAFIIS in a multisubunit complex required for activated transcription.
Reese JC, Apone L, Walker SS, Griffin LA, Green MR
Nature. 1994 ; 371 (6497) : 523-527.
PMID 7935765
 
Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.
Morohoshi F, Arai K, Takahashi EI, Tanigami A, Ohki M
Genomics. 1996 ; 38 (1) : 51-57.
PMID 8954779
 
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M
Gene. 1998 ; 221 (2) : 191-198.
PMID 9795213
 
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
Sjgren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G
Cancer research. 1999 ; 59 (20) : 5064-5067.
PMID 10537274
 
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
Panagopoulos I, Mencinger M, Dietrich CU, Bjerkehagen B, Saeter G, Mertens F, Mandahl N, Heim S
Oncogene. 1999 ; 18 (52) : 7594-7598.
PMID 10602519
 
The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.
Bertolotti A, Bell B, Tora L
Oncogene. 1999 ; 18 (56) : 8000-8010.
PMID 10637511
 
TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes.
Green MR
Trends in biochemical sciences. 2000 ; 25 (2) : 59-63.
PMID 10664584
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2000Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa). Atlas Genet Cytogenet Oncol Haematol. September 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/TAF2NID256.html

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indexed on : Sat Jun 27 16:42:04 CEST 2009

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