Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

Written2000-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other namesTAFIIN
TAF2N (TATA box binding protein (TBP)-associated factor, RNA polymerase II, N)
RBP56 (RNA binding protein 56)
TAFII68
HGNC (Hugo) TAF15
LocusID (NCBI) 8148
Atlas_Id 256
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 34136459 and ends at 34174246 bp from pter ( according to hg19-Feb_2009)  [Mapping TAF15.png]
Fusion genes
(updated 2016)
CHN1 (2q31.1) / TAF15 (17q12)NR4A3 (9q22.33) / TAF15 (17q12)OSCP1 (1p34.3) / TAF15 (17q12)
PLA2G2A (1p36.13) / TAF15 (17q12)ST8SIA6 (10p12.33) / TAF15 (17q12)TAF15 (17q12) / AP2B1 (17q12)
TAF15 (17q12) / CHN1 (2q31.1)TAF15 (17q12) / CNBP (3q21.3)TAF15 (17q12) / DCAF8 (1q23.2)
TAF15 (17q12) / GLTSCR2 (19q13.33)TAF15 (17q12) / MAN1A2 (1p12)TAF15 (17q12) / NR4A3 (9q22.33)
TAF15 (17q12) / OSCP1 (1p34.3)TAF15 (17q12) / PARM1 (4q13.3)TAF15 (17q12) / TEC (4p12)
TAF15 (17q12) / ZNF384 (12p13.31)ZNF384 (12p13.31) / TAF15 (17q12)

DNA/RNA

Description spans 37kb; 16 exons
Transcription 2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp

Protein

Description 589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term
Expression wide; in the fetus and in the adult
Localisation nuclear
Function single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription
Homology with EWSR1 and FUS

Mutations

Somatic overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation

Implicated in

Note
Entity extraskeletal myxoid chondrosarcomas with t(9;17)(q22;q11) --> 5 prime TAF2N/ 3 prime TEC
Disease a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities
  

Breakpoints

 

Bibliography

The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.
Bertolotti A, Bell B, Tora L
Oncogene. 1999 ; 18 (56) : 8000-8010.
PMID 10637511
 
TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes.
Green MR
Trends in biochemical sciences. 2000 ; 25 (2) : 59-63.
PMID 10664584
 
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M
Gene. 1998 ; 221 (2) : 191-198.
PMID 9795213
 
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
Panagopoulos I, Mencinger M, Dietrich CU, Bjerkehagen B, Saeter G, Mertens F, Mandahl N, Heim S
Oncogene. 1999 ; 18 (52) : 7594-7598.
PMID 10602519
 
Yeast TAFIIS in a multisubunit complex required for activated transcription.
Reese JC, Apone L, Walker SS, Griffin LA, Green MR
Nature. 1994 ; 371 (6497) : 523-527.
PMID 7935765
 
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
Sjögren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G
Cancer research. 1999 ; 59 (20) : 5064-5067.
PMID 10537274
 

Citation

This paper should be referenced as such :
Huret, JL
TAF15 (TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):190-191.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TAF2NID256.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;17)(p13;q11) TAF15/ZNF384

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Bone: Chondrosarcoma
Soft Tissues: Extraskeletal myxoid chondrosarcoma
Soft tissue tumors: an overview

