TFG (TRK-fused gene)

Identity

Other names	TF6
Hugo	TFG
Location	3q11-q12

DNA/RNA

Description	39.51 kbp
Transcription	8 exons; 1948 bp mRNA.
Pseudogene	one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)

Protein

Description	400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS.
Expression	Ubiquitously expressed.
Localisation	Not examined (TFG-ALK fusion protein is localized in cytoplasm).
Function	unknown
Homology	Homologous to murine Tfg.

Implicated in

Entity	Anaplastic large cell lymphoma
Cytogenetics	t(2;3)(p23;q21)
Hybrid/Mutated Gene	TFG-ALK
Abnormal Protein	TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
Entity	Thyroid papillary carcinoma
Cytogenetics	t(1;3)(q21;q11)
Hybrid/Mutated Gene	TFG-NTRK1
Abnormal Protein	TFG-NTRK1
Entity	Extraskeletal myxoid chondrosarcoma
Hybrid/Mutated Gene	TFG-NR4A3

Breakpoints

External links

	Nomenclature
Hugo	TFG
GDB	TFG
Entrez_Gene	TFG  10342  TRK-fused gene
	Cards
Atlas	TFGID281
GeneCards	TFG
Ensembl	TFG [Search_View]   ENSG00000114354 [Gene_View]
Genatlas	TFG
GeneLynx	TFG
eGenome	TFG
euGene	10342
	Genomic and cartography
GoldenPath	TFG  -     chr3:101910850-101950500 +  3q12.2   [Description]    (hg18-Mar_2006)
Ensembl	TFG - 3q12.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TFG
	Gene and transcription
Genbank	AB097040 [ ENTREZ ]
Genbank	AB097041 [ ENTREZ ]
Genbank	AK093456 [ ENTREZ ]
Genbank	AK123588 [ ENTREZ ]
Genbank	AK127920 [ ENTREZ ]
RefSeq	NM_001007565 [ SRS ]    NM_001007565 [ ENTREZ ]
RefSeq	NM_006070 [ SRS ]    NM_006070 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_005612 [ SRS ]    NT_005612 [ ENTREZ ]
RefSeq	NW_921807 [ SRS ]    NW_921807 [ ENTREZ ]
AceView	TFG AceView - NCBI
Unigene	Hs.518123 [ SRS ]    Hs.518123 [ NCBI ]     HS518123 [ spliceNest ]
Fast-db	10354 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q92734 [ SRS]    Q92734 [ EXPASY ]     Q92734 [ INTERPRO ]
Interpro	IPR000270 OPR_PB1 [ SRS ]    IPR000270 OPR_PB1 [ EBI ]
CluSTr	Q92734
Pfam	PF00564 PB1 [ SRS ]    PF00564 PB1 [ Sanger ]    pfam00564 [ NCBI-CDD ]
Smart	SM00666 PB1 [EMBL]
Blocks	Q92734
HPRD	03932
	Protein Interaction databases
DIP	Q92734
IntAct	Q92734
	Polymorphism : SNP, mutations, diseases
OMIM	602498    [ map ]
GENECLINICS	602498
SNP	TFG [dbSNP-NCBI]
SNP	NM_001007565 [SNP-NCI]
SNP	NM_006070 [SNP-NCI]
SNP	TFG [GeneSNPs - Utah]  TFG] [HGBASE - SRS]
HAPMAP	TFG [HAPMAP]
COSMIC	TFG [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TFG
	General knowledge
Family Browser	TFG [UCSC Family Browser]
SOURCE	NM_001007565
SOURCE	NM_006070
SMD	Hs.518123
SAGE	Hs.518123
GO	nucleotide binding [Amigo]  nucleotide binding
GO	transmembrane receptor protein tyrosine kinase activity [Amigo]  transmembrane receptor protein tyrosine kinase activity
GO	signal transducer activity [Amigo]  signal transducer activity
GO	receptor activity [Amigo]  receptor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	transferase activity [Amigo]  transferase activity
GO	identical protein binding [Amigo]  identical protein binding
GO	positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  positive regulation of I-kappaB kinase/NF-kappaB cascade
PubGene	TFG
TreeFam	TFG
CTD	10342 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TFG Related clones (RZPD - Berlin)
	PubMed
PubMed	25 Pubmed reference(s) in LocusLink

Bibliography

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.

Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA

Molecular and cellular biology. 1995 ; 15 (11) : 6118-6127.

PMID 7565764

Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.

Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P

Genomics. 1997 ; 41 (3) : 327-331.

PMID 9169129

TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.

Hernˆ°ndez L, Pinyol M, Hernˆ°ndez S, BeˆÝ S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E

Blood. 1999 ; 94 (9) : 3265-3268.

PMID 10556217

Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.

Hernˆ°ndez L, BeˆÝ S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fernˆ°ndez A, Pulford K, Mason D, Morris SW, Santos E, Campo E

The American journal of pathology. 2002 ; 160 (4) : 1487-1494.

PMID 11943732

TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.

Hisaoka M, Ishida T, Imamura T, Hashimoto H

Genes, chromosomes & cancer. 2004 ; 40 (4) : 325-328.

PMID 15188455

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2004	Masanori Hisaoka, Hiroshi Hashimoto

Citation

This paper should be referenced as such :

Hisaoka M, Hashimoto H . TFG (TRK-fused gene). Atlas Genet Cytogenet Oncol Haematol. September 2004 . URL : http://AtlasGeneticsOncology.org/Genes/TFGID281.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:27:37 2008