CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case

Valeria AS De Melo, Alistair G Reid

Clinics

Age and sex :	43 year(s) old male patient.
Organomegaly :	no splenomegaly ; enlarged lymph nodes

Blood

WBC : 9.8 x 109/l; Hb : 11.5 g/dl; platelets : 28 x 109/l;

Cyto pathology classification

Precise diagnosis : Atypical chronic myeloid leukaemia

Survival

Date of diagnosis: 02-1992

Treatment : Chemo/Radiation/bone marrow transplantation

Complete remission was obtained

Treatment related death : +

Relapse : -

Status : Dead 06-1994

Survival : 28 month(s)

Karyotype

Sample : Bone marrow ; culture time : CM FUDR 48 h ; banding : G-banding

Results : 46,XY,t(8;13)(p12;q12)[8]/46,XY[2]

Partial karyotype showing the t(8;13)(p12;q12) - G-banding

Comments

Eight of the metaphases examined showed a translocation between chromosomes 8 and 13. There was no evidence of a Philadelphia translocation. The t(8;13) is usually found in myeloproliferative syndromes with FGFR1 involvement and a poor prognosis

Internal links

Atlas Card

t(8;13)(p12;q12)

Bibliography

t(8;13)(p12;q12) - updated.

Pebusque MJ, Cross NCP

Atlas Genet Cytogenet Oncol Haematol. 2001 ; 5 (numero 1) : 97-100.

Contributor(s)

Written

12-2006

Valeria AS De Melo, Alistair G Reid

Citation

This paper should be referenced as such :

De Melo VAS, Reid AG . t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case. Atlas Genet Cytogenet Oncol Haematol. December 2006 . URL : http://AtlasGeneticsOncology.org/Reports/0813ReidID100018.html

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indexed on : Mon Aug 11 21:22:54 2008

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