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WNT1 (wingless-type MMTV integration site family, member 1)

Written2013-12Irini Theohari, Lydia Nakopoulou
1st Department of Pathology, Medical School, University of Athens, Athens, Greece

(Note : for Links provided by Atlas : click)

Identity

Alias_namesINT1
wingless-type MMTV integration site family
Other aliasBMND16
OI15
HGNC (Hugo) WNT1
LocusID (NCBI) 7471
Atlas_Id 462
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49372236 and ends at 49376396 bp from pter ( according to hg19-Feb_2009)  [Mapping WNT1.png]
 
  Genomic location of WNT1 gene at chromosome 12 (plus strand).

DNA/RNA

 
Description The WNT1 gene spans a genomic region of 4161 bases on plus strand. The DNA of WNT1 consists of 4 exons and the coding sequence starts in the first exon.
Transcription The WNT1 gene has one protein coding transcript which consists of 370 amino acids.

Protein

Description Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling.
Localisation Secreted, extracellular space, extracellular matrix.
Function Probable developmental protein. May be a signaling molecule important in CNS (central nervous system) development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

Mutations

Somatic There are several WNT1 mutations identified related with osteogenesis imperfecta. Several confirmed somatic mutations of the WNT1 gene have also been reported, according to COSMIC, which are associated with carcinomas of the endometrium, lung, large intestine, prostate and kidney.

Implicated in

Note
  
Entity Esophageal cancer
Note It has been shown, in cell cultures of esophageal cancer, that WNT1 results in cytoplasmic accumulation of beta-catenin and activates TCF-dependent transcription (Mizushima et al., 2002). Overexpression of mRNA and protein levels of WNT1 have been positively associated with lymph node metastasis, advanced pathological stage and prognosis of patients with esophageal squamous cell carcinoma (Lv et al., 2012).
  
  
Entity Breast cancer
Note WNT1 has been shown to be markedly elevated in grade I tumors, but declined as tumor grade declined (Wong et al., 2002). Ectopic expression of WNT1, triggers the DNA damage response (DDR) and an ensuing cascade of events resulting in tumorigenic conversion of primary human mammary epithelial cells. WNT1-transformed cells have high telomerase activity and compromised p53 and Rb function, grow as spheres in suspension, and in mice form tumors that closely resemble medullary carcinomas of the breast (Ayyanan et al., 2006). siRNA anti-WNT1 has been shown to induce apoptosis in human breast cancer cell lines (Wieczorek et al., 2008). WNT1 immunoreactivity has been found to be inversely related to histological grade, Ki-67 and p53, positively to , HER-2 and caspase-3 and has been correlated with favorable prognosis of patients with stage II breast cancer (Mylona et al., 2013).
  
  
Entity Basal cell carcinoma of head and neck
Note Overexpression of WNT1 has been positively associated with cytoplasmic beta-catenin (Lo Muzio et al., 2002).
  
  
Entity Sarcoma
Note WNT1 blockade by either monoclonal antibody or siRNA induces cell death in sarcoma cells (Mikami et al., 2005).
  
  
Entity Non-small cell lung cancer (NSCLC)
Note The expression of WNT1 has been positively correlated with c-Myc, cyclin D1, VEGF-A, MMP-7, Ki-67 and intratumoral microvessel density and has been found to negatively influence patients' survival (Huang et al., 2008). WNT1 overexpression has been positively associated with the Ki-67 proliferation index and c-Myc and has been found to exert an unfavorable impact on patients' survival (Nakashima et al., 2008). WNT1 expression has been found to be an independent prognostic factor of poor survival (Xu et al., 2011).
  
  
Entity Gastric cancer
Note The expression levels of WNT1 are positively correlated with tumor size, tumor invasive depth, lymph node metastasis, pTNM stage and negatively influences patients' 5-year survival rate (Zhang and Xue, 2008).
  
