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Chromosome 21

Chromosome 21 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret
Chromosome 21 diagrams ISCN 2009 - Courtesy Nicole Chia

Leukaemia     

21q22 rearrangements (RUNX1) in treatment related leukemia
dup(21q) amplified (RUNX1)
del(21)(q21q22) USP16/RUNX1
+21 or trisomy 21
t(1;21)(p36;q22) RUNX1/PRDM16
t(1;21)(p35;q22) RUNX1/YTHDF2
t(1;21)(p32;q22) RUNX1/?
t(1;21)(p22;q22) RUNX1/CLCA2
t(1;21)(q12;q22) RUNX1/?
t(1;21)(q21;q22) RUNX1/ZNF687
t(2;21)(p11;q22) RUNX1/?
t(2;21)(q11;q22)
t(3;21)(p12;q22) RUNX1/?
t(3;21)(q26;q22) RUNX1/MECOM
t(3;21)(q26;q22) RUNX1/MECOM in treatment related leukemia
t(4;21)(q31;q22) RUNX1/?
t(4;21)(q31;q22) RUNX1/SH3D19
t(4;21)(q35;q22) RUNX1/?
t(5;21)(q13;q22) RUNX1/?
t(6;21)(p22;q22) RUNX1-?
t(7;21)(p22;q22) RUNX1/USP42
t(7;21)(p15;q22) RUNX1/?
t(8;21)(q22;q22) RUNX1/RUNX1T1
t(8;21)(q22;q22) RUNX1/RUNX1T1 in treatment related leukemia
t(8;21)(q23;q22) RUNX1/ZFPM2
t(8;21)(q24;q22) RUNX1/TRPS1
t(9;21)(p22;q22)
t(9;21)(q34;q22) RUNX1 truncated
t(X;21)(p22;q22) RUNX1/RPL22
t(X;21)(p11;q22) RUNX1/?
t(X;21)(q26;q22) ELF4/ERG
t(11;21)(p14;q22) RUNX1/KIAA1549L
t(11;21)(q13;q22) RUNX1/MACROD1
t(11;21)(q21;q22) RUNX1/LPXN
t(12;21)(p13;q22) ETV6/RUNX1
t(12;21)(q12;q22) RUNX1 truncated
t(12;21)(q24;q22) RUNX1/?
t(14;21)(q11;q22) TRA/OLIG2
t(14;21)(q22;q22) RUNX1/?
t(15;21)(q22;q22) RUNX1/?
t(16;21)(p11;q22) FUS/ERG
t(16;21)(q24;q22) RUNX1/CBFA2T3
t(17;21)(q11.2;q22) RUNX1/?
t(18;21)(q21;q22) RUNX1/?
t(19;21)(q13.4;q22) RUNX1 truncated
t(20;21)(q11;q22) RUNX1/?
t(20;21)(q13;q22) RUNX1/?
t(20;21)(q13.2;q22.12) ZFP64/RUNX1

Solid Tumors     

t(1;21)(q32;q22) SLC45A3/ERG
t(3;21)(q27;q22) TMPRSS2/ETV5
t(7;21)(p21;q22) TMPRSS2/ETV1
t(8;21)(q24;q22) NDRG1/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(q13;q22) HERPUD1/ERG
t(17;21)(q21;q22) TMPRSS2/ETV4
t(17;21)(q24;q22) BRWD1/CCDC46
t(21;21)(q22;q22) TMPRSS2/ERG
t(21;22)(q21;q12) EWSR1/ERG
t(21;22)(q21;q12) EWSR1/ERG

Cancer prone diseases     

Familial platelet disorder with predisposition to acute myelogenous leukemia

All Genes by Location (Kb)

Chromosome 21 by location

Losses / Amplicons     

BONE/SOFT TISSUE



External links     

  • Chromosome 21 - HUGO Chromosomes
  • Chromosome 21 - GoldenPath - Santa Cruz
  • Chromosome 21 - Ensembl Project
  • Chromosome 21 - Map View - NCBI
  • Chromosome 21 - OMIM Gene map
  • Chromosome 21 - Genomic Variants
  • Chromosome 21 - HAPMAP Project
  • Chromosome 21 - Genome Channel - ORNL
  • Chromosome 21 - LaunchPad HGMIS
  • Chromosome 21 - Human Protein Atlas
  • Chromosome 21 - Array BAC clone - Roswell Park Cancer Institute
  • Chromosome 21 - Human BAC Resource (NCBI)
  • Chromosome 21 FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Mouse homology - OMIM - NCBI
  • Chromosome 21 Cancer GeneWeb
  • Human Proteomics Initiative (UniProt)
  • Cytogenetic marker FISH (Abbott)
  • FISH Probes DAKO
  • SureFISH Probes
  • CytoCell
  • Kreatech Diagnostic/

  • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    ADAMTS1 28208.606 21q21.3
    CSTB 45193.546 21q22.3
    DYRK1A 38792.602 21q22.13
    ERG 39751.950 21q22.3
    ETS2 40177.231 21q22.3
    MIR125B2 17962.557 21q21.1
    NRIP1 16333.556 21q11.2
    OLIG2 34398.216 21q22.11
    PTTG1IP 46269.500 21q22.3
    RUNX1 36160.098 21q22.3
    S100B 48018.531 21q22.3
    TFF1 43782.391 21q22.3
    TFF2 43766.467 21q22.3
    TFF3 43731.777 21q22.3
    TIAM1 32490.736 21q22.1
    TMPRSS2 42836.478 21q22.3
    TMPRSS3 43791.996 21q22.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    ABCC13 15646.120 21q11.2
    ABCG1 43639.267 21q22.3
    ADAMTS5 28290.231 21q21.3
    ADARB1 46494.493 21q22.3
    AGPAT3 45345.279 21q22.3
    AIRE 45705.721 21q22.3
    ANKRD20A11P 15316.096 21q11.2
    ANKRD30BP2 14415.105 21q11.2
    APP 27252.861 21q21.2
    ATP5J 27096.791 21q21.1
    ATP5O 35275.757 21q22
    B3GALT5 40984.867 21q22.3
    B3GALT5-AS1 40969.075 21q22.2
    BACE2 42539.728 21q22.3
    BACH1 30671.220 21q22.1
    BACH1-IT2 30744.821 21q21.3
    BAGE 11057.796 21p11.1
    BAGE2 11020.842 21p
    BAGE3 11020.842 21p11.2
    BAGE4 11020.842 21p11.1
    BAGE5 11020.842 13cen
    BRWD1 40668.363 21q22.2
    BRWD1-AS1 40687.633 -
    BRWD1-IT2 40685.833 21q22.2
    BTG3 18965.968 21q21.1
    C21orf140 35772.410 -
    C21orf2 45748.827 21q22.3
    C21orf33 45553.494 21q22.3
    C21orf58 47720.344 21q22.3
    C21orf59 33973.984 21q22.11
    C21orf62 34162.984 21q22.1
    C21orf62-AS1 34144.411 21q22.11
    C21orf91 19161.284 21q21.1
    C21orf91-OT1 19149.721 21q21.1
    C2CD2 43305.219 21q22.3
    CBR1 37442.222 21q22.1
    CBR3 37507.263 21q22.2
    CBR3-AS1 37504.065 21q22.12
    CBS 44473.301 21q22.3
    CCT8 30428.643 21q21.3
    CHAF1B 37757.689 21q22.2
    CHODL 19618.192 21q11.2
    CHODL-AS1 19207.989 21q21.1
    CLDN14 37832.920 21q22.3
    CLDN17 31538.241 21q22.1
    CLDN8 31586.324 21q22.1
    CLIC6 36041.688 21q22.12
    COL18A1 46875.424 21q22.3
    COL18A1-AS1 46839.631 21q22.3
    COL18A1-AS2 46827.301 -
    COL6A1 47401.663 21q22.3
    COL6A2 47518.033 21q22.3
    CRYAA 44589.118 21q22.3
    CRYZL1 34961.648 21q22.1
    CXADR 18885.224 21q21.1
    CYP4F29P 15215.454 21q11
    CYYR1 27838.528 21q21.2
    CYYR1-AS1 27778.262 -
    D21S2088E 24733.426 -
    D21S2090E 31462.035 -
    DIP2A 47878.862 21q22.3
    DIP2A-IT1 47882.384 21q22.3
    DNAJC28 34860.362 21q22.11
    DNMT3L 45666.222 21q22.3
    DONSON 34949.859 21q22.1
    DOPEY2 37536.839 21q22.2
    DSCAM 41384.343 21q22.2-q22.3
    DSCAM-AS1 41755.010 21q22.2
    DSCAM-IT1 41990.433 -
    DSCR10 39578.250 21q22.13
    DSCR3 38595.726 21q22.2
    DSCR4 39426.313 21q22.2
    DSCR9 38592.627 21q22
    ERVH48-1 44336.913 21q22.3
    EVA1C 33784.745 21q22.11
