Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
| Dic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome |
| Written | 2008-05 | Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne |
| Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL) |
| Clinics |
| Age and sex : | 76 year(s) old female patient. |
| Previous History : | no preleukemia |
| no previous malignant disease | |
| no inborn condition of note |
| Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 6.7 x 109/L ; Hb : 7.5 g/dL ; platelets : 450 x 109/L; |
| Bone marrow : 52 ringed sideroblast (Perls staining) |
| Cyto pathology classification |
| Cytology : - |
| Immunophenotype : - |
| Rearranged Ig Tcr : - |
| Electron microscopy : - |
| Precise diagnosis : myelodysplastic syndrome (MDS): refractory anemia with ringed sideroblast (RARS) |
| Survival |
| Date of diagnosis: 05-1994 |
| Treatment : norethandrolone |
| Complete remission was obtained |
| Treatment related death : - |
| Relapse : - |
| Status : Dead 04-1997 |
| Survival : 37 month(s) |
| Karyotype |
| Sample : bone marrow ; culture time : 48 h ; banding : RHG |
| Results : 46,XX,[3]/47,XX,+8[3]/47,XX,+8,-15,+dic(1;15)(p11;p11)[8] |
| Other molecular cytogenetics technics : NA |
| Other molecular studies |
| technics : NA |
| Other findings |
| results : NA |
 |
| Partial karyotype at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 8. |
| Comments |
| This is an MDS case presenting this recurrent abnormality, with a 3 years survival. In this case the death is not related to disease (non-small cell lung carcinoma). |
| Internal links |
| Citation |
| This paper should be referenced as such : |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Reports/dic115inMyelodRocheID100037.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sun May 10 17:22:52 CEST 2020 |
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