Nervous system: Medulloblastoma

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

Nervous system: Medulloblastoma

Written	2000-07	Anne Marie Capodano
		Laboratoire de Cytogénétique Oncologique, Hpital de la Timone, 264 rue Saint Pierre, 13005 Marseille, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C710-C714,C717-C719,C720-C725,C716 BRAIN, & CRANIAL NERVES, & SPINAL CORD, (EXCL. VENTRICLE, CEREBELLUM) / CEREBELLUM

ICD-Morpho 9470/3 Medulloblastoma, NOS

Atlas_Id 5065

Phylum Central Nervous system::Medulloblastoma

Clinics and Pathology

Disease Medulloblastomas are malignant invasive embryonal tumours of the cerebellum with a tendency to metastasize in the central nervous system (CNS). This tumor is more frequently found in children.

Epidemiology It represents 10 at 20 % of brain tumours and 30 % of tumours localized in posterior fossa; annual incidence is 0,5 per 100 000 children; peak of occurrence at 7 years.

Histological features of a typical medulloblastoma: Homer-Wright rosettes - Anne Marie Capodano.

Pathology Belongs to the primitive neurectodermal tumours (PNET): highly malignant embryonal tumours of the CNS with predominant neuronal differentiation.
Several variants medulloblastoma are recognized in the OMS classification :
Classic medulloblastoma composed of densely jacked round-cells with round to oval hyperchromatic nuclei.
Desmoplastic medulloblastoma represents a variant with abundant reticulin and collagen.
Large cell medulloblastoma is a rare variant composed of cells with large round nuclei.
Immuno histo chemistry : Classic medulloblastoma is strongly immuno-reactive for Vimentin. Some tumours are immunoreactive for NSE, Synaptophysine and GSAP.

Treatment The treatment associates total surgical resection and radiotherapy or, according to the age, chemotherapy.

Prognosis Survival without recurrence is 50 at 70 %; depends on the quality of surgical resection and on the presence of metastases at the time of diagnosis.

Cytogenetics

Cytogenetics
Morphological
The most common specific abnormality in medulloblastomas, which is present in approximately 50 % of cases, is isochromosome 17q [i(17q)]. The breakpoint is in the proximal portion of p-arm at 17p11.2, so that the resultant structure is dicentric. In a few cases, partial or complete loss of 17p occurs through interstitial deletion, unbalanced translocation or monosomy 17.
Chromosome 1 is also involved in medulloblastomas. The most frequent abnormalities are unbalanced translocations, deletions and duplications. Rearrangements of chromosome 1 often result in trisomy 1q without loss of the p-arm.
Others less common chromosomal changes are: deletions of 6q, 9q, 10q, 11q, 11p and 16q, monosomy 22 and in rare cases double minutes.

i(17q) - R-banding.

Cytogenetics Molecular
Isochromosome 17 q has been observed in interphase nuclei using fluorescence in situ hybridization. This technique is used in particular when only a few metaphases are obtained or when only normal diploid cells are obtained in culture.

Genes involved and Proteins

Note
Studies on loss of heterozygosity (LOH) have confirmed loss of portions of 17p in 30-45 % of cases. Some studies showed a correlation between LOH for 17p and a poor response to therapy and shortened survival. Mutations of p53 gene located on 17p13 have been found in only 5-10 % of these tumors.
Expression of PAX5 and PAX6 mRNA was shown in 70 % of medulloblastomas. The precise mechanism by which these genes are involved remains unknown.
Inactivation of PTCH tumor suppressor gene occurs in a subset of medulloblastomas.

Bibliography

Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system.

Biegel JA, Rorke LB, Packer RJ, Sutton LN, Schut L, Bonner K, Emanuel BS

Genes, chromosomes & cancer. 1989 ; 1 (2) : 139-147.

PMID 2487154

Structural chromosomal abnormalities in human medulloblastoma.

Bigner SH, Mark J, Friedman HS, Biegel JA, Bigner DD

Cancer genetics and cytogenetics. 1988 ; 30 (1) : 91-101.

PMID 3422050

Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma.

Bigner SH, Vogelstein B

Brain pathology (Zurich, Switzerland). 1990 ; 1 (1) : 12-18.

