| Identification and characterization of the tuberous sclerosis gene on chromosome 16. |
| European Chromosome 16 Tuberous Sclerosis Consortium, European Chromosome 16 Tuberous Sclerosis Consortium |
| Cell. 1993 ; 75 (7) : 1305-1315. |
| PMID 8269512 |
| |
| 9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC1 gene. |
| Carbonara C, Longa L, Grosso E, Borrone C, Garrˆ® MG, Brisigotti M, Migone N |
| Human molecular genetics. 1994 ; 3 (10) : 1829-1832. |
| PMID 7849708 |
| |
| Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. |
| Green AJ, Smith M, Yates JR |
| Nature genetics. 1994 ; 6 (2) : 193-196. |
| PMID 8162074 |
| |
| Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas. |
| Henske EP, Neumann HP, Scheithauer BW, Herbst EW, Short MP, Kwiatkowski DJ |
| Genes, chromosomes & cancer. 1995 ; 13 (4) : 295-298. |
| PMID 7547639 |
| |
| Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. |
| Wienecke R, Kˆnig A, DeClue JE |
| The Journal of biological chemistry. 1995 ; 270 (27) : 16409-16414. |
| PMID 7608212 |
| |
| Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. |
| Soucek T, Pusch O, Wienecke R, DeClue JE, Hengstschlˆ§ger M |
| The Journal of biological chemistry. 1997 ; 272 (46) : 29301-29308. |
| PMID 9361010 |
| |
| The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. |
| Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS |
| The Journal of biological chemistry. 1997 ; 272 (10) : 6097-6100. |
| PMID 9045618 |
| |
| Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. |
| Henry KW, Yuan X, Koszewski NJ, Onda H, Kwiatkowski DJ, Noonan DJ |
| The Journal of biological chemistry. 1998 ; 273 (32) : 20535-20539. |
| PMID 9685410 |
| |
| Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. |
| Plank TL, Yeung RS, Henske EP |
| Cancer research. 1998 ; 58 (21) : 4766-4770. |
| PMID 9809973 |
| |
| Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. |
| van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P |
| Human molecular genetics. 1998 ; 7 (6) : 1053-1057. |
| PMID 9580671 |
| |
| gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. |
| Ito N, Rubin GM |
| Cell. 1999 ; 96 (4) : 529-539. |
| PMID 10052455 |
| |
| Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. |
| Kobayashi T, Minowa O, Kuno J, Mitani H, Hino O, Noda T |
| Cancer research. 1999 ; 59 (6) : 1206-1211. |
| PMID 10096549 |
| |
| Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. |
| Onda H, Lueck A, Marks PW, Warren HB, Kwiatkowski DJ |
| The Journal of clinical investigation. 1999 ; 104 (6) : 687-695. |
| PMID 10491404 |
| |
| Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. |
| Carsillo T, Astrinidis A, Henske EP |
| Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (11) : 6085-6090. |
| PMID 10823953 |
| |
| A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. |
| Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E, Noda T, Hino O |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8762-8767. |
| PMID 11438694 |
| |