Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Chromosome 21

Chromosome 21 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret
Chromosome 21 diagrams ISCN 2009 - Courtesy Nicole Chia

Leukaemia     

21q22 rearrangements (RUNX1) in treatment related leukemia
dup(21q) amplified (RUNX1)
del(21)(q21q22) USP16/RUNX1
+21 or trisomy 21
t(1;21)(p36;q22) RUNX1/PRDM16
t(1;21)(p35;q22) RUNX1/YTHDF2
t(1;21)(p32;q22) RUNX1/?
t(1;21)(p22;q22) RUNX1/CLCA2
t(1;21)(q12;q22) RUNX1/?
t(1;21)(q21;q22) RUNX1/ZNF687
t(2;21)(p11;q22) RUNX1/?
t(2;21)(q11;q22)
t(3;21)(p12;q22) RUNX1/?
t(3;21)(q26;q22) RUNX1/MECOM
t(3;21)(q26;q22) RUNX1/MECOM in treatment related leukemia
t(4;21)(q31;q22) RUNX1/?
t(4;21)(q31;q22) RUNX1/SH3D19
t(4;21)(q35;q22) RUNX1/?
t(5;21)(q13;q22) RUNX1/?
t(6;21)(p22;q22) RUNX1-?
t(7;21)(p22;q22) RUNX1/USP42
t(7;21)(p15;q22) RUNX1/?
t(8;21)(q22;q22) RUNX1/RUNX1T1
t(8;21)(q22;q22) RUNX1/RUNX1T1 in treatment related leukemia
t(8;21)(q23;q22) RUNX1/ZFPM2
t(8;21)(q24;q22) RUNX1/TRPS1
t(9;21)(p22;q22)
t(9;21)(q34;q22) RUNX1 truncated
t(X;21)(p22;q22) RUNX1/RPL22
t(X;21)(p11;q22) RUNX1/?
t(X;21)(q26;q22) ELF4/ERG
t(11;21)(q13;q22) RUNX1/MACROD1
t(11;21)(q21;q22) RUNX1/LPXN
t(12;21)(p13;q22) ETV6/RUNX1
t(12;21)(q12;q22) RUNX1 truncated
t(12;21)(q24;q22) RUNX1/?
t(14;21)(q11;q22) TRA/OLIG2
t(14;21)(q22;q22) RUNX1/?
t(15;21)(q22;q22) RUNX1/?
t(16;21)(p11;q22) FUS/ERG
t(16;21)(q24;q22) RUNX1/CBFA2T3
t(17;21)(q11.2;q22) RUNX1/?
t(18;21)(q21;q22) RUNX1/?
t(19;21)(q13.4;q22) RUNX1 truncated
t(20;21)(q11;q22) RUNX1/?
t(20;21)(q13;q22) RUNX1/?
t(20;21)(q13.2;q22.12) ZFP64/RUNX1

Solid Tumors     

t(1;21)(q32;q22) SLC45A3/ERG
t(3;21)(q27;q22) TMPRSS2/ETV5
t(7;21)(p21;q22) TMPRSS2/ETV1
t(8;21)(q24;q22) NDRG1/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(q13;q22) HERPUD1/ERG
t(17;21)(q21;q22) TMPRSS2/ETV4
t(21;21)(q22;q22) TMPRSS2/ERG
t(21;22)(q21;q12) EWSR1/ERG
t(21;22)(q21;q12) EWSR1/ERG

Cancer prone diseases     

Familial platelet disorder with predisposition to acute myelogenous leukemia

All Genes by Location (Kb)

Chromosome 21 by location

Losses / Amplicons     

BONE/SOFT TISSUE



External links     

  • Chromosome 21 - HUGO Chromosomes
  • Chromosome 21 - GoldenPath - Santa Cruz
  • Chromosome 21 - Ensembl Project
  • Chromosome 21 - Map View - NCBI
  • Chromosome 21 - OMIM Gene map
  • Chromosome 21 - Genomic Variants
  • Chromosome 21 - HAPMAP Project
  • Chromosome 21 - Genome Channel - ORNL
  • Chromosome 21 - LaunchPad HGMIS
  • Chromosome 21 - Human Protein Atlas
  • Chromosome 21 - Array BAC clone - Roswell Park Cancer Institute
  • Chromosome 21 - Human BAC Resource (NCBI)
  • Chromosome 21 FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Mouse homology - OMIM - NCBI
  • Chromosome 21 Cancer GeneWeb
  • Human Proteomics Initiative (UniProt)
  • Cytogenetic marker FISH (Abbott)
  • FISH Probes DAKO
  • SureFISH Probes
  • CytoCell
  • Kreatech Diagnostic/

  • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    ADAMTS1 28208.606 21q21.3
    CSTB 45193.546 21q22.3
    DYRK1A 38792.602 21q22.13
    ERG 39751.950 21q22.3
    ETS2 40177.231 21q22.3
    MIR125B2 17962.557 21q21.1
    NRIP1 16333.556 21q11.2
    OLIG2 34398.216 21q22.11
    PTTG1IP 46269.500 21q22.3
    RUNX1 36160.098 21q22.3
    S100B 48018.531 21q22.3
    TFF1 43782.391 21q22.3
    TFF2 43766.467 21q22.3
    TFF3 43731.777 21q22.3
    TIAM1 32490.736 21q22.1
    TMPRSS2 42836.478 21q22.3
    TMPRSS3 43791.996 21q22.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    ABCG1 43639.267 21q22.3
    ADAMTS5 28290.231 21q21.3
    ADARB1 46494.493 21q22.3
    AIRE 45705.721 21q22.3
    ANKRD30BP2 14415.105 21q11.2
    APP 27252.861 21q21.2
    ATP5J 27096.791 21q21.1
    ATP5O 35275.757 21q22
    B3GALT5 40984.867 21q22.3
    BACE2 42539.728 21q22.3
    BACH1 30671.220 21q22.1
    BAGE 11057.796 21p11.1
    BAGE2 11020.842 21p
    BAGE3 11020.842 21p11.2
    BAGE4 11020.842 21p11.1
    BAGE5 11020.842 13cen
    BRWD1 40668.363 21q22.2
    BTG3 18965.968 21q21.1
    C21orf33 45553.494 21q22.3
    CBR1 37442.222 21q22.1
    CBR3 37507.263 21q22.2
    CBR3-AS1 37504.065 21q22.12
    CBS 44473.301 21q22.3
    CHAF1B 37757.689 21q22.2
    CHODL 19618.192 21q11.2
    CHODL-AS1 19207.989 21q21.1
    CLDN14 37832.920 21q22.3
    CLDN17 31538.241 21q22.1
    CLDN8 31586.324 21q22.1
    COL18A1 46875.424 21q22.3
    COL6A1 47401.663 21q22.3
    CRYAA 44589.118 21q22.3
    CXADR 18885.224 21q21.1
    CYYR1 27838.528 21q21.2
    DNMT3L 45666.222 21q22.3
    FAM3B 42688.661 21q22.3
    GABPA 27107.258 21q21-q22.1
    GART 34876.238 21q22.11
    HMGN1 40714.241 21q22.3
    HSPA13 15743.437 21q11.1
    HUNK 33245.628 21q22.1
    ICOSLG 45642.878 21q22.3
    IFNAR1 34697.214 21q22.1
    IFNAR2 34602.200 21q22.1
    IFNGR2 34775.202 21q22.1
    IL10RB 34638.665 21q22.11
    ITGB2 46305.868 21q22.3
    ITSN1 35014.784 21q22.1-q22.2
    JAM2 27011.594 21q21.2
    KCNE1 35818.986 21q22.1-q22.2
    KCNE2 35736.323 21q22.12
    KCNJ6 38996.785 21q22.1
    LINC00328 10205.788 21p11.2
    LIPI 15481.135 21q11.2
    MCM3AP 47655.039 21q22.3
    MIR155 26946.292 21q21.3
    MIR155HG 26934.457 21q21.3
    MIR99A 17911.409 21q21.1
    MIRLET7C 17912.148 21q21.1
    MORC3 37692.487 21q22.13
    MX1 42792.485 21q22.3
    NCAM2 22370.633 21q21
    OLIG1 34442.450 21q22.11
    PCBP3 47269.875 21q22.3
    PCNT 47744.036 21q22.3
    PDE9A 44073.862 21q22.3
    PFKL 45719.917 21q22.3
    PIGP 38437.664 21q22.2
    PKNOX1 44394.620 21q22.3
    PRMT2 48055.507 21q22.3
    PSMG1 40547.372 21q22.3
    RCAN1 35888.740 21q22.1-q22.2
    RIPK4 43159.529 21q22.3
    RRP1B 45079.432 21q22.3
    SAMSN1 15857.549 21q11
    SIK1 44834.398 21q22.3
    SIM2 38071.991 21q22.2
    SLC19A1 46934.629 21q22.3
    SLC37A1 43919.742 21q22.3
    SLC5A3 35445.823 21q22.11
    SOD1 33031.935 21q22.11
    SON 34915.344 21q22.1-q22.2
    SUMO3 46225.532 21q22.3
    SYNJ1 34001.069 21q22.2
    TCP10L 33947.151 21p22.11
    TMPRSS15 19641.433 21q21
    TRAPPC10 45432.206 21q22.3
    TRPM2 45773.484 21q22.3
    U2AF1 44513.066 21q22.3
    UBE2G2 46188.495 21q22.3
    USP16 30396.938 21q22.11
    USP25 17102.344 21q11.2

    GeneCards  

    Contributor(s)

    WrittenJul 2004Philippe Dessen, Sakari Knuutila, Jean-Loup Huret
    UpdatedOct 2014Philippe Dessen, Jean-Loup Huret

    Citation

    This paper should be referenced as such :
    Dessen P, Knuutila S, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jul 2004 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    Dessen P, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Oct 2014 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Mon Oct 13 15:23:00 CEST 2014


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