| Identity |
| HGNC (Hugo) | TPM4 |
| LocusID (NCBI) | 7171 |
| Location | 19p13.1 |
| Location_base_pair | Starts at 16178317 and ends at 16213813 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Transcription | alternate transcripts |
| Protein |
| Description | 248 amino acids, 29 kDa. Coiled-coil structure |
| Function | Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown |
| Homology | Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25 |
| Implicated in |
| Entity | Inflammatory myofibroblastic tumors with t(2;19)(p23;p13.1) |
| Disease | rare soft tissue tumour found in children and young adults |
| Prognosis | good prognosis |
| Hybrid/Mutated Gene | 5' CLTC - 3' ALK |
| Abnormal Protein | 221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein. |
| Oncogenesis | TPM4-ALK is contitutively activated |
| External links |
| Bibliography |
| Deciphering the design of the tropomyosin molecule. |
| Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501. |
| PMID 11438684 |
| Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. |
| Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ |
| Cancer research. 1999 ; 59 (12) : 2776-2780. |
| PMID 10383129 |
| Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. |
| Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R |
| Journal of molecular biology. 2000 ; 302 (3) : 593-606. |
| PMID 10986121 |
| Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. |
| Ladanyi M |
| The American journal of pathology. 2000 ; 157 (2) : 341-345. |
| PMID 10934137 |
| TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. |
| Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA |
| The American journal of pathology. 2000 ; 157 (2) : 377-384. |
| PMID 10934142 |
| Deciphering the design of the tropomyosin molecule. |
| Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501. |
| PMID 11438684 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2001 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . TPM4 (tropomyosin ). Atlas Genet Cytogenet Oncol Haematol. August 2001 . URL : http://AtlasGeneticsOncology.org/Genes/TPM4ID359.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37785/1/08-2001-TPM4ID359.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Apr 28 15:00:25 CEST 2012 |
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