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TRG@ (T cell Receptor Gamma)

Identity

Other namesTRG (T cell Receptor Gamma)
HGNC (Hugo) TRG@
Location 7p15-p14
Location_base_pair Starts at 38268315 and ends at 38323448 bp from pter ( according to hg18-Mar_2006)
 
  for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark
Note The human TRG locus is located on chromosome 7, at band 7p15-p14 The orientation of the locus has been determined by the analysis of chromosome 7 inversions inv(7)(p15-q35), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukaemia.

DNA/RNA

 
  TRG
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark
Description
  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5' TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3' of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes

    • Protein

    Description
  • Proteins encoded by the TRG locus are the T cell receptor gamma chains. They result from the recombination (or rearrangement), at the DNA level, of two genes: TRGV and TRGJ, with deletion of the intermediary DNA to create a rearranged TRGV-J gene. The rearranged TRGV-J gene is transcribed with one of the two TRGC genes and translated into an T cell receptor gamma chain
  • Translation of the variable germline genes involved in the TRGV-J rearrangements are available at IMGT Repertoire Protein displays. TRG V-J rearrangements can be analysed using the IMGT/V-QUEST tool.

    • Mutations

    Note Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints
      

    External links

    Nomenclature
    HGNC (Hugo)TRG@   12271
    Entrez_Gene (NCBI)TRG@  6965  T cell receptor gamma locus
    Cards
    AtlasTCRGID268
    GeneCards (Weizmann)TRG@
    Ensembl (Hinxton)ENSG00000124678 [Gene_View]  TRG@ [Vega]
    AceView (NCBI)TRG@
    Genatlas (Paris)TRG@
    euGene (Indiana)6965
    SOURCE (Stanford)
    Gene Expression (Array Express) ENSG00000124678
    Genomic and cartography
    GoldenPath (UCSC)TRG@  -     chr7:38268315-38323448 -  7p14   [Description]    (hg18-Mar_2006)
    EnsemblTRG@ - 7p14 [CytoView]
    Mapping of homologs : NCBITRG@ [Mapview]
    OMIM186970   
    Gene and transcription
    Gene : Genbank (Entrez)AJ583012 AJ583014
    Reference sequence (RefSeq transcript) :SRS
    Reference transcript : Entrez
    RefSeq genomic : SRSAC_000050 AC_000068 AC_000139 NC_000007 NG_001336 NT_007819 NT_079592 NW_001839003 NW_923240
    RefSeq genomic : EntrezAC_000050 AC_000068 AC_000139 NC_000007 NG_001336 NT_007819 NT_079592 NW_001839003 NW_923240
    Consensus coding sequences : CCDS NCBITRG@
    Cluster EST : UnigeneHs.534032 [ SRS ] Hs.534032 [ NCBI ]
    Protein : pattern, domain, 3D structure
    Protein : UniProt/SwissProtP03986 (SRS) P03986 (Expasy) P03986 (Uniprot)
    With graphics : InterProP03986
    Splice isoforms : VarSplice FASTAP03986(VarSplice FASTA)
    Domaine pattern : Prosite (SRS)IG_LIKE (PS50835)   
    Domain pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
    Domains : Interpro (SRS)Ig-like    Ig-like_fold    Ig_C1-set   
    Domains : Interpro (EBI)Ig-like    Ig-like_fold    Ig_C1-set   
    Related proteins : CluSTrP03986
    Domain families : Pfam SRSC1-set (PF07654)   
    Domain families : Pfam SangerC1-set (PF07654)   
    Domain families : Pfam NCBIpfam07654   
    Domain families : Smart EMBLIGc1 (SM00407)  
    Blocks (Seattle)P03986
    Crystal structure of protein : PDB SRS1HXM   
    Crystal structure of protein : PDBSum1HXM   
    Crystal structure of protein : IMB1HXM   
    Crystal structure of protein : PDB RSDB1HXM   
    Protein Interaction databases
    DIP (DOE-UCLA)P03986
    IntAct (EBI)P03986
    Polymorphism : SNP, mutations, diseases
    Single Nucleotide Polymorphism (SNP) : dbSNP NCBITRG@
    SNP : GeneSNP UtahTRG@
    SNP : HGBaseTRG@
    Genetic variants : HAPMAPTRG@
    Mutations and Diseases : HGMDTRG@
    Hereditary diseases : OMIM186970   
    Hereditary diseases : GENETests186970   
    Diseases : Genetic AssociationTRG@
    General knowledge
    Homologs : HomoloGeneTRG@
    Homology/Alignments : Family Browser UCSCTRG@
    Phylogenetic Trees/Animal Genes : TreeFamTRG@
    Chemical/Protein Interactions : CTD6965
    Keywords Ontology : AmiGOtransmembrane receptor activity  integral to plasma membrane  immune response  membrane  
    Keywords Ontology : EGO-EBItransmembrane receptor activity  integral to plasma membrane  immune response  membrane  
    Pathways : BIOCARTA
    Pathways : KEGG
    Other databases
    Other database- IMGT
    Probes
    ProbeProbes IMGT
    Probes : ImagenesTRG@ Related clones (RZPD - Berlin)
    Literature
    PubMed29 Pubmed reference(s) in Entrez
    PubGeneTRG@

    Bibliography

    Nomenclature of the human T cell Receptor genes (Review)
    Lefranc MP
    Current Protocols in Immunology. 2000.
     
    The T cell Receptor FactsBook (Review)
    Lefranc MP and Lefranc G
    Academic Press, London, UK (. 1939.
     
    Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)
    Lefranc MP
    The immunologist,. 2000.
     
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

    Search in all EBI   NCBI

    Contributor(s)

    Written07-2000Marie-Paule Lefranc
    Updated09-2003Marie-Paule Lefranc

    Citation

    This paper should be referenced as such :
    Lefranc MP . TRG@ (T cell Receptor Gamma). Atlas Genet Cytogenet Oncol Haematol. July 2000 .
    URL : http://AtlasGeneticsOncology.org/Genes/TCRGID268.html
    Lefranc MP . TRG@ (T cell Receptor Gamma). Atlas Genet Cytogenet Oncol Haematol. September 2003 .
    URL : http://AtlasGeneticsOncology.org/Genes/TCRGID268.html

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    indexed on : Sat Feb 27 10:50:33 CET 2010
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