TFF2 (TreFoil Factor 2)

2000-12-01 Catherine Tomasetto Affiliation

I.G.B.M.C., BP 163, 1 rue Laurent Fries, 67404 Illkirch, France

Identity

HGNC

TFF2

LOCATION

21q22.3

LOCUSID

7032

ALIAS

SML1,SP

DNA/RNA

Description

5.1 kb gene, 4 exons

Transcription

600 bp

Proteins

Description

precursor: 129 amino acids; mature peptide: 106 amino acids; 3-dimentional structure was solved; the129 amino acids TFF2 protein contains a signal peptide; the mature secreted peptide of 106 amino acids contains two TFF (TreFoil Factor) domains and one acidic C-terminal domain

Expression

under normal condition, TFF2 is expressed in mucus neck cells of the fundus, basal cells of the antral and pyloric glands and by the Brunners glands of the duodenum

Localisation

secreted in gastric fluid

Function

in repair and epithelial restitution of the gastro-intestinal mucosa

Homology

TFF2 belongs to the Trefoil peptide Family (TFF) and possesses two tandemly duplicated TFF motifs each being homologous to the TFF motif of TFF1 and TFF3. The TFF motif spans about 40 amino acids and is formed by 6 conserved residues involved in specific disulfides bridges

Implicated in

Entity name

TFF2 was found implicated in inflamatory bowel diseases, cancers of gastrointestinal organs such as stomach and pancreas; in constrast to TFF1 and TFF3, TFF2 expression was not found in breast carcinomas

Bibliography

Pubmed ID	Last Year	Title	Authors
8566596	1996	Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats.	Babyatsky MW et al
8081739	1993	Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides.	Gajhede M et al
8314841	1993	The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.	Lefebvre O et al
7806031	1995	Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration.	Playford RJ et al
3041593	1988	Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.	Rio MC et al
1985035	1991	Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract.	Rio MC et al
9070946	1997	The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.	Seib T et al
1829922	1991	Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma.	Theisinger B et al
2737304	1989	A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins).	Thim L et al
2857575	1985	The amino acid sequence of pancreatic spasmolytic polypeptide.	Thim L et al
2303034	1990	hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.	Tomasetto C et al
1735955	1992	Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma.	Welter C et al
8419234	1993	Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.	Wright NA et al

Other Information

Locus ID:

NCBI: 7032
MIM: 182590
HGNC: 11756
Ensembl: ENSG00000160181

Variants:

dbSNP: 7032
ClinVar: 7032
TCGA: ENSG00000160181
COSMIC: TFF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160181	ENST00000291526	Q03403

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22329990	2012	Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection.	83
19204726	2009	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	63
20801119	2010	Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.	48
19064997	2009	Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines.	26
16166422	2005	Expression of trefoil factor family members correlates with patient prognosis and neoangiogenesis.	20
25124036	2014	Human trefoil factor 2 is a lectin that binds α-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.	20
17332476	2007	Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.	17
26201258	2015	TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review).	16
17982272	2007	Biosynthesis of gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins.	15
21472131	2011	Trefoil factors: tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma.	15

Citation

Catherine Tomasetto

TFF2 (TreFoil Factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2000-12-01

Online version: http://atlasgeneticsoncology.org/gene/264/tff2