Chromosome

Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Chromosome 21

Chromosome 21 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret

Chromosome 21 diagrams ISCN 2009 - Courtesy Nicole Chia

ENTITIES: by Chromosome band

21 21p 21q 21p13 21p12 21p11 21p10 21q10 21q11 21q21 21q22

Leukaemia     

21q22 rearrangements (RUNX1) in treatment related leukemia
dup(21q) amplified (RUNX1)
del(21)(q21q22) USP16/RUNX1
+21 or trisomy 21
t(1;21)(p36;q22) RUNX1/PRDM16
t(1;21)(p35;q22) RUNX1/YTHDF2
t(1;21)(p32;q22) RUNX1/?
t(1;21)(p22;q22) RUNX1/CLCA2
t(1;21)(q12;q22) RUNX1/?
t(1;21)(q21;q22) RUNX1/ZNF687
t(2;21)(p11;q22) RUNX1/?
t(2;21)(q11;q22)
t(3;21)(p12;q22) RUNX1/?
t(3;21)(q26;q22) RUNX1/MECOM
t(3;21)(q26;q22) RUNX1/MECOM in treatment related leukemia
t(4;21)(q31;q22) RUNX1/?
t(4;21)(q31;q22) RUNX1/SH3D19
t(4;21)(q35;q22) RUNX1/?
t(5;21)(q13;q22) RUNX1/?
t(6;21)(p22;q22) RUNX1-?
t(7;21)(p22;q22) RUNX1/USP42
t(7;21)(p15;q22) RUNX1/?
t(8;21)(q22;q22) RUNX1/RUNX1T1
t(8;21)(q22;q22) RUNX1/RUNX1T1 in treatment related leukemia
t(8;21)(q23;q22) RUNX1/ZFPM2
t(8;21)(q24;q22) RUNX1/TRPS1
t(9;21)(p22;q22)
t(9;21)(q34;q22) RUNX1 truncated
t(X;21)(p22;q22) RUNX1/RPL22
t(X;21)(p11;q22) RUNX1/?
t(X;21)(q26;q22) ELF4/ERG
t(11;21)(p14;q22) RUNX1/KIAA1549L
t(11;21)(q13;q22) RUNX1/MACROD1
t(11;21)(q21;q22) RUNX1/LPXN
t(12;21)(p13;q22) ETV6/RUNX1
t(12;21)(q12;q22) RUNX1 truncated
t(12;21)(q24;q22) RUNX1/?
t(14;21)(q11;q22) TRA/OLIG2
t(14;21)(q22;q22) RUNX1/?
t(15;21)(q22;q22) RUNX1/?
t(16;21)(p11;q22) FUS/ERG
t(16;21)(q24;q22) RUNX1/CBFA2T3
t(17;21)(q11.2;q22) RUNX1/?
t(18;21)(q21;q22) RUNX1/?
t(19;21)(q13.4;q22) RUNX1 truncated
t(20;21)(q11;q22) RUNX1/?
t(20;21)(q13;q22) RUNX1/?
t(20;21)(q13.2;q22.12) ZFP64/RUNX1

Solid Tumors     

t(1;21)(p35;q22) ITSN1/MATN1
t(1;21)(q32;q22) SLC45A3/ERG
t(3;21)(p11;q21) POU1F1/TMPRSS15
t(3;21)(q27;q22) TMPRSS2/ETV5
t(7;21)(p21;q22) TMPRSS2/ETV1
t(8;21)(q11;q21) UBE2V2/NRIP1
t(8;21)(q24;q22) NDRG1/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(p11;q22) FUS/ERG
t(16;21)(q13;q22) HERPUD1/ERG
t(17;21)(q21;q22) TMPRSS2/ETV4
t(17;21)(q24;q22) BRWD1/CCDC46
t(19;21)(p13;q22) ITSN1/ZNF490
t(21;21)(q22;q22) TMPRSS2/ERG
t(21;22)(q21;q12) EWSR1/ERG
t(21;22)(q21;q12) EWSR1/ERG

Cancer prone diseases     

Familial platelet disorder with predisposition to acute myelogenous leukemia

All Genes by Location (Kb)

