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Chromosome 21

Chromosome 21 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret
Chromosome 21 diagrams ISCN 2009 - Courtesy Nicole Chia

Leukaemia     

t(1;21)(p36;q22)
t(1;21)(p32;q22)
t(1;21)(p35;q22)
t(1;21)(q12;q22)
t(1;21)(q21;q22)
t(2;21)(p11;q22)
t(2;21)(q11;q22)
t(3;21)(p12;q22)
t(3;21)(q26;q22) in treatment related leukemia
t(3;21)(q26;q22)
t(4;21)(q31;q22)
t(4;21)(q31;q22)
t(4;21)(q35;q22)
t(5;21)(q13;q22)
t(6;21)(p22;q22)
t(7;21)(p15;q22)
t(7;21)(p22;q22)
t(8;21)(q22;q22) in treatment related leukemia
t(8;21)(q23;q22)
t(8;21)(q24;q22)
t(8;21)(q22;q22)
t(9;21)(p22;q22)
t(9;21)(q34;q22)
t(X;21)(p11;q22)
t(X;21)(q26;q22)
t(X;21)(p22;q22)
t(11;21)(q13;q22)
t(12;21)(q12;q22)
t(12;21)(q24;q22)
t(12;21)(p12;q22)
t(14 ;21)(q11;q22)
t(14;21)(q22;q22)
t(15;21)(q22;q22)
t(16;21)(q24;q22)
t(16;21)(p11;q22)
t(17;21)(q11.2;q22)
t(18;21)(q21;q22)
t(19;21)(q13.4;q22)
t(20;21)(q11;q22)
t(20;21)(q13;q22)
21q22 rearrangements in treatment related leukemia
dup(21q) amplified (RUNX1)
-21 or monosomy 21 (solely)
+21 or trisomy 21

Solid Tumors     

t(16;21)(p11;q22)
t(21;22)(q12;q12)
t(17;22)(q12;q12)

Cancer prone diseases     

Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML)

All Genes by Location (Kb)
Chromosome 21 by location

Losses / Amplicons     

BONE/SOFT TISSUE

External links     

  • Chromosome 21 - HUGO Chromosomes
  • Chromosome 21 - GoldenPath - Santa Cruz
  • Chromosome 21 - Ensembl Project
  • Chromosome 21 - Map View - NCBI
  • Chromosome 21 - OMIM Gene map
  • Chromosome 21 - Genomic Variants
  • Chromosome 21 - HAPMAP Project
  • Chromosome 21 - Genome Channel - ORNL
  • Chromosome 21 - LaunchPad HGMIS
  • Chromosome 21 - Human Protein Atlas
  • Chromosome 21 - Array BAC clone - Roswell Park Cancer Institute
  • Chromosome 21 - Human BAC Resource (NCBI)
  • Chromosome 21 FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Mouse homology - OMIM - NCBI
  • Chromosome 21 Cancer GeneWeb
  • Chromosome 21 GeneCards (Weizmann)
  • Human Proteomics Initiative (Expasy)

    • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    ADAMTS1 28208.607 21q21.2
    CSTB 45194.083 21q22.3
    ERG 39772.495 21q22.3
    NRIP1 16333.562 21q11.2
    OLIG2 34398.292 21q22.11
    PTTG1IP 46269.512 21q22.3
    TFF1 43782.390 21q22.3
    TFF3 43733.668 21q22.3
    TIAM1 32492.621 21q22.1|21q22.11
    TMPRSS3 43791.999 21q22.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    ADAMTS5 28295.967 21q21.3
    ADARB1 46494.514 21q22.3
    AIRE 45705.762 21q22.3
    ANKRD30BP2 14415.104 21q11.2
    B3GALT5 41029.253 21q22.3
    BACE2 42540.083 21q22.3
    BAGE 11056.646 21p11.1
    BAGE2 11020.841 21p
    BAGE3 11020.841 21p11.2
    BAGE4 11020.841 21p11.1
    BAGE5 11020.841 13cen
    BTG3 18965.972 21q21.1
    CBR1 37442.221 21q22.13
    CBR3 37510.174 21q22.2
    CBS 44473.633 21q22.3
    CHAF1B 37757.693 21q22.13
    CLDN8 31586.498 21q22.11
    COL18A1 46875.402 21q22.3
    COL6A1 47401.683 21q22.3
    CRYAA 44589.159 21q22.3
    CXADR 18885.447 21q21.1
    CYYR1 27838.667 21q21.2
    DNMT3L 45666.222 21q22.3
    DYRK1A 38739.235 21q22.13
    HMGN1 40714.241 21q22.3|21q22.2
    HUNK 33373.856 21q22.1
    ICOSLG 45646.716 21q22.3
    IFNAR1 34729.385 21q22.1|21q22.11
    IFNAR2 34614.186 21q22.1|21q22.11
    ITGB2 46305.905 21q22.3
    ITSN1 35014.945 21q22.1-q22.2
    KCNE1 35821.543 21q22.1-q22.2|21q22.12
    KCNJ6 38997.648 21q22.1|21q22.1
    MCM3AP 47655.182 21q22.3
    OLIG1 34442.458 21q22.11
    PCBP3 47269.874 21q22.3
    PCNT 47744.801 21q22.3
    PFKL 45719.978 21q22.3
    PIGP 38437.676 21q22.2
    PRMT2 48063.445 21q22.3
    RCAN1 35987.058 21q22.1-q22.2|21q22.12
    RIPK4 43159.527 21q22.3
    RRP1B 45079.468 21q22.3
    SAMSN1 15857.554 21q11
    SIK1 44834.397 21q22.3
    SLC19A1 46913.485 21q22.3
    SLC5A3 35476.483 21q22.12
    SOD1 33032.003 21q22.1|21q22.11
    SON 34915.374 21q22.1-q22.2|21q22.11
    SUMO3 46226.630 21q22.3
    SYNJ1 34001.072 21q22.2
    TRPM2 45773.138 21q22.3
    U2AF1 44513.213 21q22.3
    UBE2G2 46188.955 21q22.3
    USP16 30408.661 21q22.11
    USP25 17102.513 21q11.2

    GeneCards  

    Contributor(s)

    WrittenJul 2004Philippe Dessen, Sakari Knuutila, Jean-Loup Huret
    Updated Jean-Loup Huret, Philippe Dessen

    Citation

    This paper should be referenced as such :
    Dessen P, Knuutila S, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jul 2004 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    Dessen P, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Wed Sep 1 08:32:02 CEST 2010
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