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CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma
 
Written2007-07Elvira D Rodrigues Pereira Velloso, Cristina Ratis, Sérgio A B Brasil, João Carlos Guerra, Nydia Bacal; Cristóvão P Mangueira LM Pitangueira
Clinical Laboratory Hospital Israelita Albert Einstein, São Paulo, Brazil (EDRPV)(CR)(NB)(CPMLMP); Centro de Hematologia São Paulo, São Paulo, Brazil (SABB)(JCG)
Clinics
Age and sex : 75 year(s) old female patient.
Previous History : B- cell Lymphoproliferative disorder for 8 years
Organomegaly : hepatomegaly ; splenomegaly ; enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 5 x 109/L (4); Hb : 13 g/dL (6); platelets : 169 x 109/L; blasts : 3 % (35 x 109/l (lymphoid cells)).
Bone marrow : 28% of lymphoid mature cells
Cyto pathology classification
Cytology : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma. Atypical CLL.
Immunophenotype : 25% of total bone marrow cells are positive : CD20++, CD22+, CD25+, CD38, CD79b++, HLA-DR, sIgM, sIgD e sKappa ++.
Rearranged Ig Tcr : not done
Pathology : Inguinal Lymph node biopsy (August, 2005): Diffuse large B-cell Lymphoma, Ki-67: 70%, ciclina D1 -, CD20 +, BCL2 +.
Electron microscopy : not done
Precise diagnosis : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma.
Survival
Date of diagnosis: (07-2007)
Treatment : wide previous history (long previous history of chemotherapy), no chemotherapy after July, 2007
Complete remission : None
Treatment related death : -
Relapse : -
Status : Alive 09-2007
Survival : 2 month(s)
Karyotype
Sample : bone marrow cells ; culture time : 72 h, ours with and without TPA (o-tetradecanoyl phorbol-13-acetate) ; banding : G
Results : 47,XX, t(1;6) (p35;p25),+12[13]/46,XX[7]
Karyotype at relapse : not done
Other molecular cytogenetics technics : not done
Other molecular studies
technics : not done
Partial karyotype, G- band
Comments
In 2005, the Belgian group described the t(1;6)(p35.3;p25.2) in 8 patients with unmutated B-CLL. As in this case, this rare cytogenetic entity has been described in typical or atypical CLL (8/8 cases), with evolution to diffuse large B-cell Lymphoma (3/8 cases); trisomy 12 been a common additional abnormality (3/8 cases).
Internal links
Atlas Cardt(1;6)(p35;p25)
Bibliography
Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in unmutated B-CLL.
Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 77-82.
PMID 15510210
 

Citation

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