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Kidney: Chromophobe renal cell carcinoma

Identity

ICD-Topo C649
ICD-Morpho 8317/3
Phylum Urinary system:Kidney:Adult:Renal cell carcinoma:Chromophobe renal cell carcinoma:

Classification

    Chromophobe renal cell carcinoma (ChRCC) is a distinct subtype of renal cell carcinoma, possibly originating from the intercalated cells of the collecting tubules, as oncocytoma .

Clinics and Pathology

Epidemiology It comprises approximately 5% of all renal tumors.
Pathology
  • Large polygonal cells with pale, flocculent cytoplasm and very distinct plasmalemmal outlines. The cells are arranged in solid nests or tubules. Ultrastructurally, the flocculence of the cytoplasm has been found to be due to large numbers of minute vesicles. Hale's colloid iron histochemical characteristically colors the cytoplasm diffusely blue. Although two histological variants are recognized, a typical and an eosinophilic one (increased numbers of mitochondria), both cell types may occur in the same tumor.
  • Rare example of composite oncocytoma/chromophobe RCC tumors have been described leading, to the hypothesis that the two types of tumors may be related. Recently, immunohistochemical staining for the RCC antigen and CD10 has been proposed as a possiblly useful adjunct in the differential diagnoses of chromophobe RCC vs clear cell type RCC and chromophobe RCC vs oncocytoma. There is evidence that chromophobe RCCs are less likely to behave aggressively than otherwise similar clear cell type RCCs.
  • Cytogenetics

    Cytogenetics
    Morphological
    Chromophobe RCCs generally have a tendency to grow very slowly in vitro in comparison to all other type of renal tumors. This may be a reason why cytogenetic reports are scarce and usually few metaphases of poor quality were available for investigation. A low chromosome number ranging between 32-39, without discernable structural changes was the most frequent cytogenetic finding. Chromosomes 1, 2, 6, 10, 13, 17 and 21 were most frequently lost. Additional structural aberrations have been described. Endoreduplication of the cells with hypodiploid karyotype has been observed. It is of interest, the presence of an hypodiploid clone can be disclosed by a DNA index of 0.86. The low chromosome number has been confirmed by other techniques such as flow cytometry, comparative genomic hybridization (CGH), restriction fragment length polymorphism (RFLP) analysis, and polymorphic microsatellite markers.

    Other genes implicated (Data extracted from papers in the Atlas)

    Genes FLCN LRIG1 MIR141 MIR200C NR3C2 PRSS8

    Translocations implicated (Data extracted from papers in the Atlas)

    External links

    Mitelman database
    COSMICHisto = - Site = kidney (COSMIC)
    arrayMapTopo ( C64) Morph ( 8317/3) - arrayMap (Zurich)
    Other databasecBioPortal: Kidney Chromophobe (TCGA, Provisional)

    Bibliography

    Binucleated cells in a human renal cell carcinoma with 34 chromosomes.
    Kovacs G, Soudah B, Hoene E
    Cancer genetics and cytogenetics. 1988 ; 31 (2) : 211-215.
    PMID 3349439
     
    The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct.
    Strkel S, Steart PV, Drenckhahn D, Thoenes W
    Virchows Archiv. B, Cell pathology including molecular pathology. 1989 ; 56 (4) : 237-245.
    PMID 2565618
     
    Chromophobe cell carcinoma: analysis of five cases.
    Bonsib SM, Lager DJ
    The American journal of surgical pathology. 1990 ; 14 (3) : 260-267.
    PMID 2305931
     
    Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma. Evidence that -Y, -1 may be a characteristic anomaly in renal oncocytomas.
    Crotty TB, Lawrence KM, Moertel CA, Bartelt DH Jr, Batts KP, Dewald GW, Farrow GM, Jenkins RB
    Cancer genetics and cytogenetics. 1992 ; 61 (1) : 61-66.
    PMID 1638482
     
    Low chromosome number in chromophobe renal cell carcinomas.
    Kovacs A, Kovacs G
    Genes, chromosomes & cancer. 1992 ; 4 (3) : 267-268.
    PMID 1382570
     
    Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.
    Speicher MR, Schoell B, du Manoir S, Schrck E, Ried T, Cremer T, Strkel S, Kovacs A, Kovacs G
    The American journal of pathology. 1994 ; 145 (2) : 356-364.
    PMID 7519827
     