PMID 1669688

Differentiation in the medulloblastoma. A histological and immunohistochemical study.

Burger PC, Grahmann FC, Bliestle A, Kleihues P

Acta neuropathologica. 1987 ; 73 (2) : 115-123.

PMID 3604579

Deletion mapping of the medulloblastoma locus on chromosome 17p.

Cogen PH, Daneshvar L, Metzger AK, Edwards MS

Genomics. 1990 ; 8 (2) : 279-285.

PMID 1979050

Desmoplastic versus classic medulloblastoma: comparison of DNA content, histopathology and differentiation.

Giangaspero F, Chieco P, Ceccarelli C, Lisignoli G, Pozzuoli R, Gambacorta M, Rossi G, Burger PC

Virchows Archiv. A, Pathological anatomy and histopathology. 1991 ; 418 (3) : 207-214.

PMID 1900966

Molecular genetic studies of chromosome 11 and chromosome 22q DNA sequences in pediatric medulloblastomas.

Lescop S, Lellouch-Tubiana A, Vassal G, Besnard-Guerin C

Journal of neuro-oncology. 1999 ; 44 (2) : 119-127.

PMID 10619495

Diagnostic markers in paediatric medulloblastoma: a Paediatric Oncology Group Study.

McLendon RE, Friedman HS, Fuchs HE, Kun LE, Bigner SH

Histopathology. 1999 ; 34 (2) : 154-162.

PMID 10064395

Detection of an i(17q) chromosome by fluorescent in situ hybridization with a chromosome 17 alpha satellite DNA probe.

Nakagawa H, Inazawa J, Misawa S, Tanaka S, Takashima T, Taniwaki M, Abe T, Kashima K

Cancer genetics and cytogenetics. 1992 ; 62 (2) : 140-143.

PMID 1394099

Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.

Reardon DA, Michalkiewicz E, Boyett JM, Sublett JE, Entrekin RE, Ragsdale ST, Valentine MB, Behm FG, Li H, Heideman RL, Kun LE, Shapiro DN, Look AT

Cancer research. 1997 ; 57 (18) : 4042-4047.

PMID 9307291

Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma.

Vagner-Capodano AM, Zattara-Cannoni H, Gambarelli D, Gentet JC, Genitori L, Lena G, Graziani N, Raybaud C, Choux M, Grisoli F

Cancer genetics and cytogenetics. 1994 ; 78 (1) : 1-6.

PMID 7987794

Detection of 1q polysomy in interphase nuclei of human solid tumors with a biotinylated probe.

Viegas-Péquignot E, Jeanpierre M, Dutrillaux AM, Gerbault-Seureau M, Muleris M, Dutrillaux B

Human genetics. 1989 ; 81 (4) : 311-314.

PMID 2539324

Citation

This paper should be referenced as such :

Capodano, AM

Nervous system tumors: Medulloblastoma

Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):147-148.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Tumors/MedulloblastomaID5065.html

Other genes implicated (Data extracted from papers in the Atlas) [ 46 ]

Genes ADCYAP1 AXIN1 BAP1 BMP4 BRCA2 CASP8 CCNB1 CD44 COL1A2 CTNNB1
ERBB2 FOXF1 FZD4 GPC3 HGF HIC1 ILK IRS1 ITGA9 MAPRE1
MIR135A1 MIR7-1 MYBBP1A MYC NKX2-1 MYCN NOTCH2 NTRK3 OTX2 PALB2
PAX2 PIWIL2 PRAME PTCH2 PTCH1 PTCH1 REST SGK1 SHH SIRT1
SLIT2 SOX11 SOX4 STAG2 STMN1 UBE2C

External links

arrayMap Topo ( C71,C72) arrayMap ((UZH-SIB Zurich) [auto + random 100 samples .. if exist ] [tabulated segments]

Other database Tumor Portal - Broad Institute

Other database cBioPortal: Medulloblastoma (Broad, Nature 2012)

Other database cBioPortal: Medulloblastoma (ICGC, Nature 2012)

Other database cBioPortal: Medulloblastoma (PCGP, Nature 2012)

Other database Medulloblastoma ( intOGen )

Other database Medulloblastoma ( intOGen )

Disease database Nervous system: Medulloblastoma

REVIEW articles automatic search in PubMed

Last year articles automatic search in PubMed

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.

