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WDR77 (WD repeat domain 77)

Written2008-10Garrett Daniels, Zhenxing Wang, Peng Lee
Department of Pathology, New York University School of Medicine, 423 East 23rd St., New York, USA (GD, PL) ; The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA (ZW)

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)MEP50
p44
Other aliasHKMT1069
MGC2722
Nbla10071
RP11-552M11.3
p44/Mep50
HGNC (Hugo) WDR77
LocusID (NCBI) 79084
Atlas_Id 44142
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 111439890 and ends at 111449308 bp from pter ( according to hg19-Feb_2009)  [Mapping WDR77.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
WDR77 (1p13.2) / HERPUD1 (16q13)WDR77 (1p13.2) / WDR77 (1p13.2)

DNA/RNA

Description Spans 9.3kb/ 7.9kb; 10 exons.
Transcription 2428/ 1029 nucleotides mRNA.

Protein

Description 342 amino acids. 44 kDa protein. 5 WD repeats (Hosohata et al., 2003).
Expression p44 is expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, pancreas, and uterus (Hosohata et al., 2003).
In adult prostate, p44 is expressed as nuclear protein in glandular epithelial cells and not in stromal cells (Zhou et al., 2006).
In testis, p44 expression is seen in germ cells and Leydig cells, but not expressed in peritubular myocytes and Sertoli's cells (Liang et al., 2006).
Localisation p44 has both nuclear and cytolasmic localization patterns (Zhou et al., 2006; Liang et al., 2006; Peng et al., 2008). In benign prostate and testicular cells, p44 is found predominantly in the nucleus. In prostate cancer and malignant testicular cells (seminomas and leydig cell tumor), p44 is found in the cytoplasm. The p44 cytoplasmic translocation may be an indicative marker of cancer in these tissues.
Function p44 interacts with androgen receptor and acts as a positive coactivator for androgen-dependent AR transactivation (Hosohata, 2003). Nuclear p44 causes an androgen-dependent G1 arrest growth inhibition in prostate cells expressing androgen receptor (Zhou et al., 2006; Peng et al., 2008). Cytoplasmic and nuclear p44 may have opposite functions, as introduction of p44 to the cytoplasm accelerates growth (Peng et al., 2008).
p44 is part of the PRMT5 (protein arginine methyl transferase 5) complex important for methylosome activity (Hosohata et al., 2003; Friesen et al., 2002). p44 interacts with FCP1 phosphatase (Licciardo et al., 2002) and histone H2A (Furuno et al., 2006).
Homology WD repeats commonly seen for multiple protein interactions.

Mutations

Note Unknown

Implicated in

Note
  
Entity Androgen-dependent prostate cancer
Disease In androgen-dependent prostate cancer p44 is found predominantly in the cytoplasm, as opposed to nuclear localization in benign tissue (Zhou et al., 2006). Translocation from the nucleus in benign cells to the cytoplasm is strongly associated with prostate tumorigenesis (Zhou et al., 2006; Peng et al., 2008). Cytoplasmic expressed p44 also leads to increased growth in androgen dependent prostate cell line LNCaP (Peng et al., 2008).
  
  
Entity Androgen-independent prostate cancer
Disease In androgen-independent cancers p44 is found both in the nucleus and the cytoplasm (Peng et al., 2008). P44 may be able to serve as a diagnostic marker of androgen-independent prostate cancer.
  
  
Entity Testicular cancer
Disease Testicular tumor cells have an increased cytoplasmic localization of p44 similar to the pattern observed in prostate cancer (Jiang et al., 2006). This is also similar to the pattern seen in the germ cells of fetal testis that express cytoplasmic p44. P44 is predominantly found in the nucleus of benign testicular cells and adult testis germ cells. Translocation of p44 to the cytoplasm in testis cells shows an association with tumorigenesis.
  

Bibliography

A novel WD repeat protein component of the methylosome binds Sm proteins.
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G.
J Biol Chem. 2002 Mar 8;277(10):8243-7.
PMID 11756452
 
Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.
Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K.
Biochem Biophys Res Commun. 2006 Jul 7;345(3):1051-8.
PMID 16712789
 
Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription.
Hosohata K, Li P, Hosohata Y, Qin J, Roeder RG, Wang Z.
Mol Cell Biol. 2003 Oct;23(19):7019-29.
PMID 12972618
 
The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.
Liang JJ, Wang Z, Chiriboga L, Greco MA, Shapiro E, Huang H, Yang XJ, Huang J, Peng Y, Melamed J, Garabedian MJ, Lee P.
J Urol. 2007 May;177(5):1918-22.
PMID 17437848
 
The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP.
Licciardo P, Amente S, Ruggiero L, Monti M, Pucci P, Lania L, Majello B.
Nucleic Acids Res. 2003 Feb 1;31(3):999-1005.
PMID 12560496
 
Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer.
Peng Y, Chen F, Melamed J, Chiriboga L, Wei J, Kong X, McLeod M, Li Y, Li CX, Feng A, Garabedian MJ, Wang Z, Roeder RG, Lee P.
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5236-41.
PMID 18356297
 
Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells.
Zhou L, Wu H, Lee P, Wang Z.
J Mol Endocrinol. 2006 Oct;37(2):283-300.
PMID 17032745
 

Citation

This paper should be referenced as such :
Daniels, G ; Wang, Z ; Lee, P
WDR77 (WD repeat domain 77)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(9):666-667.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/WDR77ID44142ch1p13.html


