CASE REPORTS in HAEMATOLOGY |
A case of pre-B ALL with t(8;14)(q11;q32) |
Written | 2001-06 | Gitte Birk Kerndrup, Steen Rosthøj |
Institute of Pathology-Chromosome Laboratory, Odense University Hospital, DK-5000 Odense C., Denmark and The Department of Paediatric Oncology, Aalborg Hospital, DK-8000 Aalborg, Denmark |
Clinics |
Age and sex : | 11 year(s) old male patient. |
Previous History : | no preleukemia |
no previous malignant disease | |
no inborn condition of note |
Organomegaly : hepatomegaly ; splenomegaly ; no enlarged lymph nodes ; no central nervous system involvement |
Blood |
WBC : 4.3 x 109/L ; Hb : 3.3 g/dL ; platelets : 16 x 109/L; blasts : 2 % . |
Bone marrow : 99 blasts |
Cyto pathology classification |
Cytology : ALL-L1 |
Immunophenotype : CD19+/CD10+/Tdt+ |
Rearranged Ig Tcr : IgH: +, TCR: + |
Precise diagnosis : pre-B ALL |
Survival |
Date of diagnosis: 08-2000 |
Complete remission was obtained |
Status : Alive |
Survival : 10 month(s) |
Karyotype |
Sample : Peripheral blood sample ; culture time : 24 h, culture ; banding : G-banding |
Results : 49,XY,+X,t(8;14)(q11;q32),+12,+21[15]/46,XY[10] |
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t(8;14)(q11;q32) G- banding - Gitte Birk Kerndrup, Steen Rosthøj |
Comments |
This case, an eleven year old boy does not have Down syndrome or other inborn genetic conditions. His spleen and liver were remarkably enlarged (spleen: to the umbilical plane, liver: 4 fingers below the costal margin). He had no lymph node involvement, nor CNS- or testis disease. He did not, on flowcytometric immune phenotyping, show evidence of bilineage differentation. The phenotype was the usual for a pre-B ALL (CD10+/CD19+/Tdt+). |
Internal links |
Atlas Card | t(8;14)(q11;q32) |
Case Report | A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32) |
Case Report | A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia |
Bibliography |
t(8;14)(q11;q32). |
Huret JL |
Atlas Genet Cytogenet Oncol Haematol.. |
Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study. |
Kaleem Z, Shuster JJ, Carroll AJ, Borowitz MJ, Pullen DJ, Camitta BM, Zutter MM, Watson MS |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (2) : 238-240. |
PMID 10673739 |
Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group. |
Forestier E, Johansson B, Borgström G, Kerndrup G, Johansson J, Heim S |
European journal of haematology. 2000 ; 64 (3) : 194-200. |
PMID 10997886 |
Citation |
This paper should be referenced as such : |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Reports/t814KerndrupID100001.html |
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