Atlas of Genetics and Cytogenetics in Oncology and Haematology
TCTA (T-cell leukemia translocation-associated gene)
| Identity |
| HGNC (Hugo) | TCTA |
| Location | 3p21 |
| Location_base_pair | Starts at 49424643 and ends at 49428913 bp from pter ( according to hg18-Mar_2006) [Mapping] |
| DNA/RNA |
 | |
| DNA diagram | |
| Transcription | 2.1 kb mRNA |
| Protein |
| Description | 103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61) |
| Expression | wide, especially in kidneys |
| Localisation | may be a membrane associated protein, as there is a hydrophobic domain |
| Function | unknown |
| Homology | none is known |
| Implicated in |
| Entity | t(1;3)(p32;p21)/T-cell ALL --> TAL1 - TCTA |
| Disease | T-cell ALL |
| Hybrid/Mutated Gene | head to head orientation of TAL1 and TCTA |
| Abnormal Protein | no fusion protein, but possibly promoter exchange and gene disregulation |
| To be noted |
| on day 04 Feb 1998, nothing new has appeared since the above coted paper |
| External links |
| Nomenclature | |
|---|---|
| HGNC (Hugo) | TCTA 11692 |
| Entrez_Gene (NCBI) | TCTA 6988 T-cell leukemia translocation altered gene |
| Cards | |
| Atlas | TCTA |
| GeneCards (Weizmann) | TCTA |
| Ensembl (Hinxton) | ENSG00000145022 [Gene_View] TCTA [Vega] |
| AceView (NCBI) | TCTA |
| Genatlas (Paris) | TCTA |
| euGene (Indiana) | 6988 |
| SOURCE (Stanford) | NM_022171 |
| Genomic and cartography | |
| GoldenPath (UCSC) | TCTA - 3p21 chr3:49424643-49428913 + 3p21 [Description] (hg18-Mar_2006) |
| Ensembl | TCTA - 3p21 [CytoView] |
| Mapping of homologs : NCBI | TCTA [Mapview] |
| OMIM | 600690 |
| Gene and transcription | |
| Gene : Genbank (Entrez) | AA181568 AK000824 AK311839 BC005157 CB054963 |
| Reference sequence (RefSeq transcript) :SRS | NM_022171 |
| Reference transcript : Entrez | NM_022171 |
| RefSeq genomic : SRS | AC_000046 AC_000135 NC_000003 NT_022517 NW_001838877 NW_921651 |
| RefSeq genomic : Entrez | AC_000046 AC_000135 NC_000003 NT_022517 NW_001838877 NW_921651 |
| Consensus coding sequences : CCDS NCBI | TCTA |
| Cluster EST : Unigene | Hs.517962 [ SRS ] Hs.517962 [ NCBI ] |
| Alternative Splicing : Fast-db (Paris) | 6638 |
| Protein : pattern, domain, 3D structure | |
| Protein : UniProt/SwissProt | P57738 (SRS) P57738 (Expasy) P57738 (Uniprot) |
| With graphics : InterPro | P57738 |
| Splice isoforms : VarSplice FASTA | P57738(VarSplice FASTA) |
| Domains : Interpro (SRS) | T-cell_leukemia_transloc-assoc |
| Domains : Interpro (EBI) | T-cell_leukemia_transloc-assoc |
| Related proteins : CluSTr | P57738 |
| Domain families : Pfam SRS | |
| Domain families : Pfam Sanger | |
| Domain families : Pfam NCBI | |
| Blocks (Seattle) | P57738 |
| Crystal structure of protein : PDB SRS | |
| Crystal structure of protein : PDBSum | |
| Crystal structure of protein : IMB | |
| Crystal structure of protein : PDB RSDB | |
| HPRD | 15977 |
| Protein Interaction databases | |
| DIP (DOE-UCLA) | P57738 |
| IntAct (EBI) | P57738 |
| Polymorphism : SNP, mutations, diseases | |
| Single Nucleotide Polymorphism (SNP) : dbSNP NCBI | TCTA |
| SNP : GeneSNP Utah | TCTA |
| SNP : HGBase | TCTA |
| Genetic variants : HAPMAP | TCTA |
| Mutations and Diseases : HGMD | TCTA |
| Hereditary diseases : OMIM | 600690 |
| Hereditary diseases : GENETests | 600690 |
| Diseases : Genetic Association | TCTA |
| General knowledge | |
| Homologs : HomoloGene | TCTA |
| Homology/Alignments : Family Browser UCSC | TCTA |
| Phylogenetic Trees/Animal Genes : TreeFam | TCTA |
| Chemical/Protein Interactions : CTD | 6988 |
| Keywords Ontology : AmiGO | |
| Keywords Ontology : EGO-EBI | |
| Pathways : BIOCARTA | |
| Pathways : KEGG | |
| Other databases | |
| Probes | |
| Probes : Imagenes | TCTA Related clones (RZPD - Berlin) |
| Literature | |
| PubMed | 6 Pubmed reference(s) in Entrez |
| PubGene | TCTA |
| Bibliography |
| Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. |
| Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR |
| Cancer research. 1995 ; 55 (9) : 1917-1921. |
| PMID 7728759 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 01-1998 | Jean-Loup Huret |
| Updated | 03-1998 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| - . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. January 1998 . URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html |
| Huret JL . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html |
| Huret JL . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. . URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jun 27 16:40:15 CEST 2009 |
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