Bone: Giant cell tumour

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Bone: Giant cell tumour

Written	2003-06	Ramses G Forsyth, Pancras CW Hogendoorn
		N. Goormaghtigh Institute of Pathology, 5 Blok A, University Hospital Ghent, B-9000 Ghent, Belgium

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Identity

ICD-Topo C400-C403,C408-C414,C418-C419 BONES & JOINTS

ICD-Morpho 9250/1 Giant cell tumour

Atlas_Id 5150

Phylum Bones::Giant cell tumor

Other names Osteoclastoma
Giant cell tumour of bone

A characteristic well-defined eccentric, lytic subchondral lesion involving the epiphysis and metaphysis. The borders are well defined and usually not sclerotic. Pathologic fracture is present in 5-10% of giant cell tumours. Dynamic MRI shows a fast uptake and a slow wash out of contrast.

Clinics and Pathology

Disease Locally destructive, benign and mono-ostotic tumoral lesion, typically presenting in the meta-epiphysis of long tubular bones with predilection for the knee region of skeletally mature patients (more than 95% of the patients is older than 25 years). Poly-ostotic lesions are exceptionally rare, counting for less than 1% of all cases. In these cases especially brown tumour of hyperparathyreoidism should be considered, which may look histologically identical. Although defined as a benign lesion, adjacent soft tissue invasion, angiovascular invasion and pulmonary metastases (1%) may occur.

Phenotype / cell stem origin Not yet determined.

Embryonic origin Mesoderm.

Etiology The exact origin is still unknown, but data obtained from ultrastructural analyses and cell cultures, suggest that the stromal cell, or mononuclear spindle cell, is neoplastic. The mononuclear rounded cells and the osteoclastic giant cells are seen as reactive. Therefore, some suggest that stromal cell tumour is a better name, because this fits more precisely the concept of the mononuclear spindled cell (stromal cell) as neoplastic.

Epidemiology This tumour represents 8% of all primary and approximately 20% of benign primary bone tumours. Mostly affecting adults in the third, fourth and fifth decade of life (72%). It is very rarely seen under the age of 10 years (1,3%). There is a slight female predominance (male/female ratio: 46,6%/53,4%).

Clinics Pain of several weeks to months duration and a constantly expanding mass on X-ray, primary in the epiphysis, leading to cortex destruction, pathological fracture and soft tissue invasion. Finally ulceration of the skin occurs if not threatened. A pathological fracture could occasionally be the first sign of this tumour.

Mixture of three cellular components composites the tumour: tumoral spindle shaped mononuclear cells, reactive rounded mononuclear cells and diffusely scattered osteoclast type giant cells. Note that mitoses are strictly limited to the first cell type.

Pathology A mixture of four components can be distinguished:
spindled-shaped and rounded mononuclear cells,
osteoclastic-type giant cells and small blood vessels.
The spindle-shaped mononuclear cells are regarded as neoplastic on results from electron microscopy and cell cultures. The origin of this cell type is still unknown, but it is thought to arise from the primitive mesenchymal stromal cell. Conventional mitotic figures are restricted to mononuclear cells. If atypical forms or strong nuclear atypia is noted, a secondary sarcomatous malignancy is almost always present. Secondary changes may be present like osteoid deposits, foci of fibrosis, collections of foamy cells or cystic degeneration. Secondary aneurysmal bone cyst formation is present in 6,5% of the cases. Mostly this is restricted to younger patients (median of 14 years) and low histological grade giant cell tumours.
As mentioned earlier, this tumour can histological be graded into 3 grades according to Jaffe (1940) or into 4 grades (Netherlands Committee on Bone Tumours). According to the latter grading system, grade 1 en 2 are considered as being benign, grade 3 as borderline malignant and grade 4 as malignant tumours. Grade 4 tumours show histological overlap with malignant fibrous hystiocytoma of bone. Although many authors are sceptic about grading giant cell tumours, this shows a good correlation with clinical outcome.
In that time no adjuvant chirurgical treatment, like cryosurgery or phenol additive was used. Nowadays the usefulness of grading in relation to recurrences is highly influenced by more effective surgical adjuvant techniques. According to literature still 20% of the giant cell tumours will recur, despite of these new surgical techniques. Together with the risk of developing pulmonal metastases, grading of giant cell tumours is in our view still valuable. In this grading system mitoses, pleiomorphism of the spindled mononuclear cells, giant cells and the individual size of the giant cells will be taken into account. Most important is the mitotic activity. When mitoses are occasional observed the risk of developing recurrences and pulmonal metastases is neglectable. If more than 1 mitosis is present per 1 high power field, patients are significantly at risk for developing recidives and pulmonal metastases (23%). Grade 2 tumours do have the highest prevalency (grade 1: 4%, grade 2: 88%, grade 3: 5%, grade 4: 3%).