  
Entity Neuroblastoma
Note Knockdown of endogenous WNT1 expression results in cell death and inhibits cell growth (Zhang et al., 2009).
  
  
Entity Osteogenesis imperfecta (OI)
Note This disease is a heritable bone fragiility disorder that is usually due to dominant mutations in COL1A1 or COL1A2 and is characterized by reduced bone mass and recurrent fractures. Genetic variations in WNT1 define the bone mineral density quantitative trait locus 16 (BMND16) [MIM:615221]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures. The disease is caused by mutations affecting the gene of WNT1 (Fahiminiya et al., 2013; Faqeih et al., 2013; Laine et al., 2013; Pyott et al., 2013).
  
  
Entity Osteoporosis (OSTEOP)
Note A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. Disease susceptibility is associated with variations affecting the gene of WNT1 (Keupp et al., 2013; Laine et al., 2013).
  

Bibliography

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.
Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, Brisken C.
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3799-804. Epub 2006 Feb 24.
PMID 16501043
 
Mutations in WNT1 are a cause of osteogenesis imperfecta.
Fahiminiya S, Majewski J, Mort J, Moffatt P, Glorieux FH, Rauch F.
J Med Genet. 2013 May;50(5):345-8. doi: 10.1136/jmedgenet-2013-101567. Epub 2013 Feb 23.
PMID 23434763
 
WNT1 mutation with recessive osteogenesis imperfecta and profound neurological phenotype.
Faqeih E, Shaheen R, Alkuraya FS.
J Med Genet. 2013 Jul;50(7):491-2. doi: 10.1136/jmedgenet-2013-101750. Epub 2013 May 24.
PMID 23709755
 
Wnt1 overexpression promotes tumour progression in non-small cell lung cancer.
Huang CL, Liu D, Ishikawa S, Nakashima T, Nakashima N, Yokomise H, Kadota K, Ueno M.
Eur J Cancer. 2008 Nov;44(17):2680-8. doi: 10.1016/j.ejca.2008.08.004. Epub 2008 Sep 13.
PMID 18790633
 
Mutations in WNT1 cause different forms of bone fragility.
Keupp K, Beleggia F, Kayserili H, Barnes AM, Steiner M, Semler O, Fischer B, Yigit G, Janda CY, Becker J, Breer S, Altunoglu U, Grunhagen J, Krawitz P, Hecht J, Schinke T, Makareeva E, Lausch E, Cankaya T, Caparros-Martin JA, Lapunzina P, Temtamy S, Aglan M, Zabel B, Eysel P, Koerber F, Leikin S, Garcia KC, Netzer C, Schonau E, Ruiz-Perez VL, Mundlos S, Amling M, Kornak U, Marini J, Wollnik B.
Am J Hum Genet. 2013 Apr 4;92(4):565-74. doi: 10.1016/j.ajhg.2013.02.010. Epub 2013 Mar 14.
PMID 23499309
 
WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta.
Laine CM, Joeng KS, Campeau PM, Kiviranta R, Tarkkonen K, Grover M, Lu JT, Pekkinen M, Wessman M, Heino TJ, Nieminen-Pihala V, Aronen M, Laine T, Kroger H, Cole WG, Lehesjoki AE, Nevarez L, Krakow D, Curry CJ, Cohn DH, Gibbs RA, Lee BH, Makitie O.
N Engl J Med. 2013 May 9;368(19):1809-16. doi: 10.1056/NEJMoa1215458.
PMID 23656646
 
WNT-1 expression in basal cell carcinoma of head and neck. An immunohistochemical and confocal study with regard to the intracellular distribution of beta-catenin.
Lo Muzio L, Pannone G, Staibano S, Mignogna MD, Grieco M, Ramires P, Romito AM, De Rosa G, Piattelli A.
Anticancer Res. 2002 Mar-Apr;22(2A):565-76.
PMID 12014624
 