    FAM207A 46359.955 21q22.3
    FAM3B 42688.661 21q22.3
    FLJ41733 44783.212 21q22.3
    FLJ42200 25801.054 21q21.2
    FTCD 47556.176 21q22.3
    GABPA 27107.258 21q21-q22.1
    GART 34876.238 21q22.11
    GRIK1 30925.866 21q22
    GRIK1-AS1 31120.494 21q22.11
    GRIK1-AS2 30968.360 21q22.11
    H2BFS 44985.070 21q22.3
    HLCS 38123.189 21q22.1
    HMGN1 40714.241 21q22.3
    HSF2BP 44949.072 21q22.3
    HSPA13 15743.437 21q11.1
    HUNK 33245.628 21q22.1
    ICOSLG 45642.878 21q22.3
    IFNAR1 34697.214 21q22.1
    IFNAR2 34602.200 21q22.1
    IFNGR2 34775.202 21q22.1
    IGSF5 41117.334 21q22.2
    IL10RB 34638.665 21q22.11
    IL10RB-AS1 34637.937 21q22.11
    ITGB2 46305.868 21q22.3
    ITGB2-AS1 46340.950 21q22.3
    ITSN1 35014.784 21q22.1-q22.2
    JAM2 27011.594 21q21.2
    KCNE1 35818.986 21q22.1-q22.2
    KCNE2 35736.323 21q22.12
    KCNJ15 39628.620 21q22.2
    KCNJ6 38996.785 21q22.1
    KRTAP10-10 46057.273 21q22.3
    KRTAP10-11 46066.331 21q22.3
    KRTAP10-1 45959.068 21q22.3
    KRTAP10-12 46117.087 21q22.3
    KRTAP10-2 45970.318 21q22.3
    KRTAP10-3 45977.906 21q22.3
    KRTAP10-4 45993.606 21q22.3
    KRTAP10-5 45999.332 21q22.3
    KRTAP10-6 46011.149 21q22.3
    KRTAP10-7 46020.497 21q22.3
    KRTAP10-8 46031.996 21q22.3
    KRTAP10-9 46047.040 21q22.3
    KRTAP11-1 32252.964 21q22.1
    KRTAP12-1 46101.491 21q22.3
    KRTAP12-2 46086.106 21q22.3
    KRTAP12-3 46077.849 21q22.3
    KRTAP12-4 46074.130 21q22.3
    KRTAP13-1 31768.392 21q22.11
    KRTAP13-2 31743.709 21q22.1
    KRTAP13-3 31797.711 21q22.1
    KRTAP13-4 31802.594 21q22.1
    KRTAP15-1 31812.646 21q22.1
    KRTAP19-1 31852.364 21q22.1
    KRTAP19-2 31859.509 21q22.1
    KRTAP19-3 31863.782 21q22.1
    KRTAP19-4 31869.174 21q22.1
    KRTAP19-5 31874.190 21q22.1
    KRTAP19-6 31913.854 21q22.1
    KRTAP19-7 31933.417 21q22.1
    KRTAP19-8 32410.478 21q22.11
    KRTAP20-1 31988.774 21q22.1
    KRTAP20-2 32007.583 21q22.1
    KRTAP20-3 32015.183 21q22.11
    KRTAP20-4 31992.946 21q22.11
    KRTAP21-1 32127.457 21q22.1
    KRTAP21-2 32119.269 21q22.1
    KRTAP21-3 32090.843 21q22.11
    KRTAP22-1 31973.440 21q22.1
    KRTAP22-2 31962.424 21q22.11
    KRTAP23-1 31720.717 21q22.1
    KRTAP24-1 31653.627 21q22.11
    KRTAP25-1 31661.463 21q22.1
    KRTAP26-1 31691.450 21q22.11
    KRTAP27-1 31709.331 21q22.11
    KRTAP6-1 31986.005 21q22.1
    KRTAP6-2 31971.005 21q22.1
    KRTAP6-3 31964.759 21q22.1
    KRTAP7-1 32201.358 21q22.1
    KRTAP8-1 32185.015 21q22.1
    LCA5L 40777.770 21q22.2
    LINC00111 43099.462 21q22.3
    LINC00112 43136.596 21q22.3
    LINC00113 29094.698 21q21.3
    LINC00114 40110.949 21q22.2
    LINC00159 33452.794 21q22.11
    LINC00160 36096.105 21q22.12
    LINC00161 29911.640 21q21.3
    LINC00162 46419.122 21q22.2
