CASE REPORTS in HAEMATOLOGY |
A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32) |
Written | 2001-06 | Petr Balicek, Jana Rabasova, Jiri Hak |
Division of Medical Genetics, University Hospital, 500 05 Hradec Kralove, Czech Republic |
Clinics |
Age and sex : | 17 year(s) old male patient. |
Previous History : | no preleukemia |
no previous malignant disease |
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
Blood |
WBC : 32.9 x 109/L ; Hb : 7.7 g/dL ; platelets : 9 x 109/L; blasts : 90 % . |
Cyto pathology classification |
Cytology : ALL - L1 |
Immunophenotype : CD10 (CALLA) positive; CD66 positive |
Precise diagnosis : Early pre-B ALL |
Survival |
Date of diagnosis: 04-2001 |
Treatment : Treated on protocol BFM 95 - medium risk group. |
Complete remission was obtained |
Comments : second cytogenetic examination: 47,XY,+21[70] - complete cytogenetic response. |
Status : Dead |
Survival : 1 month(s) |
Karyotype |
Sample : bone marrow ; culture time : 24 h ; banding : R |
Results : 47,XY, der(14)t(8;14)(q11;q32),+21 "c" [17]/47,XY,+21 "c" [3] |
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der(14) t(8;14)(q11;q32) R- banding; the constitutional trisomy 21 is shown only on the bottom mitosis (left); chromosome 8 paint (right) - Petr Balicek, Jana Rabasova, Jiri Hak. |
Call for collaboration |
- Both bone marrow samples are stored: Bone marrow cell suspension, isolated RNA and DNA from the first examination you can get at address: Dr. Jan Trka - jan.trka@lfmotol.cuni.cz - Isolated nucleic acids (both RNA and DNA) and cDNA from the second examination are available at the address below: Dr. Zdenek Fiedler - fiedler@lfhk.cuni.cz |
Internal links |
Atlas Card | t(8;14)(q11;q32) |
Case Report | A case of pre-B ALL with t(8;14)(q11;q32). |
Case Report | A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia |
Bibliography |
Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia. |
Secker-Walker LM, Hawkins JM, Prentice HG, Mackie PH, Heerema NA, Provisor AJ |
Cancer genetics and cytogenetics. 1993 ; 70 (2) : 148-150. |
PMID 8242599 |
Down syndrome, acute lymphoblastic leukemia, and t(8;14)(q11;q32) |
Lee AC, Chan LC, Kwong KW |
Cancer genetics and cytogenetics. 1996 ; 88 (1) : page 92. |
PMID 8630990 |
t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. November 1999 |
Huret JL |
URL.. |
Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study. |
Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240. |
PMID 10673739 |
Relationship of chromosome 21 and acute leukemia in children with Down syndrome. |
Taub JW |
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. 2001 ; 23 (3) : 175-178. |
PMID 11305722 |
Citation |
This paper should be referenced as such : |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Reports/t814BalicekID100002.html |
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