Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals   Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA


do you wish to send a case report ?


CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
A t(4;12)(q11;p13) in a patient with coincident CLL at the same time of AML diagnosis
 
Written2007-05Paola Dal Cin, Daniel J DeAngelo, Richard M Stone
(PDC) Department of Pathology, Brigham and Womens Hospital ; (DJD, RMS) Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA
Clinics
Age and sex : 56 year(s) old male patient.
Previous History : no preleukemia
no previous malignant disease (, but coincident CLL at the same time of AML diagnosis. No prior therapy for CLL)
no inborn condition of note
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement (symptoms (no LP done))
Blood
WBC : 52.2 x 109/L ; Hb : 10.2 g/dL ; platelets : 158.0 x 109/L; blasts : 86 % ((peripheral blood)).
Bone marrow : Bone Marrow Differential : Cellularity : o.k.- Megakaryocytes : present - Blasts : 66% "blast like" immature forms - Promyelocytes : 1% - Myeloid Activity : 13% - Erythroid Activity : 6% - Lymphocytes : 13% - Other : -
Cyto pathology classification
Cytology : M0
Immunophenotype : A population of immature cells positive for CD45(dim), HLA-DR, CD7, CD34 (majority) and myeloid markers CD33 and CD13, with absence of staining for B cell, monocytic, and other T cell markers, consistent with myeloblast. A minor clonal kappa positive (moderate intensity) population of CD5 positive B cells which were negative for CD23 was also detected, suggesting a co-existing CD5 positive B cell lymphoproliferative disorder. A minor population of CD19 positive B cells co-expresses CD5 and exhibits monotypic surface immunoglobulin kappa light chain staining, consistent with involvement by the patient's known B cell lymphoproliferative disorder.
Rearranged Ig Tcr : n/a
Pathology : Cellular aspirate with prominent population of "blast-like" large cells with dispersed chromatin, distinct nucleoli and modest amounts of blue, agranular cytoplasm.
Electron microscopy : n/a
Precise diagnosis : Acute Myelogenous Leukemia and Chronic Lymphocytic Leukemia
Survival
Date of diagnosis: 01-2002
Treatment : Induction: ADE consisting of daunorubicin, cytarabine and etoposide plus PSC-833 (he was randomized to the treatment arm) on CALGB 19808. Consolidation with high-dose cytarabine and etoposide with stem cell harvest as per CALGB 19808.Auto stem cell transplant: on April 24, 2002. Conditioning regimen consisted of busulfan and etoposide as per CALGB 19808.
Complete remission was obtained
Comments : on BM on Feb 8, 2002
Treatment related death : -
Relapse : + June 17, 2003
Phenotype at relapse : AML M0
Status : Dead 06-2003
Survival : 21 month(s)
Karyotype
Sample : Bone Marrow ; culture time : 24 h ; banding : GTG
Results : 46,XY,t(4;12)(q11-12;p13)[18]/46,XY[2]
Karyotype at relapse : 46,XY,t(4;12)(q11-q2;p13),+16,-17[1]/46,XY[19]
Other molecular studies
technics : FISH with LSI (TEL/AML1 ES Dual Color Translocation Probe (Vysis, Inc.)) on metaphases
results : ish der(4)(dimTEL+), der(12)(dimTEL+)
Partial GTG-banding karyotype showing t(4;12)(q11;p13) (a ). Partial FISH analysis showing the ETV6 hybridization signals on derivative chromosomes 4 and 12, and on the normal chromosome 12 (b)é
Comments
The findings are consistent with AML. Although histologic features of chronic lymphocytic leukemia (CLL) are not seen, flow cytometric analysis shows a small subset of monoclonal B cells, consistent with persistent involvement by the patient's known CLL.
Internal links
Atlas Cardt(4;12)(q11-q21;p13)
Case Report
Case Reportt(4;12)(q11;p13) in an acute myeloid leukemia without maturation with myelodysplasia

Citation

This paper should be referenced as such :
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Reports/0412DalCinID100023.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 27 11:27:33 CEST 2017


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals   Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.