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TRG (T cell Receptor Gamma)

Written2000-07Marie-Paule Lefranc
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)TRG@ (T cell Receptor Gamma)
HGNC Alias nameT-cell antigen receptor, gamma polypeptide
 T-cell receptor, gamma cluster
 T-cell rearranging gene, gamma
HGNC Previous nameTCRG
HGNC Previous nameTCRG, TRG@
LocusID (NCBI) 6965
Atlas_Id 268
Location 7p14  [Link to chromosome band 7p14]
  for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPATA48 (7p12.2)::TRG (7p14)TRG (7p14)::NSD2 (4p16.3)TRG (7p14)::NTRK1 (1q23.1)
TRG (7p14)::TCL1A (14q32.13)TRG (7p14)::TRG (7p14)
Note The human TRG locus is located on chromosome 7, at band 7p15-p14 The orientation of the locus has been determined by the analysis of chromosome 7 inversions inv(7)(p15-q35), involving the TRG and TRB loci in ataxia telangiectasia patients, and in leukaemia.


V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5' TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3' of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes
  • Protein

  • Proteins encoded by the TRG locus are the T cell receptor gamma chains. They result from the recombination (or rearrangement), at the DNA level, of two genes: TRGV and TRGJ, with deletion of the intermediary DNA to create a rearranged TRGV-J gene. The rearranged TRGV-J gene is transcribed with one of the two TRGC genes and translated into an T cell receptor gamma chain
  • Translation of the variable germline genes involved in the TRGV-J rearrangements are available at IMGT Repertoire Protein displays. TRG V-J rearrangements can be analysed using the IMGT/V-QUEST tool.
  • Mutations

    Note Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints


    Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)
    Lefranc MP
    The immunologist,. 2000.
    The T cell Receptor FactsBook (Review)
    Lefranc M-P and Lefranc G
    Academic Press, London, UK (398 pages), 2001. ISBN: 124413528


    This paper should be referenced as such :
    Lefranc, MP
    TRG (T cell receptor gamma)
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):123-124.
    Free journal version : [ pdf ]   [ DOI ]

    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 11 ]
      Breast implant-associated anaplastic large cell lymphoma
    Hepatosplenic T-cell lymphoma (HSTCL)
    Intestinal T-cell lymphoma
    Pediatric T-Cell Acute Lymphoblastic Leukemia
    T-lineage acute lymphoblastic leukemia (T-ALL)
    T-cell large granular lymphocyte leukaemia
    inv(7)(p14q34) TRB::TRG
    inv(7)(p14q34) TRG::TRB
    t(7;14)(p14;q32) TRG::TCL1A
    t(7;14)(p14;q32) TRG::IGH

    External links

    HGNC (Hugo)TRG   12271
    Atlas Explorer : (Salamanque)TRG
    Entrez_Gene (NCBI)TRG    T cell receptor gamma locus
    AliasesTCRG; TRG@
    GeneCards (Weizmann)TRG
    Ensembl hg19 (Hinxton) [Gene_View]
    Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  - [Contig_View]  TRG [Vega]
    TCGA cBioPortalTRG
    AceView (NCBI)TRG
    Genatlas (Paris)TRG
    SOURCE (Princeton)TRG
    Genetics Home Reference (NIH)TRG
    Genomic and cartography
    GoldenPath hg38 (UCSC)TRG  -  
    GoldenPath hg19 (UCSC)TRG  -  
    GoldenPathTRG - [CytoView hg19]  TRG - [CytoView hg38]
    Genome Data Viewer NCBITRG [Mapview hg19]  
    Gene and transcription
    Genbank (Entrez)-
    RefSeq transcript (Entrez)
    Consensus coding sequences : CCDS (NCBI)TRG
    Gene ExpressionTRG [ NCBI-GEO ]   TRG [ EBI - ARRAY_EXPRESS ]   TRG [ SEEK ]   TRG [ MEM ]
    Gene Expression Viewer (FireBrowse)TRG [ Firebrowse - Broad ]
    GenevisibleExpression of TRG in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)6965
    GTEX Portal (Tissue expression)TRG
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)TRG
    Protein Interaction databases
    Ontologies - Pathways
    PubMed58 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

    Search in all EBI   NCBI

    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Thu Jan 20 14:18:42 CET 2022

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