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Chromosome 4

Chromosome 4 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret
Chromosome 4 diagrams ISCN 2009 - Courtesy Nicole Chia

Leukaemia     

del(4)(q12q12) FIP1L1/PDGFRA
+4 or trisomy 4
ins(9;4)(q33;q12q25) CDK5RAP2/PDGFRA
t(2;4)(p23;q25-q35)
t(2;4)(p22;q12) STRN/PDGFRA
t(3;4)(p21;q34)
t(3;4)(q27;p13) RHOH/BCL6
t(4;5)(q21;q33) PRKG2/PDGFRB
t(4;5)(q31;q31)
t(4;10)(q12;p11) KIF5B/PDGFRA
t(4;11)(p12;q23) KMT2A/FRYL
t(4;11)(q21;p15) NUP98/RAP1GDS1
t(4;11)(q21;q23) KMT2A/AFF1
t(4;11)(q35;q23) KMT2A/SORBS2
t(4;12)(p16;p13) ETV6/FGFR3
t(4;12)(q12;p13) CHIC2/ETV6
t(4;12)(q12;p13) PDGFRA/ETV6
t(4;14)(p16;q32) IGH/FGFR3 and WHSC1
t(4;16)(q26;p13) IL2/TNFRSF17
t(4;17)(q12;q21) FIP1L1/RARA
t(4;21)(q31;q22) RUNX1/?
t(4;21)(q31;q22) RUNX1/SH3D19
t(4;21)(q35;q22) RUNX1/?
t(4;22)(q12;q11.2) BCR/PDGFRA

Solid Tumors     

t(2;4)(p23;q21) SEC31A/ALK
t(2;4)(p23;q21) SEC31A/ALK
t(4;19)(q35;q13) CIC/DUX4
t(4;19)(q35;q13) CIC-DUX4
t(4;22)(q35;q12) EWSR1/DUX4
t(4;22)(q35;q12) EWSR1/DUX4
t(4;22)(q35;q12) EWSR1/DUX4
t(4;22)(q35;q12) EWSR1/DUX4

Cancer prone diseases     

Familial /sporadic gastrointestinal stromal tumors (GISTs)
Piebaldism

All Genes by Location (Kb)

Chromosome 4 by location

Losses / Amplicons     

BONE/SOFT TISSUE



External links     

  • Chromosome 4 - HUGO Chromosomes
  • Chromosome 4 - GoldenPath - Santa Cruz
  • Chromosome 4 - Ensembl Project
  • Chromosome 4 - Map View - NCBI
  • Chromosome 4 - OMIM Gene map
  • Chromosome 4 - Genomic Variants
  • Chromosome 4 - HAPMAP Project
  • Chromosome 4 - Genome Channel - ORNL
  • Chromosome 4 - LaunchPad HGMIS
  • Chromosome 4 - Human Protein Atlas
  • Chromosome 4 - Array BAC clone - Roswell Park Cancer Institute
  • Chromosome 4 - Human BAC Resource (NCBI)
  • Chromosome 4 FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Mouse homology - OMIM - NCBI
  • Chromosome 4 Cancer GeneWeb
  • Human Proteomics Initiative (UniProt)
  • Cytogenetic marker FISH (Abbott)
  • FISH Probes DAKO
  • SureFISH Probes
  • CytoCell
  • Kreatech Diagnostic/

  • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    AFF1 87856.154 4q21.3
    AFP 74301.936 4q13.3
    AMBN 71457.975 4q21
    AREG 75310.815 4q13.3
    CD38 15779.931 4p15.32
    CHIC2 54875.958 4q11
    CXCL10 76942.269 4q21
    CXCL5 74861.359 4q13.3
    EIF4E 99799.607 4q21-q25
    FAT1 187508.937 4q35.2
    FGF2 123747.863 4q26
    FGFR3 1795.039 4p16.3
    FRYL 48499.380 4p12
    HNRNPD 83274.467 4q21
    HTRA3 8271.489 4p16.1
    ING2 184427.235 4q35.1
    KIT 55524.095 4q11-q12
    MAD2L1 120980.579 4q27
    MAPK10 86936.276 4q22-q23
    MED28 17616.273 4p16
    NFKB1 103422.486 4q24
    NPY1R 164245.117 4q31.3-q32
    NR3C2 148999.915 4q31.1
    NUDT6 123813.799 4q26
    PF4 74846.542 4q12-q21
    PHOX2B 41746.099 4p13
    PTPN13 87515.468 4q21.3
    RAP1GDS1 99182.527 4q23-q25
    RASL11B 53728.495 4q12
    RASSF6 74437.267 4q21.1
    RCHY1 76404.247 4q21.1-q21.3
    REST 57775.079 4q12
    RHOH 40198.527 4p13
    S100P 6695.566 4p16
    SFRP2 154701.742 4q31.3
    SLIT2 20255.187 4p15.2
    SORBS2 186506.598 4q35.1
    SPP1 88896.802 4q22.1
    SPRY1 124317.950 4q
    SYNPO2 119809.996 4q26
    TACC3 1723.217 4p16.3
    WHSC1 1873.123 4p16.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    AASDH 57204.451 4q12
    ABCE1 146019.156 4q31
    ABCG2 89011.416 4q22.1
    ACOX3 8368.009 4p15.3
    ACSL1 185676.749 4q35
    ADAM29 175839.509 4q34.1
    ADAMTS3 73146.686 4q21
    ADD1 2845.584 4p16.3
    ADH1A 100197.523 4q23
    ADH1B 100227.544 4q23
    ADH1C 100257.649 4q23
    ADH4 100044.833 4q22
    ADH5 99992.130 4q23
    ADH6 100125.879 4q23
    ADH7 100333.418 4q23-q24
    ADRA2C 3768.296 4p16.3
    AFAP1 7760.440 4p16
    AFM 74347.462 4q13.3
    AGA 178351.929 4q34.3
    AGPAT9 84457.260 4q21.23
    AIMP1 107236.767 4q24
    ALB 74269.972 4q13.3
    ANK2 113739.239 4q25-q26
    ANKRD17 73940.502 4q21.1-q21.21
    ANP32C 165118.159 4q32.3
    ANTXR2 80898.662 4q21.3
    ANXA10 169013.688 4q32.3
    ANXA3 79472.742 4q21.21
    ANXA5 122589.152 4q27
    ARFIP1 153701.089 4q31.3
    ARHGAP10 148653.453 4
    ARHGAP24 86396.284 4q22.1
    ARHGEF38 106473.777 4q24
    ATOH1 94750.078 4q22
    ATP10D 47487.410 4p12
    ATP5I 666.225 4p16.3
    ATP8A1 42410.392 4p13
    BDH2 103998.782 4q24
    BLOC1S4 6717.842 4p16.1
    BMP3 81952.119 4q21
    BMPR1B 95679.128 4q23-q24
    BST1 15704.573 4p15
    BTC 75671.448 4q13.3
    C1QTNF7 15341.560 4p15.3
    C4orf17 100432.161 4q23
    C4orf22 81256.874 4q21.21
    C4orf36 87797.358 4q21.3
    CAMK2D 114372.188 4q26
    CASP3 185548.850 4q34
    CASP6 110609.785 4q25
    CCDC110 186366.338 4q35.1
    CCKAR 26483.018 4
    CCNA2 122737.599 4q27
    CCNG2 78078.357 4q21.22
    CCNI 77969.177 4q21.1
    CCRN4L 139936.913 4q31.1
    CCSER1 91048.684 4q22.1
    CDKL2 76501.704 4q21.21
    CDKN2AIP 184365.789 4q35.1
    CDS1 85504.057 4q21
    CENPE 104026.963 4q24-q25
    CENPU 185615.219 4q35.1
    CFI 110661.848 4q25
