Atlas of Genetics and Cytogenetics in Oncology and Haematology
TFG (TRK-fused gene)
| Identity |
| Other names | TF6 |
| HGNC (Hugo) | TFG |
| Location | 3q11-q12 |
| Location_base_pair | Starts at 101910850 and ends at 101950501 bp from pter ( according to hg18-Mar_2006) [Mapping] |
| DNA/RNA |
| Description | 39.51 kbp |
| Transcription | 8 exons; 1948 bp mRNA. |
| Pseudogene | one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220) |
| Protein |
| Description | 400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS. |
| Expression | Ubiquitously expressed. |
| Localisation | Not examined (TFG-ALK fusion protein is localized in cytoplasm). |
| Function | unknown |
| Homology | Homologous to murine Tfg. |
| Implicated in |
| Entity | Anaplastic large cell lymphoma |
| Cytogenetics | t(2;3)(p23;q21) |
| Hybrid/Mutated Gene | TFG-ALK |
| Abnormal Protein | TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD) |
| Entity | Thyroid papillary carcinoma |
| Cytogenetics | t(1;3)(q21;q11) |
| Hybrid/Mutated Gene | TFG-NTRK1 |
| Abnormal Protein | TFG-NTRK1 |
| Entity | Extraskeletal myxoid chondrosarcoma |
| Hybrid/Mutated Gene | TFG-NR4A3 |
| Breakpoints |
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| External links |
| Bibliography |
| The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. |
| Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA |
| Molecular and cellular biology. 1995 ; 15 (11) : 6118-6127. |
| PMID 7565764 |
| Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. |
| Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P |
| Genomics. 1997 ; 41 (3) : 327-331. |
| PMID 9169129 |
| TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. |
| Hernˆ°ndez L, Pinyol M, Hernˆ°ndez S, BeˆÝ S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E |
| Blood. 1999 ; 94 (9) : 3265-3268. |
| PMID 10556217 |
| Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. |
| Hernˆ°ndez L, BeˆÝ S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fernˆ°ndez A, Pulford K, Mason D, Morris SW, Santos E, Campo E |
| The American journal of pathology. 2002 ; 160 (4) : 1487-1494. |
| PMID 11943732 |
| TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. |
| Hisaoka M, Ishida T, Imamura T, Hashimoto H |
| Genes, chromosomes & cancer. 2004 ; 40 (4) : 325-328. |
| PMID 15188455 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 09-2004 | Masanori Hisaoka, Hiroshi Hashimoto |
| Citation |
| This paper should be referenced as such : |
| Hisaoka M, Hashimoto H . TFG (TRK-fused gene). Atlas Genet Cytogenet Oncol Haematol. September 2004 . URL : http://AtlasGeneticsOncology.org/Genes/TFGID281.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jun 27 16:41:18 CEST 2009 |
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