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t(6;6)(p21;p21) MDGA1/PTK7

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

Atlas_Id 100805
Phylum Nervous system: Central Nervous system::
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Nervous system: Central Nervous system:Astrocytoma, grade III-IV/Glioblastoma

Genes involved and Proteins

Gene NameMDGA1
Location 6p21.2

Gene NamePTK7
Location 6p21.1

Bibliography

A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival
Zheng S, Fu J, Vegesna R, Mao Y, Heathcock LE, Torres-Garcia W, Ezhilarasan R, Wang S, McKenna A, Chin L, Brennan CW, Yung WK, Weinstein JN, Aldape KD, Sulman EP, Chen K, Koul D, Verhaak RG
Genes Dev 2013 Jul 1;27(13):1462-72
PMID 23796897
 
The landscape and therapeutic relevance of cancer-associated transcript fusions
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54
PMID 25500544
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(6;6)(p21;p21) MDGA1/PTK7

External links

Mitelman database t(6;6)(p21;p21) [CaseList]     t(6;6)(p21;p21) [Transloc - MCList]   MDGA1/PTK7 Fusion - MCList]
COSMIC[ MDGA1 ]   [ PTK7 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(6;6)(p21;p21) MDGA1/PTK7
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


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indexed on : Fri Jun 22 17:59:18 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.