Table : Grading of giant cell tumours according to the Netherlands Committee on Bone Tumors.

Treatment Surgical intervention is the only treatment of choice. Mostly a curettage followed by local adjuvant cryosurgery or phenol instillation is sufficient to eradicate this lesion and to save the joint. The use of polymethylmetacrylate for filling the cavity after curettage additively decreases the percentage of recurrences. An added advantage of using cement is that recurrences are detected sooner. Sometimes 'en bloc' resection is needed to be curative. Pulmonal metastases are treated by local excision.

Evolution Non-treatment always leads to destruction of cortical bone, to soft tissue invasion and finally to ulceration of the skin. Local recurrences can occur following proper treatment, mostly indicating less radical initial resection.

Prognosis Good, despite of recurrences and pulmonary metastases. In general much is depending on the surgical technique and expertise in combination with the histological grade of this tumour. Although pulmonary metastases may occur in rare cases, angiovascular invasion does not have any significant influence on its prognosis. The mortality rate due to giant cell tumour is about 4%.

Cytogenetics

Note No recurrent chromosomal structural or numeric aberrations of importance have been detected yet.
When confronted with a rearrangement, especially concerning 16q22 or 17p3, an associated aneurysmal bone cyst should be excluded.

Cytogenetics
Morphological The most frequent chromosomal anomaly is telomeric association. Comparing telomere length of giant cell tumours to this of leukocytes of the same patient, a reduction has been demonstrated. Most commonly affected telomeres are 11p, 13p, 14p, 15p, 19q, 20q and 21p.

Bibliography

Giant cell tumor of bone. Chromosomal analysis of 48 specimens and review of the literature.

Bridge JA, Neff JR, Mouron BJ

Cancer genetics and cytogenetics. 1992 ; 58 (1) : 2-13.

PMID 1728946

Giant cell tumor of bone: a clinicopathologic study of prognostic factors.

Masui F, Ushigome S, Fujii K

Pathology international. 1998 ; 48 (9) : 723-729.

PMID 9778111

Chromosomal anomalies exclusive of telomeric associations in giant cell tumor of bone.

McComb EN, Johansson SL, Neff JR, Nelson M, Bridge JA

Cancer genetics and cytogenetics. 1996 ; 88 (2) : 163-166.

PMID 8640728

Cytogenetics of fine needle aspiration biopsies of sarcomas.

Molenaar WM, van den Berg E, Dolfin AC, Zorgdrager H, Hoekstra HJ

Cancer genetics and cytogenetics. 1995 ; 84 (1) : 27-31.

PMID 7497439

Radiologic Atlas of Bone Tumors.

Mulder JD, Kroon HM, Schü HE, Taconis WK

Amsterdam. : page El.

Giant cell tumour

Reid R, Banerjee SS, Sciot R

Pathology and genetics of tumours of soft tissue and bone (WHO. 2002.

Clonality studies in giant cell tumor of bone.

Schwartz HS, Eskew JD, Butler MG

Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2002 ; 20 (2) : 387-390.

PMID 11918322

Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study group.

