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TFG (TRK-fused gene)

Written2004-09Masanori Hisaoka, Hiroshi Hashimoto
Department of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)TF6
HGNC (Hugo) TFG
HGNC Alias symbTF6
FLJ36137
SPG57
HGNC Previous nameTRK-fused gene
LocusID (NCBI) 10342
Atlas_Id 281
Location 3q12.2  [Link to chromosome band 3q12]
Location_base_pair Starts at 100709494 and ends at 100748964 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TFG.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRG7 (3q12.2)::TFG (3q12.2)ALK (2p23.2)::TFG (3q12.2)MET (7q31.2)::TFG (3q12.2)
NR4A3 (9q22.33)::TFG (3q12.2)NTRK1 (1q23.1)::TFG (3q12.2)PCNP (3q12.3)::TFG (3q12.2)
PRDM2 (1p36.21)::TFG (3q12.2)TFG (3q12.2)::ADGRG7 (3q12.2)TFG (3q12.2)::ALK (2p23.2)
TFG (3q12.2)::LINC01545 (Xp11.23)TFG (3q12.2)::MET (7q31.2)TFG (3q12.2)::NR4A3 (9q22.33)
TFG (3q12.2)::NR4A3 (9q31.1)TFG (3q12.2)::NTRK1 (1q23.1)TFG (3q12.2)::ROS1 (6q22.1)
TFG (3q12.2)::TRPC5 (Xq23)TFG (3q12.2)::ZBTB11 (3q12.3)

DNA/RNA

Description 39.51 kbp
Transcription 8 exons; 1948 bp mRNA.
Pseudogene one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)

Protein

Description 400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS.
Expression Ubiquitously expressed.
Localisation Not examined (TFG-ALK fusion protein is localized in cytoplasm).
Function unknown
Homology Homologous to murine Tfg.

Implicated in

Note
  
Entity Anaplastic large cell lymphoma
Cytogenetics
Hybrid/Mutated Gene TFG-ALK
Abnormal Protein TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
  
  
Entity Thyroid papillary carcinoma
Cytogenetics t(1;3)(q21;q11)
Hybrid/Mutated Gene TFG-NTRK1
Abnormal Protein TFG-NTRK1
  
  
Entity Extraskeletal myxoid chondrosarcoma
Hybrid/Mutated Gene TFG-NR4A3
  

Breakpoints

 
 

Bibliography

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.
Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA
Molecular and cellular biology. 1995 ; 15 (11) : 6118-6127.
PMID 7565764
 
Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.
Hern´ndez L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fern´ndez A, Pulford K, Mason D, Morris SW, Santos E, Campo E
The American journal of pathology. 2002 ; 160 (4) : 1487-1494.
PMID 11943732
 
TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.
Hisaoka M, Ishida T, Imamura T, Hashimoto H
Genes, chromosomes & cancer. 2004 ; 40 (4) : 325-328.
PMID 15188455
 
Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.
Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P
Genomics. 1997 ; 41 (3) : 327-331.
PMID 9169129
 

Citation

This paper should be referenced as such :
Hisaoka, M ; Hashimoto, H
TFG (TRK-fused gene)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(4):303-304.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  Anaplastic large cell lymphoma (ALCL)
t(2;3)(p23;q21) TFG::ALK
t(2;11)(p23;q12.3) EEF1G::ALK
dup(3)(q12q12):t(3;3)(q12;q12) ADGRG7::TFG
t(3;3)(q12;q12) TFG::ADGRG7


External links

 

