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CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 4
 
Written2005-01Kavita S Reddy, Kathy Richkind
Genzyme Genetics, Orange, CA. Kavita.reddy@gmail.com
Clinics
Age and sex : 66 year(s) old female patient.
Previous History : no preleukemia
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 4.16 x 109/L ; Hb : 13.5 g/dL ; platelets : 103 x 109/L;
Cyto pathology classification
Precise diagnosis : Myelodysplastic syndrome (MDS): pancytopenia and thrombocytopenia
Survival
Relapse : -
Status : No clinical information
Survival : 1 month(s)
FOOT SIZE=2>Karyotype
Sample : BM ; culture time : 24/48 h, unstimulated cultures ; banding : G-banding
Results : 46,X,t(X;20)(q13;q13.3)[3].ish t(X;20)(q11.2-12;q13.3) (wcpX+, wcp20+, AR_; wcp20+, D20S108+, AR+, wcpX+)/46,XX[18]
Other molecular cytogenetics results : 46,X,t(X;20)(q13;q13.3)[3].ish t(X;20)(q11.2-12;q13.3) (wcpX+,wcp20+,AR_;wcp20+,D20S108+,AR+,wcpX+)/46,XX[18]
Other findings
results : In case 4, the breakpoint on X-chromosome was found to be more proximal between Xq11.2q-12 by FISH using androgen receptor probe
Fig. 1. Partial karyotypes of the translocation t(X;20)(q13;q13.3) for cases 1ï4 (top to bottom). Arrows indicate the derivatives 20 and X.
Fig 2: Case 4: X-centromere probe DXZ1 (green) hybridized to the normal X and the derivative X (arrows). The androgen receptor (Xq12) AR (red) probe hybridized to derivative 20 and the normal X (arrows). The breakpoint on the X chromosome is proximal to AR. The karyotype is 46,X,t(X;20)(q13;q13.3).ish t(X;20)(q11.2q12;q13.3)(wcpX+, wcp20+, AR_; wcp20+, D20S180_, AR+, wcpX+). The revised breakpoints identified with FISH analysis are highlighted in bold.
Internal links
Atlas Cardt(X;20)(q13;q13)
Case ReportTranslocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 1
Case ReportTranslocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2
Case ReportTranslocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 3
Bibliography
Biclonal acute monoblastic leukemia showing del(7q) and trisomies 9 and 22.
Wong KF, Kwong YL, Tang KC
Cancer genetics and cytogenetics. 1995 ; 82 (1) : 70-72.
PMID 7627939
 
Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders.
Gray BA, Cornfield D, Bent-Williams A, Zori RT
Cancer genetics and cytogenetics. 2003 ; 141 (2) : 169-174.
PMID 12606138
 
Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders.
Reddy KS, Richkind K, Ross M, Seirra R
Cancer genetics and cytogenetics. 2005 ; 157 (1) : 70-73.
PMID 15676151
 

Citation

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