    CHRNA9 40337.346 4p14
    CISD2 103790.135 4q24
    CLCN3 170541.672 4q33
    CLOCK 56294.068 4q12
    COL25A1 109745.038 4q25
    COPS4 83956.239 4q21.22
    COQ2 84184.977 4q21.23
    COX18 73920.413 4q13.3
    COX7B2 46736.847 4p12
    CPE 166300.097 4q32.3
    CRMP1 5822.491 4p16.1
    CSN3 71108.333 4q21.1
    CTBP1 1205.228 4p16
    CXCL11 76954.840 4q21
    CXCL13 78432.907 4q21
    CXCL1 74735.109 4q13.3
    CXCL2 74962.754 4q13.3
    CXCL3 74902.312 4q21
    CXCL6 74702.273 4q13.3
    CXCL8 74606.223 4q13-q21
    CXCL9 76922.623 4q21
    CXXC4 105389.463 4q22-q24
    CYTL1 5016.314 4p16-p15
    DCK 71859.265 4q13.3-q21.1
    DCLK2 150999.426 4q31.3
    DCTD 183811.244 4q35.1
    DGKQ 952.672 4p16.3
    DKK2 107842.959 4q25
    DMP1 88571.454 4q21
    DNAJB14 100817.407 4q23
    DOK7 3465.033 4p16.2
    DSPP 88529.681 4q21.3
    EDNRA 148402.069 4q31.22
    EGF 110834.040 4q25
    ELF2 139978.871 4q28
    ELOVL6 110970.229 4q25
    EMCN 101316.498 4q22.1
    ENOPH1 83351.633 4q21.3
    ENPEP 111397.229 4q25
    ENPP6 185009.859 4q35.1
    EPGN 75174.187 4q13.3
    EPHA5 66185.281 4q13.1
    EREG 75230.860 4q21.21
    EXOC1 56719.816 4q12
    F11 187187.118 4q35
    FABP2 120238.405 4q28-q31
    FAM13A-AS1 89630.940 4q22.1
    FAM149A 187070.327 4q35.1
    FAM175A 84382.094 4q21.23
    FAM198B 159045.732 4q32.1
    FAT4 126237.567 4q28.1
    FBXO8 175157.810 4q34.1
    FBXW7 153242.410 4q31.3
    FDCSP 71091.788 4q13
    FGA 155504.280 4q28
    FGB 155484.132 4q28
    FGF5 81189.419 4q21
    FGFBP1 15937.193 4p15.32
    FGFRL1 1005.610 4p16
    FGG 155525.286 4q28
    FHDC1 153864.135 4q31.3
    FIP1L1 54243.820 4q12
    FRG1 190861.974 4q35
    G3BP2 76567.953 4q21.1
    GAB1 144257.983 4q31.1
    GAK 843.066 4p16
    GALNT7 174089.904 4q31.1
    GC 72607.411 4q12-q13
    GNRHR 68603.099 4q21.2
    GRIA2 158141.736 4q32.1
    GRID2 93225.550 4q22
    GRK4 2965.343 4p16.3
    GSTCD 106631.970 4q24
    GSX2 54966.248 4q12
    GUCY1A3 156587.862 4q31.3-q33
    GYPA 145030.456 4q31.21
    H2AFZ 100869.244 4q23
    HAND2-AS1 174451.609 4q34.1
    HELQ 84328.499 4q21.23
    HELT 185940.083 4q35.1
    HERC3 89513.574 4q21
    HERC5 89378.268 4q22.1-q23
    HERC6 89299.891 4q22
    HGFAC 3443.726 4p16
    HHIP 145567.148 4q31.21-q31.3
    HMGB2 174252.527 4q31
    HOPX 57514.154 4q12
    HPGD 175411.328 4q34-q35
    HPGDS 95219.707 4q22.2
    HPSE 84213.614 4q21.3
    HS3ST1 11399.988 4p16
    HSD17B11 88257.677 4q22.1
    HSP90AB2P 13335.038 4p15.33
    HSPA4L 128703.453 4q28
    HTN3 70894.130 4q13
    HTT 3076.237 4p16.3
    IBSP 88720.702 4q21.1
    IGFBP7 57898.404 4q12
    IL15 142557.749 4q31
    IL21 123533.783 4q26-q27
    IL2 123372.626 4q26-q27
    INPP4B 142949.182 4q31.1
    INTS12 106603.785 4q24
    IRF2 185308.876 4q34.1-q35.1
    JADE1 129730.778 4q26-q27
    KCNIP4 20730.239 4p15.32
    KCTD8 44175.920 4p13
    KDR 55944.426 4q11-q12
    KIAA0922 154387.498 4q31.3
