Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
| A new case of t(16;21)(q24;q22) in a secondary AML-M2 following breast cancer therapy |
| Written | 2005-08 | Hélène Bruyère, Wilson Yeung, Peter Tsang |
| Department of Pathology and Laboratory Medicine, Vancouver General Hospital, UBC, Canada, Helene.Bruyere@vch.ca and Division of Hematology, Vancouver General Hospital, UBC, Canada |
| Clinics |
| Age and sex : | 61 year(s) old female patient. |
| Previous History : | no preleukemia |
| no inborn condition of note |
| Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 2.4 x 109/L ; Hb : 10.7 g/dL ; platelets : 48 x 109/L; blasts : 2 % . |
| Bone marrow : Neutrophils 0.05 ; Band cells 0.05 ; Metamyelocytes 0.13 ; Myelocytes 0.02 ; Promyelocytes 0.02 ; Blasts 0.51 ; Late normoblasts 0.13 ; Plasma cells 0.01 ; Lymphocytes 0.05 ; Monocytes 0.01 ; Eosinophils 0.02 |
| Cyto pathology classification |
| Cytology : AML-M2 |
| Immunophenotype : Positive for HLA-DR, CD34, CD117, CD13, CD33, MPO, CD56 and CD19 ; Partial Tdt ; Negative for CD7 |
| Precise diagnosis : Hypoplastic AML, therapy related |
| Survival |
| Date of diagnosis: 04-2005 |
| Treatment : Three cycles of AraC and Danuribicin ; Related bone marrow transplantation planned for September 2005 |
| Complete remission : None |
| Status : Alive 07-2005 |
| Survival : 3 month(s) |
| Karyotype |
| Sample : Bone marrow ; culture time : 24 h ; banding : GTG |
| Results : 47,XX,+8,t(16;21)(q24;q22)[13]/46,XX[3] |
 |
| Partial karyotype showing the t(16;21) and a +8 |
| Comments |
| The t(16;21)(q24;q22) is mainly found in t-MDS/t-AML (14/16 cases (1-10)), following breast cancer therapy (five cases (7,8,10)), lymphoma (four cases), Hodgkin's disease, lung and oviductal cancers and AML-M3 (one case each). Trisomy 8, the secondary change found in the current case, is also reported in most if not all patients with previous breast cancer (7,8,10). To note, three out of five patients had lymphoid positive antigenes (5,7, current case). All of the nine patients whose treatments were reported (3-9), plus the current case, were treated with a combination of alkylating agents and topoisomerase II inhibitors, +/- radiotherapy. |
| Internal links |
| Atlas Card | t(16;21)(q24;q22) |
| Case Report | A case of trisomy 8 and loss of the Y-chromosome as secondary aberrations in a ten year old boy with de novo AML FAB M2 and t(16;21)(q24;q22) |
| Bibliography |
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| Citation |
| This paper should be referenced as such : |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Reports/1621BruyereID100013.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Aug 16 13:43:50 CEST 2018 |
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