Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in
HAEMATOLOGY (Paper co-edited with the European LeukemiaNet) |
| A new case of t(5;14)(q31;q32) in a pediatric acute lymphoblastic leukemia presenting with hypereosinophilia |
| Clinics |
| Age and sex : | 11 year(s) old male patient. |
| Previous History : | preleukemia (The patient presented with a chronic eosinophilic leukemia 3 months before developing ALL.) |
| no previous malignant disease | |
| no inborn condition of note | |
| Organomegaly : | hepatomegaly (4 cm from below costal rib) ; splenomegaly (3 cm from below costal rib) ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 48 with 62% of eosinophils x 109/l; Hb : 7.0 g/dl; platelets : 79 x 109/l; blasts : 15% |
| Cyto pathology classification |
| Immunophenotype : Pre-B ALL (EGIL classification B III). The blasts expressed CD45, CD19, CD10, CD34, HLA-DR, cCD79a, cCD22, Tdt and cytoplasmic micro chain, partial CD20 and CD33 and were negative for CD2, CD7, CD13, CD15, CD117 and CD3. |
| Precise diagnosis : Acute lymphoblastic leukemia following a chronic eosinophilic leukemia. |
| Survival |
| Date of diagnosis: 03-2008 |
| Treatment : Chemotherapy for ALL (12-ALLIC 02 protocol) |
| Complete remission was obtained |
| Treatment related death : - |
| Relapse : + |
| Phenotype at relapse : During continuation phase hypereosinophilia was observed in peripheral blood, but low percentage of lymphoblasts was detected during 2-3 weeks before relapse. After this finding, the patient presented CNS infiltration by eosinophils (70% of WBC detected in CSF). He presented a bone marrow infiltration by dysplastic eosinophils and less than 5% of lymphoblasts after 18 months from achieving CR and a hematological relapse was diagnosed. |
| Status : Dead 06-2010 |
| Survival : 21 month(s) |
| Karyotype |
| Sample : Bone marrow ; culture time : 24 h ; banding : G banding |
| Results : Karyotype at time of diagnosis of ALL: 46,XY,t(5;14)(q31;q32)[4]/46,XY[12] |
| Karyotype at relapse : 46,XY,t(3;8)(p21;q24),t(5;14)(q31;q32)[2]/46,XY[18] |
| Other molecular studies |
| technics : RT-PCR non evaluable, due to control gene non amplifiable. |
 |
| Partial GTG banded karyotype showing t(5;14)(q31;q32). |
| Comments |
| To our knowledge nine cases (8M/1F) of ALL with eosinophilia and t(5;14)(q31;q32) have been reported in the literature. Five of them were described in childhood ALL. The prognosis of t(5;14)(q31;q32) seems to be very poor. Our patient relapsed and died 21 months after diagnoses. |
| Internal links |
| Atlas Card | t(5;14)(q31;q32) |
| Bibliography |
| Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)]. |
| Tono-oka T, Sato Y, Matsumoto T, Ueno N, Ohkawa M, Shikano T, Takeda T. |
| Med Pediatr Oncol. 1984;12(1):33-7. |
| PMID 6583469 |
| Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review. |
| Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL. |
| J Clin Oncol. 1987 Mar;5(3):382-90. (REVIEW) |
| PMID 3546615 |
| Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome. |
| McConnell TS, Foucar K, Hardy WR, Saiki J. |
| J Clin Oncol. 1987 Dec;5(12):2042-4. |
| PMID 3479532 |
| Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity? |
| Baumgarten E, Wegner RD, Fengler R, Ludwig WD, Schulte-Overberg U, Domeyer C, Schuurmann J, Henze G. |
| Acta Haematol. 1989;82(2):85-90. |
| PMID 2508400 |
| The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. |
| Grimaldi JC, Meeker TC. |
| Blood. 1989 Jun;73(8):2081-5. |
| PMID 2499362 |
| Acute lymphoblastic leukemia with eosinophilia. |
| Fishel RS, Farnen JP, Hanson CA, Silver SM, Emerson SG. |
| Medicine (Baltimore). 1990 Jul;69(4):232-43. |
| PMID 2374508 |
| Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. |
| Meeker TC, Hardy D, Willman C, Hogan T, Abrams J. |
| Blood. 1990 Jul 15;76(2):285-9. |
| PMID 2114933 |
| Non-random involvement of chromosome 5 in ALL. |
| Chen Z, Morgan R, Sandberg AA. |
| Cancer Genet Cytogenet. 1992 Jul 1;61(1):106-7. |
| PMID 1638475 |
| Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia. |
| Heerema NA, Palmer CG, Weetman R, Bertolone S. |
| Leukemia. 1992 Mar;6(3):185-92. |
| PMID 1564954 |
| Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14). |
| Knuutila S, Alitalo R, Ruutu T. |
| Genes Chromosomes Cancer. 1993 Dec;8(4):219-23. |
| PMID 7512364 |
| Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia. |
| Gmidene A, Sennana H, Elghezal H, Ziraoui S, Youssef YB, Elloumi M, Issaoui L, Harrabi I, Raynaud S, Saad A. |
| Hematol Oncol. 2008 Jun;26(2):91-7. |
| PMID 18271061 |
| Contributor(s) |
| Written | 09-2011 | Marta Gallego, Mariela Coccé, María Felice, Jorge Rossi, Silvia Eandi, Gabriela Sciuccati, Cristina Alonso |
| Laboratorio de Citogenetica - Servicio de Genetica - Servicio de Inmunologia y Reumatologia - Servicio de Hemato-Oncologia, Hospital de Pediatria "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina |
| Citation |
| This paper should be referenced as such : |
| Gallego M, Coccé M, Felice M, Rossi J, Eandi S, Sciuccati G, Alonso C . . Atlas Genet Cytogenet Oncol Haematol. Septem
ber 2011 . URL : http://AtlasGeneticsOncology.org/Genes/t514q31q32GallegoID100055.html |
This paper is referenced by INIST as such : |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:39:55 CET 2013 |
For comments and suggestions or contributions, please contact us