External links

Nomenclature
HGNC (Hugo)WDR77   29652
Cards
AtlasWDR77ID44142ch1p13
Entrez_Gene (NCBI)WDR77  79084  WD repeat domain 77
AliasesHKMT1069; MEP-50; MEP50; Nbla10071; 
p44; p44/Mep50
GeneCards (Weizmann)WDR77
Ensembl hg19 (Hinxton)ENSG00000116455 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116455 [Gene_View]  chr1:111439890-111449308 [Contig_View]  WDR77 [Vega]
ICGC DataPortalENSG00000116455
TCGA cBioPortalWDR77
AceView (NCBI)WDR77
Genatlas (Paris)WDR77
WikiGenes79084
SOURCE (Princeton)WDR77
Genetics Home Reference (NIH)WDR77
Genomic and cartography
GoldenPath hg38 (UCSC)WDR77  -     chr1:111439890-111449308 -  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR77  -     1p13.2   [Description]    (hg19-Feb_2009)
EnsemblWDR77 - 1p13.2 [CytoView hg19]  WDR77 - 1p13.2 [CytoView hg38]
Mapping of homologs : NCBIWDR77 [Mapview hg19]  WDR77 [Mapview hg38]
OMIM611734   
Gene and transcription
Genbank (Entrez)AB073603 AB074171 AF052183 AF478464 AK022860
RefSeq transcript (Entrez)NM_001317062 NM_001317063 NM_001317064 NM_024102
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR77
Cluster EST : UnigeneHs.204773 [ NCBI ]
CGAP (NCI)Hs.204773
Alternative Splicing GalleryENSG00000116455
Gene ExpressionWDR77 [ NCBI-GEO ]   WDR77 [ EBI - ARRAY_EXPRESS ]   WDR77 [ SEEK ]   WDR77 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR77 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79084
GTEX Portal (Tissue expression)WDR77
Human Protein AtlasENSG00000116455-WDR77 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQA1
Splice isoforms : SwissVarQ9BQA1
PhosPhoSitePlusQ9BQA1
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR77
DMDM Disease mutations79084
Blocks (Seattle)WDR77
PDB (SRS)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
PDB (PDBSum)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
PDB (IMB)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
PDB (RSDB)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
Structural Biology KnowledgeBase4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
SCOP (Structural Classification of Proteins)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
CATH (Classification of proteins structures)4GQB    4X60    4X61    4X63    5C9Z    5EMJ    5EMK    5EML    5EMM    5FA5   
SuperfamilyQ9BQA1
Human Protein Atlas [tissue]ENSG00000116455-WDR77 [tissue]
Peptide AtlasQ9BQA1
HPRD14387
IPIIPI00012202   IPI00909184   IPI00908660   IPI00647794   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQA1
IntAct (EBI)Q9BQA1
FunCoupENSG00000116455
BioGRIDWDR77
STRING (EMBL)WDR77
ZODIACWDR77
Ontologies - Pathways
QuickGOQ9BQA1
Ontology : AmiGOspliceosomal snRNP assembly  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  regulation of transcription from RNA polymerase II promoter  positive regulation of cell proliferation  methyl-CpG binding  protein-arginine N-methyltransferase activity  ligand-dependent nuclear receptor transcription coactivator activity  methylosome  peptidyl-arginine N-methylation  secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  negative regulation of epithelial cell proliferation involved in prostate gland development  
Ontology : EGO-EBIspliceosomal snRNP assembly  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  regulation of transcription from RNA polymerase II promoter  positive regulation of cell proliferation  methyl-CpG binding  protein-arginine N-methyltransferase activity  ligand-dependent nuclear receptor transcription coactivator activity  methylosome  peptidyl-arginine N-methylation  secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development  negative regulation of epithelial cell proliferation involved in prostate gland development  
REACTOMEQ9BQA1 [protein]
REACTOME PathwaysR-HSA-3214858 [pathway]   
NDEx NetworkWDR77
Atlas of Cancer Signalling NetworkWDR77
Wikipedia pathwaysWDR77
Orthology - Evolution
OrthoDB79084
GeneTree (enSembl)ENSG00000116455
Phylogenetic Trees/Animal Genes : TreeFamWDR77
HOVERGENQ9BQA1
HOGENOMQ9BQA1
Homologs : HomoloGeneWDR77
Homology/Alignments : Family Browser (UCSC)WDR77
Gene fusions - Rearrangements
Tumor Fusion PortalWDR77
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR77 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR77
dbVarWDR77
ClinVarWDR77
1000_GenomesWDR77 
Exome Variant ServerWDR77
ExAC (Exome Aggregation Consortium)ENSG00000116455
GNOMAD BrowserENSG00000116455
Genetic variants : HAPMAP79084
Genomic Variants (DGV)WDR77 [DGVbeta]
DECIPHERWDR77 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR77 
Mutations
ICGC Data PortalWDR77 
TCGA Data PortalWDR77 
Broad Tumor PortalWDR77
OASIS PortalWDR77 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR77  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR77
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR77
DgiDB (Drug Gene Interaction Database)WDR77
DoCM (Curated mutations)WDR77 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR77 (select a term)
intoGenWDR77
NCG5 (London)WDR77
Cancer3DWDR77(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611734   
Orphanet
DisGeNETWDR77
MedgenWDR77
Genetic Testing Registry WDR77
NextProtQ9BQA1 [Medical]
TSGene79084
GENETestsWDR77
Target ValidationWDR77
Huge Navigator WDR77 [HugePedia]
snp3D : Map Gene to Disease79084
BioCentury BCIQWDR77
ClinGenWDR77
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79084
Chemical/Pharm GKB GenePA142670581
Clinical trialWDR77
Miscellaneous
canSAR (ICR)WDR77 (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR77
EVEXWDR77
GoPubMedWDR77
iHOPWDR77
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 15:06:08 CET 2017

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