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t(3;12)(q28;q14) HMGA2/LPP

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 6601
Phylum Soft Tissue::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

Clinics and Pathology

Disease Soft Tissue:Soft Tissue tumours: Benign Lipomatous: Lipoma: t(3;12)(q28;q14) HMGA2/LPP

Genes involved and Proteins

Gene NameHMGA2
Location 12q14.3

Gene NameLPP
Location 2q37.1

Bibliography

Clinicopathological features of lipomas with gene fusions involving HMGA2
Hatano H, Morita T, Ogose A, Hotta T, Kobayashi H, Segawa H, Uchiyama T, Takenouchi T, Sato T
Anticancer Res 2008 Jan-Feb;28(1B):535-8
PMID 18383898
 
Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains
Ashar HR, Fejzo MS, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K
Cell 1995 Jul 14;82(1):57-65
PMID 7606786
 
Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours
Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJ
Nat Genet 1995 Aug;10(4):436-44
PMID 7670494
 
LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family
Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ
Genomics 1996 Aug 15;36(1):118-29
PMID 8812423
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;12)(q28;q14) HMGA2/LPP

External links

Mitelman database t(3;12)(q28;q14) [CaseList]     t(3;12)(q28;q14) [Transloc - MCList]   HMGA2/LPP Fusion - MCList]
COSMIC[ HMGA2 ]   [ LPP ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(3;12)(q28;q14) HMGA2/LPP
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Mon May 14 14:00:30 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.