CASE REPORTS in HAEMATOLOGY (Paper co-edited with the European LeukemiaNet)

Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 4

WARNING: on Feb 2008, we have been aware that this case had simultaneously been published in another Journal (namely Cancer Genet Cytogenet), although double reports are objectionable.

Kavita S Reddy, Kathy Richkind

Clinics

Age and sex :	66 year(s) old female patient.
Previous History :	no preleukemia

Blood

WBC : 4.16 x 109/l; Hb : 13.5 g/dl; platelets : 103 x 109/l;

Cyto pathology classification

Precise diagnosis : Myelodysplastic syndrome (MDS): pancytopenia and thrombocytopenia

Survival

Relapse : -

Status : No clinical information

Survival : 1 month(s)

Karyotype

Sample : BM ; culture time : 24/48 h, unstimulated cultures ; banding : G-banding

Results : 46,X,t(X;20)(q13;q13.3)[3].ish t(X;20)(q11.2-12;q13.3) (wcpX+, wcp20+, AR_; wcp20+, D20S108+, AR+, wcpX+)/46,XX[18]

Other molecular cytogenetics results : 46,X,t(X;20)(q13;q13.3)[3].ish t(X;20)(q11.2-12;q13.3) (wcpX+,wcp20+,AR_;wcp20+,D20S108+,AR+,wcpX+)/46,XX[18]

Other findings

results : In case 4, the breakpoint on X-chromosome was found to be more proximal between Xq11.2q-12 by FISH using androgen receptor probe

Fig. 1. Partial karyotypes of the translocation t(X;20)(q13;q13.3) for cases 1•4 (top to bottom). Arrows indicate the derivatives 20 and X.

Fig 2: Case 4: X-centromere probe DXZ1 (green) hybridized to the normal X and the derivative X (arrows). The androgen receptor (Xq12) AR (red) probe hybridized to derivative 20 and the normal X (arrows). The breakpoint on the X chromosome is proximal to AR. The karyotype is 46,X,t(X;20)(q13;q13.3).ish t(X;20)(q11.2q12;q13.3)(wcpX+, wcp20+, AR_; wcp20+, D20S180_, AR+, wcpX+). The revised breakpoints identified with FISH analysis are highlighted in bold.

Internal links

Atlas Card	t(X;20)(q13;q13)
Case Report	Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 1
Case Report	Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 2
Case Report	Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 3

Bibliography

Biclonal acute monoblastic leukemia showing del(7q) and trisomies 9 and 22.

Wong KF, Kwong YL, Tang KC

Cancer genetics and cytogenetics. 1995 ; 82 (1) : 70-72.

PMID 7627939

Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders.

Gray BA, Cornfield D, Bent-Williams A, Zori RT

Cancer genetics and cytogenetics. 2003 ; 141 (2) : 169-174.

PMID 12606138

Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders.

Reddy KS, Richkind K, Ross M, Seirra R

Cancer genetics and cytogenetics. 2005 ; 157 (1) : 70-73.

PMID 15676151

Contributor(s)

Written

01-2005

Kavita S Reddy, Kathy Richkind

Citation

This paper should be referenced as such :

Reddy KS, Richkind KE . Translocation (X;20)(q13;q13.3): a nonrandom abnormality in four patients with myeloid disorders: case 4. Atlas Genet Cytogenet Oncol Haematol. January 2005 . URL : http://AtlasGeneticsOncology.org/Reports/0X20ReddyID100012.html

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indexed on : Mon Aug 11 21:22:55 2008

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