CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
Dic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera |
Written | 2008-05 | Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne |
Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL) |
Clinics |
Age and sex : | 72 year(s) old female patient. |
Previous History : | no preleukemia |
no previous malignant disease | |
no inborn condition of note |
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
Blood |
WBC : 6.5 x 109/L ; Hb : 19 g/dL ; platelets : 350 x 109/L; |
Cyto pathology classification |
Cytology : - |
Immunophenotype : - |
Rearranged Ig Tcr : - |
Pathology : MPD, PV |
Electron microscopy : - |
Precise diagnosis : Polycytemia vera. |
Survival |
Date of diagnosis: 07-1990 |
Treatment : Hydroxyurea |
Complete remission was obtained |
Treatment related death : - |
Relapse : + |
Phenotype at relapse : AML with unknown phenotype due to bone marrow aspiration failure. |
Status : Dead 09-2001 |
Survival : 134 month(s) |
Karyotype |
Sample : bone marrow ; culture time : 48 h ; banding : RHG |
Results : 46,XX,-15,+dic(1;15)[13] |
Karyotype at relapse : 46,XX,del(7)(q22;q34),-15,+dic(1;15)(p11;p11)[18] |
Other molecular cytogenetics technics : NA |
Other molecular studies |
technics : NA |
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Karyotype at diagnosis presenting the isolated dic(1;15)(p11;p11). |
Comments |
This is an additional MPD case presenting this recurrent abnormality, with 11 years survival. However in this case the death is related to disease (respiratory distress on leukostasis). |
Internal links |
Citation |
This paper should be referenced as such : |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Reports/dic115inPVRocheID100038.html |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 5 19:11:59 CET 2020 |
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