Chromosome 21 by location

Losses / Amplicons     

BONE/SOFT TISSUE



External links     

  • Chromosome 21 - HUGO Chromosomes
  • Chromosome 21 - GoldenPath - Santa Cruz
  • Chromosome 21 - Ensembl Project
  • Chromosome 21 - Map View - NCBI
  • Chromosome 21 - Genome Home Reference
  • Chromosome 21 - OMIM Gene map
  • Chromosome 21 - Genomic Variants
  • Chromosome 21 - HAPMAP Project
  • Chromosome 21 - Genome Channel - ORNL
  • Chromosome 21 - LaunchPad HGMIS
  • Chromosome 21 - Human Protein Atlas
  • Chromosome 21 - Array BAC clone - Roswell Park Cancer Institute
  • Chromosome 21 - Human BAC Resource (NCBI)
  • Chromosome 21 FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Mouse homology - OMIM - NCBI
  • Chromosome 21 Cancer GeneWeb
  • Human Proteomics Initiative (UniProt)
  • Cytogenetic marker FISH (Abbott)
  • FISH Probes DAKO
  • SureFISH Probes
  • CytoCell
  • Kreatech Diagnostic/

  • Genes

    Annotated genes
    Symbol(↓)Location hg19 (Kb)(↓)    Band(↓)
    ADAMTS1 28208.606     21q21.2
    CSTB 45193.546     21q22.3
    DYRK1A 38792.602     21q22.13
    ERG 39751.950     21q22.3
    ETS2 40177.231     21q22.2
    MIR125B2 17962.557     21q21.1
    NRIP1 16333.556     21q11.2
    OLIG2 34398.216     21q22.11
    PTTG1IP 46269.500     21q22.3
    RUNX1 36160.098     21q22.3
    S100B 48018.531     21q22.3
    TFF1 43782.391     21q22.3
    TFF2 43766.467     21q22.3
    TFF3 43731.777     21q22.3
    TIAM1 32490.736     21q22.11
    TMPRSS2 42836.478     21q22.3
    TMPRSS3 43791.996     21q22.3