Sciot R, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Tallini G, Van den Berghe H, Vanni R, Willén H

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2000 ; 13 (11) : 1206-1210.

PMID 11106078

Giant-cell tumour of bone metastasising to the lungs. A long-term follow-up.

Siebenrock KA, Unni KK, Rock MG

The Journal of bone and joint surgery. British volume. 1998 ; 80 (1) : 43-47.

PMID 9460951

Cytogenetic study of 249 consecutive patients examined for a bone tumor.

Tarkkanen M, Kaipainen A, Karaharju E, Böhling T, Szymanska J, Heliö H, Kivioja A, Elomaa I, Knuutila S

Cancer genetics and cytogenetics. 1993 ; 68 (1) : 1-21.

PMID 8330278

Telomeric fusion is a major cytogenetic aberration of giant cell tumors of bone.

Zheng MH, Siu P, Papadimitriou JM, Wood DJ, Murch AR

Pathology. 1999 ; 31 (4) : 373-378.

PMID 10643009

Citation

This paper should be referenced as such :

Forsyth, RG ; Hogendoorn, PCW

Bone: Giant cell tumour

Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):193-196.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Tumors/BoneGiantCellTumID5150.html

Other genes implicated (Data extracted from papers in the Atlas) [ 4 ]

Genes BCL2L1 CPM EWSR1 THBS2

External links

arrayMap Topo ( C40,C41) arrayMap ((UZH-SIB Zurich) [auto + random 100 samples .. if exist ] [tabulated segments]

Disease database Bone: Giant cell tumour

REVIEW articles automatic search in PubMed

Last year articles automatic search in PubMed

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.

ICD-Topo	C400-C403,C408-C414,C418-C419 BONES & JOINTS
ICD-Morpho	9250/1 Giant cell tumour
Atlas_Id	5150
Phylum	Bones::Giant cell tumor

Other names	Osteoclastoma
	Giant cell tumour of bone


	A characteristic well-defined eccentric, lytic subchondral lesion involving the epiphysis and metaphysis. The borders are well defined and usually not sclerotic. Pathologic fracture is present in 5-10% of giant cell tumours. Dynamic MRI shows a fast uptake and a slow wash out of contrast.

Disease	Locally destructive, benign and mono-ostotic tumoral lesion, typically presenting in the meta-epiphysis of long tubular bones with predilection for the knee region of skeletally mature patients (more than 95% of the patients is older than 25 years). Poly-ostotic lesions are exceptionally rare, counting for less than 1% of all cases. In these cases especially brown tumour of hyperparathyreoidism should be considered, which may look histologically identical. Although defined as a benign lesion, adjacent soft tissue invasion, angiovascular invasion and pulmonary metastases (1%) may occur.
Phenotype / cell stem origin	Not yet determined.
Embryonic origin	Mesoderm.
Etiology	The exact origin is still unknown, but data obtained from ultrastructural analyses and cell cultures, suggest that the stromal cell, or mononuclear spindle cell, is neoplastic. The mononuclear rounded cells and the osteoclastic giant cells are seen as reactive. Therefore, some suggest that stromal cell tumour is a better name, because this fits more precisely the concept of the mononuclear spindled cell (stromal cell) as neoplastic.
Epidemiology	This tumour represents 8% of all primary and approximately 20% of benign primary bone tumours. Mostly affecting adults in the third, fourth and fifth decade of life (72%). It is very rarely seen under the age of 10 years (1,3%). There is a slight female predominance (male/female ratio: 46,6%/53,4%).
Clinics	Pain of several weeks to months duration and a constantly expanding mass on X-ray, primary in the epiphysis, leading to cortex destruction, pathological fracture and soft tissue invasion. Finally ulceration of the skin occurs if not threatened. A pathological fracture could occasionally be the first sign of this tumour.


	Mixture of three cellular components composites the tumour: tumoral spindle shaped mononuclear cells, reactive rounded mononuclear cells and diffusely scattered osteoclast type giant cells. Note that mitoses are strictly limited to the first cell type.

