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A case of pre-B ALL with t(8;14)(q11;q32)
Written2001-06Gitte Birk Kerndrup, Steen Rosthøj
Institute of Pathology-Chromosome Laboratory, Odense University Hospital, DK-5000 Odense C., Denmark and The Department of Paediatric Oncology, Aalborg Hospital, DK-8000 Aalborg, Denmark
Age and sex : 11 year(s) old male patient.
Previous History : no preleukemia
no previous malignant disease
no inborn condition of note
Organomegaly : hepatomegaly ; splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
WBC : 4.3 x 109/L ; Hb : 3.3 g/dL ; platelets : 16 x 109/L; blasts : 2 % .
Bone marrow : 99 blasts
Cyto pathology classification
Cytology : ALL-L1
Immunophenotype : CD19+/CD10+/Tdt+
Rearranged Ig Tcr : IgH: +, TCR: +
Precise diagnosis : pre-B ALL
Date of diagnosis: 08-2000
Complete remission was obtained
Status : Alive
Survival : 10 month(s)
Sample : Peripheral blood sample ; culture time : 24 h, culture ; banding : G-banding
Results : 49,XY,+X,t(8;14)(q11;q32),+12,+21[15]/46,XY[10]
t(8;14)(q11;q32) G- banding - Gitte Birk Kerndrup, Steen Rosthøj
This case, an eleven year old boy does not have Down syndrome or other inborn genetic conditions. His spleen and liver were remarkably enlarged (spleen: to the umbilical plane, liver: 4 fingers below the costal margin). He had no lymph node involvement, nor CNS- or testis disease. He did not, on flowcytometric immune phenotyping, show evidence of bilineage differentation. The phenotype was the usual for a pre-B ALL (CD10+/CD19+/Tdt+).
Internal links
Atlas Cardt(8;14)(q11;q32)
Case ReportA case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)
Case ReportA new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia
Huret JL
Atlas Genet Cytogenet Oncol Haematol..
Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.
Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240.
PMID 10673739
Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group.
Forestier E, Johansson B, Borgström G, Kerndrup G, Johansson J, Heim S
European journal of haematology. 2000 ; 64 (3) : 194-200.
PMID 10997886


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