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inv(12)(q13q13) NAB2/STAT6

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 6608
Phylum Soft Tissue::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

Clinics and Pathology

Disease Soft Tissue:Soft Tissue tumours: Fibroblastic/Myofibroblastic tumours: Extrapleural solitary fibrous tumour: inv(12)(q13q13) NAB2/STAT6

Genes involved and Proteins

Gene NameNAB2

Gene NameSTAT6
Location 12q13

Bibliography

 
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein
Schweizer L, Koelsche C, Sahm F, Piro RM, Capper D, Reuss DE, Pusch S, Habel A, Meyer J, Göck T, Jones DT, Mawrin C, Schittenhelm J, Becker A, Heim S, Simon M, Herold-Mende C, Mechtersheimer G, Paulus W, König R, Wiestler OD, Pfister SM, von Deimling A
Acta Neuropathol 2013 May;125(5):651-8
PMID 23575898
 
Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor
Mohajeri A, Tayebwa J, Collin A, Nilsson J, Magnusson L, von Steyern FV, Brosjö O, Domanski HA, Larsson O, Sciot R, Debiec-Rychter M, Hornick JL, Mandahl N, Nord KH, Mertens F
Genes Chromosomes Cancer 2013 Oct;52(10):873-86
PMID 23761323
 
 
 
 
 
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors
Chmielecki J, Crago AM, Rosenberg M, O'Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M
Nat Genet 2013 Feb;45(2):131-2
PMID 23313954
 
 
 


Translocations implicated (Data extracted from papers in the Atlas)

 inv(12)(q13q13) NAB2/STAT6

External links

Mitelman database inv(12)(q13q13) [CaseList]     inv(12)(q13q13) [Transloc - MCList]   NAB2/STAT6 Fusion - MCList]
COSMIC[ NAB2 ]   [ STAT6 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaseinv(12)(q13q13) NAB2/STAT6
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Mon May 14 13:48:59 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.