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TFF2 (TreFoil Factor 2)

Identity

Other namesSP (Spasmolytic Polypeptide)
HGNC TFF2
Location 21q22.3
Location_base_pair Starts at 42639538 and ends at 42644277 bp from pter ( according to hg18-Mar_2006).
Local_order belongs to the TFF cluster

DNA/RNA

Description 5.1 kb gene, 4 exons
Transcription 600 bp

Protein

Description precursor: 129 amino acids; mature peptide: 106 amino acids; 3-dimentional structure was solved; the129 amino acids TFF2 protein contains a signal peptide; the mature secreted peptide of 106 amino acids contains two TFF (TreFoil Factor) domains and one acidic C-terminal domain
Expression under normal condition, TFF2 is expressed in mucus neck cells of the fundus, basal cells of the antral and pyloric glands and by the Brunner's glands of the duodenum
Localisation secreted in gastric fluid
Function in repair and epithelial restitution of the gastro-intestinal mucosa
Homology TFF2 belongs to the Trefoil peptide Family (TFF) and possesses two tandemly duplicated TFF motifs each being homologous to the TFF motif of TFF1 and TFF3. The TFF motif spans about 40 amino acids and is formed by 6 conserved residues involved in specific disulfides bridges

Implicated in

Entity TFF2 was found implicated in inflamatory bowel diseases, cancers of gastrointestinal organs such as stomach and pancreas; in constrast to TFF1 and TFF3, TFF2 expression was not found in breast carcinomas
  

External links

Nomenclature
HGNCTFF2   11756
Entrez_GeneTFF2  7032  trefoil factor 2
Cards
AtlasTFF2ID264
GeneCardsTFF2
EnsemblENSG00000160181 [Gene_View]  TFF2 [Vega]
GenatlasTFF2
Genomic and cartography
GoldenPathTFF2  -  21q22.3   chr21:42639538-42644277 -  21q22.3   [Description]    (hg18-Mar_2006)
EnsemblTFF2 - 21q22.3 [CytoView]
NCBIMapview
OMIM182590 Disease map [OMIM]
HomoloGeneTFF2
Gene and transcription
GenbankAA307808 [ ENTREZ ]
GenbankBC032820 [ ENTREZ ]
GenbankBM817851 [ ENTREZ ]
GenbankBM853946 [ ENTREZ ]
GenbankX51698 [ ENTREZ ]
RefSeqNM_005423 [ SRS ]    NM_005423 [ ENTREZ ]
RefSeqAC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeqAC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeqNC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeqNT_030188 [ SRS ]    NT_030188 [ ENTREZ ]
RefSeqNW_001838714 [ SRS ]    NW_001838714 [ ENTREZ ]
RefSeqNW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
CCDSTFF2 CCDS - NCBI
AceViewTFF2 AceView - NCBI
UnigeneHs.2979 [ SRS ]    Hs.2979 [ NCBI ]
Protein : pattern, domain, 3D structure
SwissProtQ03403 [ SRS]    Q03403 [ EXPASY ]     Q03403 [ INTERPRO ]     Q03403 [ UNIPROT ] Q03403 [ VarSplice FASTA ]
PrositePS00025 P_TREFOIL [ SRS ]    PS00025 P_TREFOIL [ Expasy ]
InterproIPR000519 P_trefoil [ SRS ]    IPR000519 P_trefoil [ EBI ]
CluSTrQ03403
PfamPF00088 Trefoil [ SRS ]    PF00088 Trefoil [ Sanger ]    pfam00088 [ NCBI-CDD ]
SmartSM00018 PD [EMBL]
BlocksQ03403
HPRD01682
Protein Interaction databases
DIPQ03403
IntActQ03403
Polymorphism : SNP, mutations, diseases
OMIM182590    [ map ]   
GENETests182590
SNPTFF2 [dbSNP-NCBI]  
SNPNM_005423 [SNP-NCI]  
SNPTFF2 [GeneSNPs - Utah]  TFF2] [HGBASE - SRS]
HAPMAPTFF2 [HAPMAP]  
HGMDTFF2
Genetic AssociationTFF2
CDC HuGETFF2
General knowledge
Family BrowserTFF2 [UCSC Family Browser]
SOURCENM_005423
SMDHs.2979
SAGEHs.2979
GOextracellular region [Amigo]  extracellular region
GOdigestion [Amigo]  digestion
PubGeneTFF2
TreeFamTFF2
CTD7032 [Comparative ToxicoGenomics Database]
Other databases
Probes
ProbeTFF2 Related clones (RZPD - Berlin)
PubMed
PubMed39 Pubmed reference(s) in Entrez

Bibliography

The amino acid sequence of pancreatic spasmolytic polypeptide.
Thim L, Thomsen J, Christensen M, Jˆ½rgensen KH
Biochimica et biophysica acta. 1985 ; 827 (3) : 410-418.
PMID 2857575
 
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P
Science (New York, N.Y.). 1988 ; 241 (4866) : 705-708.
PMID 3041593
 
A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins).
Thim L
FEBS letters. 1989 ; 250 (1) : 85-90.
PMID 2737304
 
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R
The EMBO journal. 1990 ; 9 (2) : 407-414.
PMID 2303034
 
Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.
Rio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, Bellocq JP, Chambon P
Gastroenterology. 1991 ; 100 (2) : 375-379.
PMID 1985035
 
Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma.
Theisinger B, Welter C, Seitz G, Rio MC, Lathe R, Chambon P, Blin N
European journal of cancer (Oxford, England : 1990). 1991 ; 27 (6) : 770-773.
PMID 1829922
 
Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma.
Welter C, Theisinger B, Seitz G, Tomasetto C, Rio MC, Chambon P, Blin N
Laboratory investigation; a journal of technical methods and pathology. 1992 ; 66 (2) : 187-192.
PMID 1735955
 
Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides.
Gajhede M, Petersen TN, Henriksen A, Petersen JF, Dauter Z, Wilson KS, Thim L
Structure (London, England : 1993). 1993 ; 1 (4) : 253-262.
PMID 8081739
 
The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.
Lefebvre O, Wolf C, Kˆ©dinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC
The Journal of cell biology. 1993 ; 122 (1) : 191-198.
PMID 8314841
 
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
Wright NA, Poulsom R, Stamp G, Van Noorden S, Sarraf C, Elia G, Ahnen D, Jeffery R, Longcroft J, Pike C
Gastroenterology. 1993 ; 104 (1) : 12-20.
PMID 8419234
 
Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration.
Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Boulton RA, Thim L, Hanby AM
Gastroenterology. 1995 ; 108 (1) : 108-116.
PMID 7806031
 
Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats.
Babyatsky MW, deBeaumont M, Thim L, Podolsky DK
Gastroenterology. 1996 ; 110 (2) : 489-497.
PMID 8566596
 
The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.
Seib T, Blin N, Hilgert K, Seifert M, Theisinger B, Engel M, Dooley S, Zang KD, Welter C
Genomics. 1997 ; 40 (1) : 200-202.
PMID 9070946
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written12-2000Catherine Tomasetto

Citation

This paper should be referenced as such :
Tomasetto C . TFF2 (TreFoil Factor 2). Atlas Genet Cytogenet Oncol Haematol. December 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/TFF2ID264.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 27 13:30:26 2008


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