Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
| Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma |
| Elvira D Rodrigues Pereira Velloso, Cristina Ratis, Sérgio A B Brasil, João Carlos Guerra, Nydia Bacal; Cristóvão P Mangueira LM Pitangueira |
| Clinics |
| Age and sex : | 75 year(s) old female patient. |
| Previous History : | B- cell Lymphoproliferative disorder for 8 years |
| Organomegaly : | hepatomegaly ; splenomegaly ; enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 5,4 x 109/l; Hb : 13,6 g/dl; platelets : 169 x 109/l; blasts : 3,35% (x 109/l (lymphoid cells)) |
| Bone marrow : 28% ( of lymphoid mature cells) |
| Cyto pathology classification |
| Cytology : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma. Atypical CLL. |
| Immunophenotype : 25% of total bone marrow cells are positive : CD20++, CD22+, CD25+, CD38, CD79b++, HLA-DR, sIgM, sIgD e sKappa ++. |
| Rearranged Ig Tcr : not done |
| Pathology : Inguinal Lymph node biopsy (August, 2005): Diffuse large B-cell Lymphoma, Ki-67: 70%, ciclina D1 -, CD20 +, BCL2 +. |
| Electron microscopy : not done |
| Precise diagnosis : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma. |
| Survival |
| Date of diagnosis: (07-2007) |
| Treatment : wide previous history (long previous history of chemotherapy), no chemotherapy after July, 2007 |
| Complete remission : None |
| Treatment related death : - |
| Relapse : - |
| Status : Alive 09-2007 |
| Survival : 2 month(s) |
| Karyotype |
| Sample : bone marrow cells ; culture time : 72 h, ours with and without TPA (o-tetradecanoyl phorbol-13-acetate) ; banding : G |
| Results : 47,XX, t(1;6) (p35;p25),+12[13]/46,XX[7] |
| Karyotype at relapse : not done |
| Other molecular cytogenetics technics : not done |
| Other molecular studies |
| technics : not done |
 |
| Partial karyotype, G- band |
| Comments |
| In 2005, the Belgian group described the t(1;6)(p35.3;p25.2) in 8 patients with unmutated B-CLL. As in this case, this rare cytogenetic entity has been described in typical or atypical CLL (8/8 cases), with evolution to diffuse large B-cell Lymphoma (3/8 cases); trisomy 12 been a common additional abnormality (3/8 cases). |
| Internal links |
| Atlas Card | t(1;6)(p35;p25) |
| Bibliography |
| Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in unmutated B-CLL. |
| Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 77-82. |
| PMID 15510210 |
| Contributor(s) |
| Written | 07-2007 | Elvira D Rodrigues Pereira Velloso, Cristina Ratis, Sérgio A B Brasil, João Carlos Guerra, Nydia Bacal; Cristóvão P Mangueira LM Pitangueira |
| Citation |
| This paper should be referenced as such : |
| Rodrigues Pereira Velloso ED, Ratis . Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma. Atlas Genet Cytogenet Oncol Haematol. July 2007 . URL : http://AtlasGeneticsOncology.org/Reports/0106RodriguesID100030.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jul 14 16:35:28 2008 |
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