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inv(10)(p11q11) KIF5B/RET

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 6940
Phylum Lung::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

Clinics and Pathology

Disease Lung:Lung, Heart, Skin, Other: Lung: Non-small cell carcinoma: Squamous cell carcinoma: inv(10)(p11q11) KIF5B/RET

Genes involved and Proteins

Gene NameKIF5B
Location 10p11.22

Gene NameRET
Location 10q11.21

Bibliography

A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
Ju YS, Lee WC, Shin JY, Lee S, Bleazard T, Won JK, Kim YT, Kim JI, Kang JH, Seo JS
Genome Res 2012 Mar;22(3):436-45
PMID 22194472
 
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
Lipson D, Capelletti M, Yelensky R, Otto G, Parker A, Jarosz M, Curran JA, Balasubramanian S, Bloom T, Brennan KW, Donahue A, Downing SR, Frampton GM, Garcia L, Juhn F, Mitchell KC, White E, White J, Zwirko Z, Peretz T, Nechushtan H, Soussan-Gutman L, Kim J, Sasaki H, Kim HR, Park SI, Ercan D, Sheehan CE, Ross JS, Cronin MT, Jänne PA, Stephens PJ
Nat Med 2012 Feb 12;18(3):382-4
PMID 22327622
 
RET, ROS1 and ALK fusions in lung cancer
Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, Lim Choi Y, Satoh Y, Okumura S, Nakagawa K, Mano H, Ishikawa Y
Nat Med 2012 Feb 12;18(3):378-81
PMID 22327623
 
KIF5B-RET fusions in lung adenocarcinoma
Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, Iwakawa R, Ogiwara H, Oike T, Enari M, Schetter AJ, Okayama H, Haugen A, Skaug V, Chiku S, Yamanaka I, Arai Y, Watanabe S, Sekine I, Ogawa S, Harris CC, Tsuda H, Yoshida T, Yokota J, Shibata T
Nat Med 2012 Feb 12;18(3):375-7
PMID 22327624
 
KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung
Yokota K, Sasaki H, Okuda K, Shimizu S, Shitara M, Hikosaka Y, Moriyama S, Yano M, Fujii Y
Oncol Rep 2012 Oct;28(4):1187-92
PMID 22797671
 
The transcriptional landscape and mutational profile of lung adenocarcinoma
Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, Bleazard T, Lee J, Jung YJ, Kim JO, Shin JY, Yu SB, Kim J, Lee ER, Kang CH, Park IK, Rhee H, Lee SH, Kim JI, Kang JH, Kim YT
Genome Res 2012 Nov;22(11):2109-19
PMID 22975805
 
Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions
Suehara Y, Arcila M, Wang L, Hasanovic A, Ang D, Ito T, Kimura Y, Drilon A, Guha U, Rusch V, Kris MG, Zakowski MF, Rizvi N, Khanin R, Ladanyi M
Clin Cancer Res 2012 Dec 15;18(24):6599-608
PMID 23052255
 
RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
Wang R, Hu H, Pan Y, Li Y, Ye T, Li C, Luo X, Wang L, Li H, Zhang Y, Li F, Lu Y, Lu Q, Xu J, Garfield D, Shen L, Ji H, Pao W, Sun Y, Chen H
J Clin Oncol 2012 Dec 10;30(35):4352-9
PMID 23150706
 
 


Translocations implicated (Data extracted from papers in the Atlas)

 inv(10)(p11q11) KIF5B/RET

External links

Mitelman database inv(10)(p11q11) [CaseList]    inv(10)(p11q11) [Transloc - MCList] KIF5B/RET [Fusion - MCList]
COSMIC[ KIF5B ]   [ RET ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaseinv(10)(p11q11) KIF5B/RET
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Tue Feb 6 17:45:40 CET 2018


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