ICD-Topo	C710-C714,C717-C719,C720-C725,C716 BRAIN, & CRANIAL NERVES, & SPINAL CORD, (EXCL. VENTRICLE, CEREBELLUM) / CEREBELLUM
ICD-Morpho	9470/3 Medulloblastoma, NOS
Atlas_Id	5065
Phylum	Central Nervous system::Medulloblastoma

Disease	Medulloblastomas are malignant invasive embryonal tumours of the cerebellum with a tendency to metastasize in the central nervous system (CNS). This tumor is more frequently found in children.
Epidemiology	It represents 10 at 20 % of brain tumours and 30 % of tumours localized in posterior fossa; annual incidence is 0,5 per 100 000 children; peak of occurrence at 7 years.


	Histological features of a typical medulloblastoma: Homer-Wright rosettes - Anne Marie Capodano.

Pathology	Belongs to the primitive neurectodermal tumours (PNET): highly malignant embryonal tumours of the CNS with predominant neuronal differentiation. Several variants medulloblastoma are recognized in the OMS classification : Classic medulloblastoma composed of densely jacked round-cells with round to oval hyperchromatic nuclei. Desmoplastic medulloblastoma represents a variant with abundant reticulin and collagen. Large cell medulloblastoma is a rare variant composed of cells with large round nuclei. Immuno histo chemistry : Classic medulloblastoma is strongly immuno-reactive for Vimentin. Some tumours are immunoreactive for NSE, Synaptophysine and GSAP.
Treatment	The treatment associates total surgical resection and radiotherapy or, according to the age, chemotherapy.
Prognosis	Survival without recurrence is 50 at 70 %; depends on the quality of surgical resection and on the presence of metastases at the time of diagnosis.

Cytogenetics Morphological	The most common specific abnormality in medulloblastomas, which is present in approximately 50 % of cases, is isochromosome 17q [i(17q)]. The breakpoint is in the proximal portion of p-arm at 17p11.2, so that the resultant structure is dicentric. In a few cases, partial or complete loss of 17p occurs through interstitial deletion, unbalanced translocation or monosomy 17. Chromosome 1 is also involved in medulloblastomas. The most frequent abnormalities are unbalanced translocations, deletions and duplications. Rearrangements of chromosome 1 often result in trisomy 1q without loss of the p-arm. Others less common chromosomal changes are: deletions of 6q, 9q, 10q, 11q, 11p and 16q, monosomy 22 and in rare cases double minutes.


	i(17q) - R-banding.

Cytogenetics Molecular	Isochromosome 17 q has been observed in interphase nuclei using fluorescence in situ hybridization. This technique is used in particular when only a few metaphases are obtained or when only normal diploid cells are obtained in culture.

Genes	ADCYAP1	AXIN1	BAP1	BMP4	BRCA2	CASP8	CCNB1	CD44	COL1A2	CTNNB1
	ERBB2	FOXF1	FZD4	GPC3	HGF	HIC1	ILK	IRS1	ITGA9	MAPRE1
	MIR135A1	MIR7-1	MYBBP1A	MYC	NKX2-1	MYCN	NOTCH2	NTRK3	OTX2	PALB2
	PAX2	PIWIL2	PRAME	PTCH2	PTCH1	PTCH1	REST	SGK1	SHH	SIRT1
	SLIT2	SOX11	SOX4	STAG2	STMN1	UBE2C

arrayMap	Topo ( C71,C72) arrayMap ((UZH-SIB Zurich) [auto + random 100 samples .. if exist ] [tabulated segments]


Other database	Tumor Portal - Broad Institute
Other database	cBioPortal: Medulloblastoma (Broad, Nature 2012)
Other database	cBioPortal: Medulloblastoma (ICGC, Nature 2012)
Other database	cBioPortal: Medulloblastoma (PCGP, Nature 2012)
Other database	Medulloblastoma ( intOGen )
Other database	Medulloblastoma ( intOGen )
Disease database	Nervous system: Medulloblastoma

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed