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CASE REPORTS in HAEMATOLOGY
A case of pre-B ALL with t(8;14)(q11;q32)
 
Written2001-06Gitte Birk Kerndrup, Steen Rosthøj
Institute of Pathology-Chromosome Laboratory, Odense University Hospital, DK-5000 Odense C., Denmark and The Department of Paediatric Oncology, Aalborg Hospital, DK-8000 Aalborg, Denmark
Clinics
Age and sex : 11 year(s) old male patient.
Previous History : no preleukemia
no previous malignant disease
no inborn condition of note
Organomegaly : hepatomegaly ; splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement
Blood
WBC : 4.3 x 109/L ; Hb : 3.3 g/dL ; platelets : 16 x 109/L; blasts : 2 % .
Bone marrow : 99 blasts
Cyto pathology classification
Cytology : ALL-L1
Immunophenotype : CD19+/CD10+/Tdt+
Rearranged Ig Tcr : IgH: +, TCR: +
Precise diagnosis : pre-B ALL
Survival
Date of diagnosis: 08-2000
Complete remission was obtained
Status : Alive
Survival : 10 month(s)
Karyotype
Sample : Peripheral blood sample ; culture time : 24 h, culture ; banding : G-banding
Results : 49,XY,+X,t(8;14)(q11;q32),+12,+21[15]/46,XY[10]
t(8;14)(q11;q32) G- banding - Gitte Birk Kerndrup, Steen Rosthøj
Comments
This case, an eleven year old boy does not have Down syndrome or other inborn genetic conditions. His spleen and liver were remarkably enlarged (spleen: to the umbilical plane, liver: 4 fingers below the costal margin). He had no lymph node involvement, nor CNS- or testis disease. He did not, on flowcytometric immune phenotyping, show evidence of bilineage differentation. The phenotype was the usual for a pre-B ALL (CD10+/CD19+/Tdt+).
Internal links
Atlas Cardt(8;14)(q11;q32)
Case ReportA case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)
Case ReportA new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia
Bibliography
t(8;14)(q11;q32).
Huret JL
Atlas Genet Cytogenet Oncol Haematol..
 
Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.
Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240.
PMID 10673739
 
Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group.
Forestier E, Johansson B, Borgström G, Kerndrup G, Johansson J, Heim S
European journal of haematology. 2000 ; 64 (3) : 194-200.
PMID 10997886
 

Citation

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