Written | 2000-07 | Marie-Paule Lefranc |
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France |
Identity |
Alias (NCBI) | TRG@ (T cell Receptor Gamma) |
HGNC (Hugo) | TRG |
HGNC Alias name | "T-cell antigen receptor, gamma polypeptide | T-cell receptor, gamma cluster | T-cell rearranging gene, gamma" |
HGNC Previous name | TCRG | TRG@ |
HGNC Previous name | "TCRG, TRG@" |
LocusID (NCBI) | 6965 |
Atlas_Id | 268 |
Location | 7p14 [Link to chromosome band 7p14] |
![]() | |
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark | |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
SPATA48 (7p12.2) / TRG (7p14) | TRG (7p14) / NSD2 (4p16.3) | TRG (7p14) / NTRK1 (1q23.1) | |
TRG (7p14) / TCL1A (14q32.13) | TRG (7p14) / TRG (7p14) |
Note | The human TRG locus is located on chromosome 7, at band 7p15-p14 The orientation of the locus has been determined by the analysis of chromosome 7 inversions inv(7)(p15-q35), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukaemia. |
DNA/RNA |
![]() | |
TRG V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced. J-GENE: Grey: Functional . C-GENE: Blue: Functional. for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark | |
Description | |
Protein |
Description | |
Mutations |
Note | Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles) |
Implicated in |
Note | |
Entity | Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints |
Bibliography |
Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review) |
Lefranc MP |
The immunologist,. 2000. |
The T cell Receptor FactsBook (Review) |
Lefranc M-P and Lefranc G |
Academic Press, London, UK (398 pages), 2001. ISBN: 124413528 |
Citation |
This paper should be referenced as such : |
Lefranc, MP |
TRG (T cell receptor gamma) |
Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):123-124. |
Free journal version : [ pdf ] [ DOI ] |
Other Leukemias implicated (Data extracted from papers in the Atlas) [ 11 ] |
Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ] |
t(1;7)(q23;p14) TRG/NTRK1
|
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Feb 19 18:01:23 CET 2021 |
For comments and suggestions or contributions, please contact us