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TPM4 (tropomyosin )

Identity

HGNC (Hugo) TPM4
Location 19p13.1
Location_base_pair Starts at 16039317 and ends at 16074813 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Transcription alternate transcripts

Protein

Description 248 amino acids, 29 kDa. Coiled-coil structure
Function Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown
Homology Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25

Implicated in

Entity Inflammatory myofibroblastic tumors with t(2;19)(p23;p13.1)
Disease rare soft tissue tumour found in children and young adults
Prognosis good prognosis
Hybrid/Mutated Gene 5' CLTC - 3' ALK
Abnormal Protein 221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis TPM4-ALK is contitutively activated
  

External links

Nomenclature
HGNC (Hugo)TPM4   12013
Entrez_Gene (NCBI)TPM4  7171  tropomyosin 4
Cards
AtlasTPM4ID359
GeneCards (Weizmann)TPM4
Ensembl (Hinxton)ENSG00000167460 [Gene_View]  TPM4 [Vega]
AceView (NCBI)TPM4
Genatlas (Paris)TPM4
euGene (Indiana)7171
SOURCE (Stanford)NM_001145160 NM_003290
Genomic and cartography
GoldenPath (UCSC)TPM4  -  19p13.1   chr19:16039317-16074813 +  19p13.1   [Description]    (hg18-Mar_2006)
EnsemblTPM4 - 19p13.1 [CytoView]
Mapping of homologs : NCBITPM4 [Mapview]
OMIM600317   
Gene and transcription
Gene : Genbank (Entrez)AF186109 AK023385 AK300136 AK301285 AK307538
Reference sequence (RefSeq transcript) :SRSNM_001145160 NM_003290
Reference transcript : EntrezNM_001145160 NM_003290
RefSeq genomic : SRSAC_000062 AC_000151 NC_000019 NT_011295 NW_001838484 NW_927195
RefSeq genomic : EntrezAC_000062 AC_000151 NC_000019 NT_011295 NW_001838484 NW_927195
Consensus coding sequences : CCDS NCBITPM4
Cluster EST : UnigeneHs.631618 [ SRS ] Hs.631618 [ NCBI ]
Alternative Splicing : Fast-db (Paris)8374
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP67936 (SRS) P67936 (Expasy) P67936 (Uniprot)
With graphics : InterProP67936
Splice isoforms : VarSplice FASTAP67936(VarSplice FASTA)
Domaine pattern : Prosite (SRS)TROPOMYOSIN (PS00326)   
Domain pattern : Prosite (Expaxy)TROPOMYOSIN (PS00326)   
Domains : Interpro (SRS)Tropomyosin   
Domains : Interpro (EBI)Tropomyosin   
Related proteins : CluSTrP67936
Domain families : Pfam SRSTropomyosin (PF00261)   
Domain families : Pfam SangerTropomyosin (PF00261)   
Domain families : Pfam NCBIpfam00261   
Blocks (Seattle)P67936
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD11734
Protein Interaction databases
DIP (DOE-UCLA)P67936
IntAct (EBI)P67936
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITPM4
SNP : GeneSNP UtahTPM4
SNP : HGBaseTPM4
Genetic variants : HAPMAPTPM4
Somatic Mutations in Cancer : COSMICTPM4 
Translocation Breakpoints in Cancer : TICdbTPM4 
Mutations and Diseases : HGMDTPM4
Hereditary diseases : OMIM600317   
Hereditary diseases : GENETests600317   
Diseases : Genetic AssociationTPM4
General knowledge
Homologs : HomoloGeneTPM4
Homology/Alignments : Family Browser UCSCTPM4
Phylogenetic Trees/Animal Genes : TreeFamTPM4
Chemical/Protein Interactions : CTD7171
Keywords Ontology : AmiGOactin binding  cytoplasm  cytoskeleton  muscle thin filament tropomyosin  cell motion  structural constituent of muscle  
Keywords Ontology : EGO-EBIactin binding  cytoplasm  cytoskeleton  muscle thin filament tropomyosin  cell motion  structural constituent of muscle  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTPM4 Related clones (RZPD - Berlin)
Literature
PubMed15 Pubmed reference(s) in Entrez
PubGeneTPM4

Bibliography

Deciphering the design of the tropomyosin molecule.
Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501.
PMID 11438684
 
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.
Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ
Cancer research. 1999 ; 59 (12) : 2776-2780.
PMID 10383129
 
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.
Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R
Journal of molecular biology. 2000 ; 302 (3) : 593-606.
PMID 10986121
 
Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.
Ladanyi M
The American journal of pathology. 2000 ; 157 (2) : 341-345.
PMID 10934137
 
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA
The American journal of pathology. 2000 ; 157 (2) : 377-384.
PMID 10934142
 
Deciphering the design of the tropomyosin molecule.
Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501.
PMID 11438684
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written08-2001Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . TPM4 (tropomyosin ). Atlas Genet Cytogenet Oncol Haematol. August 2001 .
URL : http://AtlasGeneticsOncology.org/Genes/TPM4ID359.html

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indexed on : Sat Jun 27 16:37:39 CEST 2009

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