Guangdong Medical College, Dongguan, Guangdong 523808, China (XZ, ZH); Affina Biotechnologies, Inc., Stamford, CT USA (MIL)
The candidate tumor suppressor gene ZMYND10\/BLU, is located on the minimal deleted fragment of 110 kb in chromosomal region 3p21.3. It was initially identified by PCR in search of the b-catenin homolog in lung cancer. BLU codes for a protein with 440 amino acid residues, which contains a zinc finger myelogenous nervy domain (zMYND) motif on its carboxyl terminus. The characteristic domain defines a ZMYNND protein family, some of its member have been found in the frequently affected region translocated during acute leukemias, and were described to be transcriptional repressors. BLU\/ZMYND10 is inactivated in a variety of human tumors due to genetic or epigenetic mechanisms, but the function is largely unknown. It has been reported that similar with certain tumor suppressors, it donwregulates JNK\/MAPK signaling to exert inhibition on growth and proliferation. ZMYND10 is implicated in the respiratory ciliary dyskinesia.
NCBI: 51364 MIM: 607070 HGNC: 19412 Ensembl: ENSG00000004838
dbSNP: 51364 ClinVar: 51364 TCGA: ENSG00000004838 COSMIC: ZMYND10
Xiangning Zhang ; Michael I Lerman ; Zhiwei He
ZMYND10 (zinc finger, MYND-type containing 10)
Atlas Genet Cytogenet Oncol Haematol. 2014-07-01
Online version: http://atlasgeneticsoncology.org/gene/45815/zmynd10