Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TRG (T cell Receptor Gamma)

Written2000-07Marie-Paule Lefranc
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

(Note : for Links provided by Atlas : click)


Other aliasTRG@ (T cell Receptor Gamma)
LocusID (NCBI) 6965
Atlas_Id 268
Location 7p14  [Link to chromosome band 7p14]
Location_base_pair Starts at 38240024 and ends at 38368055 bp from pter
  for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPATA48 (7p12.2) / TRG (7p14)TRG (7p14) / NSD2 (4p16.3)TRG (7p14) / NTRK1 (1q23.1)
TRG (7p14) / TCL1A (14q32.13)TRG (7p14) / TRG (7p14)
Note The human TRG locus is located on chromosome 7, at band 7p15-p14 The orientation of the locus has been determined by the analysis of chromosome 7 inversions inv(7)(p15-q35), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukaemia.


V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5' TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3' of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes
  • Protein

  • Proteins encoded by the TRG locus are the T cell receptor gamma chains. They result from the recombination (or rearrangement), at the DNA level, of two genes: TRGV and TRGJ, with deletion of the intermediary DNA to create a rearranged TRGV-J gene. The rearranged TRGV-J gene is transcribed with one of the two TRGC genes and translated into an T cell receptor gamma chain
  • Translation of the variable germline genes involved in the TRGV-J rearrangements are available at IMGT Repertoire Protein displays. TRG V-J rearrangements can be analysed using the IMGT/V-QUEST tool.
  • Mutations

    Note Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints


    Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)
    Lefranc MP
    The immunologist,. 2000.
    The T cell Receptor FactsBook (Review)
    Lefranc M-P and Lefranc G
    Academic Press, London, UK (398 pages), 2001. ISBN: 124413528


    This paper should be referenced as such :
    Lefranc, MP
    TRG (T cell receptor gamma)
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):123-124.
    Free journal version : [ pdf ]   [ DOI ]
    On line version :

    Other Leukemias implicated (Data extracted from papers in the Atlas)

    Leukemias PediatrTCellALLID1292 t0714p15q32ID1059 TL_inv07p14q34ID3374 TL_inv07p14q34ID3375 TL_t0714p14q32ID3299

    Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

    Solid Tumors TT_t0107q23p14ID104503

    External links

    HGNC (Hugo)TRG   12271
    Entrez_Gene (NCBI)TRG  6965  T cell receptor gamma locus
    AliasesTCRG; TRG@
    GeneCards (Weizmann)TRG
    Ensembl hg19 (Hinxton) [Gene_View]
    Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr7:38240024-38368055 [Contig_View]  TRG [Vega]
    TCGA cBioPortalTRG
    AceView (NCBI)TRG
    Genatlas (Paris)TRG
    SOURCE (Princeton)TRG
    Genetics Home Reference (NIH)TRG
    Genomic and cartography
    GoldenPath hg38 (UCSC)TRG  -     chr7:38240024-38368055 7p14.1  hg19-Feb_2009   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)TRG  -     hg19-Feb_2009   [Description]    (hg19-Feb_2009)
    GoldenPathTRG - hg19-Feb_2009 [CytoView hg19]  TRG - hg19-Feb_2009 [CytoView hg38]
    Mapping of homologs : NCBITRG [Mapview hg19]  TRG [Mapview hg38]
    Gene and transcription
    Genbank (Entrez)-
    RefSeq transcript (Entrez)
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)TRG
    Gene ExpressionTRG [ NCBI-GEO ]   TRG [ EBI - ARRAY_EXPRESS ]   TRG [ SEEK ]   TRG [ MEM ]
    Gene Expression Viewer (FireBrowse)TRG [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    BioGPS (Tissue expression)6965
    GTEX Portal (Tissue expression)TRG
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)TRG
    DMDM Disease mutations6965
    Blocks (Seattle)TRG
    Protein Interaction databases
    Ontologies - Pathways
    Huge Navigator TRG [HugePedia]
    snp3D : Map Gene to Disease6965
    BioCentury BCIQTRG
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD6965
    Chemical/Pharm GKB GenePA36951
    Clinical trialTRG
    canSAR (ICR)TRG (select the gene name)
    DataMed IndexTRG
    Other database- IMGT
    PubMed58 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

    Search in all EBI   NCBI

    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Mon Aug 26 19:31:06 CEST 2019

    Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

    For comments and suggestions or contributions, please contact us