External links

Nomenclature
HGNC (Hugo)TAF15   11547
Cards
AtlasTAF2NID256
Entrez_Gene (NCBI)TAF15  8148  TATA-box binding protein associated factor 15
AliasesNpl3; RBP56; TAF2N; TAFII68
GeneCards (Weizmann)TAF15
Ensembl hg19 (Hinxton)ENSG00000270647 [Gene_View]  chr17:34136459-34174246 [Contig_View]  TAF15 [Vega]
Ensembl hg38 (Hinxton)ENSG00000270647 [Gene_View]  chr17:34136459-34174246 [Contig_View]  TAF15 [Vega]
ICGC DataPortalENSG00000270647
TCGA cBioPortalTAF15
AceView (NCBI)TAF15
Genatlas (Paris)TAF15
WikiGenes8148
SOURCE (Princeton)TAF15
Genomic and cartography
GoldenPath hg19 (UCSC)TAF15  -     chr17:34136459-34174246 +  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TAF15  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblTAF15 - 17q12 [CytoView hg19]  TAF15 - 17q12 [CytoView hg38]
Mapping of homologs : NCBITAF15 [Mapview hg19]  TAF15 [Mapview hg38]
OMIM601574   612237   
Gene and transcription
Genbank (Entrez)AI351964 AK304520 AK307637 AK313223 AK314194
RefSeq transcript (Entrez)NM_003487 NM_139215
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_023279 NT_010783 NT_187614 NW_004929407
Consensus coding sequences : CCDS (NCBI)TAF15
Cluster EST : UnigeneHs.402752 [ NCBI ]
CGAP (NCI)Hs.402752
Alternative Splicing GalleryENSG00000270647
Gene ExpressionTAF15 [ NCBI-GEO ]   TAF15 [ EBI - ARRAY_EXPRESS ]   TAF15 [ SEEK ]   TAF15 [ MEM ]
Gene Expression Viewer (FireBrowse)TAF15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8148
GTEX Portal (Tissue expression)TAF15
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92804 (Uniprot)
NextProtQ92804  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92804
Splice isoforms : SwissVarQ92804 (Swissvar)
PhosPhoSitePlusQ92804
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    Znf_RanBP2   
Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam00076    pfam00641   
Domain families : Smart (EMBL)RRM (SM00360)  ZnF_RBZ (SM00547)  
DMDM Disease mutations8148
Blocks (Seattle)TAF15
PDB (SRS)2MMY   
PDB (PDBSum)2MMY   
PDB (IMB)2MMY   
PDB (RSDB)2MMY   
Structural Biology KnowledgeBase2MMY   
SCOP (Structural Classification of Proteins)2MMY   
CATH (Classification of proteins structures)2MMY   
SuperfamilyQ92804
Human Protein AtlasENSG00000270647
Peptide AtlasQ92804
HPRD09031
IPIIPI00294426   IPI00020194   
Protein Interaction databases
DIP (DOE-UCLA)Q92804
IntAct (EBI)Q92804
FunCoupENSG00000270647
BioGRIDTAF15
STRING (EMBL)TAF15
ZODIACTAF15
Ontologies - Pathways
QuickGOQ92804
Ontology : AmiGOnucleotide binding  DNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  zinc ion binding  poly(A) RNA binding  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBInucleotide binding  DNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  zinc ion binding  poly(A) RNA binding  positive regulation of transcription, DNA-templated  
Pathways : KEGGBasal transcription factors    Transcriptional misregulation in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkTAF15
Wikipedia pathwaysTAF15
Orthology - Evolution
OrthoDB8148
GeneTree (enSembl)ENSG00000270647
Phylogenetic Trees/Animal Genes : TreeFamTAF15
Homologs : HomoloGeneTAF15
Homology/Alignments : Family Browser (UCSC)TAF15
Gene fusions - Rearrangements
Fusion : MitelmanPLA2G2A/TAF15 [1p36.13/17q12]  [t(1;17)(p36;q12)]  
Fusion : MitelmanTAF15/ZNF384 [17q12/12p13.31]  [t(12;17)(p13;q12)]  
Fusion : COSMICTAF15 [17q12]  -  NR4A3 [9q22.33]  [fusion_589]  [fusion_657]  [fusion_658]  [fusion_957]  [fusion_958]  [fusion_959]  
Fusion: TCGAPLA2G2A 1p36.13 TAF15 17q12 PRAD
Fusion: TCGATAF15 17q12 AP2B1 17q12 BRCA
Fusion: TCGATAF15 17q12 MAN1A2 1p12 BRCA
Fusion : TICdbTAF15 [17q12]  -  NR4A3 [9q22.33]
Fusion : TICdbTAF15 [17q12]  -  ZNF384 [12p13.31]
Fusion Cancer (Beijing)TAF15 [17q12]  -  CNBP [3q21.3]  [FUSC003802]
Polymorphisms : SNP, variants
NCBI Variation ViewerTAF15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF15
dbVarTAF15
ClinVarTAF15
1000_GenomesTAF15 
Exome Variant ServerTAF15
ExAC (Exome Aggregation Consortium)TAF15 (select the gene name)
Genetic variants : HAPMAP8148
Genomic Variants (DGV)TAF15 [DGVbeta]
Mutations
ICGC Data PortalTAF15 
TCGA Data PortalTAF15 
Broad Tumor PortalTAF15
OASIS PortalTAF15 [ Somatic mutations - Copy number]
Cancer Gene: CensusTAF15 
Somatic Mutations in Cancer : COSMICTAF15 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAF15
DgiDB (Drug Gene Interaction Database)TAF15
DoCM (Curated mutations)TAF15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAF15 (select a term)
intoGenTAF15
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:34136459-34174246  ENSG00000270647
CONAN: Copy Number AnalysisTAF15 
Mutations and Diseases : HGMDTAF15
OMIM601574    612237   
MedgenTAF15
Genetic Testing Registry TAF15
NextProtQ92804 [Medical]
TSGene8148
GENETestsTAF15
Huge Navigator TAF15 [HugePedia]
snp3D : Map Gene to Disease8148
BioCentury BCIQTAF15
ClinGenTAF15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8148
Chemical/Pharm GKB GenePA36322
Clinical trialTAF15
Miscellaneous
canSAR (ICR)TAF15 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAF15
EVEXTAF15
GoPubMedTAF15
iHOPTAF15
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Aug 10 18:59:12 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.