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(Paper co-edited with the European LeukemiaNet)
Dic(1;15)(p11;p11) as a non-random abnormality in atypical MPD
Written2008-05Olivier Theisen, Steven Richebourg, Jean-Luc Lai, Catherine Roche-Lestienne
Laboratoire de Genetique Medicale, Hopital Jeanne de Flandre, CHRU de Lille, France (OT, SR, JLL, CRL); Institut de Recherche sur le Cancer, Centre JP Aubert, Unite Inserm 837, Lille, France (JLL, CRL)
Age and sex : 59 year(s) old female patient.
Previous History : no preleukemia
no previous malignant disease
no inborn condition of note
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
WBC : 8.5 x 109/L ; Hb : 19 g/dL ; platelets : 600 x 109/L;
Cyto pathology classification
Cytology : -
Immunophenotype : -
Rearranged Ig Tcr : -
Pathology : MPD
Electron microscopy : -
Precise diagnosis : Atypical myeloproliferative disease, presenting polycythemia and thrombocythemia with myelofibrosis.
Date of diagnosis: 09-1988
Treatment : Hydroxyurea
Complete remission was obtained
Treatment related death : -
Relapse : +
Phenotype at relapse : AML with unknown phenotype due to bone marrow aspiration failure.
Status : Dead 12-1997
Survival : 111 month(s)
Sample : bone marrow ; culture time : 48 h ; banding : RHG
Results : 47,XX,+9,-15,+dic(1;15)(p11;p11)[20]
Karyotype at relapse : 47,XX,t(1;6)(q21;q23),+9,-15,+dic(1;15)(p11;p11)[13]
Other molecular cytogenetics technics : NA
Other molecular studies
technics : NA
Partial karyotype (R-banding) at diagnosis presenting the dic(1;15)(p11;p11) associated with trisomy 9.
This is an additional MPD case presenting this recurrent abnormality, with a 10 years survival. However in this case the death is related to the GVH disease after allograft.
Internal links
Atlas Carddic(1;15)(p11;p11)
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in essential thrombocytemia
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in Polycytemia Vera
Case ReportDic(1;15)(p11;p11) as a non-random abnormality in Myelodysplasic syndrome


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