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TCTA (T-cell leukemia translocation-associated gene)

Identity

HGNC (Hugo) TCTA
Location 3p21
Location_base_pair Starts at 49424643 and ends at 49428913 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

 
  DNA diagram
Transcription 2.1 kb mRNA

Protein

Description 103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61)
Expression wide, especially in kidneys
Localisation may be a membrane associated protein, as there is a hydrophobic domain
Function unknown
Homology none is known

Implicated in

Entity t(1;3)(p32;p21)/T-cell ALL --> TAL1 - TCTA
Disease T-cell ALL
Hybrid/Mutated Gene head to head orientation of TAL1 and TCTA
Abnormal Protein no fusion protein, but possibly promoter exchange and gene disregulation
  

To be noted

on day 04 Feb 1998, nothing new has appeared since the above coted paper

External links

Nomenclature
HGNC (Hugo)TCTA   11692
Entrez_Gene (NCBI)TCTA  6988  T-cell leukemia translocation altered gene
Cards
AtlasTCTA
GeneCards (Weizmann)TCTA
Ensembl (Hinxton)ENSG00000145022 [Gene_View]  TCTA [Vega]
AceView (NCBI)TCTA
Genatlas (Paris)TCTA
euGene (Indiana)6988
SOURCE (Stanford)NM_022171
Genomic and cartography
GoldenPath (UCSC)TCTA  -  3p21   chr3:49424643-49428913 +  3p21   [Description]    (hg18-Mar_2006)
EnsemblTCTA - 3p21 [CytoView]
Mapping of homologs : NCBITCTA [Mapview]
OMIM600690   
Gene and transcription
Gene : Genbank (Entrez)AA181568 AK000824 AK311839 BC005157 CB054963
Reference sequence (RefSeq transcript) :SRSNM_022171
Reference transcript : EntrezNM_022171
RefSeq genomic : SRSAC_000046 AC_000135 NC_000003 NT_022517 NW_001838877 NW_921651
RefSeq genomic : EntrezAC_000046 AC_000135 NC_000003 NT_022517 NW_001838877 NW_921651
Consensus coding sequences : CCDS NCBITCTA
Cluster EST : UnigeneHs.517962 [ SRS ] Hs.517962 [ NCBI ]
Alternative Splicing : Fast-db (Paris)6638
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP57738 (SRS) P57738 (Expasy) P57738 (Uniprot)
With graphics : InterProP57738
Splice isoforms : VarSplice FASTAP57738(VarSplice FASTA)
Domains : Interpro (SRS)T-cell_leukemia_transloc-assoc   
Domains : Interpro (EBI)T-cell_leukemia_transloc-assoc   
Related proteins : CluSTrP57738
Domain families : Pfam SRS
Domain families : Pfam Sanger
Domain families : Pfam NCBI
Blocks (Seattle)P57738
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD15977
Protein Interaction databases
DIP (DOE-UCLA)P57738
IntAct (EBI)P57738
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITCTA
SNP : GeneSNP UtahTCTA
SNP : HGBaseTCTA
Genetic variants : HAPMAPTCTA
Mutations and Diseases : HGMDTCTA
Hereditary diseases : OMIM600690   
Hereditary diseases : GENETests600690   
Diseases : Genetic AssociationTCTA
General knowledge
Homologs : HomoloGeneTCTA
Homology/Alignments : Family Browser UCSCTCTA
Phylogenetic Trees/Animal Genes : TreeFamTCTA
Chemical/Protein Interactions : CTD6988
Keywords Ontology : AmiGO
Keywords Ontology : EGO-EBI
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTCTA Related clones (RZPD - Berlin)
Literature
PubMed6 Pubmed reference(s) in Entrez
PubGeneTCTA

Bibliography

Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.
Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR
Cancer research. 1995 ; 55 (9) : 1917-1921.
PMID 7728759
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written01-1998Jean-Loup Huret
Updated03-1998Jean-Loup Huret

Citation

This paper should be referenced as such :
- . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. January 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html
Huret JL . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. March 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html
Huret JL . TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. .
URL : http://AtlasGeneticsOncology.org/Genes/TCTA.html

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indexed on : Sat Jun 27 16:40:15 CEST 2009

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