    LINC00163 46409.779 21q22.3
    LINC00165 46414.279 21q22.3
    LINC00189 30565.801 21q22.11
    LINC00205 46713.966 21q22.3
    LINC00307 31581.469 21q22.11
    LINC00308 23470.936 21q21.1
    LINC00310 35552.978 21q22.11
    LINC00313 44881.974 21q22.3
    LINC00314 29385.701 21q21.3
    LINC00315 46720.160 21q22.3
    LINC00316 46758.505 21q22.3
    LINC00317 23095.613 21q21.1
    LINC00319 44866.481 21q22.3
    LINC00320 22114.908 21q21.1
    LINC00322 44742.089 21q22.3
    LINC00323 42513.427 21q22.3
    LINC00328 10205.788 21p11.2
    LINC00334 46654.267 21q22.3
    LINC00479 43131.680 21q22.3
    LINC00515 26955.087 21q21.3
    LINC00527 40394.926 21q22.2
    LINC00649 35303.516 21q22.11
    LINC00945 34430.135 21q22.11
    LINC01423 39698.281 21q22
    LINC01424 46222.156 -
    LINC01425 23119.305 -
    LINC01426 36118.122 -
    LINC01436 37377.618 21q22.12
    LINC01547 46354.641 21q22.3
    LINC01548 34537.776 21q22.11
    LIPI 15481.135 21q11.2
    LOC100128198 33652.836 21q22.11
    LOC100129027 47247.755 21q22.3
    LOC100129311 44001.352 21q22.3
    LOC100130597 46953.347 21q22.3
    LOC100131190 42733.957 21q22.3
    LOC100133286 37441.940 21q22.12
    LOC100288884 10600.301 21p11.2
    LOC100506403 36744.805 -
    LOC101927797 19933.583 -
    LOC101927843 23381.477 -
    LOC101927869 25676.863 -
    LOC101927973 29488.413 21q21.3
    LOC101928107 34484.010 -
    LOC101928269 37326.977 21q22.12
    LOC101928398 40229.463 -
    LOC101928435 40346.355 -
    LOC101928796 47392.884 -
    LOC102724188 14918.354 21q11.2
    LOC150005 19301.408 21q21.1
    LOC150051 32931.558 21q22.11
    LOC284825 29420.733 21q21.3
    LOC284837 45225.641 21q22.3
    LOC339622 26212.864 21q21.1-q21.2
    LOC388813 15963.713 21q11.2
    LOC388820 35791.013 21q22.11
    LOC400863 35321.230 21q22.11
    LOC400867 40249.215 21q22.2
    LOC642852 46707.967 21q22.3
    LRRC3 45875.393 21q22.3
    LRRC3-AS1 45870.869 21q22.3
    LRRC3DN 45879.814 21q22.3
    LSS 47608.360 21q22.3
    LTN1 30300.466 21q21.3
    MAP3K7CL 30449.792 21q22.3
    MCM3AP 47655.039 21q22.3
    MCM3AP-AS1 47649.145 21q22.3
    MIR155 26946.292 21q21.3
    MIR155HG 26934.457 21q21.3
    MIR3156-3 14778.705 21
    MIR3197 42539.484 21
    MIR3648-1 9825.832 21
    MIR3687-1 9826.203 21
    MIR4327 31747.612 21
    MIR4759 28326.280 21
    MIR4760 41584.279 21
    MIR5009 28659.822 15
    MIR6070 45029.768 -
    MIR6501 34922.968 -
    MIR6508 40818.936 -
    MIR6814 43166.932 -
    MIR6815 46898.180 -
    MIR802 37093.013 21q22.12
    MIR8069-1 15096.510 -
    MIR99A 17911.409 21q21.1
    MIR99AHG 17443.553 21q11-q21.1
    MIRLET7C 17912.148 21q21.1
    MIS18A 33640.530 21q22.11
    MORC3 37692.487 21q22.13
    MRAP 33664.124 21q22.1
    MRPL39 26957.968 21q11.2-q21
