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t(2;3)(q13;p25) PAX8/PPARG

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 5136
Phylum Neuro-Endocrine::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

Clinics and Pathology

Disease Neuro-Endocrine:Neuro-Endocrine/Endocrine System: Thyroid: Follicular carcinoma: t(2;3)(q13;p25) PAX8/PPARG

Genes involved and Proteins

Gene NamePAX8
Location 2q14.1

Gene NamePPARG
Location 3p25.2


PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]
Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA
Science 2000 Aug 25;289(5483):1357-60
PMID 10958784
Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas
Marques AR, Espadinha C, Catarino AL, Moniz S, Pereira T, Sobrinho LG, Leite V
J Clin Endocrinol Metab 2002 Aug;87(8):3947-52
PMID 12161538
Simultaneous occurrence of PAX8-PPARg and RET-PTC3 rearrangements in a follicular variant of papillary thyroid carcinoma
Caria P, Dettori T, Frau DV, Di Oto E, Morandi L, Parmeggiani A, Tallini G, Vanni R
Am J Surg Pathol 2012 Sep;36(9):1415-20
PMID 22895275
Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas
Cheung L, Messina M, Gill A, Clarkson A, Learoyd D, Delbridge L, Wentworth J, Philips J, Clifton-Bligh R, Robinson BG
J Clin Endocrinol Metab 2003 Jan;88(1):354-7
PMID 12519876

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;3)(q13;p25) PAX8/PPARG

External links

Mitelman database t(2;3)(q13;p25) [CaseList]    t(2;3)(q13;p25) [Transloc - MCList] PAX8/PPARG [Fusion - MCList]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(2;3)(q13;p25) PAX8/PPARG
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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indexed on : Tue Feb 6 17:52:02 CET 2018

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