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TRG (T cell Receptor Gamma)

Written2000-07Marie-Paule Lefranc
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)TRG@ (T cell Receptor Gamma)
HGNC (Hugo) TRG
HGNC Alias nameT-cell antigen receptor, gamma polypeptide
 T-cell receptor, gamma cluster
 T-cell rearranging gene, gamma
HGNC Previous nameTCRG
 TRG@
HGNC Previous nameTCRG, TRG@
LocusID (NCBI) 6965
Atlas_Id 268
Location 7p14  [Link to chromosome band 7p14]
 
  for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPATA48 (7p12.2) / TRG (7p14)TRG (7p14) / NSD2 (4p16.3)TRG (7p14) / NTRK1 (1q23.1)
TRG (7p14) / TCL1A (14q32.13)TRG (7p14) / TRG (7p14)
Note The human TRG locus is located on chromosome 7, at band 7p15-p14 The orientation of the locus has been determined by the analysis of chromosome 7 inversions inv(7)(p15-q35), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukaemia.

DNA/RNA

 
  TRG
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Description
  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5' TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3' of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes

    • Protein

    Description
  • Proteins encoded by the TRG locus are the T cell receptor gamma chains. They result from the recombination (or rearrangement), at the DNA level, of two genes: TRGV and TRGJ, with deletion of the intermediary DNA to create a rearranged TRGV-J gene. The rearranged TRGV-J gene is transcribed with one of the two TRGC genes and translated into an T cell receptor gamma chain
  • Translation of the variable germline genes involved in the TRGV-J rearrangements are available at IMGT Repertoire Protein displays. TRG V-J rearrangements can be analysed using the IMGT/V-QUEST tool.

    • Mutations

    Note Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Note
      
    Entity Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints
      

    Bibliography

    Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)
    Lefranc MP
    The immunologist,. 2000.
     
    The T cell Receptor FactsBook (Review)
    Lefranc M-P and Lefranc G
    Academic Press, London, UK (398 pages), 2001. ISBN: 124413528
     

    Citation

    This paper should be referenced as such :
    Lefranc, MP
    TRG (T cell receptor gamma)
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):123-124.
    Free journal version : [ pdf ]   [ DOI ]

    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 11 ]
      Breast implant-associated anaplastic large cell lymphoma
    Hepatosplenic T-cell lymphoma (HSTCL)
    Intestinal T-cell lymphoma
    Pediatric T-Cell Acute Lymphoblastic Leukemia
    t(7;14)(p15;q32)
    T-lineage acute lymphoblastic leukemia (T-ALL)
    T-cell large granular lymphocyte leukaemia
    inv(7)(p14q34) TRB/TRG
    inv(7)(p14q34) TRG/TRB
    t(7;14)(p14;q32) TRG/TCL1A
    t(7;14)(p14;q32) TRG/IGH

    Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
      t(1;7)(q23;p14) TRG/NTRK1

    External links

    Nomenclature
    HGNC (Hugo)TRG   12271
    Cards
    AtlasTCRGID268
    Entrez_Gene (NCBI)TRG  6965  T cell receptor gamma locus
    AliasesTCRG; TRG@
    GeneCards (Weizmann)TRG
    Ensembl hg19 (Hinxton) [Gene_View]
    Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  - [Contig_View]  TRG [Vega]
    TCGA cBioPortalTRG
    AceView (NCBI)TRG
    Genatlas (Paris)TRG
    WikiGenes6965
    SOURCE (Princeton)TRG
    Genetics Home Reference (NIH)TRG
    Genomic and cartography
    GoldenPath hg38 (UCSC)TRG  -  
    GoldenPath hg19 (UCSC)TRG  -  
    GoldenPathTRG - [CytoView hg19]  TRG - [CytoView hg38]
    genome Data Viewer NCBITRG [Mapview hg19]  
    Gene and transcription
    Genbank (Entrez)-
    RefSeq transcript (Entrez)
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)TRG
    Gene ExpressionTRG [ NCBI-GEO ]   TRG [ EBI - ARRAY_EXPRESS ]   TRG [ SEEK ]   TRG [ MEM ]
    Gene Expression Viewer (FireBrowse)TRG [ Firebrowse - Broad ]
    GenevisibleExpression of TRG in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)6965
    GTEX Portal (Tissue expression)TRG
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)TRG
    DMDM Disease mutations6965
    Blocks (Seattle)TRG
    Protein Interaction databases
    BioGRIDTRG
    STRING (EMBL)TRG
    ZODIACTRG
    Ontologies - Pathways
    Huge Navigator TRG [HugePedia]
    snp3D : Map Gene to Disease6965
    BioCentury BCIQTRG
    ClinGenTRG
    Clinical trials, drugs, therapy
    Protein Interactions : CTD6965
    Pharm GKB GenePA36951
    Clinical trialTRG
    Miscellaneous
    canSAR (ICR)TRG (select the gene name)
    HarmonizomeTRG
    DataMed IndexTRG
    Other database- IMGT
    Probes
    Litterature
    PubMed58 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineTRG
    EVEXTRG
    GoPubMedTRG
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    indexed on : Mon Oct 12 12:53:20 CEST 2020
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