Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
| Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD |
| Clinics |
| Age and sex : | 59 year(s) old female patient. |
| Previous History : | no preleukemia |
| no previous malignant disease | |
| no inborn condition of note | |
| Organomegaly : | no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 8.5 x 109/l; Hb : 19 g/dl; platelets : 600 x 109/l; |
| Cyto pathology classification |
| Cytology : - |
| Immunophenotype : - |
| Rearranged Ig Tcr : - |
| Pathology : MPD |
| Electron microscopy : - |
| Precise diagnosis : Atypical myeloproliferative disease, presenting polycythemia and thrombocythemia with myelofibrosis. |
| Survival |
| Date of diagnosis: 09-1988 |
| Treatment : Hydroxyurea |
| Complete remission was obtained |
| Treatment related death : - |
| Relapse : + |
| Phenotype at relapse : AML with unknown phenotype due to bone marrow aspiration failure. |
| Status : Dead 12-1997 |
| Survival : 111 month(s) |
| Karyotype |
| Sample : bone marrow ; culture time : 48 h ; banding : RHG |
| Results : 47,XX,+9,-15,+dic(1;15)(p11;p11)[20] |
| Karyotype at relapse : 47,XX,t(1;6)(q21;q23),+9,-15,+dic(1;15)(p11;p11)[13] |
| Other molecular cytogenetics technics : NA |
| Other molecular studies |
| technics : NA |
 |
| Partial karyotype (R-banding) at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 9. |
| Comments |
| This is an additional MPD case presenting this recurrent abnormality, with a 10 years survival. However in this case the death is related to the GVH disease after allograft. |
| Internal links |
| Contributor(s) |
| Written | 05-2008 | Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne |
| Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL) |
| Citation |
| This paper should be referenced as such : |
| Theisen O, Richebourg S, Lai JL, Roche-Lestienne C . . Atlas Genet Cytogenet Oncol Haematol. May 2008 . URL : http://AtlasGeneticsOncology.org/Genes/dic115inaMPDRocheID100035.html |
This paper is referenced by INIST as such : |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:39:52 CET 2013 |
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