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TCTA (T-cell leukemia translocation-associated gene)

Written1998-03Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
This article is an update of :
1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

HGNC (Hugo) TCTA
HGNC Previous nameT-cell leukemia translocation altered gene
 T-cell leukemia translocation altered
LocusID (NCBI) 6988
Atlas_Id 58
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49412206 and ends at 49416476 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TCTA.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TCTA (3p21.31)::ARIH2 (3p21.31)TCTA (3p21.31)::TAL1 (1p33)TCTA (3p21.31)::TCTA (3p21.31)

DNA/RNA

 
  DNA diagram
Transcription 2.1 kb mRNA

Protein

Description 103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61)
Expression wide, especially in kidneys
Localisation may be a membrane associated protein, as there is a hydrophobic domain
Function unknown
Homology none is known

Implicated in

Note
  
Entity /T-cell ALL --> TAL1 - TCTA
Disease T-cell ALL
Hybrid/Mutated Gene head to head orientation of TAL1 and TCTA
Abnormal Protein no fusion protein, but possibly promoter exchange and gene disregulation
  

To be noted

on day 04 Feb 1998, nothing new has appeared since the above coted paper

Bibliography

Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.
Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR
Cancer research. 1995 ; 55 (9) : 1917-1921.
PMID 7728759
 

Citation

This paper should be referenced as such :
Huret, JL
TCTA (T-cell leukemia translocation-associated gene)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(2):51-51.
Free journal version : [ pdf ]   [ DOI ]
History of this paper:
Huret, JL. TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. 1998;2(2):51-51.
http://documents.irevues.inist.fr/bitstream/handle/2042/37412/03-1998-TCTA.pdf


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;3)(p32;p21) TCTA::TAL1
T-lineage acute lymphoblastic leukemia (T-ALL)


External links

 

Nomenclature
HGNC (Hugo)TCTA   11692
Cards
AtlasTCTAID58
Entrez_Gene (NCBI)TCTA    T cell leukemia translocation altered
Aliases
GeneCards (Weizmann)TCTA
Ensembl hg19 (Hinxton)ENSG00000145022 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145022 [Gene_View]  ENSG00000145022 [Sequence]  chr3:49412206-49416476 [Contig_View]  TCTA [Vega]
ICGC DataPortalENSG00000145022
TCGA cBioPortalTCTA
AceView (NCBI)TCTA
Genatlas (Paris)TCTA
SOURCE (Princeton)TCTA
Genetics Home Reference (NIH)TCTA
Genomic and cartography
GoldenPath hg38 (UCSC)TCTA  -     chr3:49412206-49416476 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCTA  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathTCTA - 3p21.31 [CytoView hg19]  TCTA - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000145022
Genome Data Viewer NCBITCTA [Mapview hg19]  
OMIM600690   
Gene and transcription
Genbank (Entrez)AA181568 AK000824 AK311839 BC005157 CB054963
RefSeq transcript (Entrez)NM_022171
Consensus coding sequences : CCDS (NCBI)TCTA
Gene ExpressionTCTA [ NCBI-GEO ]   TCTA [ EBI - ARRAY_EXPRESS ]   TCTA [ SEEK ]   TCTA [ MEM ]
Gene Expression Viewer (FireBrowse)TCTA [ Firebrowse - Broad ]
GenevisibleExpression of TCTA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6988
GTEX Portal (Tissue expression)TCTA
Human Protein AtlasENSG00000145022-TCTA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57738   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57738  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57738
PhosPhoSitePlusP57738
Domains : Interpro (EBI)TCTA   
Domain families : Pfam (Sanger)T_cell_tran_alt (PF15128)   
Domain families : Pfam (NCBI)pfam15128   
Conserved Domain (NCBI)TCTA
SuperfamilyP57738
AlphaFold pdb e-kbP57738   
Human Protein Atlas [tissue]ENSG00000145022-TCTA [tissue]
HPRD15977
Protein Interaction databases
DIP (DOE-UCLA)P57738
IntAct (EBI)P57738
BioGRIDTCTA
STRING (EMBL)TCTA
ZODIACTCTA
Ontologies - Pathways
QuickGOP57738
Ontology : AmiGOmolecular_function  protein binding  integral component of membrane  negative regulation of osteoclast differentiation  osteoclast fusion  osteoclast fusion  
Ontology : EGO-EBImolecular_function  protein binding  integral component of membrane  negative regulation of osteoclast differentiation  osteoclast fusion  osteoclast fusion  
NDEx NetworkTCTA
Atlas of Cancer Signalling NetworkTCTA
Wikipedia pathwaysTCTA
Orthology - Evolution
OrthoDB6988
GeneTree (enSembl)ENSG00000145022
Phylogenetic Trees/Animal Genes : TreeFamTCTA
Homologs : HomoloGeneTCTA
Homology/Alignments : Family Browser (UCSC)TCTA
Gene fusions - Rearrangements
Fusion : MitelmanTCTA::ARIH2 [3p21.31/3p21.31]  
Fusion : MitelmanTCTA::TAL1 [3p21.31/1p33]  
Fusion : QuiverTCTA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCTA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCTA
dbVarTCTA
ClinVarTCTA
MonarchTCTA
1000_GenomesTCTA 
Exome Variant ServerTCTA
GNOMAD BrowserENSG00000145022
Varsome BrowserTCTA
ACMGTCTA variants
VarityP57738
Genomic Variants (DGV)TCTA [DGVbeta]
DECIPHERTCTA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCTA 
Mutations
ICGC Data PortalTCTA 
TCGA Data PortalTCTA 
Broad Tumor PortalTCTA
OASIS PortalTCTA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCTA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCTA
Mutations and Diseases : HGMDTCTA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTCTA
DgiDB (Drug Gene Interaction Database)TCTA
DoCM (Curated mutations)TCTA
CIViC (Clinical Interpretations of Variants in Cancer)TCTA
NCG (London)TCTA
Cancer3DTCTA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600690   
Orphanet
DisGeNETTCTA
MedgenTCTA
Genetic Testing Registry TCTA
NextProtP57738 [Medical]
GENETestsTCTA
Target ValidationTCTA
Huge Navigator TCTA [HugePedia]
ClinGenTCTA
Clinical trials, drugs, therapy
MyCancerGenomeTCTA
Protein Interactions : CTDTCTA
Pharm GKB GenePA36412
PharosP57738
Clinical trialTCTA
Miscellaneous
canSAR (ICR)TCTA
HarmonizomeTCTA
DataMed IndexTCTA
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTCTA
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Oct 8 21:29:14 CEST 2021

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jlhuret@AtlasGeneticsOncology.org.