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A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)
 
Written2001-06Petr Balicek, Jana Rabasova, Jiri Hak
Division of Medical Genetics, University Hospital, 500 05 Hradec Kralove, Czech Republic
Clinics
Age and sex : 17 year(s) old male patient.
Previous History : no preleukemia
no previous malignant disease
Organomegaly : no hepatomegaly ; no splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 32.9 x 109/L ; Hb : 7.7 g/dL ; platelets : 9 x 109/L; blasts : 90 % .
Cyto pathology classification
Cytology : ALL - L1
Immunophenotype : CD10 (CALLA) positive; CD66 positive
Precise diagnosis : Early pre-B ALL
Survival
Date of diagnosis: 04-2001
Treatment : Treated on protocol BFM 95 - medium risk group.
Complete remission was obtained
Comments : second cytogenetic examination: 47,XY,+21[70] - complete cytogenetic response.
Status : Dead
Survival : 1 month(s)
Karyotype
Sample : bone marrow ; culture time : 24 h ; banding : R
Results : 47,XY, der(14)t(8;14)(q11;q32),+21 "c" [17]/47,XY,+21 "c" [3]
der(14) t(8;14)(q11;q32) R- banding; the constitutional trisomy 21 is shown only on the bottom mitosis (left); chromosome 8 paint (right) - Petr Balicek, Jana Rabasova, Jiri Hak.
Call for collaboration
- Both bone marrow samples are stored: Bone marrow cell suspension, isolated RNA and DNA from the first examination you can get at address: Dr. Jan Trka - jan.trka@lfmotol.cuni.cz
- Isolated nucleic acids (both RNA and DNA) and cDNA from the second examination are available at the address below: Dr. Zdenek Fiedler - fiedler@lfhk.cuni.cz
Internal links
Atlas Cardt(8;14)(q11;q32)
Case ReportA case of pre-B ALL with t(8;14)(q11;q32).
Case ReportA new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia
Bibliography
Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia.
Secker-Walker LM, Hawkins JM, Prentice HG, Mackie PH, Heerema NA, Provisor AJ
Cancer genetics and cytogenetics. 1993 ; 70 (2) : 148-150.
PMID 8242599
 
Down syndrome, acute lymphoblastic leukemia, and t(8;14)(q11;q32)
Lee AC, Chan LC, Kwong KW
Cancer genetics and cytogenetics. 1996 ; 88 (1) : page 92.
PMID 8630990
 
t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. November 1999
Huret JL
URL..
 
Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.
Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240.
PMID 10673739
 
Relationship of chromosome 21 and acute leukemia in children with Down syndrome.
Taub JW
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. 2001 ; 23 (3) : 175-178.
PMID 11305722
 

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