Association of beta-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 with the prognosis of esophageal squamous cell carcinoma.
Lv J, Cao XF, Ji L, Zhu B, Wang DD, Tao L, Li SQ.
Med Oncol. 2012 Mar;29(1):151-60. doi: 10.1007/s12032-010-9816-5. Epub 2011 Jan 23.
PMID 21259057
 
Efficacy of Wnt-1 monoclonal antibody in sarcoma cells.
Mikami I, You L, He B, Xu Z, Batra S, Lee AY, Mazieres J, Reguart N, Uematsu K, Koizumi K, Jablons DM.
BMC Cancer. 2005 May 24;5:53.
PMID 15913453
 
Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells.
Mizushima T, Nakagawa H, Kamberov YG, Wilder EL, Klein PS, Rustgi AK.
Cancer Res. 2002 Jan 1;62(1):277-82.
PMID 11782388
 
An immunohistochemical evaluation of the proteins Wnt1 and glycogen synthase kinase (GSK)-3b in invasive breast carcinomas.
Mylona E, Vamvakaris I, Giannopoulou I, Theohari I, Papadimitriou C, Keramopoulos A, Nakopoulou L.
Histopathology. 2013 May;62(6):899-907. doi: 10.1111/his.12095. Epub 2013 Mar 28.
PMID 23551536
 
Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients.
Nakashima T, Liu D, Nakano J, Ishikawa S, Yokomise H, Ueno M, Kadota K, Huang CL.
Oncol Rep. 2008 Jan;19(1):203-9.
PMID 18097596
 
WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta.
Pyott SM, Tran TT, Leistritz DF, Pepin MG, Mendelsohn NJ, Temme RT, Fernandez BA, Elsayed SM, Elsobky E, Verma I, Nair S, Turner EH, Smith JD, Jarvik GP, Byers PH.
Am J Hum Genet. 2013 Apr 4;92(4):590-7. doi: 10.1016/j.ajhg.2013.02.009. Epub 2013 Mar 14.
PMID 23499310
 
Silencing of Wnt-1 by siRNA induces apoptosis of MCF-7 human breast cancer cells.
Wieczorek M, Paczkowska A, Guzenda P, Majorek M, Bednarek AK, Lamparska-Przybysz M.
Cancer Biol Ther. 2008 Feb;7(2):268-74. Epub 2007 Nov 14.
PMID 18059186
 
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours.
Wong SC, Lo SF, Lee KC, Yam JW, Chan JK, Wendy Hsiao WL.
J Pathol. 2002 Feb;196(2):145-53.
PMID 11793365
 
Aberrant Wnt1/beta-catenin expression is an independent poor prognostic marker of non-small cell lung cancer after surgery.
Xu X, Sun PL, Li JZ, Jheon S, Lee CT, Chung JH.
J Thorac Oncol. 2011 Apr;6(4):716-24. doi: 10.1097/JTO.0b013e31820c5189.
PMID 21336184
 
Wnt pathway is involved in advanced gastric carcinoma.
Zhang H, Xue Y.
Hepatogastroenterology. 2008 May-Jun;55(84):1126-30.
PMID 18705344
 
The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line.
Zhang L, Li K, Lv Z, Xiao X, Zheng J.
Pediatr Surg Int. 2009 Dec;25(12):1065-71. doi: 10.1007/s00383-009-2481-0. Epub 2009 Sep 16.
PMID 19756656
 

Citation

This paper should be referenced as such :
Theohari, I ; Nakopoulou, L
WNT1 (wingless-type MMTV integration site family, member 1)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(8):581-583.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/WNT1ID462ch12q13.html