    KLB 39408.473 4p14
    KLF3 38665.790 4p16.1-p15.2
    KLHL2 166131.171 4q21.2
    KLHL8 88081.256 4q21.3
    KLKB1 187148.672 4q35
    LAMTOR3 100799.495 4q24-q26
    LARP7 113558.120 4q25
    LEF1 108968.701 4q23-q25
    LETM1 1813.206 4p16.3
    LNX1 54326.437 4q12
    LOC344967 40044.537 4p14
    LPHN3 62362.839 4q13.1
    LRAT 155665.163 4q32.1
    LRBA 151185.811 4q13
    LRP2BP 186285.032 4q35.1
    LRPAP1 3505.324 4p16.3
    MAB21L2 151503.077 4q31
    MAEA 1283.672 4p16.3
    MANBA 103552.643 4
    MEPE 88742.550 4q21.1
    METAP1 99916.788 4q23
    MFSD7 675.613 4p16.3
    MGST2 140586.922 4q28.3
    MIR218-1 20529.898 4p15.31
    MIR302A 113569.339 4q25
    MIR302B 113569.641 4q25
    MIR367 113569.030 4q25
    MIR573 24521.815 4p15.2
    MIR574 38869.653 4
    MIR577 115577.915 4q26
    MMAA 146540.540 4q31.1
    MORF4 174537.089 4q34.1
    MSX1 4861.392 4p16.2
    MTNR1A 187454.809 4q35
    MTTP 100485.240 4q24
    MUC7 71296.209 4q13.3
    MXD4 2249.160 4p16.3
    MYOZ2 120056.939 4q26-q27
    N4BP2 40058.524 4p14
    NAA11 80238.272 4q21.23
    NAA15 140222.676 4q31.1
    NAAA 76831.808 4q21.1
    NAF1 164047.860 4q32.2
    NAP1L5 89617.066 4q21-q22
    NAT8L 2061.239 4p16.3
    NDST3 118955.500 4q26
    NDST4 115748.927 4q26
    NEIL3 178230.991 4q34
    NEK1 170314.421 4q32.3
    NELFA 1984.441 4p16.3
    NKX6-1 85414.436 4q21.33
    NMU 56461.396 4q12
    NPNT 106816.597 4q25
    NPY2R 156129.781 4q31
    NPY5R 164265.091 4q31-q32
    NUP54 77035.812 4q21.1
    OCIAD1 48833.244 4p11
    OCIAD2 48887.397 4p12
    ODAM 71062.244 4q13.3
    OSTC 109571.741 4q25
    PALLD 169418.217 4q32.3
    PAPSS1 108534.822 4q24
    PAQR3 79839.094 4q21
    PARM1 75858.285 4q13.3-q21.3
    PCAT4 80748.625 4q21.21
    PCDH10 134070.470 4q28.3
    PCDH7 30722.037 4p15
    PCGF3 699.573 4p16.3
    PDE5A 120415.550 4q27
    PDGFC 157682.763 4q32
    PDGFRA 55095.264 4q12
    PDHA2 96761.239 4q22-q23
    PDLIM3 186421.815 4q35
    PDLIM5 95373.008 4q22
    PDS5A 39824.483 4p14
    PF4V1 74719.013 4q12-q21
    PGRMC2 129190.392 4q26
    PI4K2B 25235.653 4p15.31
    PITX2 111538.580 4q25
    PKD2 88928.799 4q22.1
    PLAC8 84015.307 4q21.22
    PLK4 128802.016 4q28
    POLN 2073.645 4p16.3
    POLR2B 57845.109 4q12
    POU4F2 147560.045 4q31.22
    PPARGC1A 23793.644 4p15.1
    PPBP 74852.156 4q12-q13
    PPEF2 76781.026 4q21.1
    PPID 159630.279 4q31.3
    PPM1K 89178.761 4q22.1
    PPP2R2C 6322.305 4p16.1
    PPP3CA 101944.587 4q24
    PRDM5 121615.929 4q25-q26
    PRKG2 82008.524 4q13.1-q21.1
    PROM1 15969.849 4p15
    PTTG2 37962.056 4p14
    RAB28 13369.347 4p15.33
    RAB33B 140374.961 4q28
    RAPGEF2 160188.998 4q32.1
    RASGEF1B 82348.219 4
    RBM47 40425.272 4p14
    RBPJ 26321.332 4p15.2
    RFC1 39289.069 4p14-p13
    RGS12 3315.874 4p16.3
    RNF150 141786.725 4q31.1
    RNF4 2471.180 4p16.3
    RPL34 109541.722 4q25
    RPS3A 152020.725 4q31.2-q31.3
    RXFP1 159442.866 4q31.3
