| Note | To date there are no cytogenetic data on soft tissue myoepithelioma as such except for one case: the stemline is described as 82,XXYY,+Y,-1,add(1)(p13),-3,del(3)(p21),-4,del(4)(q27q31),del(5)(q11q34),-6,-6,add(7)(p21), der(9)t(1;9)(q25;p22) or (q31;p23)x2,+der(9)t(9;9)(p13;q22),-10,-11,-13,-14,-18,-21,-22[4] and the sideline as 86,idem,+7,+8,+9,-der(9)t(9;9),+15,i(20)(q10),+21,add(22)(p1)[4].
This case shares some cytogenetic aberrations described in pleiomorphic adenomas of the salivary gland and basal cell (myoepithelial) adenocarcinoma of the lung especially rearrangements of chromosome 1 and 9 and some numerical chromosomal aberrations mentioned in chordomas, especially losses of chromosomes 3, 4, and to al lesser extent, 10 and 13.
These cytogenetic aberrations seem unrelated to previously reported chromosome changes usually seen in closely related entities like parachordoma and intramuscular mixed tumor in which cases mostly loss of material from the short arm of chromosome 17 was detected. It might be that soft tissue myoepithelioma is a distinct entity with some resemblance to (para)-chordoma on the one hand and myoepithelioma on the other.
It was recently observed that benign human myoepithelial tumors of diverse sources exhibit common mRNA expression profiles indicative of a tumor-suppressor phenotype. |
| Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotype. |
| Barsky SH |
| Experimental and molecular pathology. 2003 ; 74 (2) : 113-122. |
| PMID 12710942 |
| |
| Basal cell (myoepithelial) adenocarcinoma of the lung. First case with cytogenetic findings. |
| Damiani S, Magrini E, Farnedi A, Pession A |
| Histopathology. 2004 ; 45 (4) : 422-424. |
| PMID 15469487 |
| |
| Parachordoma exists--but what is it? |
| Fisher C |
| Advances in anatomic pathology. 2000 ; 7 (3) : 141-148. |
| PMID 10809219 |
| |
| Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma. |
| Folpe AL, Agoff SN, Willis J, Weiss SW |
| The American journal of surgical pathology. 1999 ; 23 (9) : 1059-1067. |
| PMID 10478665 |
| |
| Tumours of uncertain differentiation: Mixed tumour/Myoepithelioma/Parachordoma. |
| Kilpatrick SE, Limon J |
| In.. |
| |
| Parachordoma: a rare sarcoma with clonal chromosomal changes. |
| Limon J, Babińska M, Denis A, Ryś J, Niezabitowski A |
| Cancer genetics and cytogenetics. 1998 ; 102 (1) : 78-80. |
| PMID 9530345 |
| |
| Clonal chromosome aberrations in three sacral chordomas. |
| Mertens F, Kreicbergs A, Rydholm A, Willén H, Carlén B, Mitelman F, Mandahl N |
| Cancer genetics and cytogenetics. 1994 ; 73 (2) : 147-151. |
| PMID 8174090 |
| |
| Intramuscular mixed tumour with clonal chromosomal changes. |
| Pauwels P, Dal Cin P, Roumen R, van den Berghe H, Sciot R |
| Virchows Archiv : an international journal of pathology. 1999 ; 434 (2) : 167-171. |
| PMID 10071252 |
| |
| Cytogenetic analysis of a parachordoma. |
| Tihy F, Scott P, Russo P, Champagne M, Tabet JC, Lemieux N |
| Cancer genetics and cytogenetics. 1998 ; 105 (1) : 14-19. |
| PMID 9689924 |
| |
| Cytogenetic analysis of a primary salivary gland myoepithelioma. |
| el-Naggar AK, Lovell M, Callender DL, Ordonez NG, Killary AM |
| Cancer genetics and cytogenetics. 1999 ; 113 (1) : 49-53. |
| PMID 10459346 |
| |
| Cytogenetics of a soft tissue malignant myoepithelioma. |
| van den Berg E, Zorgdrager H, Hoekstra HJ, Suurmeijer AJ |
| Cancer genetics and cytogenetics. 2004 ; 151 (1) : 87-89. |
| PMID 15120917 |
| |
