CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

t(4;12)(q11;p13) in an acute myeloid leukemia without maturation with myelodysplasia

Jean Philippe Rault

Clinics

Age and sex :	67 year(s) old male patient.
Previous History :	no preleukemia
	no previous malignant disease
	no inborn condition of note
Organomegaly :	no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement

Blood

WBC : 3,6 x 109/l; Hb : 8,6 g/dl; platelets : 151 x 109/l; blasts : 56%

Cyto pathology classification

Immunophenotype : CD34 (85%), HLA DR (91%) and myeloid cluster: CD11c (7%), CD13 (97%), CD13c (99%), CD33 (98%), CD117 (81%), MPO 5% and only one lymphoid cluster CD7 (87%). Conclusion: immature myeloid population. Phenotype FAB M0

Rearranged Ig Tcr : Not done

Pathology : Secondary Acute Respiratory desease due to a bilateral alveolar pneumopathy on June 2005, without suitable microbiological data, following an aplasia phase with fever at D+16 ( chemotherapy induction step)

Electron microscopy : No

Precise diagnosis : AML type Mo with myelodysplasia

Survival

Date of diagnosis: 04-2005

Treatment : LAM SA 2002 Protocol. Idarubicine: 15mg per day from J1 to J5 / Aracytine: 180 mg per day from J1 to J7 / Belustine: 360 mg only at J1 then Aracytine and Idarubicine each three month during 15 days (6 cures).

Complete remission : None

Treatment related death : No

Relapse : No

Status : Alive 08-2005

Survival : 5 month(s)

Karyotype

Sample : Bone marrow ; culture time : 24/48 h ; banding : R

Results : 46, XY, t(4;12)(q11;p13.1) [27] / 46, XY [3]

Karyotype at relapse : No relapse

t(4;12)(q11;p13.1) R-banding

Comments

No AML/ETO t(8;21)(q22;q22) translocation, no split of MLL performed by FISH analysis

Internal links

Atlas Card	t(4;12)(q11-q21;p13)
Case Report	The rare t(4;12)(q11;p13) in an elderly patient with de novo AML with multilineage dysplasia co-expressing stem cell markers

Contributor(s)

Written

09-2005

Jean Philippe Rault

Citation

This paper should be referenced as such :

Rault JP . t(4;12)(q11;p13) in an acute myeloid leukemia without maturation with myelodysplasia. Atlas Genet Cytogenet Oncol Haematol. September 2005 . URL : http://AtlasGeneticsOncology.org/Reports/0412RaultID100014.html

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