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YPEL5 (yippee-like 5 (Drosophila))

Written2014-04Gizem Güpür, Mesut Muyan
Department of Biological Sciences, Middle East Technical University, Ankara, Turkey

(Note : for Links provided by Atlas : click)


Alias (NCBI)CGI-127
HGNC Alias symbCGI-127
HGNC Previous nameyippee-like 5 (Drosophila)
LocusID (NCBI) 51646
Atlas_Id 44614
Location 2p23.1  [Link to chromosome band 2p23]
Location_base_pair Starts at 30147007 and ends at 30160533 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping YPEL5.png]
Local_order From centromere to telomere: FAM179A-C2orf71-CLIP4-ALK-LOC101929418-YPEL5-LBH-LOC102723594-LOC285043.
  Local order of YPEL5 is shown together with leading and subsequent genes on chromosome 2.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP1CB (2p23.2)::YPEL5 (2p23.1)TJP1 (15q13.1)::YPEL5 (2p23.1)YPEL5 (2p23.1)::DGCR2 (22q11.21)
YPEL5 (2p23.1)::PPP1CB (2p23.2)


  Boxes show exons; filled boxes correspond to coding exons, empty boxes indicate noncoding exons. Lines connecting the boxes represent introns.
Description YPEL5 has 5 exons.
Transcription YPEL5 has 4 transcript variants.
Transcript variant 1: 2639 bp mRNA (NCBI Reference Sequence: NM_001127401.1).
Transcript variant 2: 2578 bp mRNA (NCBI Reference Sequence: NM_001127400.1).
Transcript variant 3: 2342 bp mRNA (NCBI Reference Sequence: NM_001127399.1).
Transcript variant 4: 2281 bp mRNA (NCBI Reference Sequence: NM_016061.2).


Description All 4 transcript variants code for the same protein. Protein yippee-like 5 [Homo sapiens] (NCBI Reference Sequence: NP_001120873.1); 121 aa protein.
Expression In human, YPEL5 is expressed in the brain, heart, kidney, lung, pancreas, placenta, skeletal muscle, colon, ovary, leukocyte, prostate, small intestine, spleen, testis, thymus, bone marrow, leukocyte, tonsil, fetal brain, fetal heart, fetal kidney, fetal liver, fetal lung, fetal skeletal muscle, fetal spleen and fetal thymus (Hosono et al., 2004).
Localisation Localized in the nucleus in a diffuse pattern, Ypel5 re-localizes in a region between two spindle poles, likely on the mitotic spindle during mitosis, suggesting a possible role in cell division (Hosono et al., 2004). Ypel5 is localized in the nucleus and on the centrosome during interphase. At prophase, it is detected at spindle poles, while during metaphase and early anaphase it becomes associated with mitotic spindle. At mid-anaphase and telophase it is localized in the spindle midzone. During cytokinesis, Ypel5 is observed only on the midbody (Hosono et al., 2010).
Function Knock-down of YPEL5 in Cos7 cells results in the suppression of cell growth by extending durations of G1 and G2+M phases. Ypel5 was shown to interact, yet by an unknown mechanism, with Ran binding protein in the microtubule organizing center (RanBPM) through SPRY domain of RanBPM. Ypel5 could also bind RanBP10, paralog of RanBPM. Ypel5 is suggested to function in cell division and cell cycle progression through interactions with RanBPM and RanBP10 (Hosono et al., 2010).
Furthermore, knockdown of YPEL5 homolog Ypel-b in medaka fish causes a malformation in embryos. Normal embryogenesis is interrupted in these embryos as a result of suppression of cell proliferation and induction of apoptosis (Hosono et al., 2010).
YPEL5 is expressed in human peripheral T cells in G0 stage and it is down-regulated upon activation by immobilized anti-CD3. In addition, transfection of YPEL5 into HeLa cells causes a decrease in cellular proliferation (Jun et al., 2007).
Homology In human, YPEL5 has 4 paralogs; YPEL1, YPEL2, YPEL3 and YPEL4. Ypel5 has 49.5% aminoacid sequence identity with Ypel1; 48.5% with Ypel2; 43.8% with Ypel3 and 44.6% with Ypel4 (Hosono et al., 2004).
Ypel5 is an ortholog of Drosophila Yippee protein and has 70.8% aminoacid sequence identity to Yippee. There are 100 YPEL family genes in 68 species including mammal, bird, amphibia, fish, protochordate, insect, nematode, coelenterate, echinoderm, protozoan, plant, and fungi. In this diverge range of organisms, YPEL family proteins shows a high level of homology with many identical residues. Thus, a consensus sequence is deduced as follows: C-X2-C-X19-G-X3-L-X5-N-X13-G-X8-C-X2-C-X4-GWXY-X10-K-X6-E. In the consensus sequence, the number of non-consensus residues, designated as X, is identical for all species examined (Hosono et al., 2004).