    Other genes
    Symbol(↓)Location hg19 (Kb)(↓)    Band(↓)
    AATBC 45225.641     21q22.3
    ABCC13 15646.120     21q11.2
    ABCG1 43639.267     21q22.3
    ADAMTS5 28290.231     21q21.3
    ADARB1 46494.493     21q22.3
    AGPAT3 45345.279     21q22.3
    AIRE 45705.721     21q22.3
    ANKRD20A11P 15316.096     21q11.2
    ANKRD30BP2 14415.105     21q11.2
    APP 27252.861     21q21.3
    ATP5J 27096.791     21q21.1
    ATP5O 35275.757     21q22.11
    B3GALT5 40984.867     21q22.3
    B3GALT5-AS1 40969.075     21q22.2
    BACE2 42539.728     21q22.3
    BACH1 30671.116     21q22.11
    BACH1-IT2 30744.821     21q21.3
    BAGE 11057.796     21p11.1 not on reference assembly
    BAGE2 11020.842     21p
    BAGE3 11020.842     21p11.2
    BAGE4 11020.842     21p11.1
    BAGE5 11020.842     13cen
    BRWD1 40668.363     21q22.2
    BRWD1-AS1 40687.633     -
    BRWD1-IT2 40685.833     21q22.2
    BTG3 18965.968     21q21.1
    C21orf140 35772.410     -
    C21orf2 45748.827     21q22.3
    C21orf33 45553.494     21q22.3
    C21orf58 47720.344     21q22.3
    C21orf59 33973.984     21q22.1
    C21orf62 34162.984     21q22.11
    C21orf62-AS1 34144.411     21q22.11
    C21orf91 19161.284     21q21.1
    C21orf91-OT1 19149.721     21q21.1
    C2CD2 43305.219     21q22.3
    CBR1 37442.222     21q22.13
    CBR3 37507.263     21q22.2
    CBR3-AS1 37504.065     -
    CBS 44473.301     21q22.3
    CCT8 30428.643     21q22.11
    CHAF1B 37757.689     21q22.13
    CHODL 19618.192     21q11.2
    CHODL-AS1 19207.989     21q21.1
    CLDN14 37832.920     21q22.3
    CLDN17 31538.241     21q22.11
    CLDN8 31586.324     21q22.11
    CLIC6 36041.688     21q22.12
    COL18A1 46875.424     21q22.3
    COL18A1-AS1 46839.631     21q22.3
    COL18A1-AS2 46827.301     -
    COL6A1 47401.663     21q22.3
    COL6A2 47518.033     21q22.3
    CRYAA 44589.118     21q22.3
    CRYZL1 34961.648     21q21.3
    CXADR 18885.224     21q21.1
    CYP4F29P 15215.454     21q11
    CYYR1 27838.528     21q21.2
    CYYR1-AS1 27778.262     -
    D21S2088E 24733.426     -
    D21S2090E 31462.035     -
    DIP2A 47878.862     21q22.3
    DIP2A-IT1 47882.384     21q22.3
    DNAJC28 34860.362     21q22.11
    DNMT3L 45666.222     21q22.3
    DONSON 34949.859     21q22.1
    DOPEY2 37536.839     21q22.2
    DSCAM 41384.343     21q22.2
    DSCAM-AS1 41755.010     -
    DSCAM-IT1 41990.433     -
    DSCR10 39578.250     21q22.13
    DSCR3 38595.726     21q22.2
    DSCR4 39426.313     21q22.2
    DSCR9 38592.627     21q22.13
    ERVH48-1 44337.361     21q22.3
    EVA1C 33784.745     21q22.11
    FAM207A 46359.955     21q22.3
    FAM3B 42688.661     21q22.3
    FLJ42200 25801.054     21q21.2
    FTCD 47556.176     21q22.3
    GABPA 27107.258     21q21.3
    GART 34876.238     21q22.11
    GRIK1 30925.866     21q22.11
    GRIK1-AS1 31120.494     21q22.11
    GRIK1-AS2 30968.360     21q22.11
    H2BFS 44985.070     21q22.3
    HLCS 38123.189     21q22.13
    HMGN1 40714.241     21q22.2
    HSF2BP 44949.072     21q22.3
    HSPA13 15743.437     21q11
    HUNK 33245.628     21q22.1
    ICOSLG 45642.878     21q22.3
    IFNAR1 34697.214     21q22.11
    IFNAR2 34602.200     21q22.11
    IFNGR2 34775.202     21q22.11
    IGHV1OR21-1 10862.837     21p11.2
    IGSF5 41117.334     21q22.2
    IL10RB 34638.665     21q22.11
    IL10RB-AS1 34637.937     21q22.11
    ITGB2 46305.869     21q22.3
    ITGB2-AS1 46340.950     -
    ITSN1 35014.784     21q22.1-q22.2
    JAM2 27011.594     21q21.2
    KCNE1 35818.986     21q22.12
    KCNE2 35736.323     21q22.12
    KCNJ15 39628.620     21q22.2
    KCNJ6 38996.525     21q22.1
    KRTAP10-10 46057.273     21q22.3
    KRTAP10-11 46066.331     21q22.3
    KRTAP10-1 45959.068     21q22.3
    KRTAP10-12 46117.087     21q22.3
    KRTAP10-2 45970.240     21q22.3
    KRTAP10-3 45977.906     21q22.3
    KRTAP10-4 45993.606     21q22.3
    KRTAP10-5 45999.332     21q22.3
    KRTAP10-6 46011.149     21q22.3
    KRTAP10-7 46020.497     21q22.3
    KRTAP10-8 46031.996     21q22.3
    KRTAP10-9 46047.040     21q22.3
    KRTAP11-1 32252.964     21q22.1
    KRTAP12-1 46101.491     21q22.3
    KRTAP12-2 46086.106     21q22.3
    KRTAP12-3 46077.849     21q22.3
    KRTAP12-4 46074.130     21q22.3
