CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome |
Written | 2008-05 | Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne |
Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL) |
Clinics |
Age and sex : | 76 year(s) old female patient. |
Previous History : | no preleukemia |
no previous malignant disease | |
no inborn condition of note |
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
Blood |
WBC : 6.7 x 109/L ; Hb : 7.5 g/dL ; platelets : 450 x 109/L; |
Bone marrow : 52 ringed sideroblast (Perls staining) |
Cyto pathology classification |
Cytology : - |
Immunophenotype : - |
Rearranged Ig Tcr : - |
Electron microscopy : - |
Precise diagnosis : myelodysplastic syndrome (MDS): refractory anemia with ringed sideroblast (RARS) |
Survival |
Date of diagnosis: 05-1994 |
Treatment : norethandrolone |
Complete remission was obtained |
Treatment related death : - |
Relapse : - |
Status : Dead 04-1997 |
Survival : 37 month(s) |
Karyotype |
Sample : bone marrow ; culture time : 48 h ; banding : RHG |
Results : 46,XX,[3]/47,XX,+8[3]/47,XX,+8,-15,+dic(1;15)(p11;p11)[8] |
Other molecular cytogenetics technics : NA |
Other molecular studies |
technics : NA |
Other findings |
results : NA |
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Partial karyotype at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 8. |
Comments |
This is an MDS case presenting this recurrent abnormality, with a 3 years survival. In this case the death is not related to disease (non-small cell lung carcinoma). |
Internal links |
Citation |
This paper should be referenced as such : |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Reports/dic115inMyelodRocheID100037.html |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 5 19:11:59 CET 2020 |
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