Atlas of Genetics and Cytogenetics in Oncology and Haematology
| CASE REPORTS in HAEMATOLOGY |
| A case of pre-B ALL with t(8;14)(q11;q32) |
| Gitte Birk Kerndrup, Steen Rosthøj |
| Clinics |
| Age and sex : | 11 year(s) old male patient. |
| Previous History : | no preleukemia |
| no previous malignant disease | |
| no inborn condition of note | |
| Organomegaly : | hepatomegaly ; splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
| Blood |
| WBC : 4.3 x 109/l; Hb : 3.3 g/dl; platelets : 16 x 109/l; blasts : 2% |
| Bone marrow : 99% (blasts) |
| Cyto pathology classification |
| Cytology : ALL-L1 |
| Immunophenotype : CD19+/CD10+/Tdt+ |
| Rearranged Ig Tcr : IgH: +, TCR: + |
| Precise diagnosis : pre-B ALL |
| Survival |
| Date of diagnosis: 08-2000 |
| Complete remission was obtained |
| Status : Alive |
| Survival : 10 month(s) |
| Karyotype |
| Sample : Peripheral blood sample ; culture time : 24 h, culture ; banding : G-banding |
| Results : 49,XY,+X,t(8;14)(q11;q32),+12,+21[15]/46,XY[10] |
 |
| t(8;14)(q11;q32) G- banding - Gitte Birk Kerndrup, Steen Rosthøj |
| Comments |
| This case, an eleven year old boy does not have Down syndrome or other inborn genetic conditions. His spleen and liver were remarkably enlarged (spleen: to the umbilical plane, liver: 4 fingers below the costal margin). He had no lymph node involvement, nor CNS- or testis disease. He did not, on flowcytometric immune phenotyping, show evidence of bilineage differentation. The phenotype was the usual for a pre-B ALL (CD10+/CD19+/Tdt+). |
| Internal links |
| Atlas Card | t(8;14)(q11;q32) |
| Case Report | A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32) |
| Case Report | A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia |
| Bibliography |
| t(8;14)(q11;q32). |
| Huret JL |
| Atlas Genet Cytogenet Oncol Haematol.. |
| Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study. |
| Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240. |
| PMID 10673739 |
| Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group. |
| Forestier E, Johansson B, Borgstrm G, Kerndrup G, Johansson J, Heim S |
| European journal of haematology. 2000 ; 64 (3) : 194-200. |
| PMID 10997886 |
| Contributor(s) |
| Written | 06-2001 | Gitte Birk Kerndrup, Steen Rosthøj |
| Citation |
| This paper should be referenced as such : |
| Kerndrup GB, Rosthøj S . A case of pre-B ALL with t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. June 2001 . URL : http://AtlasGeneticsOncology.org/Reports/t814KerndrupID100001.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:09:55 2008 |
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