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TFG (TRK-fused gene)

Written2004-09Masanori Hisaoka, Hiroshi Hashimoto
Department of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan

(Note : for Links provided by Atlas : click)

Identity

Other namesTF6
HGNC (Hugo) TFG
LocusID (NCBI) 10342
Atlas_Id 281
Location 3q12.2  [Link to chromosome band 3q12]
Location_base_pair Starts at 100428134 and ends at 100467811 bp from pter ( according to hg19-Feb_2009)  [Mapping TFG.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2016)
ADGRG7 (3q12.2) / TFG (3q12.2)ALK (2p23.2) / TFG (3q12.2)MET (7q31.2) / TFG (3q12.2)
NR4A3 (9q22.33) / TFG (3q12.2)NTRK1 (1q23.1) / TFG (3q12.2)PCNP (3q12.3) / TFG (3q12.2)
PRDM2 (1p36.21) / TFG (3q12.2)TFG (3q12.2) / ADGRG7 (3q12.2)TFG (3q12.2) / ALK (2p23.2)
TFG (3q12.2) / MET (7q31.2)TFG (3q12.2) / NR4A3 (9q22.33)TFG (3q12.2) / NTRK1 (1q23.1)
TFG (3q12.2) / ROS1 (6q22.1)TFG (3q12.2) / TEC (4p12)TFG (3q12.2) / TRPC5 (Xq23)
TFG (3q12.2) / ZBTB11 (3q12.3)

DNA/RNA

Description 39.51 kbp
Transcription 8 exons; 1948 bp mRNA.
Pseudogene one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)

Protein

Description 400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS.
Expression Ubiquitously expressed.
Localisation Not examined (TFG-ALK fusion protein is localized in cytoplasm).
Function unknown
Homology Homologous to murine Tfg.

Implicated in

Note
Entity Anaplastic large cell lymphoma
Cytogenetics t(2;3)(p23;q21)
Hybrid/Mutated Gene TFG-ALK
Abnormal Protein TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
  
Entity Thyroid papillary carcinoma
Cytogenetics t(1;3)(q21;q11)
Hybrid/Mutated Gene TFG-NTRK1
Abnormal Protein TFG-NTRK1
  
Entity Extraskeletal myxoid chondrosarcoma
Hybrid/Mutated Gene TFG-NR4A3
  

Breakpoints

 
 

Bibliography

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.
Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA
Molecular and cellular biology. 1995 ; 15 (11) : 6118-6127.
PMID 7565764
 
Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.
Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P
Genomics. 1997 ; 41 (3) : 327-331.
PMID 9169129
 
TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.
Hern´ndez L, Pinyol M, Hern´ndez S, Beà S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E
Blood. 1999 ; 94 (9) : 3265-3268.
PMID 10556217
 
Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.
Hern´ndez L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fern´ndez A, Pulford K, Mason D, Morris SW, Santos E, Campo E
The American journal of pathology. 2002 ; 160 (4) : 1487-1494.
PMID 11943732
 
TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.
Hisaoka M, Ishida T, Imamura T, Hashimoto H
Genes, chromosomes & cancer. 2004 ; 40 (4) : 325-328.
PMID 15188455
 

Citation

This paper should be referenced as such :
Hisaoka, M ; Hashimoto, H
TFG (TRK-fused gene)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(4):303-304.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TFGID281.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Anaplastic large cell lymphoma (ALCL)
t(2;3)(p23;q21) TFG/ALK

