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Skin: Clear cell hidradenoma

Written2006-05Afrouz Behboudi, Gâran Stenman
Department of Clinical Genetics, Institute of Biomedicine, Gâteborg University, Box 440, 405 30 Gâteborg, Sweden

(Note : for Links provided by Atlas : click)


ICD-Topo C440-C449 SKIN
ICD-Morpho 8402/0 Hidradenoma
Atlas_Id 5419
Phylum Lung, Heart, Skin, Other::Hidradenoma
WHO/OMS Classification Lung, Heart, Skin, Other
Other namesNodular Hidradenomas
Eccrine Acrospiromas
Morphology of a CCH with typical clear cells, squamous differentiation, and ductal structures (inset).
Reprinted partially from Publication "Genes Chromosomes Cancer;43(2), Behboudi A., Winnes M., Gorunova L., van den Oord J.J., Mertens F., Enlund F., Stenman G. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion, 202-205, Copyright (2005), with permission from John Wiley and Sons Inc."

Clinics and Pathology

Disease Clear Cell Hidradenomas of the skin (CCH) are benign sweat gland tumors of eccrine duct origin often presenting as solitary, intradermal nodules. They are usually circumscribed, nonencapsulated tumors composed of polyhedral or fusiform cells with clear or eosinophilic cytoplasm. In some tumors, epidermoid differentiation may also be encountered. CCHs rarely undergo malignant transformation.


Cytogenetics Molecular t(11;19)(q21;p13) translocation

Genes involved and Proteins

Gene NameCRTC1 (CREB regulated transcription coactivator 1)
Location 19p13.11
Note Alias: MECT1, WAMTP1, TORC1
Dna / Rna DNA: spans about 94 kb and includes 14 to 16 exons. RNA: two variants of 2342 bp and 2505 bp in size.
Protein 634 amino acids; 67300 Da

Gene NameMAML2 (mastermind-like 2)
Location 11q21
Dna / Rna DNA: spans about 365 kb and includes 5 exons. RNA: a major transcript of 7.5 kb.
Protein 1153 aa, 125000 Da; conserved N-terminal basic domain (aa 29-92) which binds to the ankyrin repeat domain of Notch receptors; two acidic domains (aa 263-360 and 1124-1153) and a C-terminal transcriptional activation domain.

Result of the chromosomal anomaly

Hybrid Gene
Nucleotide and deduced amino acid sequences of the CRTC1-MAML2 breakpoint junction. The MAML2 exon 2 sequence is shown in bold.
Reprinted partially from Publication "Exp Cell Res 292, Enlund F., Behboudi A., Andren Y., Oberg C., Lendahl U., Mark J., Stenman G., Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors, 21-28, Copyright (2004), with permission from Elsevier.
Detection 1- RT-PCR using total RNA from frozen tumor tissue or paraffin-embedded tumor tissue: amplification of the CRTC1-MAML2 fusion transcript by nested RT-PCR using the first-round primers CRTC1, 5'-AGGAGGTGGAGGAGGAGGAG-3', and MAML2, 5'-TGTTGGCAGGAGATAGGTTAACTACCTG-3' (product size 221 bp), and the second-round primers CRTC1, 5'-GAGAAGATCGCGCTGCAC-3', and MAML2, 5'-GTTAACTACCTGTTTTCTTTTCAAGG-3' (product size 127 bp). 2- Dual-color FISH on metaphase chromosomes: The CRTC1­MAML2 fusion gene may be detected by dual-color FISH, using BAC RP11-697H10 (MAML2) and cosmid LLNLR-255A4 (MECT1) as probes.
Fusion Protein
Description Schematic representation of the MAML2 protein and the CRTC1-MAML2 fusion protein.
Reprinted partially from Publication "Exp Cell Res 292, see above.
Expression Localisation Nucleus


Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G
Genes, chromosomes & cancer. 2005 ; 43 (2) : 202-205.
PMID 15729701
Histological typing of skin tumors.
Heenan PJ, Elder DE, Sobin LH
World Health Organization International Histological Classification of Tumours. 1996 february.
Skin pathology.
Weedon D
nd ed. 2002 february.


This paper should be referenced as such :
Behboudi, A ; Stenman, G
Skin: Clear cell hidradenoma of the skin (CCH)
Atlas Genet Cytogenet Oncol Haematol. 2006;10(4):285-287.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 3 ]


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;19)(q21;p13) CRTC1/MAML2

External links

Mitelman database t(11;19)(q21;p13) [CaseList]     t(11;19)(q21;p13) [Transloc - MCList]   CRTC1/MAML2 Fusion - MCList]
arrayMap Topo ( C44) arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Mitelman databaseCRTC1/MAML2[MCList]    CRTC1 (19p13.11) MAML2 (11q21)   t(11;19)(q21;p13)
TICdbCRTC1/MAML2    CRTC1 (19p13.11) MAML2 (11q21)
Disease databaseSkin: Clear cell hidradenoma
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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