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t(2;4)(q36;q31) PAX3/MAML3

Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 105453
Phylum Head and Neck: Nose-Nasopharynx::
WHO/OMS Classification Head and Neck
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Nose-Nasopharynx: Mesenchymal tumor, special type

Genes involved and Proteins

Gene NamePAX3
Location 2q36.1

Gene NameMAML3
Location 4q31.1


Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma
Wang X, Bledsoe KL, Graham RP, Asmann YW, Viswanatha DS, Lewis JE, Lewis JT, Chou MM, Yaszemski MJ, Jen J, Westendorf JJ, Oliveira AM
Nat Genet 2014 Jul;46(7):666-8
PMID 24859338
Novel PAX3-NCOA1 Fusions in Biphenotypic Sinonasal Sarcoma With Focal Rhabdomyoblastic Differentiation
Huang SC, Ghossein RA, Bishop JA, Zhang L, Chen TC, Huang HY, Antonescu CR
Am J Surg Pathol 2016 Jan;40(1):51-9
PMID 26371783
Fusion gene profile of biphenotypic sinonasal sarcoma: an analysis of 44 cases
Fritchie KJ, Jin L, Wang X, Graham RP, Torbenson MS, Lewis JE, Rivera M, Garcia JJ, Schembri-Wismayer DJ, Westendorf JJ, Chou MM, Dong J, Oliveira AM
Histopathology 2016 Dec;69(6):930-936
PMID 27454570

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;4)(q36;q31) PAX3/MAML3

External links

Mitelman database t(2;4)(q36;q31) [CaseList]     t(2;4)(q36;q31) [Transloc - MCList]   PAX3/MAML3 Fusion - MCList]
COSMIC[ PAX3 ]   [ MAML3 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(2;4)(q36;q31) PAX3/MAML3
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

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indexed on : Thu Feb 14 17:48:58 CET 2019

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