CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

A case of myeloproliferative disorder with t(5;10)(q33;q21.2)

Valeria AS De Melo, Alistair G Reid

Clinics

Age and sex :	48 year(s) old male patient.
Organomegaly :	splenomegaly

Blood

WBC : 59.1 x 109/l; Hb : 11.1 g/dl; platelets : 58 x 109/l;

Cyto pathology classification

Precise diagnosis : Myeloproliferative disorder

Survival

Date of diagnosis: 03-1999

Treatment : HU,IS, BMT

Complete remission was obtained

Treatment related death : -

Relapse : -

Status : Alive 05-2005

Survival : 75 month(s)

Karyotype

Sample : Bone marrow ; culture time : FUDR ; banding : G-banding

Results : 46,XY,t(5;10)(q33;q21.2)[16]/46,XY[8]

Other molecular studies

technics : PCR (Ratio BCR-ABL/ABL)

results : 11-2000: 0; 04-2001: 0; 03-2002: 0.18

Partial karyotype showing the t(5;10)(q33;q21.2) - G-banding

Comments

One third of the metaphases examined (8/24) were apparently normal male while the remaining majority of cells showed a balanced translocation between chromosomes 5 and 10. This translocation is poorly known: only 2 cases of atypical chronic myeloid leikemia of unknown prognosis. Further cases will help defining this rare entity.

Internal links

Atlas Card

t(5;10)(q33;q21.2)

Bibliography

t(5;10)(q33;q21).

Mecucci C.

Atlas Genet Cytogenet Oncol Haematol 2001; 5 (1): 122-123.

Contributor(s)

Written

12-2006

Valeria AS De Melo, Alistair G Reid

Citation

This paper should be referenced as such :

De Melo VAS, Reid AG . A case of myeloproliferative disorder with t(5;10)(q33;q21.2). Atlas Genet Cytogenet Oncol Haematol. December 2006 . URL : http://AtlasGeneticsOncology.org/Reports/0510ReidID100019.html

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