External links

Nomenclature
HGNC (Hugo)WNT1   12774
Cards
AtlasWNT1ID462ch12q13
Entrez_Gene (NCBI)WNT1  7471  Wnt family member 1
AliasesBMND16; INT1; OI15
GeneCards (Weizmann)WNT1
Ensembl hg19 (Hinxton)ENSG00000125084 [Gene_View]  chr12:49372236-49376396 [Contig_View]  WNT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000125084 [Gene_View]  chr12:49372236-49376396 [Contig_View]  WNT1 [Vega]
ICGC DataPortalENSG00000125084
TCGA cBioPortalWNT1
AceView (NCBI)WNT1
Genatlas (Paris)WNT1
WikiGenes7471
SOURCE (Princeton)WNT1
Genetics Home Reference (NIH)WNT1
Genomic and cartography
GoldenPath hg19 (UCSC)WNT1  -     chr12:49372236-49376396 +  12q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WNT1  -     12q13.12   [Description]    (hg38-Dec_2013)
EnsemblWNT1 - 12q13.12 [CytoView hg19]  WNT1 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBIWNT1 [Mapview hg19]  WNT1 [Mapview hg38]
OMIM164820   615220   615221   
Gene and transcription
Genbank (Entrez)BC074798 BC074799 BT019429
RefSeq transcript (Entrez)NM_005430
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_033141 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)WNT1
Cluster EST : UnigeneHs.248164 [ NCBI ]
CGAP (NCI)Hs.248164
Alternative Splicing GalleryENSG00000125084
Gene ExpressionWNT1 [ NCBI-GEO ]   WNT1 [ EBI - ARRAY_EXPRESS ]   WNT1 [ SEEK ]   WNT1 [ MEM ]
Gene Expression Viewer (FireBrowse)WNT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7471
GTEX Portal (Tissue expression)WNT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04628   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04628  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04628
Splice isoforms : SwissVarP04628
PhosPhoSitePlusP04628
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt1    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT1
DMDM Disease mutations7471
Blocks (Seattle)WNT1
SuperfamilyP04628
Human Protein AtlasENSG00000125084
Peptide AtlasP04628
HPRD01276
IPIIPI00025074   IPI00746162   
Protein Interaction databases
DIP (DOE-UCLA)P04628
IntAct (EBI)P04628
FunCoupENSG00000125084
BioGRIDWNT1
STRING (EMBL)WNT1
ZODIACWNT1
Ontologies - Pathways
QuickGOP04628
Ontology : AmiGOembryonic axis specification  branching involved in ureteric bud morphogenesis  positive regulation of protein phosphorylation  frizzled binding  frizzled binding  frizzled binding  cytokine activity  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  cell-cell signaling  myoblast fusion  positive regulation of cell proliferation  positive regulation of cell proliferation  response to wounding  cell surface  positive regulation of lamellipodium assembly  negative regulation of cell-substrate adhesion  morphogen activity  Wnt signaling pathway  Wnt signaling pathway  protein domain specific binding  spinal cord association neuron differentiation  diencephalon development  central nervous system morphogenesis  cerebellum formation  forebrain anterior/posterior pattern specification  midbrain-hindbrain boundary maturation during brain development  negative regulation of cell-cell adhesion  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  endocytic vesicle membrane  midbrain development  organ regeneration  T cell differentiation in thymus  cell proliferation in midbrain  inner ear morphogenesis  signal transduction in response to DNA damage  positive regulation of insulin-like growth factor receptor signaling pathway  transcription regulatory region DNA binding  canonical Wnt signaling pathway involved in negative regulation of apoptotic process  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of Notch signaling pathway  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  receptor agonist activity  receptor agonist activity  positive regulation of fibroblast proliferation  neuron fate determination  neuron development  positive regulation of sequence-specific DNA binding transcription factor activity  Spemann organizer formation  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  bone development  positive regulation of dermatome development  extracellular exosome  hepatocyte differentiation  cellular response to peptide hormone stimulus  hematopoietic stem cell proliferation  positive regulation of canonical Wnt signaling pathway  negative regulation of cell aging  beta-catenin destruction complex disassembly  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  embryonic brain development  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIembryonic axis