Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
| Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera |
| Written | 2008-05 | Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne |
| Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL) |
| Clinics |
| Age and sex : | 72 year(s) old female patient. |
| Previous History : | no preleukemia |
| no previous malignant disease | |
| no inborn condition of note |
| Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 6.5 x 109/L ; Hb : 19 g/dL ; platelets : 350 x 109/L; |
| Cyto pathology classification |
| Cytology : - |
| Immunophenotype : - |
| Rearranged Ig Tcr : - |
| Pathology : MPD, PV |
| Electron microscopy : - |
| Precise diagnosis : Polycytemia vera. |
| Survival |
| Date of diagnosis: 07-1990 |
| Treatment : Hydroxyurea |
| Complete remission was obtained |
| Treatment related death : - |
| Relapse : + |
| Phenotype at relapse : AML with unknown phenotype due to bone marrow aspiration failure. |
| Status : Dead 09-2001 |
| Survival : 134 month(s) |
| Karyotype |
| Sample : bone marrow ; culture time : 48 h ; banding : RHG |
| Results : 46,XX,-15,+dic(1;15)[13] |
| Karyotype at relapse : 46,XX,del(7)(q22;q34),-15,+dic(1;15)(p11;p11)[18] |
| Other molecular cytogenetics technics : NA |
| Other molecular studies |
| technics : NA |
 |
| Karyotype at diagnosis presenting the isolated dic(1;15)(p11;p11). |
| Comments |
| This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However in this case the death is related to disease (respiratory distress on leukostasis). |
| Internal links |
| Citation |
| This paper should be referenced as such : |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Reports/dic115inPVRocheID100038.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Oct 5 17:49:27 CEST 2018 |
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