    KRTAP13-1 31768.392     21q22.1
    KRTAP13-2 31743.709     21q22.1
    KRTAP13-3 31797.711     21q22.1
    KRTAP13-4 31802.594     21q22.1
    KRTAP15-1 31812.646     21q22.1
    KRTAP19-1 31852.364     21q22.1
    KRTAP19-2 31859.509     21q22.1
    KRTAP19-3 31863.782     21q22.1
    KRTAP19-4 31869.174     21q22.1
    KRTAP19-5 31874.190     21q22.1
    KRTAP19-6 31913.854     21q22.1
    KRTAP19-7 31933.417     21q22.1
    KRTAP19-8 32410.478     21q22.11
    KRTAP20-1 31988.774     21q22.1
    KRTAP20-2 32007.583     21q22.1
    KRTAP20-3 32015.183     21q22.11
    KRTAP20-4 31992.946     21q22.11
    KRTAP21-1 32127.457     21q22.1
    KRTAP21-2 32119.269     21q22.1
    KRTAP21-3 32090.843     21q22.11
    KRTAP22-1 31973.440     21q22.1
    KRTAP22-2 31962.424     21q22.11
    KRTAP23-1 31720.717     21q22.1
    KRTAP24-1 31653.627     21q22.11
    KRTAP25-1 31661.463     21q22.11
    KRTAP26-1 31691.450     21q22.11
    KRTAP27-1 31709.331     21q22.11
    KRTAP6-1 31986.005     21q22.1
    KRTAP6-2 31971.005     21q22.1
    KRTAP6-3 31964.759     21q22.1
    KRTAP7-1 32201.358     21q22.11
    KRTAP8-1 32185.015     21q22.1
    LCA5L 40777.770     21q22.2
    LINC00111 43099.462     21q22.3
    LINC00112 43136.596     21q22.3
    LINC00113 29094.698     21q21.3
    LINC00114 40110.949     21q22.2
    LINC00159 33452.794     21q22.11
    LINC00160 36096.105     21q22.12
    LINC00161 29911.640     21q21.3
    LINC00162 46419.122     21q22.3
    LINC00163 46409.779     21q22.3
    LINC00165 46414.279     21q22.3
    LINC00189 30565.801     21q22.11
    LINC00205 46713.966     21q22.3
    LINC00307 31581.469     21q22.11
    LINC00308 23470.936     21q21.1
    LINC00310 35552.978     21q22.11
    LINC00313 44881.974     21q22.3
    LINC00314 29385.701     21q21.3
    LINC00315 46720.160     21q22.3
    LINC00316 46758.505     21q22.3
    LINC00317 23095.613     21q21.1
    LINC00319 44866.481     21q22.3
    LINC00320 22114.908     21q21.1
    LINC00322 44742.089     21q22.3
    LINC00323 42513.427     21q22.2
    LINC00328 10205.788     -
    LINC00334 46654.267     21q22.3
    LINC00479 43131.680     21q22.3
    LINC00515 26955.087     21q21.3
    LINC00527 40394.926     21q22.2
    LINC00649 35347.538     -
    LINC00649 35347.538     -
    LINC00945 34430.135     21q22.11
    LINC01423 39698.281     21q22
    LINC01424 46222.156     -
    LINC01425 23119.305     -
    LINC01426 36118.122     -
    LINC01436 37377.618     21q22.12
    LINC01547 46354.641     21q22.3
    LINC01548 34537.776     21q22.11
    LIPI 15481.135     21q11.2
    LOC100128198 33652.836     21q22.11
    LOC100129027 47247.755     21q22.3
    LOC100129311 44001.352     21q22.3
    LOC100130597 46953.347     21q22.3
    LOC100131190 42733.957     21q22.3
    LOC100133286 37441.940     21q22.12
    LOC100288590 39576.235     21q22.13
    LOC100288884 10600.301     21p11.2
    LOC100505727 45905.454     -
    LOC100506403 36744.805     -
    LOC101927797 19933.583     -
    LOC101927843 23381.477     -
    LOC101927869 25676.863     -
    LOC101927973 29488.413     21q21.3
    LOC101928107 34484.010     -
    LOC101928182 35794.433     -
    LOC101928233 44019.514     -
    LOC101928255 44068.404     -
    LOC101928269 37326.977     21q22.12
    LOC101928284 44153.704     -
    LOC101928398 40229.463     -
    LOC101928435 40346.355     -
    LOC101928796 47392.884     -
    LOC102724188 14918.354     21q11.2
    LOC102724449 33025.906     -
    LOC105369306 37477.179     -
    LOC105372751 25801.095     -
    LOC105372761 28733.483     -
    LOC105372762 28731.204     -
    LOC105372779 33678.775     -
    LOC105372795 38435.341     -
    LOC105372840 47013.568     -
    LOC105377134 15399.759     -
    LOC105379426 9706.635     -
    LOC150005 19301.408     21q21.1
    LOC150051 32931.558     21q22.11
    LOC284825 29420.733     21q21.3
    LOC339622 26212.864     21q21.1-q21.2
    LOC388813 15963.713     21q11.2
    LOC388820 35791.013     21q22.11
    LOC400867 40249.215     21q22.2
    LOC400870 44783.212     21q22.3
    LOC642852 46707.967     21q22.3
    LRRC3 45875.369     21q22.3
    LRRC3-AS1 45870.869     21q22.3
    LRRC3DN 45879.814     21q22.3
