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CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome
 
Written2008-05Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne
Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)
Clinics
Age and sex : 76 year(s) old female patient.
Previous History : no preleukemia
no previous malignant disease
no inborn condition of note
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 6.7 x 109/L ; Hb : 7.5 g/dL ; platelets : 450 x 109/L;
Bone marrow : 52 ringed sideroblast (Perls staining)
Cyto pathology classification
Cytology : -
Immunophenotype : -
Rearranged Ig Tcr : -
Electron microscopy : -
Precise diagnosis : myelodysplastic syndrome (MDS): refractory anemia with ringed sideroblast (RARS)
Survival
Date of diagnosis: 05-1994
Treatment : norethandrolone
Complete remission was obtained
Treatment related death : -
Relapse : -
Status : Dead 04-1997
Survival : 37 month(s)
Karyotype
Sample : bone marrow ; culture time : 48 h ; banding : RHG
Results : 46,XX,[3]/47,XX,+8[3]/47,XX,+8,-15,+dic(1;15)(p11;p11)[8]
Other molecular cytogenetics technics : NA
Other molecular studies
technics : NA
Other findings
results : NA
Partial karyotype at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 8.
Comments
This is an MDS case presenting this recurrent abnormality, with a 3 years survival. In this case the death is not related to disease (non-small cell lung carcinoma).
Internal links
Atlas Carddic(1;15)(p11;p11)
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera

Citation

This paper should be referenced as such :
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Reports/dic115inMyelodRocheID100037.html

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