    MRPS6 35445.823 21q22.11
    MX1 42792.485 21q22.3
    MX2 42733.950 21q22.3
    N6AMT1 30248.386 21q21.3
    NCAM2 22370.633 21q21
    NDUFV3 44313.378 21q22.3
    OLIG1 34442.450 21q22.11
    PAXBP1 34113.650 21q22.11
    PAXBP1-AS1 34100.425 21q22.11
    PCBP3 47269.875 21q22.3
    PCBP3-OT1 47334.210 21q22.3
    PCNT 47744.036 21q22.3
    PCP4 41239.347 21q22.2
    PDE9A 44073.862 21q22.3
    PDXK 45138.978 21q22.3
    PFKL 45719.917 21q22.3
    PIGP 38437.664 21q22.2
    PKNOX1 44394.620 21q22.3
    PLAC4 42547.158 21
    POFUT2 46683.843 21q22.3
    POTED 14982.498 21q11.2
    PRDM15 43218.385 21q22.3
    PRMT2 48055.507 21q22.3
    PSMG1 40547.372 21q22.3
    PWP2 45527.208 21q22.3
    RBM11 15588.466 21q11
    RCAN1 35888.740 21q22.1-q22.2
    RIPK4 43159.529 21q22.3
    RIPPLY3 38378.863 21q22.2
    RNU6-67P 22657.822 13q31.1
    RRP1 45209.418 21q22.3
    RRP1B 45079.432 21q22.3
    RSPH1 43892.597 21q22.3
    RUNX1-IT1 36410.233 21q22.12
    RWDD2B 30378.080 21q22.11
    SAMSN1 15857.549 21q11
    SAMSN1-AS1 15954.523 -
    SCAF4 33043.313 21q22.1
    SETD4 37415.982 21q22.13
    SH3BGR 40817.797 21q22.3
    SIK1 44834.398 21q22.3
    SIM2 38071.991 21q22.2
    SLC19A1 46934.629 21q22.3
    SLC37A1 43919.742 21q22.3
    SLC5A3 35445.823 21q22.11
    SMIM11 35747.749 21q22.12
    SNORA80A 33749.496 21q22.11
    SOD1 33031.935 21q22.11
    SON 34915.344 21q22.1-q22.2
    SPATC1L 47581.062 21q22.3
    SSR4P1 46490.871 21q22.3
    SUMO3 46225.532 21q22.3
    SYNJ1 34001.069 21q22.2
    TCP10L 33947.151 21p22.11
    TMEM50B 34821.448 21q22.1
    TMPRSS15 19641.433 21q21
    TPTE 10906.187 21p11
    TRAPPC10 45432.206 21q22.3
    TRPM2 45773.484 21q22.3
    TRPM2-AS 45834.475 -
    TSPEAR 45917.775 21q22.3
    TSPEAR-AS1 45925.927 21q22.3
    TSPEAR-AS2 45937.098 21q22.3
    TTC3 38445.571 21q22.2
    TTC3-AS1 38559.913 -
    U2AF1 44513.066 21q22.3
    UBASH3A 43823.971 21q22.3
    UBE2G2 46188.495 21q22.3
    UMODL1 43491.426 21q22.3
    UMODL1-AS1 43522.244 21q22.3
    URB1 33683.330 21q22.11
    USP16 30396.938 21q22.11
    USP25 17102.344 21q11.2
    WDR4 44269.336 21q22.3
    WRB 40759.692 21q22.3
    YBEY 47706.267 21q22.3
    ZBTB21 43406.940 21q22.3
    ZNF295-AS1 43442.192 21q22.3

    Contributor(s)

    WrittenJul 2004Philippe Dessen, Sakari Knuutila, Jean-Loup Huret
    UpdatedDec 2014Philippe Dessen, Jean-Loup Huret

    Citation

    This paper should be referenced as such :
    Dessen P, Knuutila S, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jul 2004 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    Dessen P, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Dec 2014 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Sun Dec 21 03:39:04 CET 2014


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