Pathology	A mixture of four components can be distinguished: spindled-shaped and rounded mononuclear cells, osteoclastic-type giant cells and small blood vessels. The spindle-shaped mononuclear cells are regarded as neoplastic on results from electron microscopy and cell cultures. The origin of this cell type is still unknown, but it is thought to arise from the primitive mesenchymal stromal cell. Conventional mitotic figures are restricted to mononuclear cells. If atypical forms or strong nuclear atypia is noted, a secondary sarcomatous malignancy is almost always present. Secondary changes may be present like osteoid deposits, foci of fibrosis, collections of foamy cells or cystic degeneration. Secondary aneurysmal bone cyst formation is present in 6,5% of the cases. Mostly this is restricted to younger patients (median of 14 years) and low histological grade giant cell tumours. As mentioned earlier, this tumour can histological be graded into 3 grades according to Jaffe (1940) or into 4 grades (Netherlands Committee on Bone Tumours). According to the latter grading system, grade 1 en 2 are considered as being benign, grade 3 as borderline malignant and grade 4 as malignant tumours. Grade 4 tumours show histological overlap with malignant fibrous hystiocytoma of bone. Although many authors are sceptic about grading giant cell tumours, this shows a good correlation with clinical outcome. In that time no adjuvant chirurgical treatment, like cryosurgery or phenol additive was used. Nowadays the usefulness of grading in relation to recurrences is highly influenced by more effective surgical adjuvant techniques. According to literature still 20% of the giant cell tumours will recur, despite of these new surgical techniques. Together with the risk of developing pulmonal metastases, grading of giant cell tumours is in our view still valuable. In this grading system mitoses, pleiomorphism of the spindled mononuclear cells, giant cells and the individual size of the giant cells will be taken into account. Most important is the mitotic activity. When mitoses are occasional observed the risk of developing recurrences and pulmonal metastases is neglectable. If more than 1 mitosis is present per 1 high power field, patients are significantly at risk for developing recidives and pulmonal metastases (23%). Grade 2 tumours do have the highest prevalency (grade 1: 4%, grade 2: 88%, grade 3: 5%, grade 4: 3%).


	Table : Grading of giant cell tumours according to the Netherlands Committee on Bone Tumors.

Treatment	Surgical intervention is the only treatment of choice. Mostly a curettage followed by local adjuvant cryosurgery or phenol instillation is sufficient to eradicate this lesion and to save the joint. The use of polymethylmetacrylate for filling the cavity after curettage additively decreases the percentage of recurrences. An added advantage of using cement is that recurrences are detected sooner. Sometimes 'en bloc' resection is needed to be curative. Pulmonal metastases are treated by local excision.
Evolution	Non-treatment always leads to destruction of cortical bone, to soft tissue invasion and finally to ulceration of the skin. Local recurrences can occur following proper treatment, mostly indicating less radical initial resection.
Prognosis	Good, despite of recurrences and pulmonary metastases. In general much is depending on the surgical technique and expertise in combination with the histological grade of this tumour. Although pulmonary metastases may occur in rare cases, angiovascular invasion does not have any significant influence on its prognosis. The mortality rate due to giant cell tumour is about 4%.

Note	No recurrent chromosomal structural or numeric aberrations of importance have been detected yet. When confronted with a rearrangement, especially concerning 16q22 or 17p3, an associated aneurysmal bone cyst should be excluded.
Cytogenetics Morphological	The most frequent chromosomal anomaly is telomeric association. Comparing telomere length of giant cell tumours to this of leukocytes of the same patient, a reduction has been demonstrated. Most commonly affected telomeres are 11p, 13p, 14p, 15p, 19q, 20q and 21p.

arrayMap	Topo ( C40,C41) arrayMap ((UZH-SIB Zurich) [auto + random 100 samples .. if exist ] [tabulated segments]


Disease database	Bone: Giant cell tumour

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed