CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
Translocation t(1;6)(p35;p25) in B-cell lymphoproliferative disorder with evolution to Diffuse Large B-cell Lymphoma |
Written | 2007-07 | Elvira D Rodrigues Pereira Velloso, Cristina Ratis, Sérgio A B Brasil, João Carlos Guerra, Nydia Bacal; Cristóvão P Mangueira LM Pitangueira |
Clinical Laboratory Hospital Israelita Albert Einstein, São Paulo, Brazil (EDRPV)(CR)(NB)(CPMLMP); Centro de Hematologia São Paulo, São Paulo, Brazil (SABB)(JCG) |
Clinics |
Age and sex : | 75 year(s) old female patient. |
Previous History : | B- cell Lymphoproliferative disorder for 8 years |
Organomegaly : hepatomegaly ; splenomegaly ; enlarged lymph nodes ; no central nervous system involvement |
Blood |
WBC : 5 x 109/L (4); Hb : 13 g/dL (6); platelets : 169 x 109/L; blasts : 3 % (35 x 109/l (lymphoid cells)). |
Bone marrow : 28% of lymphoid mature cells |
Cyto pathology classification |
Cytology : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma. Atypical CLL. |
Immunophenotype : 25% of total bone marrow cells are positive : CD20++, CD22+, CD25+, CD38, CD79b++, HLA-DR, sIgM, sIgD e sKappa ++. |
Rearranged Ig Tcr : not done |
Pathology : Inguinal Lymph node biopsy (August, 2005): Diffuse large B-cell Lymphoma, Ki-67: 70%, ciclina D1 -, CD20 +, BCL2 +. |
Electron microscopy : not done |
Precise diagnosis : B-cell Lymphoproliferative disorder (Atypical CLL) with evolution to diffuse large B-cell Lymphoma. |
Survival |
Date of diagnosis: (07-2007) |
Treatment : wide previous history (long previous history of chemotherapy), no chemotherapy after July, 2007 |
Complete remission : None |
Treatment related death : - |
Relapse : - |
Status : Alive 09-2007 |
Survival : 2 month(s) |
Karyotype |
Sample : bone marrow cells ; culture time : 72 h, ours with and without TPA (o-tetradecanoyl phorbol-13-acetate) ; banding : G |
Results : 47,XX, t(1;6) (p35;p25),+12[13]/46,XX[7] |
Karyotype at relapse : not done |
Other molecular cytogenetics technics : not done |
Other molecular studies |
technics : not done |
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Partial karyotype, G- band |
Comments |
In 2005, the Belgian group described the t(1;6)(p35.3;p25.2) in 8 patients with unmutated B-CLL. As in this case, this rare cytogenetic entity has been described in typical or atypical CLL (8/8 cases), with evolution to diffuse large B-cell Lymphoma (3/8 cases); trisomy 12 been a common additional abnormality (3/8 cases). |
Internal links |
Atlas Card | t(1;6)(p35;p25) |
Bibliography |
Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in unmutated B-CLL. |
Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 77-82. |
PMID 15510210 |
Citation |
This paper should be referenced as such : |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Reports/0106RodriguesID100030.html |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 5 19:11:50 CET 2020 |
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