Implicated in

Entity Lung cancer
Note Treatment of A549 human non-small cell lung carcinoma cell line with ethanolic extract of Descurainia sophia seeds causes a dose dependent up-regulation in YPEL5 mRNA levels (Kim et al., 2013).
Prognosis YPEL5 is found to be related to survival in lung cancer patients with a hazard ratio of 0.62 (Kim et al., 2013).
Entity Chronic lymphocytic leukemia (CLL)
Abnormal Protein Reciprocal RNA chimeras of YPEL5 and PPP1CB genes are recurrently and exclusively detected in chronic lymphocytic leukemia. YPEL5/PPP1CB and PPP1CB/YPEL5 chimeras form as a result of an intergenic splicing event and there is no genomic basis for this fusion which marks a possible breakpoint. YPEL5/PPP1CB RNA chimera results in the formation of a truncated PPP1CB protein which shows a decreased phosphatase activity. This RNA chimeric fusion product acts a dominant negative protein that inhibits the function of wild type PPP1CB protein. This results in an enhanced proliferation and colony formation in B-CLL-related cells (Velusamy et al., 2013).


YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.
Hosono K, Noda S, Shimizu A, Nakanishi N, Ohtsubo M, Shimizu N, Minoshima S.
Genomics. 2010 Aug;96(2):102-11. doi: 10.1016/j.ygeno.2010.05.003. Epub 2010 May 24.
PMID 20580816
Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species.
Hosono K, Sasaki T, Minoshima S, Shimizu N.
Gene. 2004 Sep 29;340(1):31-43.
PMID 15556292
Expression of Yippee-Like 5 (YPEL5) Gene During Activation of Human Peripheral T Lymphocytes by Immobilized Anti-CD3.
Jun DY, Park HW, Kim YH.
Journal of Life Science. 2007;17(12): 1641-8.
Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug.
Kim BY, Lee J, Park SJ, Bang OS, Kim NS.
Evid Based Complement Alternat Med. 2013;2013:584604. doi: 10.1155/2013/584604. Epub 2013 Jun 27.
PMID 23935669
Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.
Velusamy T, Palanisamy N, Kalyana-Sundaram S, Sahasrabuddhe AA, Maher CA, Robinson DR, Bahler DW, Cornell TT, Wilson TE, Lim MS, Chinnaiyan AM, Elenitoba-Johnson KS.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3035-40. doi: 10.1073/pnas.1214326110. Epub 2013 Feb 4.
PMID 23382248


This paper should be referenced as such :
G Güpür, M Muyan
YPEL5 (yippee-like 5 (Drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2015;19(1):41-43.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;2)(p23;p23) YPEL5::PPP1CB
t(2;2)(p23;p23) PPP1CB::YPEL5