specification  branching involved in ureteric bud morphogenesis  positive regulation of protein phosphorylation  frizzled binding  frizzled binding  frizzled binding  cytokine activity  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  cell-cell signaling  myoblast fusion  positive regulation of cell proliferation  positive regulation of cell proliferation  response to wounding  cell surface  positive regulation of lamellipodium assembly  negative regulation of cell-substrate adhesion  morphogen activity  Wnt signaling pathway  Wnt signaling pathway  protein domain specific binding  spinal cord association neuron differentiation  diencephalon development  central nervous system morphogenesis  cerebellum formation  forebrain anterior/posterior pattern specification  midbrain-hindbrain boundary maturation during brain development  negative regulation of cell-cell adhesion  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  endocytic vesicle membrane  midbrain development  organ regeneration  T cell differentiation in thymus  cell proliferation in midbrain  inner ear morphogenesis  signal transduction in response to DNA damage  positive regulation of insulin-like growth factor receptor signaling pathway  transcription regulatory region DNA binding  canonical Wnt signaling pathway involved in negative regulation of apoptotic process  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of Notch signaling pathway  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  receptor agonist activity  receptor agonist activity  positive regulation of fibroblast proliferation  neuron fate determination  neuron development  positive regulation of sequence-specific DNA binding transcription factor activity  Spemann organizer formation  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  bone development  positive regulation of dermatome development  extracellular exosome  hepatocyte differentiation  cellular response to peptide hormone stimulus  hematopoietic stem cell proliferation  positive regulation of canonical Wnt signaling pathway  negative regulation of cell aging  beta-catenin destruction complex disassembly  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  embryonic brain development  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Pathways : BIOCARTASegmentation Clock [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Presenilin action in Notch and Wnt signaling [Genes]    ALK in cardiac myocytes [Genes]    Multi-step Regulation of Transcription by Pitx2 [Genes]    WNT Signaling Pathway [Genes]   
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
REACTOMEP04628 [protein]
REACTOME Pathways201681 [pathway]   3238698 [pathway]   373080 [pathway]   381340 [pathway]   4086400 [pathway]   4641262 [pathway]   
NDEx NetworkWNT1
Atlas of Cancer Signalling NetworkWNT1
Wikipedia pathwaysWNT1
Orthology - Evolution
OrthoDB7471
GeneTree (enSembl)ENSG00000125084
Phylogenetic Trees/Animal Genes : TreeFamWNT1
HOVERGENP04628
HOGENOMP04628
Homologs : HomoloGeneWNT1
Homology/Alignments : Family Browser (UCSC)WNT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT1
dbVarWNT1
ClinVarWNT1
1000_GenomesWNT1 
Exome Variant ServerWNT1
ExAC (Exome Aggregation Consortium)WNT1 (select the gene name)
Genetic variants : HAPMAP7471
Genomic Variants (DGV)WNT1 [DGVbeta]
DECIPHER (Syndromes)12:49372236-49376396  ENSG00000125084
CONAN: Copy Number AnalysisWNT1 
Mutations
ICGC Data PortalWNT1 
TCGA Data PortalWNT1 
Broad Tumor PortalWNT1
OASIS PortalWNT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNT1
LOVD (Leiden Open Variation Database)Osteogenesis Imperfecta Variant Database
BioMutasearch WNT1
DgiDB (Drug Gene Interaction Database)WNT1
DoCM (Curated mutations)WNT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT1 (select a term)
intoGenWNT1
NCG5 (London)WNT1
Cancer3DWNT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164820    615220    615221   
Orphanet18793    18794    11651   
MedgenWNT1
Genetic Testing Registry WNT1
NextProtP04628 [Medical]
TSGene7471
GENETestsWNT1
Huge Navigator WNT1 [HugePedia]
snp3D : Map Gene to Disease7471
BioCentury BCIQWNT1
ClinGenWNT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7471
Chemical/Pharm GKB GenePA37376
Clinical trialWNT1
Miscellaneous
canSAR (ICR)WNT1 (select the gene name)
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT1
EVEXWNT1
GoPubMedWNT1
iHOPWNT1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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