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CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case
 
Written2006-12Valeria AS De Melo, Alistair G Reid
Leukaemia Cytogenetics Unit, G Block Room G124, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Clinics
Age and sex : 43 year(s) old male patient.
Organomegaly : no hepatomegaly ; no splenomegaly ; enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 9.8 x 109/L ; Hb : 11.5 g/dL ; platelets : 28 x 109/L;
Cyto pathology classification
Precise diagnosis : Atypical chronic myeloid leukaemia
Survival
Date of diagnosis: 02-1992
Treatment : Chemo/Radiation/bone marrow transplantation
Complete remission was obtained
Treatment related death : +
Relapse : -
Status : Dead 06-1994
Survival : 28 month(s)
Karyotype
Sample : Bone marrow ; culture time : CM FUDR 48 h ; banding : G-banding
Results : 46,XY,t(8;13)(p12;q12)[8]/46,XY[2]
Partial karyotype showing the t(8;13)(p12;q12) - G-banding
Comments
Eight of the metaphases examined showed a translocation between chromosomes 8 and 13. There was no evidence of a Philadelphia translocation. The t(8;13) is usually found in myeloproliferative syndromes with FGFR1 involvement and a poor prognosis
Internal links
Atlas Cardt(8;13)(p12;q12)
Bibliography
t(8;13)(p12;q12) - updated.
Pebusque MJ, Cross NCP
Atlas Genet Cytogenet Oncol Haematol. 2001 ; 5 (numero 1) : 97-100.
 

Citation

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