External links


HGNC (Hugo)YPEL5   18329
Atlas Explorer : (Salamanque)YPEL5
Entrez_Gene (NCBI)YPEL5    yippee like 5
GeneCards (Weizmann)YPEL5
Ensembl hg19 (Hinxton)ENSG00000119801 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119801 [Gene_View]  ENSG00000119801 [Sequence]  chr2:30147007-30160533 [Contig_View]  YPEL5 [Vega]
ICGC DataPortalENSG00000119801
TCGA cBioPortalYPEL5
Genatlas (Paris)YPEL5
SOURCE (Princeton)YPEL5
Genetics Home Reference (NIH)YPEL5
Genomic and cartography
GoldenPath hg38 (UCSC)YPEL5  -     chr2:30147007-30160533 +  2p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YPEL5  -     2p23.1   [Description]    (hg19-Feb_2009)
GoldenPathYPEL5 - 2p23.1 [CytoView hg19]  YPEL5 - 2p23.1 [CytoView hg38]
Genome Data Viewer NCBIYPEL5 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB098739 AF135161 AF151885 AF172940 AK025730
RefSeq transcript (Entrez)NM_001127399 NM_001127400 NM_001127401 NM_016061
Consensus coding sequences : CCDS (NCBI)YPEL5
Gene ExpressionYPEL5 [ NCBI-GEO ]   YPEL5 [ EBI - ARRAY_EXPRESS ]   YPEL5 [ SEEK ]   YPEL5 [ MEM ]
Gene Expression Viewer (FireBrowse)YPEL5 [ Firebrowse - Broad ]
GenevisibleExpression of YPEL5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51646
GTEX Portal (Tissue expression)YPEL5
Human Protein AtlasENSG00000119801-YPEL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62699   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62699  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62699
Domaine pattern : Prosite (Expaxy)YIPPEE (PS51792)   
Domains : Interpro (EBI)Yippee    Yippee/Mis18/Cereblon    Yippee_fam   
Domain families : Pfam (Sanger)Yippee-Mis18 (PF03226)   
Domain families : Pfam (NCBI)pfam03226   
Conserved Domain (NCBI)YPEL5
AlphaFold pdb e-kbP62699   
Human Protein Atlas [tissue]ENSG00000119801-YPEL5 [tissue]
Protein Interaction databases
IntAct (EBI)P62699
Ontologies - Pathways
Ontology : AmiGOubiquitin ligase complex  ubiquitin ligase complex  protein binding  extracellular region  nucleus  centrosome  cell population proliferation  midbody  metal ion binding  mitotic spindle pole  tertiary granule lumen  ficolin-1-rich granule lumen  
Ontology : EGO-EBIubiquitin ligase complex  ubiquitin ligase complex  protein binding  extracellular region  nucleus  centrosome  cell population proliferation  midbody  metal ion binding  mitotic spindle pole  tertiary granule lumen  ficolin-1-rich granule lumen  
REACTOMEP62699 [protein]
REACTOME PathwaysR-HSA-6798695 [pathway]   
NDEx NetworkYPEL5
Atlas of Cancer Signalling NetworkYPEL5
Wikipedia pathwaysYPEL5
Orthology - Evolution
GeneTree (enSembl)ENSG00000119801
Phylogenetic Trees/Animal Genes : TreeFamYPEL5
Homologs : HomoloGeneYPEL5
Homology/Alignments : Family Browser (UCSC)YPEL5
Gene fusions - Rearrangements
Fusion : MitelmanPPP1CB::YPEL5 [2p23.2/2p23.1]  
Fusion : MitelmanYPEL5::PPP1CB [2p23.1/2p23.2]  
Fusion : FusionHubAP3S2--YPEL5    ARNT--YPEL5    C15ORF38-AP3S2--YPEL5    CXCR4--YPEL5    GPATCH8--YPEL5    IMPDH1--YPEL5    LINC01578--YPEL5    LTBP1--YPEL5    NF1--YPEL5    PPP1CB--YPEL5   
YPEL5--PPP1CB    YPEL5--PQLC1    YPEL5--ZEB2    ZNF236--YPEL5   
Fusion : QuiverYPEL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYPEL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YPEL5
Exome Variant ServerYPEL5
GNOMAD BrowserENSG00000119801
Varsome BrowserYPEL5
ACMGYPEL5 variants
Genomic Variants (DGV)YPEL5 [DGVbeta]
DECIPHERYPEL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYPEL5 
ICGC Data PortalYPEL5 
TCGA Data PortalYPEL5 
Broad Tumor PortalYPEL5
OASIS PortalYPEL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYPEL5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYPEL5
Mutations and Diseases : HGMDYPEL5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)YPEL5
DoCM (Curated mutations)YPEL5
CIViC (Clinical Interpretations of Variants in Cancer)YPEL5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry YPEL5
NextProtP62699 [Medical]
Target ValidationYPEL5
Huge Navigator YPEL5 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDYPEL5
Pharm GKB GenePA134863727
Clinical trialYPEL5
DataMed IndexYPEL5
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 14:20:38 CET 2022

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