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TCTA (T-cell leukemia translocation-associated gene)

Written1998-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated1998-03Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesT-cell leukemia translocation altered gene
Other alias
HGNC (Hugo) TCTA
LocusID (NCBI) 6988
Atlas_Id 58
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49449639 and ends at 49453909 bp from pter ( according to hg19-Feb_2009)  [Mapping TCTA.png]
Fusion genes
(updated 2016)
TCTA (3p21.31) / ARIH2 (3p21.31)TCTA (3p21.31) / TAL1 (1p33)TCTA (3p21.31) / TCTA (3p21.31)

DNA/RNA

 
  DNA diagram
Transcription 2.1 kb mRNA

Protein

Description 103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61)
Expression wide, especially in kidneys
Localisation may be a membrane associated protein, as there is a hydrophobic domain
Function unknown
Homology none is known

Implicated in

Note
  
Entity t(1;3)(p32;p21)/T-cell ALL --> TAL1 - TCTA
Disease T-cell ALL
Hybrid/Mutated Gene head to head orientation of TAL1 and TCTA
Abnormal Protein no fusion protein, but possibly promoter exchange and gene disregulation
  

To be noted

on day 04 Feb 1998, nothing new has appeared since the above coted paper

Bibliography

Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.
Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR
Cancer research. 1995 ; 55 (9) : 1917-1921.
PMID 7728759
 

Citation

This paper should be referenced as such :
Huret JL
TCTA (T-cell leukemia translocation-associated gene);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Genes/TCTAID58.html
History of this paper:
Huret, JL. TCTA (T-cell leukemia translocation-associated gene). Atlas Genet Cytogenet Oncol Haematol. 1998;2(2):51-51.
http://documents.irevues.inist.fr/bitstream/handle/2042/37412/03-1998-TCTA.pdf


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;3)(p32;p21) TCTA/TAL1
T-lineage acute lymphoblastic leukemia (T-ALL)


External links

Nomenclature
HGNC (Hugo)TCTA   11692
Cards
AtlasTCTAID58
Entrez_Gene (NCBI)TCTA  6988  T-cell leukemia translocation altered
Aliases
GeneCards (Weizmann)TCTA
Ensembl hg19 (Hinxton)ENSG00000145022 [Gene_View]  chr3:49449639-49453909 [Contig_View]  TCTA [Vega]
Ensembl hg38 (Hinxton)ENSG00000145022 [Gene_View]  chr3:49449639-49453909 [Contig_View]  TCTA [Vega]
ICGC DataPortalENSG00000145022
TCGA cBioPortalTCTA
AceView (NCBI)TCTA
Genatlas (Paris)TCTA
WikiGenes6988
SOURCE (Princeton)TCTA
Genetics Home Reference (NIH)TCTA
Genomic and cartography
GoldenPath hg19 (UCSC)TCTA  -     chr3:49449639-49453909 +  3p21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TCTA  -     3p21   [Description]    (hg38-Dec_2013)
EnsemblTCTA - 3p21 [CytoView hg19]  TCTA - 3p21 [CytoView hg38]
Mapping of homologs : NCBITCTA [Mapview hg19]  TCTA [Mapview hg38]
OMIM600690   
Gene and transcription
Genbank (Entrez)AA181568 AK000824 AK311839 BC005157 CB054963
RefSeq transcript (Entrez)NM_022171
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TCTA
Cluster EST : UnigeneHs.517962 [ NCBI ]
CGAP (NCI)Hs.517962
Alternative Splicing GalleryENSG00000145022
Gene ExpressionTCTA [ NCBI-GEO ]   TCTA [ EBI - ARRAY_EXPRESS ]   TCTA [ SEEK ]   TCTA [ MEM ]
Gene Expression Viewer (FireBrowse)TCTA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6988
GTEX Portal (Tissue expression)TCTA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57738   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57738  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57738
Splice isoforms : SwissVarP57738
PhosPhoSitePlusP57738
Domains : Interpro (EBI)TCTA   
Domain families : Pfam (Sanger)T_cell_tran_alt (PF15128)   
Domain families : Pfam (NCBI)pfam15128   
Conserved Domain (NCBI)TCTA
DMDM Disease mutations6988
Blocks (Seattle)TCTA
SuperfamilyP57738
Human Protein AtlasENSG00000145022
Peptide AtlasP57738
HPRD15977
IPIIPI00027997   
Protein Interaction databases
DIP (DOE-UCLA)P57738
IntAct (EBI)P57738
FunCoupENSG00000145022
BioGRIDTCTA
STRING (EMBL)TCTA
ZODIACTCTA
Ontologies - Pathways
QuickGOP57738
Ontology : AmiGOintegral component of membrane  
Ontology : EGO-EBIintegral component of membrane  
NDEx NetworkTCTA
Atlas of Cancer Signalling NetworkTCTA
Wikipedia pathwaysTCTA
Orthology - Evolution
OrthoDB6988
GeneTree (enSembl)ENSG00000145022
Phylogenetic Trees/Animal Genes : TreeFamTCTA
HOVERGENP57738
HOGENOMP57738
Homologs : HomoloGeneTCTA
Homology/Alignments : Family Browser (UCSC)TCTA
Gene fusions - Rearrangements
Fusion : MitelmanTCTA/ARIH2 [3p21.31/3p21.31]  
Fusion : MitelmanTCTA/TAL1 [3p21.31/1p33]  [t(1;3)(p33;p21)]  
Fusion: TCGATCTA 3p21.31 ARIH2 3p21.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCTA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCTA
dbVarTCTA
ClinVarTCTA
1000_GenomesTCTA 
Exome Variant ServerTCTA
ExAC (Exome Aggregation Consortium)TCTA (select the gene name)
Genetic variants : HAPMAP6988
Genomic Variants (DGV)TCTA [DGVbeta]
DECIPHER (Syndromes)3:49449639-49453909  ENSG00000145022
CONAN: Copy Number AnalysisTCTA 
Mutations
ICGC Data PortalTCTA 
TCGA Data PortalTCTA 
Broad Tumor PortalTCTA
OASIS PortalTCTA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCTA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTCTA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCTA
DgiDB (Drug Gene Interaction Database)TCTA
DoCM (Curated mutations)TCTA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCTA (select a term)
intoGenTCTA
NCG5 (London)TCTA
Cancer3DTCTA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600690   
Orphanet
MedgenTCTA
Genetic Testing Registry TCTA
NextProtP57738 [Medical]
TSGene6988
GENETestsTCTA
Huge Navigator TCTA [HugePedia]
snp3D : Map Gene to Disease6988
BioCentury BCIQTCTA
ClinGenTCTA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6988
Chemical/Pharm GKB GenePA36412
Clinical trialTCTA
Miscellaneous
canSAR (ICR)TCTA (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCTA
EVEXTCTA
GoPubMedTCTA
iHOPTCTA
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:50:33 CET 2017

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