Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals   Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA


do you wish to send a case report ?


CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
A case of myeloproliferative disorder with t(5;10)(q33;q21.2)
 
Written2006-12Valeria AS De Melo, Alistair G Reid
Leukaemia Cytogenetics Unit, G Block Room G124, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Clinics
Age and sex : 48 year(s) old male patient.
Organomegaly : no hepatomegaly ; splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 59.1 x 109/L ; Hb : 11.1 g/dL ; platelets : 58 x 109/L; blasts : less % (than 1).
Cyto pathology classification
Precise diagnosis : Myeloproliferative disorder
Survival
Date of diagnosis: 03-1999
Treatment : HU,IS, BMT
Complete remission was obtained
Treatment related death : -
Relapse : -
Status : Alive 05-2005
Survival : 75 month(s)
Karyotype
Sample : Bone marrow ; culture time : FUDR ; banding : G-banding
Results : 46,XY,t(5;10)(q33;q21.2)[16]/46,XY[8]
Other molecular studies
technics : PCR (Ratio BCR-ABL/ABL)
results : 11-2000: 0; 04-2001: 0; 03-2002: 0.18
Partial karyotype showing the t(5;10)(q33;q21.2) - G-banding
Comments
One third of the metaphases examined (8/24) were apparently normal male while the remaining majority of cells showed a balanced translocation between chromosomes 5 and 10. This translocation is poorly known: only 2 cases of atypical chronic myeloid leikemia of unknown prognosis. Further cases will help defining this rare entity.
Internal links
Atlas Cardt(5;10)(q33;q21.2)
Bibliography
t(5;10)(q33;q21).
Mecucci C
Atlas Genet Cytogenet Oncol Haematol. 2001 ; 5 (numero 1) : 122-123.
 

Citation

This paper should be referenced as such :
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Reports/0510ReidID100019.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 27 11:27:34 CEST 2017


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals   Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.