TRG (T cell Receptor Gamma)

Identity

HGNC	TRG@
Location	7p15-p14
	for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark

Note	The human TRG locus is located on chromosome 7, at band 7p15-p14 The orientation of the locus has been determined by the analysis of chromosome 7 inversions inv(7)(p15-q35), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukaemia.

DNA/RNA

	TRG V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced. J-GENE: Grey: Functional . C-GENE: Blue: Functional. for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark
Description	The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene. The most 5' TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3' of the locus, is the most telomeric in the TRG locus. The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes. Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations. Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene List of the human TRG genes

Protein

Description

Proteins encoded by the TRG locus are the T cell receptor gamma chains. They result from the recombination (or rearrangement), at the DNA level, of two genes: TRGV and TRGJ, with deletion of the intermediary DNA to create a rearranged TRGV-J gene. The rearranged TRGV-J gene is transcribed with one of the two TRGC genes and translated into an T cell receptor gamma chain Translation of the variable germline genes involved in the TRGV-J rearrangements are available at IMGT Repertoire Protein displays. TRG V-J rearrangements can be analysed using the IMGT/V-QUEST tool.

Mutations

Note	Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

Implicated in

Entity	Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints

External links

	Nomenclature
HGNC	TRG@   12271
Entrez_Gene	TRG@  6965  T cell receptor gamma locus
	Cards
Atlas	TCRGID268
GeneCards	TRG@
Ensembl	TRG@ [Search_View]   ENSG00000124678 [Gene_View]
Genatlas	TRG@
GeneLynx	TRG@
eGenome	TRG@
euGene	6965
	Genomic and cartography
GoldenPath	TRG@  -     chr7:38268315-38323448 -  7p14   [Description]    (hg18-Mar_2006)
Ensembl	TRG@ - 7p14 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TRG@
	Gene and transcription
Genbank	AJ583012 [ ENTREZ ]
Genbank	AJ583014 [ ENTREZ ]
RefSeq	AC_000050 [ SRS ]    AC_000050 [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	AC_000139 [ SRS ]    AC_000139 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NG_001336 [ SRS ]    NG_001336 [ ENTREZ ]
RefSeq	NT_007819 [ SRS ]    NT_007819 [ ENTREZ ]
RefSeq	NT_079592 [ SRS ]    NT_079592 [ ENTREZ ]
RefSeq	NW_001839003 [ SRS ]    NW_001839003 [ ENTREZ ]
RefSeq	NW_923240 [ SRS ]    NW_923240 [ ENTREZ ]
AceView	TRG@ AceView - NCBI
Unigene	Hs.534032 [ SRS ]    Hs.534032 [ NCBI ]     HS534032 [ spliceNest ]
	Protein : pattern, domain, 3D structure
SwissProt	P03986 [ SRS]    P03986 [ EXPASY ]     P03986 [ INTERPRO ]     P03986 [ UNIPROT ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR003597 Ig_C1-set [ SRS ]    IPR003597 Ig_C1-set [ EBI ]
CluSTr	P03986
Smart	SM00407 IGc1 [EMBL]
Blocks	P03986
PDB	1HXM [ SRS ]    1HXM [ PdbSum ],   1HXM [ IMB ]   1HXM [ RSDB ]
	Protein Interaction databases
DIP	P03986
IntAct	P03986
	Polymorphism : SNP, mutations, diseases
OMIM	186970    [ map ]
GENECLINICS	186970
SNP	TRG@ [dbSNP-NCBI]
SNP	TRG@ [GeneSNPs - Utah]  TRG@] [HGBASE - SRS]
HAPMAP	TRG@ [HAPMAP]
HGMD	TRG@
	General knowledge
Family Browser	TRG@ [UCSC Family Browser]
SMD	Hs.534032
SAGE	Hs.534032
GO	transmembrane receptor activity [Amigo]  transmembrane receptor activity
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	immune response [Amigo]  immune response
GO	membrane [Amigo]  membrane
PubGene	TRG@
TreeFam	TRG@
CTD	6965 [Comparative ToxicoGenomics Database]
	Other databases
Other database	- IMGT
	Probes
Probe	TRG@ Related clones (RZPD - Berlin)
	PubMed
PubMed	22 Pubmed reference(s) in LocusLink

Bibliography

Nomenclature of the human T cell Receptor genes (Review)

Lefranc MP

Current Protocols in Immunology. 2000.

The T cell Receptor FactsBook (Review)

Lefranc MP and Lefranc G

Academic Press, London, UK (. 1939.

Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)

Lefranc MP

The immunologist,. 2000.

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2000	Marie-Paule Lefranc
Updated	09-2003	Marie-Paule Lefranc

Citation

This paper should be referenced as such :

Lefranc MP . TRG (T cell Receptor Gamma). Atlas Genet Cytogenet Oncol Haematol. July 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TCRGID268.html

Lefranc MP . TRG (T cell Receptor Gamma). Atlas Genet Cytogenet Oncol Haematol. September 2003 . URL : http://AtlasGeneticsOncology.org/Genes/TCRGID268.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 21:17:56 2008