TFG (TRK-fused gene)

2004-09-01   Masanori Hisaoka , Hiroshi Hashimoto 

Department of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan

Identity

HGNC
LOCATION
3q12.2
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
HMSNP,SPG57,TF6,TRKT3
FUSION GENES

DNA/RNA

Description

39.51 kbp

Transcription

8 exons; 1948 bp mRNA.

Pseudogene

one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)

Proteins

Description

400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS.

Expression

Ubiquitously expressed.

Localisation

Not examined (TFG-ALK fusion protein is localized in cytoplasm).

Function

unknown

Homology

Homologous to murine Tfg.

Implicated in

Cytogenetics
Hybrid gene
TFG-ALK
Fusion protein
TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
Entity name
Thyroid papillary carcinoma
Cytogenetics
t(1;3)(q21;q11)
Hybrid gene
TFG-NTRK1
Fusion protein
TFG-NTRK1
Hybrid gene
TFG-NR4A3

Breakpoints

Atlas Image
Atlas Image

Bibliography

Pubmed IDLast YearTitleAuthors
75657641995The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.Greco A et al
119437322002Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.Hernández L et al
151884552004TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.Hisaoka M et al
91691291997Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.Mencinger M et al

Other Information

Locus ID:

NCBI: 10342
MIM: 602498
HGNC: 11758
Ensembl: ENSG00000114354

Variants:

dbSNP: 10342
ClinVar: 10342
TCGA: ENSG00000114354
COSMIC: TFG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114354ENST00000240851Q92734
ENSG00000114354ENST00000418917Q92734
ENSG00000114354ENST00000463568C9JUE0
ENSG00000114354ENST00000476228Q92734
ENSG00000114354ENST00000479672C9JTY3
ENSG00000114354ENST00000487505C9JJP5
ENSG00000114354ENST00000490574Q92734
ENSG00000114354ENST00000615993Q92734
ENSG00000114354ENST00000620299Q92734

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Thyroid cancerKEGGko05216
Pathways in cancerKEGGhsa05200
Thyroid cancerKEGGhsa05216
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197977322010TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.25
255863782015TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization.25
228831442012The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.22
234796432013Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.20
151884552004TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.19
271848552016TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion.19
165479662006The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway.13
250985392014A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function.11
222500512012Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene.10
155573412005Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein.9

Citation

Masanori Hisaoka ; Hiroshi Hashimoto

TFG (TRK-fused gene)

Atlas Genet Cytogenet Oncol Haematol. 2004-09-01

Online version: http://atlasgeneticsoncology.org/gene/281/tfg