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TFF2 (TreFoil Factor 2)

Identity

Other namesSP (Spasmolytic Polypeptide)
HGNC (Hugo) TFF2
Location 21q22.3
Location_base_pair Starts at 42639538 and ends at 42644277 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Local_order belongs to the TFF cluster

DNA/RNA

Description 5.1 kb gene, 4 exons
Transcription 600 bp

Protein

Description precursor: 129 amino acids; mature peptide: 106 amino acids; 3-dimentional structure was solved; the129 amino acids TFF2 protein contains a signal peptide; the mature secreted peptide of 106 amino acids contains two TFF (TreFoil Factor) domains and one acidic C-terminal domain
Expression under normal condition, TFF2 is expressed in mucus neck cells of the fundus, basal cells of the antral and pyloric glands and by the Brunner's glands of the duodenum
Localisation secreted in gastric fluid
Function in repair and epithelial restitution of the gastro-intestinal mucosa
Homology TFF2 belongs to the Trefoil peptide Family (TFF) and possesses two tandemly duplicated TFF motifs each being homologous to the TFF motif of TFF1 and TFF3. The TFF motif spans about 40 amino acids and is formed by 6 conserved residues involved in specific disulfides bridges

Implicated in

Entity TFF2 was found implicated in inflamatory bowel diseases, cancers of gastrointestinal organs such as stomach and pancreas; in constrast to TFF1 and TFF3, TFF2 expression was not found in breast carcinomas
  

External links

Nomenclature
HGNC (Hugo)TFF2   11756
Entrez_Gene (NCBI)TFF2  7032  trefoil factor 2
Cards
AtlasTFF2ID264
GeneCards (Weizmann)TFF2
Ensembl (Hinxton)ENSG00000160181 [Gene_View]  TFF2 [Vega]
AceView (NCBI)TFF2
Genatlas (Paris)TFF2
euGene (Indiana)7032
SOURCE (Stanford)NM_005423
Gene Expression (Array Express) ENSG00000160181
Genomic and cartography
GoldenPath (UCSC)TFF2  -  21q22.3   chr21:42639538-42644277 -  21q22.3   [Description]    (hg18-Mar_2006)
EnsemblTFF2 - 21q22.3 [CytoView]
Mapping of homologs : NCBITFF2 [Mapview]
OMIM182590   
Gene and transcription
Gene : Genbank (Entrez)AA307808 BC032820 BM817851 BM853946 X51698
Reference sequence (RefSeq transcript) :SRSNM_005423
Reference transcript : EntrezNM_005423
RefSeq genomic : SRSAC_000064 AC_000153 NC_000021 NT_011515 NW_001838714 NW_927384
RefSeq genomic : EntrezAC_000064 AC_000153 NC_000021 NT_011515 NW_001838714 NW_927384
Consensus coding sequences : CCDS NCBITFF2
Cluster EST : UnigeneHs.2979 [ SRS ] Hs.2979 [ NCBI ]
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ03403 (SRS) Q03403 (Expasy) Q03403 (Uniprot)
With graphics : InterProQ03403
Splice isoforms : VarSplice FASTAQ03403(VarSplice FASTA)
Domaine pattern : Prosite (SRS)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domain pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domains : Interpro (SRS)P_trefoil    P_trefoil_chordata    P_trefoil_CS   
Domains : Interpro (EBI)P_trefoil    P_trefoil_chordata    P_trefoil_CS   
Related proteins : CluSTrQ03403
Domain families : Pfam SRSTrefoil (PF00088)   
Domain families : Pfam SangerTrefoil (PF00088)   
Domain families : Pfam NCBIpfam00088   
Domain families : Smart EMBLPD (SM00018)  
Blocks (Seattle)Q03403
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD01682
Protein Interaction databases
DIP (DOE-UCLA)Q03403
IntAct (EBI)Q03403
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITFF2
SNP : GeneSNP UtahTFF2
SNP : HGBaseTFF2
Genetic variants : HAPMAPTFF2
Somatic Mutations in Cancer : COSMICTFF2 
Mutations and Diseases : HGMDTFF2
Hereditary diseases : OMIM182590   
Hereditary diseases : GENETests182590   
Diseases : Genetic AssociationTFF2
General knowledge
Homologs : HomoloGeneTFF2
Homology/Alignments : Family Browser UCSCTFF2
Phylogenetic Trees/Animal Genes : TreeFamTFF2
Chemical/Protein Interactions : CTD7032
Keywords Ontology : AmiGOextracellular region  digestion  
Keywords Ontology : EGO-EBIextracellular region  digestion  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTFF2 Related clones (RZPD - Berlin)
Literature
PubMed45 Pubmed reference(s) in Entrez
PubGeneTFF2

Bibliography

The amino acid sequence of pancreatic spasmolytic polypeptide.
Thim L, Thomsen J, Christensen M, Jˆ½rgensen KH
Biochimica et biophysica acta. 1985 ; 827 (3) : 410-418.
PMID 2857575
 
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P
Science (New York, N.Y.). 1988 ; 241 (4866) : 705-708.
PMID 3041593
 
A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins).
Thim L
FEBS letters. 1989 ; 250 (1) : 85-90.
PMID 2737304
 
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R
The EMBO journal. 1990 ; 9 (2) : 407-414.
PMID 2303034
 
Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.
Rio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, Bellocq JP, Chambon P
Gastroenterology. 1991 ; 100 (2) : 375-379.
PMID 1985035
 
Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma.
Theisinger B, Welter C, Seitz G, Rio MC, Lathe R, Chambon P, Blin N
European journal of cancer (Oxford, England : 1990). 1991 ; 27 (6) : 770-773.
PMID 1829922
 
Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma.
Welter C, Theisinger B, Seitz G, Tomasetto C, Rio MC, Chambon P, Blin N
Laboratory investigation; a journal of technical methods and pathology. 1992 ; 66 (2) : 187-192.
PMID 1735955
 
Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides.
Gajhede M, Petersen TN, Henriksen A, Petersen JF, Dauter Z, Wilson KS, Thim L
Structure (London, England : 1993). 1993 ; 1 (4) : 253-262.
PMID 8081739
 
The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.
Lefebvre O, Wolf C, Kˆ©dinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC
The Journal of cell biology. 1993 ; 122 (1) : 191-198.
PMID 8314841
 
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
Wright NA, Poulsom R, Stamp G, Van Noorden S, Sarraf C, Elia G, Ahnen D, Jeffery R, Longcroft J, Pike C
Gastroenterology. 1993 ; 104 (1) : 12-20.
PMID 8419234
 
Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration.
Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Boulton RA, Thim L, Hanby AM
Gastroenterology. 1995 ; 108 (1) : 108-116.
PMID 7806031
 
Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats.
Babyatsky MW, deBeaumont M, Thim L, Podolsky DK
Gastroenterology. 1996 ; 110 (2) : 489-497.
PMID 8566596
 
The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.
Seib T, Blin N, Hilgert K, Seifert M, Theisinger B, Engel M, Dooley S, Zang KD, Welter C
Genomics. 1997 ; 40 (1) : 200-202.
PMID 9070946
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written12-2000Catherine Tomasetto

Citation

This paper should be referenced as such :
Tomasetto C . TFF2 (TreFoil Factor 2). Atlas Genet Cytogenet Oncol Haematol. December 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/TFF2ID264.html

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indexed on : Sat Feb 27 10:53:30 CET 2010

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