    SAP30 174292.093 4q34.1
    SCARB2 77079.892 4q21.1
    SEC31A 83739.814 4q21.3
    SEPT11 77870.895 4q21.1
    SETD7 140427.192 4q31.1
    SGMS2 108814.420 4q25
    SH3BP2 2794.750 4p16.3
    SH3D19 152041.433 4q31.3
    SH3RF1 170015.407 4q32.3
    SLC25A31 128651.555 4q28
    SLC25A4 186064.417 4q35
    SLC26A1 981.445 4p16.3
    SLC30A9 41992.523 4p13
    SLC34A2 25657.435 4p15.2
    SLC4A4 72053.003 4q13.3
    SLC7A11 139085.248 4q28-q32
    SLC9B2 103946.652 4q24
    SMAD1 146403.957 4q31.21
    SMARCA5 144434.616 4q31.1-q31.2
    SMARCAD1 95128.996 4q22-q23
    SNCA 90645.250 4q21
    SNX25 186131.284 4q35.1
    SOD3 24797.085 4p15.2
    SPARCL1 88394.482 4q22-q25
    SPATA18 52917.593 4q11
    SPATA4 177105.725 4q34.2
    SPINK2 57676.026 4q12
    SPOCK3 167654.536 4q32.3
    SPON2 1160.721 4p16.3
    SRD5A3 56212.388 4q12
    STAP1 68424.446 4q13.2
    STIM2 26862.313 4p15.2
    STK32B 5053.527 4p16
    STOX2 184826.509 4q35.1
    STX18 4420.696 4
    SULT1E1 70706.930 4q13.1
    SYT14P1 68928.259 4q13.2
    TAPT1 16162.128 4p15.32
    TBC1D1 37892.705 4p14
    TBC1D14 6911.171 4p16.1
    TBCK 106965.474 4q24
    TENM3 183245.137 4q35
    TET2 106067.842 4q24
    THAP9 83821.837 4q21.3
    TLR10 38773.860 4p14
    TLR1 38797.876 4p14
    TLR2 154605.441 4q32
    TLR3 186990.309 4q35
    TLR6 38825.329 4p16.1
    TMEM144 159131.401 4q32.1
    TMEM184C 148538.539 4q31.22
    TMEM192 165997.230 4q32.3
    TMPRSS11A 68776.019 4q13.2
    TNIP2 2743.387 4p16.3
    TNIP3 122052.564 4q27
    TRAM1L1 118004.710 4q26
    TRIM60 165953.151 4q32.3
    TRMT10A 100467.864 4q23
    TRPC3 122800.183 4q27
    TTC29 147628.179 4q31.23
    TXK 48068.410 4p12
    UBE2D3 103715.540 4q24
    UCHL1 41258.898 4p13
    UGDH 39500.375 4p14
    UGT2A1 70454.135 4q13
    UGT2B10 69681.711 4q13.3
    UGT2B15 69512.315 4q13
    UGT2B17 69402.903 4q13
    UGT2B4 70345.883 4q13
    UGT2B7 69962.193 4q13
    UGT8 115519.611 4q26
    UNC5C 96083.656 4q21-q23
    USO1 76649.706 4q21.1
    USP17L9P 9245.605 4p16.1
    USP46 53457.127 4q12
    UVSSA 1341.104 4p16.3
    VEGFC 177604.685 4q34.3
    WDR1 10075.963 4p16.1
    WDR19 39184.024 4p14
    WWC2 184020.463 4q35.1
    YTHDC1 69176.105 4q13.3
    ZAR1 48492.269 4p11
    ZFP42 188916.925 4q35.2
    ZNF595 53.179 4p16.3

    GeneCards  

    Contributor(s)

    WrittenJul 2004Philippe Dessen, Sakari Knuutila, Jean-Loup Huret
    UpdatedAug 2014Philippe Dessen, Jean-Loup Huret

    Citation

    This paper should be referenced as such :
    Dessen P, Knuutila S, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jul 2004 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_4.html
    Dessen P, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Aug 2014 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_4.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Fri Aug 29 17:50:56 CEST 2014


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