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Bone: Chondrosarcoma
Soft Tissues: Extraskeletal myxoid chondrosarcoma
Thyroid: Papillary carcinoma/Adenocarcinoma
Soft tissue tumors: an overview
Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)TFG   11758
Cards
AtlasTFGID281
Entrez_Gene (NCBI)TFG  10342  TRK-fused gene
AliasesHMSNP; SPG57; TF6; TRKT3
GeneCards (Weizmann)TFG
Ensembl hg19 (Hinxton)ENSG00000114354 [Gene_View]  chr3:100428134-100467811 [Contig_View]  TFG [Vega]
Ensembl hg38 (Hinxton)ENSG00000114354 [Gene_View]  chr3:100428134-100467811 [Contig_View]  TFG [Vega]
ICGC DataPortalENSG00000114354
TCGA cBioPortalTFG
AceView (NCBI)TFG
Genatlas (Paris)TFG
WikiGenes10342
SOURCE (Princeton)TFG
Genomic and cartography
GoldenPath hg19 (UCSC)TFG  -     chr3:100428134-100467811 +  3q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TFG  -     3q12.2   [Description]    (hg38-Dec_2013)
EnsemblTFG - 3q12.2 [CytoView hg19]  TFG - 3q12.2 [CytoView hg38]
Mapping of homologs : NCBITFG [Mapview hg19]  TFG [Mapview hg38]
OMIM602498   604484   615658   
Gene and transcription
Genbank (Entrez)AB097040 AB097041 AB731569 AB731570 AK093456
RefSeq transcript (Entrez)NM_001007565 NM_001195478 NM_001195479 NM_006070
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_027821 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)TFG
Cluster EST : UnigeneHs.518123 [ NCBI ]
CGAP (NCI)Hs.518123
Alternative Splicing GalleryENSG00000114354
Gene ExpressionTFG [ NCBI-GEO ]   TFG [ EBI - ARRAY_EXPRESS ]   TFG [ SEEK ]   TFG [ MEM ]
Gene Expression Viewer (FireBrowse)TFG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10342
GTEX Portal (Tissue expression)TFG
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92734 (Uniprot)
NextProtQ92734  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92734
Splice isoforms : SwissVarQ92734 (Swissvar)
PhosPhoSitePlusQ92734
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)   
Domains : Interpro (EBI)PB1_dom   
Domain families : Pfam (Sanger)PB1 (PF00564)   
Domain families : Pfam (NCBI)pfam00564   
Domain families : Smart (EMBL)PB1 (SM00666)  
DMDM Disease mutations10342
Blocks (Seattle)TFG
SuperfamilyQ92734
Human Protein AtlasENSG00000114354
Peptide AtlasQ92734
HPRD03932
IPIIPI00294619   IPI00297452   IPI00788849   IPI00952872   IPI00790804   
Protein Interaction databases
DIP (DOE-UCLA)Q92734
IntAct (EBI)Q92734
FunCoupENSG00000114354
BioGRIDTFG
STRING (EMBL)TFG
ZODIACTFG
Ontologies - Pathways
QuickGOQ92734
Ontology : AmiGOGolgi membrane  signal transducer activity  protein binding  cytoplasm  cytosol  signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  COPII vesicle coating  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  signal transducer activity  protein binding  cytoplasm  cytosol  signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  COPII vesicle coating  extracellular exosome  
Pathways : KEGGPathways in cancer    Thyroid cancer   
NDEx Network
Atlas of Cancer Signalling NetworkTFG
Wikipedia pathwaysTFG
Orthology - Evolution
OrthoDB10342
GeneTree (enSembl)ENSG00000114354
Phylogenetic Trees/Animal Genes : TreeFamTFG
Homologs : HomoloGeneTFG
Homology/Alignments : Family Browser (UCSC)TFG
Gene fusions - Rearrangements
Fusion : MitelmanGPR128/3q12.2 [TFG/dup(3)(q12q12)]  
Fusion : MitelmanMET/TFG [7q31.2/3q12.2]  [t(3;7)(q12;q31)]  
Fusion : MitelmanTFG/ALK [3q12.2/2p23.2]  [t(2;3)(p23;q12)]  
Fusion : MitelmanTFG/GPR128 [3q12.2/t(3;3)(q12;q12)]  
Fusion : MitelmanTFG/MET [3q12.2/7q31.2]  [t(3;7)(q12;q31)]  
Fusion : MitelmanTFG/NR4A3 [3q12.2/9q22.33]  [t(3;9)(q12;q31)]  
Fusion : MitelmanTFG/NTRK1 [3q12.2/1q23.1]  [t(1;3)(q23;q12)]  
Fusion : MitelmanTFG/ROS1 [3q12.2/6q22.1]  [t(3;6)(q12;q22)]  
Fusion : COSMICTFG [3q12.2]  -  NTRK1 [1q23.1]  [fusion_1328]  [fusion_1331]  [fusion_1337]  
Fusion: TCGAMET 7q31.2 TFG 3q12.2 THCA
Fusion: TCGATFG 3q12.2 MET 7q31.2 THCA
Fusion: TCGATFG 3q12.2 NTRK1 1q23.1 THCA
Fusion : TICdbTFG [3q12.2]  -  ALK [2p23.2]
Fusion : TICdbTFG [3q12.2]  -  NR4A3 [9q22.33]
Fusion : TICdbTFG [3q12.2]  -  NTRK1 [1q23.1]
Polymorphisms : SNP, variants
NCBI Variation ViewerTFG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFG
dbVarTFG
ClinVarTFG
1000_GenomesTFG 
Exome Variant ServerTFG
ExAC (Exome Aggregation Consortium)TFG (select the gene name)
Genetic variants : HAPMAP10342
Genomic Variants (DGV)TFG [DGVbeta]
Mutations
ICGC Data PortalTFG 
TCGA Data PortalTFG 
Broad Tumor PortalTFG
OASIS PortalTFG [ Somatic mutations - Copy number]
Cancer Gene: CensusTFG 
Somatic Mutations in Cancer : COSMICTFG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFG
DgiDB (Drug Gene Interaction Database)TFG
DoCM (Curated mutations)TFG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFG (select a term)
intoGenTFG
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:100428134-100467811  ENSG00000114354
CONAN: Copy Number AnalysisTFG 
Mutations and Diseases : HGMDTFG
OMIM602498    604484    615658   
MedgenTFG
Genetic Testing Registry TFG
NextProtQ92734 [Medical]
TSGene10342
GENETestsTFG
Huge Navigator TFG [HugePedia]
snp3D : Map Gene to Disease10342
BioCentury BCIQTFG
ClinGenTFG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10342
Chemical/Pharm GKB GenePA36473
Clinical trialTFG
Miscellaneous
canSAR (ICR)TFG (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFG
EVEXTFG
GoPubMedTFG
iHOPTFG
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jun 11 13:06:15 CEST 2016

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