Nomenclature
HGNC (Hugo)TFG   11758
Cards
AtlasTFGID281
Entrez_Gene (NCBI)TFG    trafficking from ER to golgi regulator
AliasesHMSNP; SPG57; TF6; TRKT3
GeneCards (Weizmann)TFG
Ensembl hg19 (Hinxton)ENSG00000114354 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114354 [Gene_View]  ENSG00000114354 [Sequence]  chr3:100709494-100748964 [Contig_View]  TFG [Vega]
ICGC DataPortalENSG00000114354
TCGA cBioPortalTFG
AceView (NCBI)TFG
Genatlas (Paris)TFG
SOURCE (Princeton)TFG
Genetics Home Reference (NIH)TFG
Genomic and cartography
GoldenPath hg38 (UCSC)TFG  -     chr3:100709494-100748964 +  3q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFG  -     3q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTFG - 3q12.2 [CytoView hg19]  TFG - 3q12.2 [CytoView hg38]
ImmunoBaseENSG00000114354
Genome Data Viewer NCBITFG [Mapview hg19]  
OMIM602498   604484   615658   
Gene and transcription
Genbank (Entrez)AB097040 AB097041 AB731569 AB731570 AK093456
RefSeq transcript (Entrez)NM_001007565 NM_001195478 NM_001195479 NM_006070
Consensus coding sequences : CCDS (NCBI)TFG
Gene ExpressionTFG [ NCBI-GEO ]   TFG [ EBI - ARRAY_EXPRESS ]   TFG [ SEEK ]   TFG [ MEM ]
Gene Expression Viewer (FireBrowse)TFG [ Firebrowse - Broad ]
GenevisibleExpression of TFG in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10342
GTEX Portal (Tissue expression)TFG
Human Protein AtlasENSG00000114354-TFG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92734   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92734  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92734
PhosPhoSitePlusQ92734
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)   
Domains : Interpro (EBI)PB1_dom    PB1_TFG    TFG   
Domain families : Pfam (Sanger)PB1 (PF00564)   
Domain families : Pfam (NCBI)pfam00564   
Domain families : Smart (EMBL)PB1 (SM00666)  
Conserved Domain (NCBI)TFG
SuperfamilyQ92734
AlphaFold pdb e-kbQ92734   
Human Protein Atlas [tissue]ENSG00000114354-TFG [tissue]
HPRD03932
Protein Interaction databases
DIP (DOE-UCLA)Q92734
IntAct (EBI)Q92734
BioGRIDTFG
STRING (EMBL)TFG
ZODIACTFG
Ontologies - Pathways
QuickGOQ92734
Ontology : AmiGOprotein binding  cytoplasm  cytosol  cytosol  endoplasmic reticulum to Golgi vesicle-mediated transport  endoplasmic reticulum to Golgi vesicle-mediated transport  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  COPII vesicle coating  endoplasmic reticulum exit site  endoplasmic reticulum exit site  
Ontology : EGO-EBIprotein binding  cytoplasm  cytosol  cytosol  endoplasmic reticulum to Golgi vesicle-mediated transport  endoplasmic reticulum to Golgi vesicle-mediated transport  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  COPII vesicle coating  endoplasmic reticulum exit site  endoplasmic reticulum exit site  
Pathways : KEGGPathways in cancer    Thyroid cancer   
REACTOMEQ92734 [protein]
REACTOME PathwaysR-HSA-204005 [pathway]   
NDEx NetworkTFG
Atlas of Cancer Signalling NetworkTFG
Wikipedia pathwaysTFG
Orthology - Evolution
OrthoDB10342
GeneTree (enSembl)ENSG00000114354
Phylogenetic Trees/Animal Genes : TreeFamTFG
Homologs : HomoloGeneTFG
Homology/Alignments : Family Browser (UCSC)TFG
Gene fusions - Rearrangements
Fusion : MitelmanGPR128::3q12.2 [TFG/dup(3)(q12q12)]  
Fusion : MitelmanMET::TFG [7q31.2/3q12.2]  
Fusion : MitelmanTFG::ALK [3q12.2/2p23.2]  
Fusion : MitelmanTFG::GPR128 [3q12.2/t(3;3)(q12;q12)]  
Fusion : MitelmanTFG::MET [3q12.2/7q31.2]  
Fusion : MitelmanTFG::NR4A3 [3q12.2/9q22.33]  
Fusion : MitelmanTFG::NTRK1 [3q12.2/1q23.1]  
Fusion : MitelmanTFG::ROS1 [3q12.2/6q22.1]  
Fusion : COSMICTFG [3q12.2]  -  NTRK1 [1q23.1]  [fusion_1323]  [fusion_1331]  [fusion_1337]  
Fusion : QuiverTFG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFG
dbVarTFG
ClinVarTFG
MonarchTFG
1000_GenomesTFG 
Exome Variant ServerTFG
GNOMAD BrowserENSG00000114354
Varsome BrowserTFG
ACMGTFG variants
VarityQ92734
Genomic Variants (DGV)TFG [DGVbeta]
DECIPHERTFG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFG 
Mutations
ICGC Data PortalTFG 
TCGA Data PortalTFG 
Broad Tumor PortalTFG
OASIS PortalTFG [ Somatic mutations - Copy number]
Cancer Gene: CensusTFG 
Somatic Mutations in Cancer : COSMICTFG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFG
Mutations and Diseases : HGMDTFG
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTFG
DgiDB (Drug Gene Interaction Database)TFG
DoCM (Curated mutations)TFG
CIViC (Clinical Interpretations of Variants in Cancer)TFG
OncoKBTFG
NCG (London)TFG
Cancer3DTFG
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602498    604484    615658   
Orphanet905    18668    23317    23243    11978   
DisGeNETTFG
MedgenTFG
Genetic Testing Registry TFG
NextProtQ92734 [Medical]
GENETestsTFG
Target ValidationTFG
Huge Navigator TFG [HugePedia]
ClinGenTFG
Clinical trials, drugs, therapy
MyCancerGenomeTFG
Protein Interactions : CTDTFG
Pharm GKB GenePA36473
PharosQ92734
Clinical trialTFG
Miscellaneous
canSAR (ICR)TFG
HarmonizomeTFG
DataMed IndexTFG
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTFG
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Oct 8 21:29:23 CEST 2021

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