Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(2;3)(q13;p25) PAX8/PPARG

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Atlas_Id 105435
Phylum Neuro-Endocrine/Endocrine system: Thyroid::
WHO/OMS Classification Neuro-Endocrine/Endocrine system
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Thyroid: Adenocarcinoma

Disease Thyroid: Adenoma

Genes involved and Proteins

Gene NamePAX8
Location 2q14.1

Gene NamePPARG
Location 3p25.2


PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]
Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA
Science 2000 Aug 25;289(5483):1357-60
PMID 10958784
Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas
Marques AR, Espadinha C, Catarino AL, Moniz S, Pereira T, Sobrinho LG, Leite V
J Clin Endocrinol Metab 2002 Aug;87(8):3947-52
PMID 12161538
Simultaneous occurrence of PAX8-PPARg and RET-PTC3 rearrangements in a follicular variant of papillary thyroid carcinoma
Caria P, Dettori T, Frau DV, Di Oto E, Morandi L, Parmeggiani A, Tallini G, Vanni R
Am J Surg Pathol 2012 Sep;36(9):1415-20
PMID 22895275
Diagnostic and prognostic implications of the PAX8-PPARγ translocation in thyroid carcinomas-a TMA-based study of 226 cases
Boos LA, Dettmer M, Schmitt A, Rudolph T, Steinert H, Moch H, Sobrinho-Simões M, Komminoth P, Perren A
Histopathology 2013 Aug;63(2):234-41
PMID 23738683

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;3)(q13;p25) PAX8/PPARG

External links

Mitelman database t(2;3)(q13;p25) [CaseList]     t(2;3)(q13;p25) [Transloc - MCList]   PAX8/PPARG Fusion - MCList]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(2;3)(q13;p25) PAX8/PPARG
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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indexed on : Mon Sep 21 11:28:23 CEST 2020

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