    LSS 47608.360     21q22.3
    LTN1 30300.466     21q22.11
    MAP3K7CL 30449.792     21q22.3
    MCM3AP 47655.039     21q22.3
    MCM3AP-AS1 47649.145     21q22.3
    MIR155 26946.292     21q21.3
    MIR155HG 26934.457     -
    MIR3118-1 15017.096     -
    MIR3156-3 14778.705     -
    MIR3197 42539.484     -
    MIR3648-1 9825.832     -
    MIR3648-2 9825.832     -
    MIR3687-1 9826.203     -
    MIR3687-2 9826.203     -
    MIR4327 31747.612     -
    MIR4759 28326.280     -
    MIR4760 41584.279     -
    MIR5009 28659.822     -
    MIR6070 45029.768     -
    MIR6501 34922.968     -
    MIR6508 40818.936     -
    MIR6814 43166.932     -
    MIR6815 46898.180     -
    MIR802 37093.013     21q22.12
    MIR8069-1 15096.510     -
    MIR8069-2 15096.510     -
    MIR99A 17911.409     21q21.1
    MIR99AHG 17443.553     21q21.1
    MIRLET7C 17912.148     21q21.1
    MIS18A 33640.530     21q22.11
    MORC3 37692.487     21q22.13
    MRAP 33664.124     21q22.1
    MRPL39 26957.968     21q21.3
    MRPS6 35445.823     21q22.11
    MX1 42792.485     21q22.3
    MX2 42733.950     21q22.3
    N6AMT1 30248.386     21q21.3
    NCAM2 22370.633     21q21.1
    NDUFV3 44313.378     21q22.3
    OLIG1 34442.450     21q22.11
    PAXBP1 34113.650     21q21.3
    PAXBP1-AS1 34100.425     -
    PCBP3 47269.875     21q22.3
    PCBP3-OT1 47334.210     21q22.3
    PCNT 47744.036     21q22.3
    PCP4 41239.347     21q22.2
    PDE9A 44073.862     21q22.3
    PDXK 45138.978     21q22.3
    PFKL 45719.917     21q22.3
    PIGP 38437.664     21q22.2
    PKNOX1 44394.620     21q22.3
    PLAC4 42547.158     21q22.2
    POFUT2 46683.843     21q22.3
    POTED 14982.498     21q11.2
    PPP1R2P2 37259.369     21q22.13
    PRDM15 43218.385     21q22.3
    PRMT2 48055.507     21q22.3
    PSMG1 40547.372     21q22.3
    PWP2 45527.208     21q22.3
    RBM11 15588.466     21q11
    RCAN1 35888.740     21q22.12
    RIPK4 43159.529     21q22.3
    RIPPLY3 38378.863     21q22.2
    RNU6-67P 22657.822     -
    RRP1 45209.418     21q22.3
    RRP1B 45079.432     21q22.3
    RSPH1 43892.597     21q22.3
    RUNX1-IT1 36410.233     21q22.12
    RWDD2B 30378.080     21q22.11
    SAMSN1 15857.549     21q11
    SAMSN1-AS1 15954.523     -
    SCAF4 33043.313     21q22.1
    SETD4 37415.982     21q22.13
    SH3BGR 40817.797     21q22.3
    SIK1 44834.398     21q22.3
    SIM2 38071.433     21q22.13
    SLC19A1 46934.629     21q22.3
    SLC37A1 43919.742     21q22.3
    SLC5A3 35445.823     21q22.12
    SMIM11 35747.749     21q22.12
    SNORA80A 33749.496     21q22.11
    SOD1 33031.935     21q22.11
    SON 34915.344     21q22.11
    SPATC1L 47581.062     21q22.3
    SSR4P1 46490.871     21q22.3
    SUMO3 46225.532     21q22.3
    SYNJ1 34001.069     21q22.2
    TCONS_00029157 44777.935     -
    TCP10L 33947.151     21q22.11
    TMEM50B 34821.448     21q22.11
    TMPRSS15 19641.433     21q21.1
    TPTE 10906.187     21p11
    TRAPPC10 45432.206     21q22.3
    TRPM2 45773.484     21q22.3
    TRPM2-AS 45834.475     -
    TSPEAR 45917.775     21q22.3
    TSPEAR-AS1 45925.927     21q22.3
    TSPEAR-AS2 45937.098     21q22.3
    TTC3 38445.571     21q22.2
    TTC3-AS1 38559.913     -
    U2AF1 44513.066     21q22.3
    UBASH3A 43823.971     21q22.3
    UBE2G2 46188.495     21q22.3
    UMODL1 43491.426     21q22.3
    UMODL1-AS1 43522.244     21q22.3
    URB1 33683.330     21q22.11
    USP16 30396.938     21q22.11
    USP25 17102.344     21q11.2
    WDR4 44269.336     21q22.3
    WRB 40759.692     21q22.3
    YBEY 47706.267     21q22.3
    ZBTB21 43406.940     21q22.3
    ZNF295-AS1 43442.192     21q22.3

    Contributor(s)

    WrittenJul 2004Philippe Dessen, Sakari Knuutila, Jean-Loup Huret
    UpdatedJun 2015Philippe Dessen, Jean-Loup Huret

    Citation

    This paper should be referenced as such :
    Dessen P, Knuutila S, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jul 2004 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    Dessen P, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jun 2015 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_21.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Sat Jun 27 15:52:14 CEST 2015


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