t(1;2)(q31;p23) TPR/ALK

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

TPR

Location

1q31.1

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
91214811997Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.86
118889362002Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.45
247360822014A novel fusion of TPR and ALK in lung adenocarcinoma.34
256028012015Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions.30
95004711998Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation.17

Bibliography

Pubmed IDLast YearTitleAuthors
247360822014A novel fusion of TPR and ALK in lung adenocarcinoma.Choi YL et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(1;2)(q31;p23) TPR/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/104316/t(1;2)(q31;p23)-tpr-alk