    Chromophobe cell carcinoma of the kidney. A clinicopathologic study of 21 cases.
    Akhtar M, Kardar H, Linjawi T, McClintock J, Ali MA
    The American journal of surgical pathology. 1995 ; 19 (11) : 1245-1256.
    PMID 7573686
     
    Chromophobe cell renal carcinoma: clinicopathological features of 50 cases.
    Crotty TB, Farrow GM, Lieber MM
    The Journal of urology. 1995 ; 154 (3) : 964-967.
    PMID 7637102
     
    Establishment and characterization of two divergent cell lines derived from a human chromophobe renal cell carcinoma.
    Gerharz CD, Moll R, Strkel S, Ramp U, Hildebrandt B, Molsberger G, Koldovsky P, Gabbert HE
    The American journal of pathology. 1995 ; 146 (4) : 953-962.
    PMID 7717462
     
    Cytogenetic findings in renal cell carcinoma.
    Iqbal MA, Akhtar M, Ali MA
    Human pathology. 1996 ; 27 (9) : 949-954.
    PMID 8816891
     
    Chromophobe renal cell carcinoma. Pathologic, ultrastructural, immunohistochemical, cytofluorometric and cytogenetic findings.
    Morell-Quadreny L, Gregori-Romero M, Llombart-Bosch A
    Pathology, research and practice. 1996 ; 192 (12) : 1275-1281.
    PMID 9182300
     
    Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma.
    Schwerdtle RF, Strkel S, Neuhaus C, Brauch H, Weidt E, Brenner W, Hohenfellner R, Huber C, Decker HJ
    Cancer research. 1996 ; 56 (13) : 2927-2930.
    PMID 8674042
     
    Histopathology and classification of renal cell tumors (adenomas, oncocytoma and carcinomas). The basic cytological and histopathological elements and their use for diagnostics.
    Thoenes W, StǬrkel S, Rumpelt HJ
    Path Res Pract. 1996.
     
    Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas.
    Bugert P, Gaul C, Weber K, Herbers J, Akhtar M, Ljungberg B, Kovacs G
    Laboratory investigation; a journal of technical methods and pathology. 1997 ; 76 (2) : 203-208.
    PMID 9042156
     
    Diagnosis of chromophobe renal cell carcinoma by chromosomal analysis.
    Marras S, Faa G, Scarpa R, Valdes E, Vanni R
    Tumori. 1997 ; 83 (4) : 753-755.
    PMID 9349316
     
    Chromosome changes in a metastasis of a chromophobe renal cell tumor.
    Dijkhuizen T, van den Berg E, Strkel S, de Jong B
    Cancer genetics and cytogenetics. 1998 ; 105 (1) : 86-89.
    PMID 9689937
     
    Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining.
    Tickoo SK, Amin MB, Zarbo RJ
    The American journal of surgical pathology. 1998 ; 22 (4) : 419-424.
    PMID 9537468
     
    Multitechnical pathological diagnosis in chromophobe renal cell carcinoma.
    Balzarini P, Grigolato P, Tardanico R, Cadei M, Cunico SC, Cozzoli A, Zanotelli T, van den Berghe H, Dal Cin P
    Oncology reports. 1999 ; 6 (2) : 295-299.
    PMID 10022992
     
    Renal oncocytosis: a morphologic study of fourteen cases.
    Tickoo SK, Reuter VE, Amin MB, Srigley JR, Epstein JI, Min KW, Rubin MA, Ro JY
    The American journal of surgical pathology. 1999 ; 23 (9) : 1094-1101.
    PMID 10478670
     
    Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms.
    Avery AK, Beckstead J, Renshaw AA, Corless CL
    The American journal of surgical pathology. 2000 ; 24 (2) : 203-210.
    PMID 10680888
     
    FISH analysis in chromophobe renal-cell carcinoma.
    Iqbal MA, Akhtar M, Ulmer C, Al-Dayel F, Paterson MC
    Diagnostic cytopathology. 2000 ; 22 (1) : 3-6.
    PMID 10613963
     
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    Contributor(s)

    Written10-2001Paola Dal Cin

    Citation

    This paper should be referenced as such :
    Dal, Cin P
    Kidney: Chromophobe renal cell carcinoma
    Atlas Genet Cytogenet Oncol Haematol. 2002;6(1):47-48.
    Free online version   Free pdf version   [Bibliographic record ]
    URL : http://AtlasGeneticsOncology.org/Tumors/ChromophobeRenalID5124.html

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    indexed on : Tue Sep 23 17:33:37 CEST 2014


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