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CASE REPORTS in HAEMATOLOGY
(Paper co-edited with the European LeukemiaNet)
Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera
 
Written2008-05Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne
Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)
Clinics
Age and sex : 72 year(s) old female patient.
Previous History : no preleukemia
no previous malignant disease
no inborn condition of note
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 6.5 x 109/L ; Hb : 19 g/dL ; platelets : 350 x 109/L;
Cyto pathology classification
Cytology : -
Immunophenotype : -
Rearranged Ig Tcr : -
Pathology : MPD, PV
Electron microscopy : -
Precise diagnosis : Polycytemia vera.
Survival
Date of diagnosis: 07-1990
Treatment : Hydroxyurea
Complete remission was obtained
Treatment related death : -
Relapse : +
Phenotype at relapse : AML with unknown phenotype due to bone marrow aspiration failure.
Status : Dead 09-2001
Survival : 134 month(s)
Karyotype
Sample : bone marrow ; culture time : 48 h ; banding : RHG
Results : 46,XX,-15,+dic(1;15)[13]
Karyotype at relapse : 46,XX,del(7)(q22;q34),-15,+dic(1;15)(p11;p11)[18]
Other molecular cytogenetics technics : NA
Other molecular studies
technics : NA
Karyotype at diagnosis presenting the isolated dic(1;15)(p11;p11).
Comments
This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However in this case the death is related to disease (respiratory distress on leukostasis).
Internal links
Atlas Carddic(1;15)(p11;p11)
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome

Citation

This paper should be referenced as such :
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Reports/dic115inPVRocheID100038.html

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