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TPM4 (tropomyosin)

Written2001-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


HGNC (Hugo) TPM4
LocusID (NCBI) 7171
Atlas_Id 359
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 16076495 and ends at 16103002 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TPM4.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALK (2p23.2)::TPM4 (19p13.12)AVL9 (7p14.3)::TPM4 (19p13.12)EPS15L1 (19p13.11)::TPM4 (19p13.12)
FAM32A (19p13.11)::TPM4 (19p13.12)FAM32A (19p13.12)::TPM4 (19p13.12)GSE1 (16q24.1)::TPM4 (19p13.12)
NEK6 (9q33.3)::TPM4 (19p13.12)TPM4 (19p13.12)::ALK (2p23.2)TPM4 (19p13.12)::CNNM2 (10q24.32)
TPM4 (19p13.12)::INAFM1 (19q13.32)TPM4 (19p13.12)::METRNL (17q25.3)TPM4 (19p13.12)::PROM1 (4p15.32)
TPM4 (19p13.12)::SEC62 (3q26.2)TPM4 (19p13.12)::TBL1XR1 (3q26.32)TPM4 (19p13.12)::WHAMM (15q25.2)


Transcription alternate transcripts


Description 248 amino acids, 29 kDa. Coiled-coil structure
Function Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown
Homology Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25

Implicated in

Entity Inflammatory myofibroblastic tumors with
Disease rare soft tissue tumour found in children and young adults
Prognosis good prognosis
Hybrid/Mutated Gene 5' CLTC - 3' ALK
Abnormal Protein 221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis TPM4-ALK is contitutively activated


Deciphering the design of the tropomyosin molecule.
Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501.
PMID 11438684
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.
Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ
Cancer research. 1999 ; 59 (12) : 2776-2780.
PMID 10383129
Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.
Ladanyi M
The American journal of pathology. 2000 ; 157 (2) : 341-345.
PMID 10934137
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA
The American journal of pathology. 2000 ; 157 (2) : 377-384.
PMID 10934142
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.
Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R
Journal of molecular biology. 2000 ; 302 (3) : 593-606.
PMID 10986121


This paper should be referenced as such :
Huret, JL
TPM4 (tropomyosin )
Atlas Genet Cytogenet Oncol Haematol. 2001;5(4):273-273.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;19)(p23;p13) TPM4::ALK
t(17;19)(q25;p13) TPM4::METRNL

External links

HGNC (Hugo)TPM4   12013
LRG (Locus Reference Genomic)LRG_1339
Atlas Explorer : (Salamanque)TPM4
Entrez_Gene (NCBI)TPM4    tropomyosin 4
GeneCards (Weizmann)TPM4
Ensembl hg19 (Hinxton)ENSG00000167460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167460 [Gene_View]  ENSG00000167460 [Sequence]  chr19:16076495-16103002 [Contig_View]  TPM4 [Vega]
ICGC DataPortalENSG00000167460
TCGA cBioPortalTPM4
AceView (NCBI)TPM4
Genatlas (Paris)TPM4
SOURCE (Princeton)TPM4
Genetics Home Reference (NIH)TPM4
Genomic and cartography
GoldenPath hg38 (UCSC)TPM4  -     chr19:16076495-16103002 +  19p13.12-p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPM4  -     19p13.12-p13.11   [Description]    (hg19-Feb_2009)
GoldenPathTPM4 - 19p13.12-p13.11 [CytoView hg19]  TPM4 - 19p13.12-p13.11 [CytoView hg38]
Genome Data Viewer NCBITPM4 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AF186109 AK023385 AK095546 AK096732 AK300136
RefSeq transcript (Entrez)NM_001145160 NM_001367836 NM_001367837 NM_001367838 NM_003290
Consensus coding sequences : CCDS (NCBI)TPM4
Gene ExpressionTPM4 [ NCBI-GEO ]   TPM4 [ EBI - ARRAY_EXPRESS ]   TPM4 [ SEEK ]   TPM4 [ MEM ]
Gene Expression Viewer (FireBrowse)TPM4 [ Firebrowse - Broad ]
GenevisibleExpression of TPM4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7171
GTEX Portal (Tissue expression)TPM4
Human Protein AtlasENSG00000167460-TPM4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TPM4
Human Protein Atlas [tissue]ENSG00000167460-TPM4 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 14:19:28 CET 2022

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